PENGARUH PEMBERIAN TIAMIN INTRAVENA TERHADAP KADAR TUMOR

NECROSIS FACTOR ALPHA (TNF-) PADA PASIEN COVID-19

DI RUANG ISOLASI RSUP H. ADAM MALIK MEDAN

Annisa Syifanurhati 1, Akhyar Hamonangan Nasution2, Mhd Ihsan 2

1. Residen Anestesiologi dan Terapi Intensif FK USU, RSUP H. Adam Malik Medan
2. Departemen Anestesiologi dan Terapi Intensif FK USU, RSUP H. Adam Malik Medan

ABSTRAK

Pendahuluan : Banyak sitokin dan mediator inflamasi yang berperan dalam progresivitas
penyakit covid-19, diantaranya golongan interleukin, interferon, dan tumor necrosis faktor.
Tiamin dapat mempengaruhi sitokin proinflamasi terutama TNF α sehingga pemberian tiamin
dapat menurunkan produksi IL-6 dan TNF-α.
Tujuan : Untuk mengetahui pengaruh pemberian tiamin intravena terhadap kadar Tumor
Necrosis Factor (TNF-) pada pasien COVID-19 diruang isolasi RSUP H Adam Malik.
Metode : Penelitian ini menggunakan desain analitik one group pre test - post test di ruangan
isolasi RSUP Haji Adam Malik Medan dengan 16 sampel. Sampel diberi tiamin IV 200
mg/12 jam lalu diukur kadar TNF-α dengan metode ELISA.
Hasil : Karakteristik sampel didapatkan laki – laki dan perempuan sebanyak 8 (50%), usia
rerata sebesar 43 ±14,78, di dominasi suku jawa sebesar 9 ( 56,3%), rerata IMT sebesar 23,31
± 6,55, rerata sistolik 122,50 ± 5,77 dan diastolik 88,88 ± 6,55 dimana nilai p > 0,05
(berdistribusi normal). Rerata kadar TNF  Sebelum 204,18 ± 60,93 dan setelah pemberian
tiamin rerata TNF  sebesar 204,18 ± 60,93 didapatkan nilai P sebesar 0,001 < 0,05 (adanya
pengaruh yang signifikan)
Kesimpulan : Terdapat pengaruh penurunan yang signifikan antara kadar TNF- sebelum
dan sesudah pemberian tiamin

Kata kunci : Tiamin intravena, TNF-α, COVID-19, Tumor Necrosis Factor Alpha, Ruang
isolasi
 THE EFFECT OF INTRAVENOUS THIAMINE ADMINISTRATION ON TUMOR
NECROSIS FACTOR ALPHA (TNF- α) LEVELS ON COVID-19 PATIENTS
IN THE ISOLATION ROOM OF H. ADAM MALIK MEDAN HOSPITAL

Annisa Syifanurhati 1, Akhyar Hamonangan Nasution2, Mhd Ihsan 2

1. Residen Anestesiologi dan Terapi Intensif FK USU, RSUP H. Adam Malik Medan
2. Departemen Anestesiologi dan Terapi Intensif FK USU, RSUP H. Adam Malik Medan

ABSTRACT

Background : Many cytokines and inflammatory mediators play a role in the progression of
COVID-19 disease, including interleukins, interferons, and tumor necrosis factor. Thiamine
can affect proinflammatory cytokines, especially TNF-α so that thiamine administration can
reduce the production of IL-6 and TNF- α.
Objective: To determine the effect of intravenous thiamine administration on Tumor
Necrosis Factor (TNF-α) levels in COVID-19 patients in the isolation room of H. Adam
Malik Hospital.
Methods : This study used analytical design of one group pre test - post test in the isolation
room of Haji Adam Malik Hospital Medan with 16 samples. Samples were given thiamine IV
200 mg/12 hours and then the levels of TNF-α were measured using the ELISA method.
Results : Characteristics of the sample, males and females were 8 (50%), the mean of age
was 43 ± 14.78, the Javanese were dominated by 9 (56.3%), the mean of BMI was 23.31 ±
6.55, the mean of systolic 122.50 ± 5.77 and diastolic 88.88 ± 6.55 with the p value > 0.05
(normally distributed). The mean of TNF-α before thiamine administration was 204.18 ±
60.93 and after thiamine administration was 204.18 ± 60.93, the P value was 0.001 < 0.05
(there was significant effect)
Conclusion : There is a significant decrease in TNF-α levels before and after thiamine
administration.

Keywords : Intravenous thiamine, TNF-α, COVID-19, Tumor Necrosis Factor Alpha,

Isolation room