Jumlah Media 900 ml

Jumlah zat aktif 500 mg

Jumlah cuplikan 11

Time Point Ppm Mg Terdisolusi Faktor Koreksi mg Terdisolusi (setelah Dikoreksi)

0 0.435 0.3915 0 0.3915
1 2.157 1.9413 0.010785 1.952085
2 2.714 2.4426 0.01357 2.45617
3 4.03 3.627 0.02015 3.64715
4 5.17 4.653 0.02585 4.67885
5 7.904 7.1136 0.03952 7.15312
10 10.334 9.3006 0.05167 9.35227
15 10.98 9.882 0.0549 9.9369
20 10.891 9.8019 0.054455 9.856355
25 10.385 9.3465 0.051925 9.398425
30 10.714 9.6426 0.05357 9.69617
Mg Terdisolusi = ppm x Media Disolusi (ml)
1000 ml

Faktor Koreksi = ppm x Sampling (ml)

1000 ml

mg Terkoreksi = mg terdisolusi + F.K (sebelumnya/keseluruhan)

% disolusi = mg terkoreksi
bobot zat aktif ( Sampel)
% Terdisolusi
0.0783 % Terdisolusi x waktu
0.390417 2.5
0.491234
0.72943 2
0.93577
1.430624 1.5 % Terdisolusi
1.870454
1.98738 1
1.971271
1.879685 0.5
1.939234
0
0 5 10 15 20 25 30 35

x 100
% Terdisolusi
 KELOM
1 2 3
Volume Media 500 ml Volume Media 900 ml Volume Media
Jumlah sediaan 6 mg Jumlah sediaan 10 mg Jumlah sediaan
Volume cuplikan 5 ml Volume cuplikan 5 ml Volume cuplikan

Time Point C % Terdisolusi Time Point C % Terdisolusi Time Point C

2 1.6 3 1.5 4 10.4
5 2.4 5 2.9 5 19.3
7 3.5 7 7.5 7 27.33
10 4.6 10 7.9 10 40.55
15 5.7 15 8.6 15 70.34
30 3.2 30 9.4 30 89.26
45 2.2 45 6.5 45 91.76
 KELOMPOK
3 4 5
1L Volume Media 950 ml Volume Media 350 ml
100 mg Jumlah sediaan 4 mg Jumlah sediaan 10 mg
5 ml Volume cuplikan 5 ml Volume cuplikan 5 ml

% Terdisolusi Time Point C % Terdisolusi Time Point C % Terdisolusi

3 1.5 2 1.5
5 2.4 5 3.4
7 3.22 7 7.5
10 4 10 8.1
15 3.65 15 8.6
30 2.34 30 9.3
45 1.2 45 6.5
 6
Volume Media 500 ml
Jumlah sediaan 8 mg
Volume cuplikan 5 ml

Time Point C % Terdisolusi

1 1.5
4 3.1
7 7.5
10 7.9
15 7.2
30 6.3
45 5.2
DATA REFERENCE
Timepoint 1 2 3 Rata-rata
3 18.7 19.25 18.57 18.840
5 39.7 40.25 39.57 39.840
7 57.9 58.45 57.77 58.040
10 75.89 76.44 75.76 76.030
15 86.39 86.94 86.26 86.530
30 89.39 89.94 89.26 89.530
45 91.89 92.44 91.76 92.030

DATA TEST
timepoint 1 2 3 Rata-rata Rt-Tt
3 16.7 17.25 16.57 16.840 2.000
5 37.7 38.25 37.57 37.840 2.000
7 55.9 56.45 55.77 56.040 2.000
10 73.89 74.44 73.76 74.030 2.000
15 84.39 84.94 84.26 84.530 2.000
30 87.39 87.94 87.26 87.530 2.000
45 89.89 90.44 89.76 90.030 2.000
sigma (Rt – Tt)^2
1/n
(1/n) Ʃ (Rt – Tt)^2
1 + (1/n) Ʃ (Rt – Tt)^2
[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5
{[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
50 . log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
f2
 f2 = 50 . log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
f1 = {[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt]} . 100

HARUS BERNILAI POSITIF

(Rt-Tt)^2 |Rt-Tt| n|Rt – Tt|
4.000 2.00 6
4.000 2.00 6
4.000 2.00 6
4.000 2.00 6
4.000 2.00 6
4.000 2.00 6
4.000 2.00 6
28.000 Ʃ (n|Rt – Tt|) 42
0.333
9.333
10.333
0.311
31.109
1.493
74.644
2]^-0,5 . 100}

nRt
56.52
119.52
174.12
228.09
259.59
268.59
276.09
Ʃ nRt 1382.52
[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt] 0.0304
{[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt]} . 100 3.038
f1
DATA REFERENCE f2 = 50 . log {[1
Timepoint 1 Rata-rata
0 -0.038 -0.038
1 0.030 0.030 HARUS BERNILAI POSIT
2 0.052 0.052 Rt-Tt (Rt-Tt)^2 |Rt-Tt|
3 0.104 0.104 -0.038 0.001 0.038
4 0.149 0.149 0.030 0.001 0.030
5 0.257 0.257 0.052 0.003 0.052
10 0.353 0.353 0.104 0.011 0.104
15 0.373 0.373 0.149 0.022 0.149
20 0.375 0.375 0.257 0.066 0.257
25 0.355 0.355 0.353 0.125 0.353
30 0.368 0.368 0.373 0.139 0.373
0.375 0.141 0.375
0.355 0.126 0.355
DATA TEST 0.368 0.135 0.368
timepoint 1 Rata-rata sigma (Rt – Tt)^2 2.454
1 1/n 0.090909
2 (1/n) Ʃ (Rt – Tt)^2 0.223091
3 1 + (1/n) Ʃ (Rt – Tt)^2 1.223091
4 [1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 0.904213
5 {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100} 90.42128
10 log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100} 1.956271
15 50 . log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
20 f2 97.814
25
30
 f2 = 50 . log {[1 + (1/n) Ʃ (Rt – Tt)^2]^-0,5 . 100}
f1 = {[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt]} . 100

HARUS BERNILAI POSITIF

n|Rt – Tt| nRt
0.418 -0.418
0.33 0.33
0.572 0.572
1.144 1.144
1.639 1.639
2.827 2.827
3.883 3.883
4.103 4.103
4.125 4.125
3.905 3.905
4.048 4.048
Ʃ (n|Rt – Tt|) 26.994 Ʃ nRt 26.158
[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt] 1.0320
{[ Ʃ (n|Rt – Tt|)]/[ Ʃ nRt]} . 100
f1 103.196