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Daftar obat-obatan yang boleh untuk ibu menyusui dan ibu hamil

Lactation Risk Categories Pregnancy Risk Categories


L1 (Paling Aman) A (studi terkontrol menunjukkan tanpa resiko)
L2 (Aman) B (tidak ada bukti risiko pada manusia)
L3 (Cukup Aman) C (risiko tidak dapat dikesampingkan)
L4 (Kemungkinan Barbahaya) D (bukti positif resiko)
L5 (Kontra Indikasi) X (dikontraindikasikan untuk Ibu Hamil)

Pregnancy
Risk Lactation Risk
Generic name Trade Name AAP approved?* Category** Category**
Analgesics (Pain-killers) [more]
Acetaminophen Tylenol Approved/diseujui B L1
Colchicine Colchicine Approved D L4
Nefopam Acupan Approved - NR
Non-steroidal anti-inflammatory analgesics (NSAIDs) [more]
Azapropazone
Rheumox Approved - L2
(apazone)
Dipyrone (banned in
- Approved - NR
the US & UK)
Flufenamic acid - Approved - NR
B (1st, 2nd
Advil, Nuprin, Motrin,
Ibuprofen Approved trim.) L1
Pediaprofin
D (3rd trim.)
B (1st, 2nd
Indomethacin Indocin Approved trim.) L3
D (3rd trim.)
B (1st, 2nd
Ketorolac Toradol, Acular Approved trim.) L2
D (3rd trim.)
Mefenamic acid Ponstan, Ponstel Approved - NR
Anaprox, Naprosyn, L3
Naproxen Approved B
Naproxen, Aleve L4 (for chronic use)
Phenylbutazone Butazolidine Approved - NR
Piroxicam Feldene Approved B L2
Suprofen Profenal Approved - NR
Tolmetin Tolectin Approved C L3
Narcotic analgesics [more]
B (1st,
2nd
Butorphanol Stadol Approved trim.) L3
D (3rd
trim.)
Codeine Tylenol #3, #4 Approved C L3
Fentanyl Sublimaze Approved B L2
L2
Meperidine Demerol Approved B L3 (if used early
postpartum)
Methadone Dolophine Approved B L3
Morphine Morphine Approved B L3
Propoxyphene Darvocet N, Propacet, Darvon Approved C L2
Anesthesia, Anesthetics [more] [contents]
Halothane Fluothane Approved C L2
Lidocaine Xylocaine Approved C L2
Methohexital Brevital Approved B L3
Thiopental Pentothal Approved C L3
Antacids, GI meds [contents]
Cimetidine (Antacid) Tagamet Approved B L2
Cisapride (GI tract stimulant) Propulsid Approved C L2
Domperidone (used for nausea &
Motilum Approved - L1
vomiting, stimulates lactation) [more]
Antibiotics [contents]
Amoxicillin Larotid, Amoxil Approved B L1
Aztreonam Azactam Approved B L2
Cefadroxil Ultracef, Duricef Approved B L1
Cefazolin Ancef, Kefzol Approved B L1
Cefotaxime Claforan Approved B L2
Cefoxitin Mefoxin Approved B L1
Cefprozil Cefzil Approved C L1
Ceftazidime Ceftazidime, Fortaz, Taxidime Approved B L1
Ceftriaxone Rocephin Approved B L2
Ciprofloxacin [more] Cipro Approved C L3
Clindamycin Cleocin Approved B L3
L1
Erythromycin E-Mycin, Ery-tab, ERYC, Ilosone Approved B L3 early
postnatal
Fleroxacin - Approved - NR
Gentamicin Garamycin Approved C L2
Kanamycin Kebecil, Kantrex Approved D L2
Moxalactam Moxam Approved - NR
Nitrofurantoin Macrobid Approved B L2
Ofloxacin Floxin Approved C L2
Penicillin - Approved B L1
Streptomycin Streptomycin Approved D L3
Sulbactam - Approved - NR
Sulfisoxazole Gantrisin, Azo-Gantrisin Approved C L2
Tetracycline Achromycin, Sumycin, Terramycin Approved D L2
Ticarcillin Ticarcillin, Ticar, Timentin Approved B L1
Trimethoprim/sulfamethoxazole Proloprim, Trimpex Approved C L3
Anticoagulants [contents]
Bishydroxycoumarin (dicumarol) - Approved - NR
Warfarin Coumadin, Panwarfin Approved D L2
Anticonvulsants [contents]
Carbamazepine Tegretol, Epitol Approved C L2
Ethosuximide Zarontin Approved C L4
Magnesium sulfate Epsom salt Approved B L1
Phenytoin Dilantin Approved D L2
Valproic acid Depakene, Depakote Approved D L2
Antifungals [contents]
Fluconazole [more] Diflucan Approved C L2
Ketoconazole Nizoral Shampoo, Nizoral Approved C L2
Antihistamines [more] [contents]
Dexbrompheniramine maleate with d-
- Approved - NR
isoephedrine
Fexofenadine Allegra Approved C L2
Loratadine Claritin Approved B L1
Terfenadine Seldane Approved - NR
Triprolidine Actidil, Actifed Approved C L1
Antivirals [contents]
Acyclovir [more] Zovirax Approved C L2
Interferon-alpha [more] Alferon N, Interferon Alpha Approved C L2
Arthritis meds (see also: pain meds) [contents]
Gold salts Ridaura, Myochrysine, Solganal Approved C L5
Asthma meds (see also: steroids) [contents]
Dyphylline Dilor, Lufyllin, Dyphylline Approved C L3
Terbutaline Bricanyl, Brethine Approved B L2
Theophylline Aminophylline, Quibron, Theo-Dur Approved C L3
Contraceptives, Hormones [more] [contents]
L3 (may
Estradiol Estratab, Permarin, Menest Approved X interfere with
milk production)
Clogestone - Approved - NR
Preven, Seasonale, Norinyl,
L3 (may
Contraceptive pill with Norlestin, Ortho-Novum, Ovral,
Approved X interfere with
estrogen/progesterone Lunelle injection, Ortho-Evra patch,
milk production)
etc.
Levonorgestrel Norplant, Mirena, Plan B Approved X L2
L1
L4 (if used first 3
Medroxyprogesterone Provera, Depo-Provera, Cycrin Approved D
days
postpartum)
Norethynodrel Enovid Approved X L2
Progesterone Crinone, Prometrium Approved - L3
Cough meds [more] [contents]
Codeine Tylenol #3, #4 Approved C L3
Noscapine - Approved - NR
Decongestants [more] [contents]
L3 (for acute
use)
Pseudoephedrine Sudafed, Halofed, Novafed, Actifed Approved C
L4 (for chronic
use)
Diabetes meds [contents]
Note: Insulin has not been reviewed by the AAP. Pregnancy risk category = B; Lactation risk category = L1.
Tolbutamide Oramide, Orinase Approved D L3
Diarrhea meds [contents]
Imodium, Pepto Diarrhea Control,
Maalox Antidiarrheal Caplets,
Loperamide Approved B L2
Kaopectate II Caplets, Immodium
Advanced
** Note: Pepto-Bismol & Kaopectate (bismuth subsalicylate is the active ingredient in both) are not recommended
for routine use by nursing moms, due to the association of salicylates with Reyes syndrome in children. [more]
Diuretics [contents]
Acetazolamide Dazamide, Diamox Approved C L2
L4 (may inhibit
Bendroflumethiazide Naturetin Approved D
lactation)
Chlorothiazide Hydrodiuril Approved D L3
Chlorthalidone Hygroton Approved D L3
Hydrochlorothiazide Hydrodiuril, Esidrix, Oretic Approved D L2
Spironolactone Aldactone Approved D L2
Galactagogues (milk supply) [more] [contents]
Domperidone Motilum Approved - L1
Heart, Blood Pressure meds
[contents]
(Antiarrhythmics, Antihypertensives, Cardiac stimulants)
Antiarrhythmics
Disopyramide Norpace, Napamide Approved C L2
Flecainide Tambocor Approved C L3
Mexiletine Mexitil Approved B L2
Procainamide Pronestyl, Procan Approved C L3
Quinidine Quinaglute, Quinidex Approved C L2
Antihypertensives
L3 (if used after 30
Captopril Capoten Approved D
days)
Cardizem Sr, Dilacor-XR,
Diltiazem/Diltiazem HCL Approved C L3
Diltiazem, Cardizem CD
C (1st
trim.)
Enalapril/Enalapril Maleate Vasotec Approved L2
D (2nd,
3rd trim.)
Hydralazine Apresoline Approved C L2
Labetalol Trandate, Normodyne Approved C L2
Methyldopa Aldomet Approved C L2
Metoprolol Toprol XL, Lopressor Approved B L3
L2 (topically)
Minoxidil Loniten, Minodyl, Rogaine Approved C
L3 (orally)
Nadolol Corgard, Nadolol Approved C L4
Nifedipine Adalat, Procardia Approved C L2
Apsolox, Slow-Trasicor,
Oxprenolol Approved - NR
Trasicor
Propranolol Inderol Approved C L2
Sotalol Betapace Approved B L3
Timolol Blocadren Approved C L2
Verapamil Calan, Isoptin, Covera-HS Approved C L2
Cardiac stimulants
Digoxin Lanoxin, Lanoxicaps Approved C L2
Laxatives [more] [contents]
Cascara/Cascara Sagrada - Approved C L3
Danthron - Approved - NR
Magnesium sulfate Epsom salt Approved B L1
Senna - Approved - L3
Malaria meds [contents]
Chloroquine Aralen, Novo-chloroquine Approved C L3
Hydroxychloroquine Plaquenil Approved C L2
Pyrimethamine Daraprim Approved C L4
Quinine Quinamm Approved D L2
Medical Testing [more] [contents]
Diatrizoate - Approved - NR
Fluorescein - Approved C L3
Gadopentetic (Gadolinium) - Approved C L2
Iohexol Omnipaque Approved B L2
Iopanoic acid Telepaque Approved D L2
Metrizamide Amipaque Approved B L2
Metrizoate Isopaque Approved B L2
Migraine meds (see also: pain meds) [more] [contents]
Sumatriptan Imitrex Approved C L3
Sedatives [more] [contents]
Chloral hydrate Aquachloral, Noctec Approved C L3
Methyprylon (withdrawn from
- Approved - NR
use in US & Canada)
Bromide - Approved D L5
Secobarbital Seconal Approved D L3
Sleep Aids [contents]
Zolpidem/Zolpidem Tartrate Ambien Approved B L3
Steroids [contents]
Methylprednisolone
Solu-Medrol, Depo-Medrol,
[ high dosage Approved C L2
Medrol
methylprednisolone]
Prednisolone - Approved C L2
Deltasone, Meticorten,
Prednisone Approved C L2
Orasone
Thyroid meds [more] [contents]
Carbimazole - Approved D L3
Methimazole (active
Tapazole Approved D L3
metabolite of carbimazole)
Propylthiouracil PTU Approved D L2
Thiouracil - Approved - NR
Synthroid, Levothroid,
Levothyroxine Approved A L1
Thyroid, Levo-T, Levoxyl
Tuberculosis meds [contents]
Cycloserine Seromycin Approved C L3
Ethambutol Ethambutol, Myambutol Approved B L2
Isoniazid INH, Laniazid Approved C L3
Rifampin Rifadin, Rimactane Approved C L2
Vitamins [more] [contents]
B-1 (thiamin) - Approved - NR
B-12 (Cyanocobalamin) - Approved A L1
L2; L4 in high doses
B-6 (pyridoxine) - Approved A (may inhibit
lactation)
L3 (do not
D, vitamin Calciferol, Delta-d Approved A
overdose)
A (1st,
2nd trim.)
Folic acid - Approved L1
C (3rd
trim.)
K-1, vitamin (Phytonadione) - Approved C L1
Riboflavin/B2 - Disetujui A L1
Miscellaneous [contents]
Acitretin (Anti-psoriasis) Soriatane Disetujui - NR
Alcohol/Ethanol [more] - Disetujui D L3
Allopurinol Zyloprim, Lopurin Disetujui C L2

Antimony - Disetujui - NR
Atropine (Anticholinergic,
Belladonna, Atropine Disetujui C L3
drying agent)
Azapropazone/apazone Rheumox - L2
(Antirheumatic) Disetujui

Baclofen (muscle relaxant) Lioresal, Atrofen Disetujui C L2

Barbiturate - Disetujui - NR

Caffeine [more] Vivarin, NoDoz, Coffee Disetujui B L2

Carbetocin (Antihemorrhagic) Duratocin Disetujui - NR

Chloroform - Disetujui - NR

Cisplatin (Anti-cancer) Platinol Disetujui D L4

Dapsone (Antileprosy) Avlosulfon, DDS Disetujui C L4


Hydroxychloroquine
Plaquenil Disetujui C L2
(Antirheumatic, lupus)
Iodides - Disetujui - NR

Iodine - Disetujui - NR
Iodine (povidone-iodine, eg, in
- Disetujui - NR
a vaginal douche)
Ivermectin (Antiparasitic) Mectizan Disetujui C L3
Nalidixic acid (Urinary Anti-
NegGram Disetujui B L4
infective)
Norsteroids - Disetujui - NR
Pyridostigmine (Muscle
Mestinon, Regonol Disetujui C L2
stimulant)
Scopolamine (Motion sickness) Transderm Scope Disetujui C L3

Sulfapyridine Dagenan Disetujui - NR

Timolol (glaucoma med) Blocadren Disetujui D L3

* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.

Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding


Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should
Be Given to Nursing Mothers With Caution
NR: Not Reviewed. This drug has not yet been reviewed by the AAP.

** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2004 edition).
Lactation Risk Categories Pregnancy Risk Categories
L1 (Paling Aman) A (studi terkontrol menunjukkan tanpa resiko)
L2 (Aman) B (tidak ada bukti risiko pada manusia)
L3 (Cukup Aman) C (risiko tidak dapat dikesampingkan)
L4 (Kemungkinan Barbahaya) D (bukti positif resiko)
L5 (Kontra Indikasi) X (dikontraindikasikan untuk Ibu Hamil)

NR: Not Reviewed. This drug has


pernah kita mendegar bahwa bayi lahir tidak normal atau cacat?
banyak penyebab bayi lahir tidak normal salah satunya yaitu obat-obat yang tidak aman yang dikonsumsi
oleh ibu pada waktu sedang mengandung., berikut daftar obat yang aman maupun tidak aman untuk ibu
hamil dan menyusui

Kelompok Analgetik, NSAIDS, Obat Batuk dan Pilek,


Anti Alergi dan Asma, Anestesi

Obat untuk Penghilang Rasa Sakit (Pain Killer)


Kategori Risiko
Nama Obat AAP approved?* Risiko Menyusui** Notes
Kehamilan**
Acetaminophen (Tylenol) Approved B L1
C (1st, 2nd trim.)
Aspirin Caution L3 1
D (3rd trim.)
Approved
Azapropazone (Rheumox) - L2
Butalbital (Fioricet, Fiorinal,
NR D L3 2
Bancap, Two-dyne)
B (1st, 2nd trim.)
Butorphanol (Stadol) Approved L3
D (3rd trim.)
Celecoxib (Celebrex)) NR C L2
Codeine (in Tylenol #3, #4) Approved C L3 3
Colchicine Approved D L4
Diclofenac (Cataflam, Voltaren) NR B L2
Fentanyl (Sublimaze) Approved B L2
Flurbiprofen (Ansaid, Froben, B (1st, 2nd trim.)
NR L2
Ocufen) C (3rd trim.)
Hydrocodone (Lortab, Vicodin) NR B L3 4
Hydromorphone (Dilaudid) NR C L3 5
Ibuprofen (Advil, Nuprin, Motrin, B (1st, 2nd trim.)
Approved L1
Pediaprofen) D (3rd trim.)
B (1st, 2nd trim.)
Indomethacin (Indocin) Approved L3
D (3rd trim.)
B (1st, 2nd trim.)
Ketorolac (Toradol, Acular) Approved L2
D (3rd trim.)
L2;
Meperidine (Demerol) Approved B L3 early 6
postpartum
Methadone (Dolophine) Approved B L3 7
Morphine (Duramorph,
Approved B L3 8
Infumorph, Epimorph, MS Contin)
Nalbuphine (Nubain) NR B L2
Naproxen (Anaprox, Naprosyn, L3;
Approved B 9
Naproxen, Aleve) L4 for chronic use
Nefopam (Acupan) Approved - NR
Oxycodone (Tylox,
Percodan,Oxycontin, Roxicet, NR B L3 10
Endocet, Roxiprin, Percocet)
Pentosan polysulfate (Elmiron) NR B L2
Piroxicam (Feldene) Approved B L2
Propoxyphene (Darvocet N,
Approved C L2 11
Propacet, Darvon)
Rofecoxib (Vioxx) Withdrawn from the market 12
Secobarbital (Seconal) Approved D L3 13
Tolmetin (Tolectin) Approved C L3
Tramadol HCL (Ultram, Ultracet) NR C L3 14
Valdecoxib (Bextra) Withdrawn from the market more
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.

Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding


Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants
and Should Be Given to Nursing Mothers With Caution
NR: Not Reviewed. This drug has not yet been reviewed by the AAP.

** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
Lactation Risk Categories Pregnancy Risk Categories
L1 (safest) A (controlled studies show no risk)
L2 (safer) B (no evidence of risk in humans)
L3 (moderately safe) C (risk cannot be ruled out)
L4 (possibly hazardous) D (positive evidence of risk)
L5 (contraindicated) X (contraindicated in pregnancy)

NR: Not Reviewed. This drug has not yet been reviewed by Hale.

1. Aspirin use is discouraged in children and nursing mothers due to the risk of Reyes syndrome and
internal bleeding.
2. Fioricet (Fiorinal, Bancap, Two-dyne) contains acetaminaphen or asprin, caffeine, and butalbital. Per
Hale, baby should be observed for sedation.
3. Hale suggests weakened or premature infants be observed for sedation and apnea.
4. Hale suggests newborns be observed for sedation, apnea, constipation.
5. Per Hale, use of frequent, higher dose may result in infant sedation.
6. Per Hale, Meperidine use during labor or early postpartum has been associated with sedation, poor
sucking reflex, and neurobehavioral delay in infants.
7. Per Hale, observe infant for sedation, respiratory depression, addiction, withdrawal syndrome.
8. Per Hale, higher doses may result in infant sedation.
9. Per Hale, should be used with caution due to its long half-life and its effect on babys cardiovascular
system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible
with breastfeeding.
10. Roxicet, Endocet, Roxiprin, Percocet also contain acetaminophen. Per Hale, observe infant for
sedation.
11. Per Hale, observe infant for sedation.
12. Per Hale, observe infant for GI cramping, distress, diarrhea.
13. Per Hale, observe infant for sedation.
14. Per Hale, observe infant for sedation.

Non-steroidal anti-inflammatory analgesics (NSAIDs) [more]


AAP Kategori Risiko
Nama Generik Nama Dagang
approved?* Kehamilan** Risiko Menyusui**
Azapropazone (apazone) Rheumox Approved - L2
Dipyrone (banned in the US &
- Approved - NR
UK)
Flufenamic acid - Approved - NR
Advil, Nuprin, Motrin, B (1st, 2nd trim.)
Ibuprofen Approved L1
Pediaprofin D (3rd trim.)
B (1st, 2nd trim.)
Indomethacin Indocin Approved L3
D (3rd trim.)
B (1st, 2nd trim.)
Ketorolac Toradol, Acular Approved L2
D (3rd trim.)
Mefenamic acid Ponstan, Ponstel Approved - NR
Anaprox, Naprosyn, L3
Naproxen Approved B
Naproxen, Aleve L4 (for chronic use)
Phenylbutazone Butazolidine Approved - NR
Piroxicam Feldene Approved B L2
Suprofen Profenal Approved - NR
Tolmetin Tolectin Approved C L3
Steroid [contents]
Methylprednisolone
Solu-Medrol, Depo-Medrol,
[ high dosage Approved C L2
Medrol
methylprednisolone]
Prednisolone - Approved C L2
Deltasone, Meticorten,
Prednisone Approved C L2
Orasone
Obat Asma [contents]
Dyphylline Dilor, Lufyllin, Dyphylline Approved C L3
Terbutaline Bricanyl, Brethine Approved B L2
Aminophylline, Quibron,
Theophylline Approved C L3
Theo-Dur
Analgetik Narkotik [more]
B (1st, 2nd trim.)
Butorphanol Stadol Approved L3
D (3rd trim.)
Codeine Tylenol #3, #4 Approved C L3
Fentanyl Sublimaze Approved B L2
L2
Meperidine Demerol Approved B L3 (if used early
postpartum)
Methadone Dolophine Approved B L3
Morphine Morphine Approved B L3
Darvocet N, Propacet,
Propoxyphene Approved C L2
Darvon

Obat Batuk
Nama Obat AAP approved?* Risiko Menyusui**
Codeine yes L3 (moderately safe)
Dextromethorphan not reviewed L1 (safest)
Guaifenesin not reviewed L2 (safer)
Dekongestan (Obat Pilek)
Nama Obat AAP approved?* Risiko Menyusui**
Phenylephrine not reviewed L3 (moderately safe)
L3 (moderately safe) for acute use
Pseudoephedrine
yes L4 (possibly hazardous) for chronic use due to potential for
(Sudafed, Actifed)
decreasing milk supply
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2006 edition)
Nasal Sprays (Spray Hidung)
AAP
Nama Obat Risiko Menyusui**
approved?*
Beclomethasone
(Vanceril, Beclovent, not reviewed L2 (safer)
Beconase, Vancenase)
Cromlyn sodium
not reviewed L1 (safest)
(Nasalcrom)
Fluticasone (Flonase) not reviewed L3 (moderately safe)
Mometasone (Nasonex) not reviewed L3 (moderately safe)
Phenylephrine (in some
forms of Sinex and Neo- not reviewed L3 (moderately safe)
Synephrine)
Triamcinolone Acetonide
not reviewed L3 (moderately safe)
(Nasacort)
Antihistamin (Anti Alergi)
AAP
Nama Obat Risiko Menyusui**
approved?*
Brompheniramine not reviewed L3 (moderately safe)
Chlorpheniramine (Chlor-
not reviewed L3 (moderately safe)
Trimeton) CTM
Cetirizine (Zyrtec) not reviewed L2 (safer)
Dexbrompheniramine
maleate yes not reviewed
with d-isoephedrine
Diphenhydramine
not reviewed L2 (safer)
(Benadryl)
Doxylamine not reviewed L4 (possibly hazardous)
Fexofenadine (Allegra) yes L3 (moderately safe)
Loratadine (Claritin) yes L2 (safer)
Terfenadine (Seldane) yes not reviewed
Triprolidine (Actidil,
yes L1 (safest)
Actifed)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2002 edition)

Daftar obat-obatan yang boleh untuk ibu menyusui dan ibu hamil

Lactation Risk Categories Pregnancy Risk Categories


L1 (Paling Aman) A (studi terkontrol menunjukkan tanpa resiko)
L2 (Aman) B (tidak ada bukti risiko pada manusia)
L3 (Cukup Aman) C (risiko tidak dapat dikesampingkan)
L4 (Kemungkinan Barbahaya) D (bukti positif resiko)
L5 (Kontra Indikasi) X (dikontraindikasikan untuk Ibu Hamil)

Pregnancy
Risk Lactation Risk
Generic name Trade Name AAP approved?* Category** Category**
Analgesics (Pain-killers) [more]
Acetaminophen Tylenol Approved/diseujui B L1
Colchicine Colchicine Approved D L4
Nefopam Acupan Approved - NR
Non-steroidal anti-inflammatory analgesics (NSAIDs) [more]
Azapropazone
Rheumox Approved - L2
(apazone)
Dipyrone (banned in
- Approved - NR
the US & UK)
Flufenamic acid - Approved - NR
Advil, Nuprin, Motrin, B (1st, 2nd
Ibuprofen Approved L1
Pediaprofin trim.)
D (3rd trim.)
B (1st, 2nd
Indomethacin Indocin Approved trim.) L3
D (3rd trim.)
B (1st, 2nd
Ketorolac Toradol, Acular Approved trim.) L2
D (3rd trim.)
Mefenamic acid Ponstan, Ponstel Approved - NR
Anaprox, Naprosyn, L3
Naproxen Approved B
Naproxen, Aleve L4 (for chronic use)
Phenylbutazone Butazolidine Approved - NR
Piroxicam Feldene Approved B L2
Suprofen Profenal Approved - NR
Tolmetin Tolectin Approved C L3
Narcotic analgesics [more]
B (1st,
2nd
Butorphanol Stadol Approved trim.) L3
D (3rd
trim.)
Codeine Tylenol #3, #4 Approved C L3
Fentanyl Sublimaze Approved B L2
L2
Meperidine Demerol Approved B L3 (if used early
postpartum)
Methadone Dolophine Approved B L3
Morphine Morphine Approved B L3
Propoxyphene Darvocet N, Propacet, Darvon Approved C L2
Anesthesia, Anesthetics [more] [contents]
Halothane Fluothane Approved C L2
Lidocaine Xylocaine Approved C L2
Methohexital Brevital Approved B L3
Thiopental Pentothal Approved C L3
Antacids, GI meds [contents]
Cimetidine (Antacid) Tagamet Approved B L2
Cisapride (GI tract stimulant) Propulsid Approved C L2
Domperidone (used for nausea &
Motilum Approved - L1
vomiting, stimulates lactation) [more]
Antibiotics [contents]
Amoxicillin Larotid, Amoxil Approved B L1
Aztreonam Azactam Approved B L2
Cefadroxil Ultracef, Duricef Approved B L1
Cefazolin Ancef, Kefzol Approved B L1
Cefotaxime Claforan Approved B L2
Cefoxitin Mefoxin Approved B L1
Cefprozil Cefzil Approved C L1
Ceftazidime Ceftazidime, Fortaz, Taxidime Approved B L1
Ceftriaxone Rocephin Approved B L2
Ciprofloxacin [more] Cipro Approved C L3
Clindamycin Cleocin Approved B L3
L1
Erythromycin E-Mycin, Ery-tab, ERYC, Ilosone Approved B L3 early
postnatal
Fleroxacin - Approved - NR
Gentamicin Garamycin Approved C L2
Kanamycin Kebecil, Kantrex Approved D L2
Moxalactam Moxam Approved - NR
Nitrofurantoin Macrobid Approved B L2
Ofloxacin Floxin Approved C L2
Penicillin - Approved B L1
Streptomycin Streptomycin Approved D L3
Sulbactam - Approved - NR
Sulfisoxazole Gantrisin, Azo-Gantrisin Approved C L2
Tetracycline Achromycin, Sumycin, Terramycin Approved D L2
Ticarcillin Ticarcillin, Ticar, Timentin Approved B L1
Trimethoprim/sulfamethoxazole Proloprim, Trimpex Approved C L3
Anticoagulants [contents]
Bishydroxycoumarin (dicumarol) - Approved - NR
Warfarin Coumadin, Panwarfin Approved D L2
Anticonvulsants [contents]
Carbamazepine Tegretol, Epitol Approved C L2
Ethosuximide Zarontin Approved C L4
Magnesium sulfate Epsom salt Approved B L1
Phenytoin Dilantin Approved D L2
Valproic acid Depakene, Depakote Approved D L2
Antifungals [contents]
Fluconazole [more] Diflucan Approved C L2
Ketoconazole Nizoral Shampoo, Nizoral Approved C L2
Antihistamines [more] [contents]
Dexbrompheniramine maleate with d-
- Approved - NR
isoephedrine
Fexofenadine Allegra Approved C L2
Loratadine Claritin Approved B L1
Terfenadine Seldane Approved - NR
Triprolidine Actidil, Actifed Approved C L1
Antivirals [contents]
Acyclovir [more] Zovirax Approved C L2
Interferon-alpha [more] Alferon N, Interferon Alpha Approved C L2
Arthritis meds (see also: pain meds) [contents]
Gold salts Ridaura, Myochrysine, Solganal Approved C L5
Asthma meds (see also: steroids) [contents]
Dyphylline Dilor, Lufyllin, Dyphylline Approved C L3
Terbutaline Bricanyl, Brethine Approved B L2
Theophylline Aminophylline, Quibron, Theo-Dur Approved C L3
Contraceptives, Hormones [more] [contents]
L3 (may
Estradiol Estratab, Permarin, Menest Approved X interfere with
milk production)
Clogestone - Approved - NR
Preven, Seasonale, Norinyl,
L3 (may
Contraceptive pill with Norlestin, Ortho-Novum, Ovral,
Approved X interfere with
estrogen/progesterone Lunelle injection, Ortho-Evra patch,
milk production)
etc.
Levonorgestrel Norplant, Mirena, Plan B Approved X L2
L1
Medroxyprogesterone Provera, Depo-Provera, Cycrin Approved D L4 (if used first 3
days
postpartum)
Norethynodrel Enovid Approved X L2
Progesterone Crinone, Prometrium Approved - L3
Cough meds [more] [contents]
Codeine Tylenol #3, #4 Approved C L3
Noscapine - Approved - NR
Decongestants [more] [contents]
L3 (for acute
use)
Pseudoephedrine Sudafed, Halofed, Novafed, Actifed Approved C
L4 (for chronic
use)
Diabetes meds [contents]
Note: Insulin has not been reviewed by the AAP. Pregnancy risk category = B; Lactation risk category = L1.
Tolbutamide Oramide, Orinase Approved D L3
Diarrhea meds [contents]
Imodium, Pepto Diarrhea Control,
Maalox Antidiarrheal Caplets,
Loperamide Approved B L2
Kaopectate II Caplets, Immodium
Advanced
** Note: Pepto-Bismol & Kaopectate (bismuth subsalicylate is the active ingredient in both) are not recommended
for routine use by nursing moms, due to the association of salicylates with Reyes syndrome in children. [more]
Diuretics [contents]
Acetazolamide Dazamide, Diamox Approved C L2
L4 (may inhibit
Bendroflumethiazide Naturetin Approved D
lactation)
Chlorothiazide Hydrodiuril Approved D L3
Chlorthalidone Hygroton Approved D L3
Hydrochlorothiazide Hydrodiuril, Esidrix, Oretic Approved D L2
Spironolactone Aldactone Approved D L2
Galactagogues (milk supply) [more] [contents]
Domperidone Motilum Approved - L1
Heart, Blood Pressure meds
[contents]
(Antiarrhythmics, Antihypertensives, Cardiac stimulants)
Antiarrhythmics
Disopyramide Norpace, Napamide Approved C L2
Flecainide Tambocor Approved C L3
Mexiletine Mexitil Approved B L2
Procainamide Pronestyl, Procan Approved C L3
Quinidine Quinaglute, Quinidex Approved C L2
Antihypertensives
L3 (if used after 30
Captopril Capoten Approved D
days)
Cardizem Sr, Dilacor-XR,
Diltiazem/Diltiazem HCL Approved C L3
Diltiazem, Cardizem CD
C (1st
trim.)
Enalapril/Enalapril Maleate Vasotec Approved L2
D (2nd,
3rd trim.)
Hydralazine Apresoline Approved C L2
Labetalol Trandate, Normodyne Approved C L2
Methyldopa Aldomet Approved C L2
Metoprolol Toprol XL, Lopressor Approved B L3
L2 (topically)
Minoxidil Loniten, Minodyl, Rogaine Approved C
L3 (orally)
Nadolol Corgard, Nadolol Approved C L4
Nifedipine Adalat, Procardia Approved C L2
Apsolox, Slow-Trasicor,
Oxprenolol Approved - NR
Trasicor
Propranolol Inderol Approved C L2
Sotalol Betapace Approved B L3
Timolol Blocadren Approved C L2
Verapamil Calan, Isoptin, Covera-HS Approved C L2
Cardiac stimulants
Digoxin Lanoxin, Lanoxicaps Approved C L2
Laxatives [more] [contents]
Cascara/Cascara Sagrada - Approved C L3
Danthron - Approved - NR
Magnesium sulfate Epsom salt Approved B L1
Senna - Approved - L3
Malaria meds [contents]
Chloroquine Aralen, Novo-chloroquine Approved C L3
Hydroxychloroquine Plaquenil Approved C L2
Pyrimethamine Daraprim Approved C L4
Quinine Quinamm Approved D L2
Medical Testing [more] [contents]
Diatrizoate - Approved - NR
Fluorescein - Approved C L3
Gadopentetic (Gadolinium) - Approved C L2
Iohexol Omnipaque Approved B L2
Iopanoic acid Telepaque Approved D L2
Metrizamide Amipaque Approved B L2
Metrizoate Isopaque Approved B L2
Migraine meds (see also: pain meds) [more] [contents]
Sumatriptan Imitrex Approved C L3
Sedatives [more] [contents]
Chloral hydrate Aquachloral, Noctec Approved C L3
Methyprylon (withdrawn from
- Approved - NR
use in US & Canada)
Bromide - Approved D L5
Secobarbital Seconal Approved D L3
Sleep Aids [contents]
Zolpidem/Zolpidem Tartrate Ambien Approved B L3
Steroids [contents]
Methylprednisolone
Solu-Medrol, Depo-Medrol,
[ high dosage Approved C L2
Medrol
methylprednisolone]
Prednisolone - Approved C L2
Deltasone, Meticorten,
Prednisone Approved C L2
Orasone
Thyroid meds [more] [contents]
Carbimazole - Approved D L3
Methimazole (active
Tapazole Approved D L3
metabolite of carbimazole)
Propylthiouracil PTU Approved D L2
Thiouracil - Approved - NR
Levothyroxine Synthroid, Levothroid, Approved A L1
Thyroid, Levo-T, Levoxyl
Tuberculosis meds [contents]
Cycloserine Seromycin Approved C L3
Ethambutol Ethambutol, Myambutol Approved B L2
Isoniazid INH, Laniazid Approved C L3
Rifampin Rifadin, Rimactane Approved C L2
Vitamins [more] [contents]
B-1 (thiamin) - Approved - NR
B-12 (Cyanocobalamin) - Approved A L1
L2; L4 in high doses
B-6 (pyridoxine) - Approved A (may inhibit
lactation)
L3 (do not
D, vitamin Calciferol, Delta-d Approved A
overdose)
A (1st,
2nd trim.)
Folic acid - Approved L1
C (3rd
trim.)
K-1, vitamin (Phytonadione) - Approved C L1
Riboflavin/B2 - Disetujui A L1
Miscellaneous [contents]
Acitretin (Anti-psoriasis) Soriatane Disetujui - NR
Alcohol/Ethanol [more] - Disetujui D L3
Allopurinol Zyloprim, Lopurin Disetujui C L2

Antimony - Disetujui - NR
Atropine (Anticholinergic,
Belladonna, Atropine Disetujui C L3
drying agent)
Azapropazone/apazone
Rheumox Disetujui - L2
(Antirheumatic)
Baclofen (muscle relaxant) Lioresal, Atrofen Disetujui C L2

Barbiturate - Disetujui - NR

Caffeine [more] Vivarin, NoDoz, Coffee Disetujui B L2

Carbetocin (Antihemorrhagic) Duratocin Disetujui - NR

Chloroform - Disetujui - NR

Cisplatin (Anti-cancer) Platinol Disetujui D L4

Dapsone (Antileprosy) Avlosulfon, DDS Disetujui C L4


Hydroxychloroquine
Plaquenil Disetujui C L2
(Antirheumatic, lupus)
Iodides - Disetujui - NR

Iodine - Disetujui - NR
Iodine (povidone-iodine, eg, in
- Disetujui - NR
a vaginal douche)
Ivermectin (Antiparasitic) Mectizan Disetujui C L3
Nalidixic acid (Urinary Anti-
NegGram Disetujui B L4
infective)
Norsteroids - Disetujui - NR
Pyridostigmine (Muscle Mestinon, Regonol C L2
stimulant) Disetujui

Scopolamine (Motion sickness) Transderm Scope Disetujui C L3

Sulfapyridine Dagenan Disetujui - NR

Timolol (glaucoma med) Blocadren Disetujui D L3

* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.

Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding


Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should
Be Given to Nursing Mothers With Caution
NR: Not Reviewed. This drug has not yet been reviewed by the AAP.

** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2004 edition).
Lactation Risk Categories Pregnancy Risk Categories
L1 (Paling Aman) A (studi terkontrol menunjukkan tanpa resiko)
L2 (Aman) B (tidak ada bukti risiko pada manusia)
L3 (Cukup Aman) C (risiko tidak dapat dikesampingkan)
L4 (Kemungkinan Barbahaya) D (bukti positif resiko)
L5 (Kontra Indikasi) X (dikontraindikasikan untuk Ibu Hamil)

NR: Not Reviewed. This drug has


pernah kita mendegar bahwa bayi lahir tidak normal atau cacat?
banyak penyebab bayi lahir tidak normal salah satunya yaitu obat-obat yang tidak aman yang dikonsumsi
oleh ibu pada waktu sedang mengandung., berikut daftar obat yang aman maupun tidak aman untuk ibu
hamil dan menyusui

Kelompok Analgetik, NSAIDS, Obat Batuk dan Pilek,


Anti Alergi dan Asma, Anestesi

Obat untuk Penghilang Rasa Sakit (Pain Killer)


Kategori Risiko
Nama Obat AAP approved?* Risiko Menyusui** Notes
Kehamilan**
Acetaminophen (Tylenol) Approved B L1
C (1st, 2nd trim.)
Aspirin Caution L3 1
D (3rd trim.)
Approved
Azapropazone (Rheumox) - L2
Butalbital (Fioricet, Fiorinal,
NR D L3 2
Bancap, Two-dyne)
B (1st, 2nd trim.)
Butorphanol (Stadol) Approved L3
D (3rd trim.)
Celecoxib (Celebrex)) NR C L2
Codeine (in Tylenol #3, #4) Approved C L3 3
Colchicine Approved D L4
Diclofenac (Cataflam, Voltaren) NR B L2
Fentanyl (Sublimaze) Approved B L2
Flurbiprofen (Ansaid, Froben, B (1st, 2nd trim.)
NR L2
Ocufen) C (3rd trim.)
Hydrocodone (Lortab, Vicodin) NR B L3 4
Hydromorphone (Dilaudid) NR C L3 5
Ibuprofen (Advil, Nuprin, Motrin, B (1st, 2nd trim.)
Approved L1
Pediaprofen) D (3rd trim.)
B (1st, 2nd trim.)
Indomethacin (Indocin) Approved L3
D (3rd trim.)
B (1st, 2nd trim.)
Ketorolac (Toradol, Acular) Approved L2
D (3rd trim.)
L2;
Meperidine (Demerol) Approved B L3 early 6
postpartum
Methadone (Dolophine) Approved B L3 7
Morphine (Duramorph,
Approved B L3 8
Infumorph, Epimorph, MS Contin)
Nalbuphine (Nubain) NR B L2
Naproxen (Anaprox, Naprosyn, L3;
Approved B 9
Naproxen, Aleve) L4 for chronic use
Nefopam (Acupan) Approved - NR
Oxycodone (Tylox,
Percodan,Oxycontin, Roxicet, NR B L3 10
Endocet, Roxiprin, Percocet)
Pentosan polysulfate (Elmiron) NR B L2
Piroxicam (Feldene) Approved B L2
Propoxyphene (Darvocet N,
Approved C L2 11
Propacet, Darvon)
Rofecoxib (Vioxx) Withdrawn from the market 12
Secobarbital (Seconal) Approved D L3 13
Tolmetin (Tolectin) Approved C L3
Tramadol HCL (Ultram, Ultracet) NR C L3 14
Valdecoxib (Bextra) Withdrawn from the market more
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.

Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding


Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants
and Should Be Given to Nursing Mothers With Caution
NR: Not Reviewed. This drug has not yet been reviewed by the AAP.

** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
Lactation Risk Categories Pregnancy Risk Categories
L1 (safest) A (controlled studies show no risk)
L2 (safer) B (no evidence of risk in humans)
L3 (moderately safe) C (risk cannot be ruled out)
L4 (possibly hazardous) D (positive evidence of risk)
L5 (contraindicated) X (contraindicated in pregnancy)

NR: Not Reviewed. This drug has not yet been reviewed by Hale.

15. Aspirin use is discouraged in children and nursing mothers due to the risk of Reyes syndrome and
internal bleeding.
16. Fioricet (Fiorinal, Bancap, Two-dyne) contains acetaminaphen or asprin, caffeine, and butalbital. Per
Hale, baby should be observed for sedation.
17. Hale suggests weakened or premature infants be observed for sedation and apnea.
18. Hale suggests newborns be observed for sedation, apnea, constipation.
19. Per Hale, use of frequent, higher dose may result in infant sedation.
20. Per Hale, Meperidine use during labor or early postpartum has been associated with sedation, poor
sucking reflex, and neurobehavioral delay in infants.
21. Per Hale, observe infant for sedation, respiratory depression, addiction, withdrawal syndrome.
22. Per Hale, higher doses may result in infant sedation.
23. Per Hale, should be used with caution due to its long half-life and its effect on babys cardiovascular
system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible
with breastfeeding.
24. Roxicet, Endocet, Roxiprin, Percocet also contain acetaminophen. Per Hale, observe infant for
sedation.
25. Per Hale, observe infant for sedation.
26. Per Hale, observe infant for GI cramping, distress, diarrhea.
27. Per Hale, observe infant for sedation.
28. Per Hale, observe infant for sedation.

Non-steroidal anti-inflammatory analgesics (NSAIDs) [more]


AAP Kategori Risiko
Nama Generik Nama Dagang
approved?* Kehamilan** Risiko Menyusui**
Azapropazone (apazone) Rheumox Approved - L2
Dipyrone (banned in the US &
- Approved - NR
UK)
Flufenamic acid - Approved - NR
Advil, Nuprin, Motrin, B (1st, 2nd trim.)
Ibuprofen Approved L1
Pediaprofin D (3rd trim.)
B (1st, 2nd trim.)
Indomethacin Indocin Approved L3
D (3rd trim.)
B (1st, 2nd trim.)
Ketorolac Toradol, Acular Approved L2
D (3rd trim.)
Mefenamic acid Ponstan, Ponstel Approved - NR
Anaprox, Naprosyn, L3
Naproxen Approved B
Naproxen, Aleve L4 (for chronic use)
Phenylbutazone Butazolidine Approved - NR
Piroxicam Feldene Approved B L2
Suprofen Profenal Approved - NR
Tolmetin Tolectin Approved C L3
Steroid [contents]
Methylprednisolone
Solu-Medrol, Depo-Medrol,
[ high dosage Approved C L2
Medrol
methylprednisolone]
Prednisolone - Approved C L2
Deltasone, Meticorten,
Prednisone Approved C L2
Orasone
Obat Asma [contents]
Dyphylline Dilor, Lufyllin, Dyphylline Approved C L3
Terbutaline Bricanyl, Brethine Approved B L2
Aminophylline, Quibron,
Theophylline Approved C L3
Theo-Dur
Analgetik Narkotik [more]
B (1st, 2nd trim.)
Butorphanol Stadol Approved L3
D (3rd trim.)
Codeine Tylenol #3, #4 Approved C L3
Fentanyl Sublimaze Approved B L2
L2
Meperidine Demerol Approved B L3 (if used early
postpartum)
Methadone Dolophine Approved B L3
Morphine Morphine Approved B L3
Darvocet N, Propacet,
Propoxyphene Approved C L2
Darvon

Obat Batuk
Nama Obat AAP approved?* Risiko Menyusui**
Codeine yes L3 (moderately safe)
Dextromethorphan not reviewed L1 (safest)
Guaifenesin not reviewed L2 (safer)
Dekongestan (Obat Pilek)
Nama Obat AAP approved?* Risiko Menyusui**
Phenylephrine not reviewed L3 (moderately safe)
L3 (moderately safe) for acute use
Pseudoephedrine
yes L4 (possibly hazardous) for chronic use due to potential for
(Sudafed, Actifed)
decreasing milk supply
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2006 edition)
Nasal Sprays (Spray Hidung)
AAP
Nama Obat Risiko Menyusui**
approved?*
Beclomethasone
(Vanceril, Beclovent, not reviewed L2 (safer)
Beconase, Vancenase)
Cromlyn sodium
not reviewed L1 (safest)
(Nasalcrom)
Fluticasone (Flonase) not reviewed L3 (moderately safe)
Mometasone (Nasonex) not reviewed L3 (moderately safe)
Phenylephrine (in some
forms of Sinex and Neo- not reviewed L3 (moderately safe)
Synephrine)
Triamcinolone Acetonide
not reviewed L3 (moderately safe)
(Nasacort)
Antihistamin (Anti Alergi)
AAP
Nama Obat Risiko Menyusui**
approved?*
Brompheniramine not reviewed L3 (moderately safe)
Chlorpheniramine (Chlor-
not reviewed L3 (moderately safe)
Trimeton) CTM
Cetirizine (Zyrtec) not reviewed L2 (safer)
Dexbrompheniramine
maleate yes not reviewed
with d-isoephedrine
Diphenhydramine
not reviewed L2 (safer)
(Benadryl)
Doxylamine not reviewed L4 (possibly hazardous)
Fexofenadine (Allegra) yes L3 (moderately safe)
Loratadine (Claritin) yes L2 (safer)
Terfenadine (Seldane) yes not reviewed
Triprolidine (Actidil,
yes L1 (safest)
Actifed)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised
September 2001.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2002 edition)

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