ADLN – PERPUSTAKAAN UNIVERSITAS AIRLANGGA

KORELASI DERAJAT
HYPOXIC ISCHEMIC ENCEPHALOPATHY PADA ANAK
DENGAN NILAI FRACTIONAL ANISOTROPY
DAN MEAN DIFFUSIVITY
PADA DIFFUSION TENSOR IMAGING
Elly Yinawati1, Sri Andreani Utomo2
1
PPDS I Program Studi Ilmu Radiologi Fakultas Kedokteran Universitas
Airlangga – RSUD Dr. Soetomo Surabaya
2
Staf Pengajar Departemen Radiologi Fakultas Kedokteran Universitas Airlangga
– RSUD Dr. Soetomo Surabaya

ABSTRAK

Latar Belakang dan Tujuan : Diffusion Tensor Imaging (DTI) merupakan

sekuen MRI advance, yang dapat mendeteksi kelainan mikrostruktur dan
makrostruktur dari parenkim otak. Sekuen ini juga dapat mendeteksi abnormalitas
yang tidak tampak pada MRI konvensional. Tujuan penelitian ini adalah melihat
korelasi derajat hypoxic ischemic encephalopathy pada anak dengan nilai
fractional anisotropy dan mean diffusivity pada diffusion tensor imaging di RSUD
Dr. Soetomo.

Metode dan Bahan : Menggunakan metode observational analitik cross

sectional. Didapatkan 35 sampel pada periode 1 Maret hingga 31 Agustus 2016.

Hasil : Dari 35 sampel dibagi menjadi 2 kelompok usia, yaitu kelompok usia 1 (0-
24 bulan) dan kelompok 2 (diatas 24 bulan). Didapatkan 16 subjek HIE derajat 1,
12 subjek HIE derajat II, 7 subjek HIE derajat III. Pada kelompok usia 1, HIE
derajat I memiliki rerata persentase perubahan FA : 71.94% + 18.66%; MD :
28.06% + 17.98%; HIE derajat II memiliki rerata persentase perubahan FA :
78.51% + 4.63%; MD : 61.69% + 8.11%; HIE derajat III memiliki rerata
persentase perubahan FA : 77.29% + 6.94%; MD : 61.35% + 14.71%. Sedangkan
pada kelompok usia 2, HIE derajat I memiliki rerata persentase perubahan FA :
71.80% + 17.86%; MD : 40.35% + 30.89%; HIE derajat II memiliki rerata
persentase perubahan FA : 86.10% + 4.07%; MD : 72.55% + 75.50%; HIE derajat
III memiliki rerata persentase perubahan FA : 88.47% + 3.23%; MD : 116.14% +
92.15%.

Kesimpulan : Tidak terdapat korelasi antara nilai FA dengan HIE derajat I, II, III
pada kelompok usia I; terdapat korelasi yang kuat antara nilai MD dengan HIE
derajat I, II, III pada kelompok usia 1; terdapat korelasi yang sedang antara nilai
FA dengan HIE derajat I, II, III pada kelompok usia 2; tidak terdapat korelasi
antara nilai MD dengan HIE derajat I, II, III pada kelompok usia 2.

Kata kunci : Hypoxic ischemic encephalopathy, Fractional Anisotropy, Mean

Diffusivity, Diffusion Tensor Imaging, Magnetic Resonance Imaging
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LAPORAN PENELITIAN KORELASI DERAJAT HYPOXIC... ELLY YINAWATI

 ADLN – PERPUSTAKAAN UNIVERSITAS AIRLANGGA

CORRELATION BETWEEN HYPOXIC ISCHEMIC

ENCEPHALOPATHY GRADE IN CHILDREN WITH
FRACTIONAL ANISOTROPY AND MEAN DIFFUSIVITY
SCORE IN DIFFUSION TENSOR IMAGING
Elly Yinawati1, Sri Andreani Utomo2
1
Radiology Resident Faculty of Medicine Airlangga University – Dr. Soetomo
2
Radiology Staff Lecturer Departement of Radiology Faculty Medicine Airlangga
University – Dr. Soetomo Hospital Surabaya

ABSTRACT

Background and Purpose : Diffusion Tensor Imaging (DTI) is an advanced MRI

sequence, which can detect microstructure and macrostructure brain parenchyme
abnormality. This sequence also can detect the abnormality which not shown in
convensional MRI. Purpose of this study is to predict the correlation between
hypoxic ischemic encephalopthy grade in children with fractional anisotropy and
mean diffusivity score in diffusion tensor imaging at Dr. Soetomo Hospital.

Materials and Methods : The subjects were taken with cross sectional method.
There were 35 sample between March 1st until August 31st 2016.

Results : 35 subjects were divided in to 2 groups, group 1 (age between 0-24

months old); group 2 (after 24 months old). There were 16 subjects with HIE
grade I, 12 subjects with HIE grade II, 7 subjects with HIE grade III. In group 1,
the mean percentage change of FA at HIE grade I : 71.94% + 18.66%; MD :
28.06% + 17.98%; mean percentage change of FA at HIE grade II : 78.51% +
4.63%; MD : 61.69% + 8.11%; the mean percentage change of FA at HIE grade
III : 77.29% + 6.94%; MD : 61.35% + 14.71%. In group 2, the mean percentage
change of FA at HIE grade I : 71.80% + 17.86%; MD : 40.35% + 30.89%; the
mean percentage change of FA at HIE grade II : 86.10% + 4.07%; MD : 72.55% +
75.50%; the mean percentage change of FA at HIE grade III : 88.47% + 3.23%;
MD : 116.14% + 92.15%.

Conclusions : There was no correlation between FA score with HIE grade I, II,
III in group 1; there was strong correlation between MD score with HIE grade I,
II, III in group 1; there was medium correlation between FA score with HIE grade
I, II, III in group 2; there was no correlation between MD score with HIE grade I,
II, III in group 2.

Keywords : Hypoxic ischemic encephalopathy, Fractional Anisotropy, Mean

Diffusivity, Diffusion Tensor Imaging, Magnetic Resonance Imaging

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LAPORAN PENELITIAN KORELASI DERAJAT HYPOXIC... ELLY YINAWATI