#BringItAllBack
Indonesia
Brazil
Langkah
menurunkan kadar Kadar Glukosa
glukosa darah glukosa ditransport ke
darah tinggi dalam sel
Sel β pankreas
(Insulin) mensekresi insulin
otot, lemak
dan hati
Sal.
cerna
Pankreas
2 menit
• Incretin Mimetics :
Exenatide (Byetta™ – AstraZeneca)
Liraglutide (Victoza® – Novo Nordisk)
• Incretin Enchancers :
Saxagliptin (Onglyza™ – Kalbe Farma)
Linagliptin (Trajenta™ – Boehringer Ingelheim)
Sitagliptin (Januvia™ – Merck Sharp & Dohme)
Vildagliptin (Galvus® – Novartis)
DPP-IV Inhibitors Market
17,06%
MARKET SIZE: 186 M
60 GROWTH: 12,36% 16%
40 6,41% 8%
Sebagai Market-leader dan pertumbuhan
terbesar adalah Boehringer-Ingelheim
30 4%
1,45%
Market DPP-IV Inhibitors murni bertumbuh dari
sektor Reguler, dan semua obat belum off-
20 0%
patent
-3,03%
10 -4%
0 -8%
B.INGELHEIM MSD NOVARTIS A.ZENECA
Q4 14 Q4 15 Q4 16 GR 2016
DPP-IV Inhibitors Market
60 ITMA MAT Q4 2016 A10N (TC IV)
Miliar Rupiah
110%
Market leader adalah Trajenta (Boehringer
50 Ingelheim) memliki brand equity yang sangat
kuat, dengan sales 48 M / tahun dan masih
sangat agresif dengan support ilmiah dalam
70%
40 dan luar negeri
51%
Pertumbuhan yang lebih di gerakan oleh
32% 33%
golongan DPP-IV Inhibitor kombinasi +
30
Metformin, dimana saat ini mengarah ke Terapi 30%
13% Agreif pada pasien DM Tipe-2
7% 8%
20 -1%
Dengan strategi yang tepat, Kombiglyze-XR
-16%yang sangat besar khususnya -10%
memiliki potensi
di dokter Internist dan Endokrin
10
- -50%
TRAJENTA - JANUMET GALVUSMET - JANUVIA - TRAJENTA DUO GALVUS - KOMBIGLYZE - ONGLYZA -
B.INGELHEIM - MSD NOVARTIS MSD - B.INGELHEIM NOVARTIS A.ZENECA A.ZENECA
Q4 16 Growth
International Guidelines
ONGLYZA (Saxagliptin 5 mg)
Manufactured by AstraZeneca Pharmaceuticals LP, Mount
Vernon, IN 47620, USA.
Packaged by Bristol-Myers Squibb S.r.l. 03012 Anagni, Italy.
For AstraZeneca UK Limited, Macclesfield, Cheshire, SK10
2NA, United Kingdom
Imported by PT AstraZeneca Indonesia, Cikarang, Bekasi –
Indonesia
Reg. No.: DKI1196300817A1
Store below 30°C.
Pack size : Box of 2 blisters @ 14 film-coated tablets
Penurunan HbA1c ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
Efek Samping
● ● ● ● ● ● ● ● ● ● ●
Hipoglikemia
Peningkatan Berat
Badan ↓↓ ↑ ↑↑ ↓ ↑↑↑
Diabetes +
Diabetes + Diabetes + Obat Diabetes Diabetes HbA1c
Positioning Gangguan
Obesitas Dislipidemia Lini Pertama > 7,5%
Fungsi Hati
Saxagliptin Metformin
Gut Gut
Lower levels of the incretin hormone
GLP-1 are released from the gut
Decreases
Decreases(↓)
(↓)intestinal
intestinal
S
DPP-4
in patients with type 2 diabetes
Saxagliptin inhibits DPP-4 enzyme glucose
glucose
absorption
absorption
Enzymes
activity
Saxagliptin increases (↑) incretin
concentrations in the bloodstream
Pancreas Pancreas
Pancreas
…in response to ↑ GLP-1 concentrations: Insulin secretion
Insulin remains
secretion remainsunchanged
unchanged
↓ glucagon release ↑ insulin release while fasting insulininsulin
while fasting levels levels
and and
from cells from cells day-long
day-longplasma
plasma insulin response
insulin may
response may
decrease decrease
Liver
Liver
…in response to ↓ glucagon release:
↓ glucose output by the liver
↓ hepatic glucose output
Muscle/Fat Muscle/Fat
…in response to ↑ insulin release: Improves
Improves insulin
insulin sensitivity
sensitivity and
and ↑
↑ peripheral glucose uptake ↑glucose
glucose uptake
uptake and andutilization
utilization
Baseline HbA1C <8% - >10% >7.5% - <11% >7.5% - >9% >7.5% - <11%
HbA1C reduction
combination with 3.3% 3% 1.7% 3.2%
metformin
TRAJENTA TAB FLM CTD 5MG 30 BLIS 389,328 once daily 12,977.59
TRAJENTA DUO TAB FLM CTD 2.5MG/500 30 BLIS 199,605 twice a day 13,306.97
TRAJENTA DUO TAB FLM CTD 2.5MG/850 30 BLIS 199,605 twice a day 13,306.97
TRAJENTA DUO TAB FLM CTD 2.5MG/1G 30 BLIS 199,605 twice a day 13,306.97
JANUVIA TAB FLM CTD 100MG 28 362,342 once daily 12,940.79
JANUVIA TAB FLM CTD 50MG 28 362,342 once daily 12,940.79
JANUMET TAB FLM CTD 50MG/500 28 BLIS 182,381 twice a day 13,027.21
JANUMET TAB FLM CTD 50MG/1G 28 BLIS 182,381 twice a day 13,027.21
GALVUS TAB 50MG 28 BLIS 175,000 twice a day 12,500.00
GALVUSMET TAB FLM CTD 50MG/500 30 BLIS 187,500 twice a day 12,500.00
GALVUSMET TAB FLM CTD 50MG/850 30 BLIS 187,500 twice a day 12,500.00
ONGLYZA TAB FLM CTD 5MG 28 BLIS 302,781 once daily 10,813.61
KOMBIGLYZE TAB FC XR 5MG/500 28 BLIS 313,725 once daily 11,204.46
Brand Communication
(2) Steady Release of Insulin Overnight
THANK YOU