In Indonesia, based on the results of the Household Health Survey (SKRT) in 1995, it shows that TB
disease is the third leading cause of death after cardiovascular disease and respiratory diseases in all age
groups, and number one in the infectious diseases group. Tuberculosis is a direct infectious disease
caused by bacteria / TB germs. Currently there are various types of antimicrobial chemicals that can be
used as disinfectants to inhibit and kill germs, such as phenol, alcohol, aldehyde, chlorine, metal weight,
and compounds including soap and detergents. Soap is produced through the saponification process,
which is the hydrolysis of fat into fatty acids and glycerol in alkaline conditions. This study aims to
determine the effect of various types of soap on the efficiency of reducing tuberculosis germs in sputum
patients with positive TB. This study was arranged in a factorial design randomized complete group with
three replications. The research data were analyzed statistically using a 1% diversity analysis and if there
was a significant effect, then the 5% DMRT test was carried out to determine the difference in effect
between treatment averages. Sputum of positive TB patients tested in this study contained an average of
67 germs of tuberculosis.