Perhitungan

Perhitungan Dapar
Jenis dapar/kombinasi
Target pH
Kapsitas dapar
Diketahui : pKa1
pKa2

:
:
:
=
=

Dapar fosfat/ sodium fosfat dibasic, monobasic

8.0
pH stabil sodium sulfacinamide 8.0-9.5
0.8-8.0
= 0.01
2.15
BM Monosodium Fosfat
7.20
BM disodium Fosfat

pKa
7.20
Ka
Ka
pH

pKa3
=
12.38
= - Log [Ka]
= - Log [Ka]
= 10-32
= 6.3 x 10-8
= - Log [H+]

= - Log [H+]

[H+]

= 10-8

H +

H +

= 2,303 x C [ Ka ]

[ Ka ]

0.1

6.3 x 10
1 x 10
6.3 x 10

8
[ 8 ][1 x 10 ]

= 2,303 x C

[ 8]
[ 8]

0.1

6.3 x 10
39.69 x 10
[ 16 ]
= 2,303 x C [ 16 ]

= 138
= 142

0.1

= 2,303 x C x 0.1587

0.3654 C

0.1

0.1
0.3654

0.2736 moL/L

pH

= pKa + log

= 7.2 + log

[Garam]
[ Asam]

[Garam]
[ Asam ]

log

[Garam]
[ Asam]

= 7.2- 8

log

[Garam]
[ Asam]

= 0.8

[G]
[A]

= 6.31

[Garam]

= 6.31 [Asam]

C
= [Garam]+ [Asam]
0.184 = 6.31[Asam]+ [Asam]
0.184 = 7.631 [Asam]
0.2736
[Asam]
=
7.631 = 0.03585
[Garam]= 6.31 [Asam]
= 6.31 [0.03585]
= 0.2262

Massa disodium Fosfat

Massa monosodium Fosfat

=
=
=
=
=
=

BM x [Garam] x V
142 x 0.2262x 0.1
3.212%
BM x [Asam] x V
138 x 0.03585x 0.1
0.4947%

Perhitungan Bahan
Sodium Sulfacinamide =

0.5 gr
x 100 =10
5m:

PVA

1.4
x 5.5=0.077 gr
100

Na. Meta Bisulfit

0.1
x 5.5=0.0055 gr
100

Disodium Fosfat

3.212
x 5.5=0.1767 gr
100

Sodium Fosfat

0.4947
x 5.5=0.0272 gr
100

Benzalkonium Klorida =

Aqua Pro Injeksi

0.005
x 5.5=0.000275 gr
100

100% - (10+1.4+0.1+3.212+0.4947+0.005)

100% - 15.2117%

84.7883%

84.7883
100

x 5.5 = 4.66 mL