BAB IV

PENUTUP

4.1 Kesimpulan
Transdermal merupakan sistem penghantaran obat yang menggunakan kulit sebagai
tempat pemberian obat. Mikrokapsul merupakan proses stabilisasi senyawa aktif dalam
mempertahankan sifat kimia, fisik, dan biologisnya, dari degradasi lingkungan (suhu, cahaya,
kelembaban) (Shirish H. Sonawane, 2020). Metode mikrokapsul digunakan dalam sistem
penghantaran obat untuk membentuk cangkang yang bertujuan melindungi bahan aktif, dan
mencegahnya terlepas sebelum mencapai lokasi yang ditargetkan.
Teknologi enkapsulasi terdiri dari 3 metode yaitu metode kimia, metode fisko-kimia, dan
metode fisko-mekanis. Metode kimia melibatkan reaksi polimerisasi secara interfasial dan in
situ, metode fisko-kimia yaitu koaservasi dan Rapid Expansion of Supercritical Fluid, metode
fisko-mekanis atau metode lain seperti Spray drying-congealing, Fluidized-bed, penguapan
larutan.
Penghantaran transdermal terdiri dari patch, semisolid, dan microneedle. Ada beberapa
evaluasi pada sediaan patch transdermal, yaitu bobot dan ketebalan patch, daya tahan lipat
tambalan, kehilangan pengeringan, dan penyerapan kelembaban.

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