TUGAS INDIVIDU KMB III

1. Carilah 1 jurnal (free download) terkait masalah sistem perkemihan

(ISK, BPH, GGK, Hemodialisa, dsb….)
2. Jurnal boleh berbahasa Indonesia atau berbahasa Inggris, maksimal 5
tahun terakhir (jurnal yang dicari tahun 2016-2020)
*) Jurnal berbahasa Indonesia bisa dicari melalui : pencarian google,
google scholar, atau bisa juga melalui mendeley (dengan
memasukan kata kuci tema yang akan dicari)
*) Jurnal berbahasa inggris bisa dicari melalui : pubmed (dengan
memasukan kata kuci tema yang akan dicari), atau bisa juga melalui
mendeley
3. Lakukan telaah kritis jurnal sesuai dengan contoh (terlampir)
4. Format laporan:
Cover disertai judul artikel jurnal, logo STIKES, nama dosen pengampu,
dan nama mahasiswa
Kata Pengantar
Daftar Isi
BAB I Pendahuluan, berisi Latar Belakang, tujuan dan manfaat dari
telaah kritis
BAB 2 Hasil Telaah Kritis
BAB 3 Kesimpulan
LAMPIRAN ARTIKEL JURNAL FULL TEXT
5. Masing-masing buat power point nya juga
6. Laporan dan power point nya paling lambat dikumpulkan hari selasa
tanggal 10 November 2020 jam 23.59
7. Hari Rabu tgl 11 November 2020 persentasi jam 13.30 WIB melalui
zoom.
8. Mahasiswa yang presentasi akan di acak saat Hari H.
 TELAAH KRITIS JURAL

“Comparison of the efficacy of levocetirizine 5 mg and

desloratadine 5 mg in chronic idiopathic urticaria”

Disusun untuk memenuhi tugas

Mata Kuliah KMB III
Dosen Pengampu…………………………………….

LOGO

Oleh:
…………………………..

PROGRAM STUDI S1 KEPERAWATAN

STIKES WIJAYA HUSADA BOGOR
2020
 BAB I
PENDAHULUAN

A. Latar Belakang
B. Tujuan
C. Manfaat
 BAB II
TELAAH KRITIS
ARTIKEL PENELITIAN KESEHATAN

“Comparison of the efficacy of levocetirizine 5 mg and

desloratadine 5 mg in chronic idiopathic urticaria”

A. Bukti ilmiah yang didapat

Abstract
1. Latar belakang
Nonsedating H1-antihistamines are recommended for the treatment of
urticaria by the recent EAACI/GA2LEN/EDF guidelines. The aim of
this study was to compare the efficacy, after 4 weeks of treatment,
with levocetirizine 5 mg and desloratadine 5 mg, both once daily in
the morning, in symptomatic chronic idiopathic urticaria (CIU)
patients
2. Metode
This multi-center, randomized, double-blind study involved 886
patients (438 on levocetirizine and 448 on desloratadine). The primary
objective was to compare their efficacy on the mean pruritus severity
score after 1 week of treatment. Mean pruritus severity score over
4 weeks and pruritus duration score, number and size of wheals, mean
CIU composite score (sum of the scores for pruritus severity and
numbers of wheals), quality of life, and the patient’s and
investigator’s global satisfaction with treatment, were secondary
efficacy measures.
3. Hasil
Levocetirizine led to a significantly greater decrease in pruritus
severity than desloratadine over the first treatment week; mean
pruritus severity scores of 1.02 and 1.18 for levocetirizine and
desloratadine, respectively (P < 0.001). The result was similar for the
entire 4-week treatment period (P = 0.004). In addition, levocetirizine
decreased pruritus duration and the mean CIU composite scores to a
significantly greater extent than desloratadine during the first week
(P = 0.002 and 0.005, respectively) and over the entire study
(P = 0.009 and P < 0.05, respectively). Similarly, levocetirizine
increased the patients’ global satisfaction after one and 4 weeks
 (P = 0.012 and 0.021, respectively), compared with desloratadine.
Safety and tolerability were similar in both groups.
4. Kesimpulan
Levocetirizine 5 mg was significantly more efficacious than
desloratadine 5 mg in the treatment of CIU symptoms.

B. Kajian kritis Umum

1. Judul
Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5
mg in chronic idiopathic urticaria
a. Pernyataan sudah mencerminkan isi artikel
b. Sudah terdapat variable penelitian
c. Mencerminkan metode penelitian

2. Penulis
P. C. Potter1, A. Kapp2, M. Maurer3, G. Guillet4, A. M. Jian5, P. Hauptmann6, A. Y.
Finlay7
1. Allergy Diagnostic and Clinical Research Unit, University of Cape Town Lung
Institute, Cape Town, South Africa
2. Department of Dermatology and Allergology, Hannover Medical School, Hannover,
Germany
3. Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–
Universitätsmedizin, Berlin, Germany
4. Centre Hospitalier Universitaire de Poitiers, Service de Dermatologie, Poitiers,
France
5. Policlinica de Diagnostic Rapid, Brasov, Romania
6. Dermatologische Praxis, Salzwedel, Germany
7. Department of Dermatology, Cardiff University, School of Medicine, Cardiff, U
*Correspondence: Prof. Paul C Potter Allergy Diagnostic and Clinical Research Unit
University of Cape Town Lung Institute George Street Mowbray 7700 Western
Cape South Africa

Penulis menunjukkan kapabilitas dalam meneliti terkait masalah

sistem integumen
C. Kajian kritis mengenai Isi

1. Apakah penelitian ini valid?

Bukti terdiri dari:
a. Apakah pengambilan
sampel dilakukan
secara acak ?
Ya.
This was a multi-center, randomized,
double-blind, parallel-group clinical
efficacy study study involved 886
patients (438 on levocetirizine and
448 on desloratadine).

Ya.
b. Apakah pengambilan Patients with physical urticaria
sample dijelaskan (e.g.solar, heat, cold, aquagenic,
secara rinci (kriteria cholinergic, contact, pressure, etc.),
inklusi dan eklusi)? drug induced urticaria, urticarial
vasculitis, senile pruritus or
hereditary angioedema were
excluded, as were patients with any
dermatological or any other clinically
significant disease

c. Apakah pengamatan Ya.

/follow up responden The primary objective of the study
dilakukan secara cukup was to compare the clinical efficacy
panjang dan lengkap ? of 1 weeks treatment with
levocetirizine 5 mg vs desloratadine 5
mg, both administered once daily in
the morning, assessed as the mean
pruritus severity score in patients
suffering from CIU. The effect of 1–4
weeks treatment with levocetirizine 5
 mg and desloratadine 5 mg on the
mean pruritus severity score,
meanpruritus duration, the number
and size of wheals, mean CIU
composite score (sum of the pruritus
severity score and the score for the
numbers of wheals), QOL, and the
patients and investigators global
satisfaction with treatment were also
evaluated as secondary efficacy
measures.

d. Apakah responden tidak Tidak

diberitahu selama patients providing written informed
penelitian berlangsung? consent were assessed for
demographic characteristics and
medical history. Each patient
underwent a physical examination
and was provided with a Daily
Record Card (DRC) to record the
severity of pruritus over the past 24 h
(evaluated on a 4-point scale
retrospectively), the number and the
size of the wheals, the duration of
pruritus, any adverse events and use
of concomitant medications

e. Apakah semua Ya
responden dalam Male and female out-patients aged 18
kelompok yang diacak years and over, with a clinical history
dianalisa ? of CIU (i.e. episodes of hives of
characteristic wheal and lare
appearance, occurring regularly, at
least three times a week) for a period
of at least 6 weeks during the last 3
 months without an identifiable cause
were recruited into the study

f. Apakah responden
diperlakukan sama ?
Ya
The primary objective of the study
was to compare the clinical efficacy
of 1 week’s treatment with
levocetirizine 5 mg vs desloratadine
5 mg, both administered once daily in
the morning, assessed as the mean
pruritus severity score in patients
suffering from CIU

2. Apakah hasil penelitian yang valid ini penting?

Ya, penting
Levocetirizine led to a significantly greater decrease in pruritus
severity than desloratadine over the first treatment week; mean
pruritus severity scores of 1.02 and 1.18 for levocetirizine and
desloratadine, respectively (P < 0.001). The result was similar
for the entire 4-week treatment period (P = 0.004). In addition,
levocetirizine decreased pruritus duration and the mean CIU
composite scores to a significantly greater extent than
desloratadine during the first week (P = 0.002 and 0.005,
respectively) and over the entire study (P = 0.009 and P < 0.05,
respectively). Similarly, levocetirizine increased the patients’
global satisfaction after one and 4 weeks (P = 0.012 and 0.021,
respectively),

3. Apakah hasil penelitian ini dapat diterapkan di

masyarakat?
a. Apakah hasil penelitian Ya. kondisi yang sama dari
dapat diterapkan di responden karena memenuhi
masyarakat? inklusi dari pasien pada
 penelitian tersebut. Sedangkan
yang termasuk kriteria eksklusi
adalah:
patients who had received CNS
acting agents (including
tranquilizers, antidepressants,
sedatives, hypnotics or
antiepileptics) at any time were
excluded. Pregnant or breast
feeding women were also
excluded.

b. Apakah masyarakat Menguntungkan

mempunyai potensi yang Dari penelitian dapat kita kita
menguntungkan atau ketahui bahwa Levocetirizine
merugikan bila hasil lebih efektif dari pada
penelitian ini diterapkan ? desloratidine dalam mengurangi
urtikaria.
Levocetirizine 5 mg was
significantly more efficacious
than desloratadine 5 mg in the
treatment of CIU symptoms
The demonstrated clinical
advantage of levocetirizine
5 mg once daily over
desloratadine 5 mg once daily,
both taken in the morning,
possibly warrants levocetirizine
5 mg as a favorable treatment
option for management of adult
subjects with chronic idiopathic
urticaria.
 BAB III
KESIMPULAN

A. Kelebihan Jurnal
B. Kekurangan Jurnal
LAMPIRAN FULL TEXT JURNAL