Pembatasan Protein Makanan Menghambat

Pertumbuhan Tumor dalam Model Xenograft

Manusia dari Kanker Prostat dan Payudara Manusia
Mushthafa Habiburrahman
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Pendahuluan
 Pendahuluan
Pca dan BC pada Tingkat kematian Pca Asupan protein,
pria wanita di dan BC di Jepang salah satu pengatur
Negara Barat dan Singapura level sirkulasi IGF-1

Apakah pengurangan asupan

protein dapat menghambat
Prevalensi Pca dan BC Hipotesa pergeseran Tingkat sirkulasi pertumbuhan PCa dan BC?
sebelumnya di Jepang pola makan radikal IGF-1 dikaitkan
dan Singapura risiko PCa dan BC
Metode dan Hasil
 Pembatasan
protein
menghambat
pertumbuhan
tumor pada model
kanker payudara
dan prostat
manusia.
 Everolimus
Everolimus
Everolimus adalah agen antitumor yang
bekerja dengan mengikat mTOR dan
menghambat pensinyalan aliran hilirnya.

mTOR
mTOR berfungsi sebagai pengatur pertumbuhan,
proliferasi, motilitas, sintesis protein, autophagy,
dan transkripsi sel.

Houghton, P.J., 2010. CCR Drug Updates. Clin Cancer Res, 16(5), p.1368.

Diet rendah protein menurunkan kadar serum IGF-1 dan menghambat
pertumbuhan tumor dalam kombinasi dengan everolimus
Diet rendah protein menurunkan aktivitas mTOR dan proliferasi
Pembatasan protein menginduksi modifikasi epigenetik
 Diet protein nabati menghambat pertumbuhan
tumor secara independen dari kandungan protein
Mekanisme Molekuler
Diskusi
Diskusi

Pengurangan protein dalam makanan

menghasilkan penghambatan
pertumbuhan PCa dan BC

Efek penghambatan ini dikaitkan dengan

penurunan kadar
• PSA dan IGF-1 serum,
• regulasi aktivitas intratumor mTOR
• penanda histon spesifik yang
menunjukkan modulasi epigenetik.

Penghambatan tumor juga dicapai oleh

perubahan kualitas (yaitu komposisi asam
amino dari hewani dan nabati} dari makanan
protein.
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