Seventh Edition
Elaine N. Marieb
3. Output motorik
Respons terhadap stimulus yang terintegrasi
Respons dengan aktivasi otot atau kelenjar
Klasifikasi Struktural
Sistem saraf
• Sistem saraf pusat
otak
medulla spinalis
• Sistem saraf perifer
saraf yang berada di luar otak dan medulla
spinalis
Klasifikasi fungsional dari Sistem
Saraf Perifer
Divisi Sensorik (afferent)
Serabut saraf yang bertugas membawa
infosmasi KE sistem saraf pusat
Figure 7.1
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Klasifikasi fungsional dari Sistem
Saraf Perifer
Divisi Motorik (efferent)
Serabut saraf yang membawa impuls DARI
sistem saraf pusat
Figure 7.1
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Klasifikasi fungsional dari Sistem
Saraf Perifer
Divisi Motorik (efferent)
Dua subdivisi
Sistem saraf somatik = volunter
Sistem saraf autonom = involunter
Figure 7.1
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Organisasi Sistem Saraf
Figure 7.2
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Jaringan saraf : sel penunjang
(Neuroglia atau Glia)
Astrosit
Melimpah,
sel berbentuk
bintang Brace
neurons
Membentuk
barrier antara
kapiler
dan neuron
Figure 7.3a
Mengontrol
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Jaringan saraf : sel penunjang
(Neuroglia atau Glia)
Microglia (CNS)
Fagosit, Spider-like
Membuang debris
debris
Sel Ependymal (CNS)
Membatasi rongga dalam
otak dan medulla spinalis
Mengatur sirkulasi cairan
serebrospinalis
Figure 7.3b, c
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Jaringan saraf : sel penunjang
(Neuroglia atau Glia)
Oligodendrosit
(CNS)
Produksi
selubung myelin
disekitar
serabut saraf di
sistem
saraf pusat Figure 7.3d
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Neuroglia vs. Neuron
• Neuroglia bisa membelah diri.
• Neuron tidak mampu membelah diri
• Sebagian besar tumor otak adalah
“gliomas” yang tumbuh dari neuroglia
• Sebagian besar tumor otak melibatkan
sel neuroglia , bukan neuron.
• Consider the role of cell division in
cancer!
Sel penunjang dari sistem saraf
perifer
Sel satelit
Proteksi badan sel neuron
Sel Schwann
Membentuk selubung myelin pada sistem
saraf perifer
Figure 7.3e
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Jaringan saraf: Neuron
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Anatomi Neuron
Badan sel
Nucleus
Large
nucleolus
Figure 7.4a
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Anatomi Neuron
Prosesus
Dendrit –
konduksi impuls
menuju badan
sel
Akson –
konduksi impuls
dari badan sel
ke tempat lain
(only 1!)
Figure 7.4a
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Axons dan impuls saraf
Sel Schwann –
produksi selubung
myelin in jelly-roll like
fashion
Nodus Ranvier –
gaps in myelin
sheath along the
axon
Figure 7.5
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Application
• In Multiple Scleroses the myelin sheath
is destroyed.
• The myelin sheath hardens to a tissue
called the scleroses.
• This is considered an autoimmune disease.
• Why does MS appear to affect the muscles?
Lokasi badan sel neuron
Figure 7.6
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Klasifikasi struktural neuron
Neuron Multipolar – banyak penonjolan
dari badan selnya
Figure 7.8a
Figure 7.8b
Figure 7.8c
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Starting a Nerve Impulse
Depolarization – a
stimulus depolarizes
the neuron’s
membrane
A deploarized
membrane allows
sodium (Na+) to flow
inside the
membrane
The exchange of ions
initiates an action Figure 7.9a–c
potential in the
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The Action Potential
If the action potential (nerve impulse)
starts, it is propagated over the
entire axon
Potassium ions rush out of the neuron
after sodium ions rush in, which
repolarizes the membrane
The sodium-potassium pump restores
the original configuration
This action requires ATP
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Nerve Impulse Propagation
The impulse
continues to move
toward the cell body
Impulses travel
faster when fibers
have a myelin
sheath
Figure 7.9c–e
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Continuation of the Nerve Impulse
between Neurons
Impulses are able to cross the synapse
to another nerve
Neurotransmitter is released from a nerve’s
axon terminal
The dendrite of the next neuron has
receptors that are stimulated by
the neurotransmitter
An action potential is started in the
dendrite
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How Neurons Communicate at
Synapses
Figure 7.10
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The Reflex
Arc
Reflex – rapid, predictable, and
involuntary responses to
stimuli
Reflex arc – direct route from a sensory
neuron, to an interneuron, to an
effector
Figure 7.11a
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Simple Reflex
Arc
Figure 7.11b, c
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Types of Reflexes and Regulation
Autonomic reflexes
Smooth muscle regulation
Heart and blood pressure regulation
Regulation of glands
Digestive system regulation
Somatic reflexes
Activation of skeletal
muscles
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Sistem Saraf Pusat (SSP) /
Central Nervous System (CNS)
SSP berkembang dari neural tube
embrionik
The neural tube becomes the brain and
spinal cord
The opening of the neural tube becomes
the ventricles
Four chambers within the brain
Filled with cerebrospinal fluid
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Sistem
saraf
pusat
Regio Otak
Hemisfer
Cerebri
Diencep
halon
Batang otak
(medulla Figure 7.12
oblongata)
Cerebellum
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Hemisfer cerebri (Cerebrum)
Sepasang
(kanan dan
kiri)
bagian superior
otak
Include more
than half of
the brain
mass Figure 7.13a
Girus =
bagian yang
menonjol
Sulcus =
saluran
antara 2 girus
Figure 7.13a
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Area motorik dan sensorik otak
Figure 7.14
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Area khusus dalam Cerebrum
Figure 7.13c
Substansia
grisea
Lapisan
luar
Terdiri atas
badan sel
neuron
Figure 7.13a
Substansia alba
Traktus fibrosa
Contoh: corpus
callosum yang
menghubungkan
kedua hemisfer
cerebri
Figure 7.13a
Figure 7.15
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Hypothalamus
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Batang otak
Figure 7.15a
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Pons
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Medulla Oblongata
Bagian paling rendah dari batang otak
Akan berlanjut dengan medulla spinalis
Includes important fiber tracts
Berisi pusat:
Kontrol denyut jantung
Regulasi tekanan darah
Pernafasan
Menelan
Muntah
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Cerebellum
Figure 7.15a
Figure 9.2a
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Cummings.
CNS: Physical Support
Figure 9.2b
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Cummings.
Cavitas cranialis
Cavitas cranialis basis cranii
Proteksi SSP
Figure 7.16a
Cairan serebrospinalis
Blood brain barrier
Figure 7.16a
Dura mater
Lapisan penutup eksterna dua lapis
Periosteum – melekat pada permukaan
cranium
Lamina Meningealis – penutup luar
otak
Melipat ke dalam pada beberapa
tempat
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Meninges
Arachnoid layer
Lapisan
tengah Web-
like
Pia mater
Lapisan interna
Langsung
melekat pada
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Cerebrospinal Fluid
Figure 7.17a
Figure 7.17b
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Traumatic Brain Injuries (TBI)
Concussion
Slight or mild brain injury
Bleeding & tearing of nerve fibers happened
Recovery likely with some memory loss
Contusion
A more severe TBI
Nervous tissue destruction occurs
Nervous tissue does not regenerate
Cerebral edema
Swelling from the inflammatory response
May compress and kill brain tissue
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• Cerebral edema
– Swelling from the inflammatory response
– May compress and kill brain tissue
• Subdural hematoma
– Collection of blood below the dura
• Standards for these conditions were
revised in 2004.Please check out TBIs at
Mayoclinic.com for more current
information on diagnostic terminology.
Cerebrovascular Accident (CVA)
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Alzheimer’s Disease
Progressive degenerative brain disease
Mostly seen in the elderly, but may
begin in middle age
Structural changes in the brain include
abnormal protein deposits and
twisted fibers within neurons
Victims experience memory loss,
irritability, confusion and ultimately,
hallucinations and death
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Medulla spinalis
Memanjang dari
medulla oblongata
hingga setinggi T12
Di bawah T12 adalah
cauda equina
(sekumpulan serabut
saraf spinalis)
Pelebaran terjadi di
regio cervicalis
dan lumbaris Figure 7.18
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Anatomi medulla spinalis
Bagian eksterior adalah substansia alba
– traktus konduksi
Figure 7.19
Figure 7.19
Figure 7.19
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Sistem saraf perifer
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Struktur Saraf
Endoneurium
melingkupi setiap
serabut
Sekelompok serabut
saraf diikat menjadi
fasikulus oleh
perineurium
Fasikulus
dikumpulkan oleh by
epineurium Figure 7.20
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Klasifikasi Saraf
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Nervus Spinalis
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Nervus Spinalis
Figure 7.22a
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Sistem Saraf
Autonom
Merupakan cabang involunter dari
sistem saraf
Hanya terdiri dari serabut motorik
Dibagi menjadi dua divisi:
Divisi simpatis
Divisi parasimpatis
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Perbandingan Antara
Saraf Somatic dan
Autonom
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Anatomi Sistem Saraf
Autonom
Figure 7.25
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Fungsi
Autonomik
Simpatis– “fight-or-flight”
Respons pada stimulus unusual
Takes over to increase activities
Remember as the “E” division = exercise,
excitement, emergency, and
embarrassment
http://www.gwc.maricopa.edu/class/bio201/cn/
cra nial.htm
Nervus Olfactorius
Mukosa Olfactorius (SVA)→ Cribriform foramina → Bulbus
Olfactory
CN I: OLFACTORIUS
• Nervus cranialis I
• Fungsi :
– penghidu
• Clinical test for
damage:
– determine whether a
person can smell
something aromatic
Nervus Opticus
Sel Ganglion (SSA) → canalis Opticus → Corpus geniculatum
lateral
CN II: OPTICUS
• Nervus cranialis II
• Fungsi:
– Vision/penglihatan
• Clinical test for damage:
– tests peripheral vision
and visual acuity
• Kerusakan :
– kebutaan
Nervus Oculomotorius
• Components
– General somatic efferent fibers (GSE)
– General visceral efferent fibers (GVE)
• Main action supplies
– Superior, inferior and medial recti; inferior obliquus; levator palpebrae superioris
– Sphincter pupillea and ciliary muscle
• Ciliary ganglion: lies between optic nerve and lateral rectus
Oculomotor
nerve
CN III: OCULOMOTORIUS
• Nervus cranialis III
• Fungsi:
– Gerakan mata, membuka kelopak
mata, konstriksi pupil, focusing,
propriosepsi
• Clinical tests for injury:
– differences in pupil size;
pupillary response to light; eye
tracking
• Efek kerusakan
– dropping eyelid, dilasi
pupil, double vision
CN IV: TROCHLEARIS
• Nervus cranialis IV
• Fungsi: gerakan mata dan
propriosepsi
• Clinical test for injury: ability
to rotate eye inferolaterally
• Efek kerusakan – double vision,
patient tilts head toward
affected side
Nervus Trigeminus
CN V: TRIGEMINUS
• Nervus cranialis V
• Fungsi: nervus sensoris pada
wajah
• Clinical test for injury:
– corneal reflex; sense of
touch, pain, and temperature;
clench teeth; move mandible
side to side
• Efek kerusakan:
– Kehilangan sensasi dan
gangguan pengunyahan
Nervus Abducens
CN VI: ABDUCENS
• Nervus cranialis VI
• Fungsi: gerakan mata
• Clinical test: lateral eye movement
• Kerusakan : tidak mampu memutar bola
mata ke samping; pada istirahat – mata
rotadi ke arah medial karena aktivitas otot
antagonis
Lesi nervus abducens
Nervus Facialis
CN VII: FACIALIS
• Nervus cranialis VII
• Fungsi: ekspresi wajah; perasa di
lidah (sensorik)
• Clinical test: motor functions – close eyes,
smile, whistle, frown, raise eyebrows;
taste
• Efek kerusakan: ketidakmampuan
mengontrol otot wajah; gangguan perasa
di lidah
Nervus Vestibulocochlearis
Vestibular ganglion(SSA) ↘ ↗ Vestibular nuclei
Internal acoustic meatus
Cochlear ganglion (SSA) ↗ ↘
Cochlear nuclei
CN VIII:
VESTIBULOCOCHLEARIS
• Nervus cranialis VIII
• Fungsi: pendengaran dan
equilibrium (keseimbangan)
• Clinical tests: test hearing, balance,
and ability to walk a straight line
• Efek kerusakan: tuli, pusing, mual,
kehilangan keseimbangan dan
nystagmus
CN IX: GLOSSOPHARINGEUS
• Nervus cranial IX
• Fungsi: menelan, salivasi, muntah; sensasi nyeri,
tekanan dan rasa di lidah; sensasi nyeri pada faring
dan telinga eksterna
• Clinical tests: gag reflex, swallowing, and
coughing
• Efek kerusakan: kesulitan menelan
CN X: VAGUS
• Nervus cranialis X
• Fungsi: menelan, merasakan makanan, berbicara,
respirasi, cardiovaskuler, regulasi saluran
gastrointestinal; sensai lapar, kenyag dan fungsi
intestinal discomfort
• Clinical tests: test with cranial nerve IX
• Efek kerusakan: suara serak atau menghilang;
gangguan menelan dan motilitas pencernaan
NERVU
S
VAGUS
Internal
branch
External
branch
CN XI: ACCESSORIUS
• Nervus cranialis XI
• Fungsi: menelan; gerakan kepala, leher dan bahu
• Clinical tests: rotate head and shrug shoulders
against resistance
• Efek kerusakan: gangguan gerak kepala, leher
dan bahu; paralysis m. sternocleidomastoid
Nervus Hipoglossus
Hypoglossal nerve
CN XII: HIPOGLOSSUS
• Nervus cranialis XII
• Fungsi: gerakan lidah ketika
berbicara, manipulasi makanan, dan
menelan
• Clinical test: tongue function
• Efek kerusakan: gangguan bicara
dan menelan; atrofi lidah; lidah
tidak bisa menjulur keluar (protrusi)
SISTEM INDERA
Eye Anatomy
http://everlastingelephants.blogspot.com/2009/08/what-is-eye-cataract.html
Eye Anatomy
• Conjunctiva (Conj):
– Thin, clear layer of skin
– Covering of the front of
eye
– Covers the sclera and the
inside of the eyelids http://www.images.missionforvisionusa.org/anatomy/2005/11/conjunctiva-answers.html
– Function:
• Keeps bacteria and foreign
material from getting
behind eye
Eye Anatomy
• Sclera (S):
– “White of the eye”
– Tough, opaque tissue that
extends around the eye
– Surrounds the eye and
gives the eye its
http://www.thirdeyehealth.com/sclera.html
shape
– The sclera is attached to
the extraocular muscles
Eye Anatomy
• Extraocular Muscles
– 6 extraocular muscles th at
are attached to each eye
– Help move the eye left,
right, up, down and
diagonally
– These 6 muscles are: http://media.photobucket.com/image/introduction%20to%20eye%20anatomy/trimurtulu/Eye.jpg
• Superior rectus
• Inferior rectus
• Medial rectus
• Lateral rectus
Overview of the anatomy of the external
ear, middle ear and internal ear
Gross Anatomy of the Middle Ear
Gross Anatomy of the Inner Ear
Anatomy of the Cochlea