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PI3K/Akt Signaling
PI3 Kinase/Akt Signaling
BCR Antigen
Cytokine
Receptor
RTK CD19

Integrin mIg GPCR

a/β a/β
mIg

DNA Damage
BCAP

PI3K

PI3K
IRS-1 Jak1
Gab1
PI3K

ATM/ATR DNA-PK Syk Lyn

FAK

PI3K
Gab2
PI3K

Gα
Gβγ GTP
Paxillin

ILK
PTEN Akt mTORC2
PIP3
PIP3 PTEN PP2A PHLPP1/2
CTMP
TRAF6 NEDD1-4
S6 Neutrophil
TBK1 Membrane Respiratory
Protein Synthesis

Membrane PDK1 PDK1 Recruitment p47phox

Recruitment Burst
and Activation
and Activation Organization
p70 S6K Lamin A of Nuclear
Proteins

Other
Tpl2
NF-κB
PDCD4 Pathway
IKKα
TSC2
4E- mTORC1 Cardiovascular
TSC1 eNOS Homeostasis
Inhibits BP1
Autophagy
GABAAR Synaptic
ATG13 Signaling
PRAS40 Akt
Blocks

science
XIAP Huntingtin
Aggregation
Inhibits Apoptosis Promotes
M2 Ataxin-1 Neuroprotection

Neuro
FoxO1 MD Aggregation
PFKFB2
Bad GS Neurodegeneration
p53 K-3
-3 Glycolysis
Bim -3
14 PIP5K
AS160 Hexok
inase
II
Bcl-2
Su

Skp2 SCF ATP-Citrate

rvi

Lyase Glucose
va

Bax Palladin Transport

l

GS
Myt1 p27 Kip1
Girdin
ism

Apoptosis Fatty Acid

ol
ab

Cytosolic Wee1 Synthesis

p21
et

Sequestration
M

Waf1/Cip1 Glycogen e
Synthesis c os
u
mTORC1 Cyclin D1 Gl mTORC2
Migration CDK2 Cyclin A
Raptor Sin1 PRR5
GβL Mi
mTOR gra Rictor GβL
tion
Cell Cycle
DEPTOR mTOR
DEPTOR
Proliferation

rev.03/20/20
rev. 03/20/20
Pathway Diagram Key © 2003–2020 Cell Signaling Technology, Inc.