Inflammatory Drugs
(NSAIDs)
PDMA
OBJEKT
IF
1. Memberi definisi ‘Non-Steroidal
Anti-Inflammatory Drugs
(NSAIDs)’.
2. Menyatakan tujuan/ indikasi ubat.
3. Menyatakan dos dan contoh ubat.
4. Menyatakan kaedah pemberian
ubat.
1. Menyatakan tindakan ubat.
2. Menerangkan kesan sampingan
dan kontraindikasi ubat.
3. Memberikan nasihat spesifik
dalam pengambilan ubat.
NSAIDs
• Sejenis ubat analgesic (non-
narcotic)
• Tidak tergolong dalam
kumpulan ubat steroid.
• Maka tidak menghasilkan
kesan sampingan berkaitan
steroid.
• Walaupun bukan dari
kumpulan steroid, NSAIDs
mempunyai kesan
• Anti-inflammatory
• Analgesics
• Antipyretics
Tindakan ubat
• Diclofenac sodium
(Voltaren)
• Ibuprofen (Brufen)
• Indomethacin (Indocid)
• Ketoprofen (Orudis)
• Mefenamic Acid (Ponstan)
• Naproxen (Naprosyn)
• Piroxicam (Feldene)
1. Diclofenac sodium
(Voltaren)
Tindakan
• Antipyretics
• Analgesics
• Anti-inflammatory
Indication
• Rheumatoid arthritis
• Osteoarthritis
• Spondylitis
• Acute gout
• Post operative inflammation
1(a). Diclofenac sodium
50mg tablet
(Voltaren)
Category: B
Dose
Dose
• Apply tds-qid & gently rub
1(c). Diclofenac sodium
12.5mg/ 25mg/ 50mg suppositories
(Voltaren)
Category: A
Dose
• Adult:
• 75-150mg/day (divided dose)
• Peads 1-12 yr:
• 12.5-25mg/day
2. Ibuprofen 200mg tablet
(Brufen)
Category: B
Tindakan
• Antipyretics
• Analgesics
• Anti-inflammatory
Indication
Tindakan
• Antipyretics
• Analgesics
• Anti-inflammatory
Indication
• Rheumatoid arthritis
• Spondylitis
• Mild to moderate
osteoarthritis
• Acute gouty arthritis
• Acute shoulder pain
3(a). Indomethacin
25mg capsule
(Indocid)
Category: B
Dose
• Adult:
• 50-200mg/day (divided dose)
• Peads:
• Not recommended
Category: B
Dose
• Adult:
• 100mg ON
• Peads:
• Not recommended
4. Ketoprofen
(Orudis)
Tindakan
• Analgesics
• Anti-inflammatory
Indication
Category: A
Dose
• Apply twice daily
• Max: 20g/day
4(d). Ketoprofen
30mg transdermal patch (Orudis)
Category: A
Dose
• Apply 1 plaster to the
affected area bd
5. Mefenamic Acid
250mg capsule/ tablet
(Ponstan)
Category: B
Tindakan
• Antipyretics
• Analgesics
• Anti-inflammatory
Indication
Tindakan
• Analgesics
• Anti-inflammatory
Indication
Tindakan
• Analgesics
• Anti-inflammatory
Indication
• Mild to moderate pain
• Rheumatoid arthritis
• Osteoarthritis
• Spondylitis
• Acute gout
• Primary dysmenorrhea
Dose
• Arthritis & spondylitis:
• 20mg/day
• Maintenance: 10-30mg/day
(single or divided dose)
• Acute gout:
• 40mg/day (single or divided
dose) for 4-6 days
• Musculoskeletal disorders:
• 40mg/day (single dose or
divided dose) for 2 days
• Then 20mg/day for 7-14
days
• Renal:
– Hematuria
– Elevated blood urea
nitrogen
• Cardiovascular:
– Congestive heart failure
– Decreased or increased BP
• Hematologic:
– Pancytopenia
– Leukopenia
– Thrombocytopenia
– Aplastic anemia
• Skin:
– Rash
– Irritation
– Skin eruption
– Steven-Johnson syndrome
• Metabolic/ endocrinologic:
– Decreased appetite
– Weight increase or decrease
– Menstrual disorders
• Special senses:
– Visual disturbances
– Blurred vision
– Photophobia
– Tinnitus
– rhinitis
Contraindication
• Allergic to NSAIDs
• Pregnancy
• Lactation
• Labor
• Renal & hepatic impairment
• Bleeding disorders
Cautious
• Impaired hearing
• Cardiovascular disease
• GI condition
• Hypertension
• Elderly
Interactions
• Anti-coagulants, lithium
– Risiko pendarahan
• Diuretics, anti-hypertensives
– Kesan diuretics &
antihypertensives berkurang
• Paracetamol (long-term)
– Renal impairment
Nasihat
• Ubat diambil selepas sarapan
(kurangkan GI symptom)
• Periksa simptom pendarahan
salur GI (najis gelap)
• Elakkan pengambilan alkohol
• Monitor berat badan selalu
(kehadiran edema)
• Lapor kepada pegawai
perubatan & hentikan
pengambilan ubat jika berlaku
kesan sampingan seperti:
– Vertigo, ruam, hematuria,
gangguan pendengaran &
pengelihatan
Soalan
1. Berikan definisi ubat NSAIDs?
2. Terangkan cara tindakan ubat
NSAIDs?
3. Senaraikan contoh ubat NSAIDs
dan indikasinya?
4. Nyatakan kesan sampingan dan
kontraindikasi ubat NSAIDs?