INTERAKSI OBAT PADA PASIEN OSTEOARTHRITIS DI

INSTALASI RAWAT JALAN RUMAH SAKIT UMUM

DAERAH Dr. H. ABDUL MOELEK
BANDAR LAMPUNG

Proposal Skripsi

Oleh :

Adella Reviani
173110003

FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM

UNIVERSITAS TULANG BAWANG LAMPUNG
BANDAR LAMPUNG
2021
 HALAMAN PERSETUJUAN

Judul skripsi : Interaksi Obat Pada Pasien Osteoartrhitis di Instalasi

Rawat Jalan Rumah Sakit Umum Abdul Moelek
Bandar Lampung.

Nama Mahasiswa : Adella Reviani

No. Pokok Mahasiswa : 173110003

Program Studi : Farmasi

Fakultas : Matematika Dan Ilmu Pengetahuan Alam

MENYETUJUI

Komisi Pembimbing

Pembimbing I Pembimbing II

apt, Lilik Koernia W,S.farm,MPH Novita Tri Wahyuni,S.KM,M.Kes

Ketua Program Studi

Mashuri Yusuf ,S.Si,M.Farm

 DAFTAR ISI

Halaman
JUDUL .......................................................................................................i

HALAMAN PENGESAHAN....................................................................ii

BAB I. PENDAHULUAN .........................................................................1

A. Latar Belakang...............................................................................1

B. Rumusan Masalah..........................................................................5

C. Tujuan Penelitian...........................................................................5

D. Manfaat penelitian.........................................................................6

BAB II. TINJAUAN PUSTAKA ...........................................................7

A. Osteoarthritis..................................................................................7

1. Definisi Osteoarthritis...............................................................7

2. Klasifikasi Osteoarthritis...........................................................8

3. Etiologi Osteoarthritis...............................................................8

4. Epidemologi Osteoarthritis.......................................................8

5. Faktor Resiko Osteoarthritis.....................................................9

6. Patofisiologi Osteoarthritis........................................................9

7. Manifestasi Klinis.....................................................................10

8. Gejala Klinis..............................................................................10

9. Penatalaksaan Osteoarthritis.....................................................10

a. Terapi Non Farmakologi......................................................11

b. Terapi Farmakologi..............................................................11
 B. Interaksi Obat.................................................................................15

1. Definisi Interaksi Obat..............................................................16

2. Mekanisme Interaksi Obat........................................................16

3. Tingkat Keparahan Interaksi Obat............................................20

C. Rumah Sakit...................................................................................21

1. Pengertian Rumah Sakit............................................................21

2. Klasifikasi Rumah Sakit............................................................21

3. Fungsi Rumah Sakit..................................................................21

4. Standar Pelayanan Kefarmasian Rumah Sakit..........................22

D. Rekam Medik.................................................................................22

E. Penggolongan Usia .......................................................................22

F. Rancangan Penelitian.....................................................................23

1. Prinsip Penelitian......................................................................24

2. Kerangka Konsep Penelitian.....................................................25

3. Kerangka Teori..........................................................................26

4. Definisi Operasional..................................................................27

5. Populasi, Sampel, dan Metode Pengambilan Sampel...............27

6. Kriteria Sampel.........................................................................28

7. Teknik Pengumpulan Data........................................................29

8. Analisis Data.............................................................................30

9. Tempat dan Waktu Penelitian...................................................30

BAB III METODE PENELITIAN ..........................................................31

A. Instrumen Penelitian......................................................................31

B. Prosedur Penelitian........................................................................31

C. Izin Penelitian................................................................................32
 D. Etika Penelitian..............................................................................33

E. Jadwal Penelitian...........................................................................34

F. Alur Penelitian...............................................................................35

DAFTAR PUSTAKA .....................................................................................36

LAMPIRAN ...................................................................................................37
 DAFTAR TABEL

Tabel

2.1 Klasifikasi Osteoarthritis ..........................................................................8

2.2 Faktor Resiko Osteoartritis .......................................................................9

2.3 Pembagian dosis NSAID ..........................................................................13

2.4 Data farmakokinetik Kortikosteroid .........................................................14

2.5 Data Farmakokinetik Analgesik Narkotika ..............................................15

2.8 Definisi Operasional .................................................................................28

 DAFTAR GAMBAR

Gambar

2.1 Sendi yang terkena Osteoartritis.............................................................10

2.2 Algoritma Tatalaksan Osteoartritis..........................................................12

2.3 Kerangka Konsep................................................................................26

2.4 Kerangka Teori...................................................................................27

3.1 Alur Penelitian ..........................................................................................31