ABSTRAK

HUBUNGAN KADAR SGPT DAN SGOT TERHADAP DENSITAS

PARASITEMIA PADA PASIEN MALARIA DI WILAYAH PUSKESMAS
JARO MARET 2020

Maulisa Khasanah

Dian Nurmansyah, Rahma Maulida

Malaria adalah penyakit infeksi disebabkan oleh Protozoa dari genus Plasmodium
ditularkan oleh gigitan nyamuk Anopheles. Lima spesies penyebab malaria yaitu,
Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium
malariae, Plasmodium Knowlesi. Hati adalah organ pertama yang terlibat dalam
reproduksi parasit malaria. Peningkatan kadar SGOT dan SGPT terhadap densitas
parasitemia dikarenakan adanya peningkatan jumlah parasit secara terus menerus
dapat mengakibatkan peradangann sel-sel hati sehingga terjadi histopatologi dan
sistem fungsional hepar dan juga karena adanya siklus ekso-eritrositik dari infeksi
parasit penyebab malaria menginvasi sel hati dan menghncurkan eritrosit . Tujuan
penelitian ini untuk mengetahui adanya hubungan kadar SGPT dan SGOT terhadap
densitas parasitemia pada pasien malaria di wilayah Puskesmas Jaro Maret 2020.
Penelitian ini bersifat survey analitik dengan teknik pengambilan sampel secara
Accidental total sampling. Penelitian ini mendapatkan 15 responden. Metode
pengukuran adalah kinetik enzimatik yang menggunakan alat Analyzer Biosystem
A2. Analisa data menggunakan aplikasi spss .Berdasaran hasil penelitian didapatkan
kadar SGPT normal sebanyak 7 orang dan yang memiliki kadar SGPT tidak normal
sebanyak 8 orang. kadar SGOT normal sebanyak 8 orang dan yang memiliki kadar
SGOT tidak normal sebanyak 7 orang. Hasil analisa data uji Rank Spearman didapat
hasil hubungan kadar SGPT terhadap densitas parasitemia dengan taraf signifikansi
0,05 didapat p-value 0.0000001 < 0,05 dan hasil hubungan rho kadar SGOT
terhadap densitas parasitemia dengan taraf signifikansi 0,05 didapat p-value 0.00006
< 0,05. Berdasarkan kriteria keputusan di atas maka dapat disimpulkan ada hubungan
antara densitas parasitemia dengan kadar SGPT dan SGOT.

Kata Kunci : Densitas Parasitemia, Kadar SGOT, Kadar SGPT

 ABSTRACT

CORELATION SGPT AND SGOT LEVELS ON DENSITY OF

PARASITEMIA IN MALARIA PATIENTS PUSKESMAS JARO MARET
2020

Maulisa Khasanah

Dian Nurmansyah, Rahma Maulida

Malaria is an infectious disease caused by Protozoa of the genus Plasmodium

transmitted by Anopheles mosquito bites. Five species that cause malaria, namely,
Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium
malariae, Plasmodium Knowlesi. The liver is the first organ involved in reproduction
of malaria parasites. Increased levels of SGOT and SGPT to the density of
parasitemia due to the continuous increase in the number of parasites can cause
inflammation of liver cells resulting in histopathology and liver functional system and
also because of the ecso-erythrocytic cycle of parasitic infections that cause malaria
to invade liver cells and destroy erythrocytes. The purpose of this study was to
determine the relationship of SGPT and SGOT levels to the parasitemia density in
malaria patients in the Jaro Health Center area March 2020. This study was an
analytical survey with Accidental total sampling technique. This study got 15
respondents. The measurement method is enzymatic kinetic using the Biosystem
Analyzer A2 tool. Analysis of the data using the application of spss. Based on the
results of the study obtained normal levels of SGPT by 7 people and those with
abnormal levels of SGPT by 8 people. normal SGOT levels were 8 people and those
who had abnormal SGOT levels were 7 people. The results of Spearman Rank test
data analysis showed the relationship of SGPT levels to parasitemia density with a
significance level of 0.05 obtained p-value 0.0000001 <0.05 and the results of the
relationship of rho SGOT levels to parasitemia density with a significance level of
0.05 obtained p-value of 0.00006 < 0.05. Based on the decision criteria above, it can
be concluded that there is a relationship between the density of parasitemia with
SGPT and SGOT levels.

Keyword : Parasitemia Density, SGOT, SGPT