T (Jam) Cp (ng/mL) Cp terminal C Residual 1 Cp Distribusi

0.5 6.30 6.8770273963808 -0.5770273963808 5.49490579127614

1 16.45 6.8154118357407 9.63458816425928 5.01694630715806
1.5 22.21 6.7543483271857 15.4556516728143 4.58056083306598
2 12.33 6.6938319245381 5.63616807546191 4.18213316644073
3 10.10 6.5744208734373 3.52557912656272 3.4862318133421
12 6.25 5.5911584067605 0.658841593239551 0.67761326679805
18 5.25 5.0187780819222 0.231221918077798 0.2273695624846
22 4.80
55 2.34
78 1.75

Persamaan :
Y=(6,0814-0,182x)+(6,9392-0,018x)-(3,758-0,5828x)
 C residual 2 AUC
6.0719331876569 5.6875
KOMPARTEMEN 2 TERBUKA
4.6176418571012 9.665
10.875090839748 8.635 100.00

1.4540349090212 11.215
0.0393473132206 73.575
0.0187716735585 34.5
0.0038523555932 20.1 10.00
117.81
47.035

AUC TOTAL 328.2225 1.00

0 10 20 30 40 50 60 70 80

Kurva Arbsorbsi
12

10

8 f(x) = 3.75797712382043 exp( 0.582797893337684 x )

R² = 0.443657426452389
6

0
0.4 0.6 0.8 1 1.2 1.4
ERBUKA Kurva Distribusi
4
3.5
f(x) = 6.01841889499297 exp( − 0.182002379621816 x )
3 R² = 0.999682988321348
2.5
2
1.5
1
0.5
0
50 60 70 80 90 2 4 6 8 10 12 14 16 18 20

Kurva Terminal
6.00

5.00

893337684 x ) f(x) = 6.93915357963218 exp( − 0.018278430827459 x )

4.00 R² = 0.981239352725929

3.00

2.00

1.00

0.00
1.2 1.4 1.6 10 20 30 40 50 60 70 80 90
16 18 20

80 90
T (Jam) Cp (ng/mL) CP Terminal Cp Residual 1 Cp Distribusi Cp Residual 2
0.5 6.89 8.89244108523664 -2.00244108524 3.55414285344 5.55658393867425
1 17.01 8.870237748259 8.139762251741 3.30393414659 4.83582810515515
1.5 24.33 8.84808985029617 15.4819101497 3.07133992502 12.4105702246871
2 13.03 8.82599725292371 4.204002747076 2.85512014359 1.34888260348935
3 11.11 8.78197740797942 2.328022592021 2.4672740656 0.139251473577717
12 9.16 8.3955482875435 0.764451712456 0.66306246605 0.101389246403974
18 8.40 8.14742233733742 0.252577662663 0.27612929137 0.023551628707036
22 8.03
55 6.75
78 6.11
AUC TOTAL

Persamaan :
Y=(3,8233-0,146x)+(8,9147-0,005x)-(3,1048-0,8036x)
AUC
5.975
10.335 KOMPARTEMEN 2 TERBUKA
9.34
100
12.07
91.215
52.68
32.86 10 Column B

CP
243.87
147.89

1
606.235 0 10 20 30 40 50 60 70 80 90
WAKTU

KURVA ELIMINASI
9
8
f(x) = 8.91470145225144 exp( − 0.004906138590236 x )
7 R² = 0.9972553353593
6
5 Column B
CP

4 Exponential (Column B)
3
2
1
0
10 20 30 40 50 60 70 80 90
WAKTU
KA KURVA DISTRIBUSI
2.5
f(x) = 3.82325829615522 exp( − 0.146149173779357 x )
2 R² = 0.987205445783348

1.5 Column D
Column B CP
Exponential (Column D)
1

0.5

0
90 2 4 6 8 10 12 14 16 18 20
WAKTU

KURVA ABSORBSI
14
0236 x ) 12
10
f(x) = 3.10484291879552 exp( 0.803565027044531 x )
Column B 8 R² = 0.62355252685384
Column F
Exponential (Column B)
Cp

6 Exponential (Column F)

4
2
0
0.4 0.6 0.8 1 1.2 1.4 1.6
waktu
(Column D)

l (Column F)
Clozapine Tunggal

Cp =(6,0814-0,182x)+(6,9392-0,018x)-(3,758-0,5828x)

Clozapine Kombinasi Flufoxamine

Cp=(3,8233-0,146x)+(8,9147-0,005x)-(3,1048-0,8036x)
 Parameter Clozapine Tunggal Clozapine Kombinasi
Ke Beta 0.018 0.005
Ke Alpha 0.182 0.146
Ka 0.5828 0.8036
T 1/2 Beta 38.5 138.6
T 1/2 Alpha 3.80769230769231 4.74657534246575
CL 14558.4755830172 33236.1476513033
Cmax 5.55104446658756 10.129219094588
Tmax 6.15008531761276 6.35356977786432
F 0.6 0.6
A 6.0184 3.8233
B 6.9392 8.9147
C 3.758 3.1048
AUC 412.131061785008 1805.26337256319

NAMA OBAT satuan Mg satuan ng

Dosis Clozapine 10 10000000
Dosis Fluvoxamine 100 100000000
 SATUAN
jam-1
jam-1
jam-1
jam
jam
L
µ/ml
jam/menit
N
 Parameter Clozapine Tunggal Clozapine Kombinasi
Ke Beta 0.018 0.005
Ke Alpha 0.182 0.146
Ka 0.5828 0.8036
T 1/2 Beta 38.5 138.6
T 1/2 Alpha 3.80769230769231 4.74657534246575
CL 14558.4755830172 33236.1476513033
Cmax 5.55104446658756 10.129219094588
Tmax 6.15008531761276 6.35356977786432
F 0.6 0.6
A 6.0184 3.8233
B 6.9392 8.9147
C 3.758 3.1048
AUC 412.131061785008 1805.26337256319

NAMA OBAT satuan Mg satuan ng

Dosis Clozapine 10 10000000
Dosis Fluvoxamine 100 100000000
Persentase (%) Perubahan Interpretasi Hasil
72.2222222222222 terjadi penurunan
19.7802197802198 terjadi penurunan
37.8860672614962 terjadi penurunan
260 terjadi kenaikan
24.6575342465754 terjadi kenaikan
128.294147019582 terjadi kenaikan
82.4741119541921 terjadi penurunan
3.30864451048854 terjadi kenaikan
0 tidak terjadi penurunan dan kenaikan seimbang
36.4731490097036 terjadi kenaikan
28.4686995619092 terjadi kenaikan
17.3815859499734 terjadi kenaikan
338.031378839609 terjadi kenaikan