0,693

K =
t½
0,693
= 7,3 jam

= 0,094/ jam
a. Fraksi = 1 – e-k.
= 1 – e-0,094.8
= 1 – e-0,752
= 1 – 0,471
= 0,529
dosis
D maks ∞ =
1−e−k .
1000 mg
= −0,094.8
1−e
1000 mg
=
1−e−0,752
1000 mg
= 1−0,471
1000 mg
= 0,529

= 1890,35 mg
D min ∞ = D maks ∞ - Dinv
= 1890,35 mg – 1000 mg
= 890,35 mg
¿ 1−e−n . k. -k.t
b. C4 = Vd ( )e
1−e−k .
1000 mg 1−e−3 .0,094 . 8 -0,094 . 4
= ( )e
11,2 L 1−e−0,094 .8
1−e−2,256 -0,376
= 89,28 mg/L ( )e
1−e−0,752
1−0,104
= 89,28 mg/L ( 1−0,471 ) 0,686
0,896
= 89,28 mg/L ( ) 0, 686
0,529
= 89,28 mg/L . 1,693 . 0,686
= 103,689 mg/L
 ¿ 1−e−n . k. -k.t
C6 = Vd ( )e
1−e−k .
1000 mg 1−e−3 .0,094 . 8 -0,094 . 6
= ( )e
11,2 L 1−e−0,094 .8
1−e−2,256 -0,564
= 89,28 mg/L ( )e
1−e−0,752
1−0,104
= 89,28 mg/L ( 1−0,471 ) 0,568
0,896
= 89,28 mg/L ( ) 0,568
0,529
= 89,28 mg/L . 1,693 . 0,568
= 85,853 mg/L
¿ 1
c. Css maks = Vd ( −k . )
1−e
1000 mg 1
= 11,2 L ( )
1−e−0,094 .8
1
= 89,28 mg/L ( )
1−e−0,752
1
= 89,28 mg/L ( )
1−0,471
1
= 89,28 mg/L ( 0,529 )

= 89,28 mg/L . 1,890

= 168,73 mg/L
Css min = Css max . e-k. 
= 168,73 mg/L . e-0,094 . 8
= 168,73 mg/L . e-0,752
= 168,73 mg/L . 0,471
= 79,47 mg/L
CL = k.Vd
= 0,094/ jam . 11,2 L
= 1,052 L/jam
F . Dosis
Css Av =
CL. τ
0,529 . 1000 mg
=
1,052 L/ jam . 8 jam
 529 mg
=
8,416 L
= 62,85 mg/L
¿ 1
d. Css = Vd ( ) e-k.t
1−e−k .
1000 mg 1
= ( −0,094 .8 ) e
-0,094.4
11,2 L 1−e
1
= 89,28 mg/L ( ) e-0,376
1−e−0,752
1
= 89,28 mg/L ( ) 0,686
1−0,471
1
= 89,28 mg/L ( 0,529 ) 0,686

= 89,28 mg/L . 1,890 . 0,686

= 115,74 mg/L
e. CL = k.Vd
= 0,094/ jam . 11,2 L
= 1,052 L/jam
AUC = Css av x 
= 62,85 mg/L . 6 jam
= 377,1 mg jam/L