Dewi Yuniar (0710083) Stephanie Viola Warokko (0710064) Noverio Michael S. Tarukallo (0710023) Florence Fedora (0710004)
Supervisor: dr. Daniel Pratikno, Sp.OT
DEPARTMENT OF SURGERY Maranatha Christian University IMMANUEL HOSPITAL BANDUNG 2011 BONE HEALING I. Pendahuluan Bila tlg fracture tjd serangkaian proses mulai mobilisasi sel radang sampai kembalinya btk tlg ke keadaan sblm fracture ( Rockwood,1991) Bone healing = proses regenerasi : tlg yg rusak diganti dgn tlg yg baru tanpa jar.parut (sikatrik) Bone healing melibatkan peran sel mesenkim & sel hematopoetik II. Tahapan bone healing Rockwood (1991): - inflammatory phase - reparative phase - remodeling phase Gambar 1. Tahapan penyembuhan fraktur dan perkiraan waktu yang dibutuhkan mulai fase hematoma sampai fase remodeling (Yeo Li, 1994). 1. Fase inflamasi Jejas pembuluh darah rusak vasokonstriksi clotting & agregasi trombosit Clotting mengandung sel inflamasi (neutropil & makrofag) sekresi sitokin (IL-1 & IL-6) reaksi inflamasi Trombosit yg teragregasi sekresi mediator sitokin & growth factors (PDGF,IGF-1,EGF,TGF-) Growth factors yg terbentuk mengakibatkan endotel & fibroblas bergerak ke tempat jejas terbentuk jaringan granulasi yg kaya pembuluh darah (provisional matrix) suplai O 2 & nutrisi lancar 2. Fase reparasi Dimulai dgn terbentuknya hematom yg banyak mengandung pembuluh darah Sel inflamasi mensekresi growth factor : sel mesenkim bergerak ke tempat jejas sel mesenkim berproliferasi & diferensiasi mjd fibroblas dan osteoblas Fibroblas dan osteoblas akan mensintesa jaringan fibrous,kartilago dan woven bone (fracture callus) Kalus yg terbentuk pd periosteum : hard callus Kalus yg terbentuk pd medulla : soft callus
Kalus akan dimineralisasi oleh osteoblast dan kondrosit menjadi matriks tlg yg mengandung serat kolagen. Kondrosit membantu stabilisasi kadar glikosaminoglikan dgn cara mensekresi enzim proteoglikenase 3. Fase remodeling Remodeling ttd 2 proses : - bone formation yg dilakukan oleh osteoblas - bone resorption yg dilakukan oleh osteoklas Kerjasama antara osteoblas dan osteoklas dlm bone remodeling coupling phenomenon Aktivitas penyerapan dan pembentukan tlg dipengaruhi oleh elektronegatifitas daerah fraktur
Gambar 2. Aktivitas penyerapan tulang yang dilakukan sel osteoklas dikontrol osteoblas melalui jalur OPG/RANK/RANK-L. Diferensiasi osteoklas precursor menjadi osteoklas dapat terjadi bila reseptor RANK yang terdapat pada osteoklas precursor berikatan dengan ligan yang disekresi oleh osteoblas. Di samping itu osteoblas juga mensekresikan osteoprotegerin yang bersifat inhibisi terhadap RANKL. Anak panah yang berada di sisi kiri osteoblas meningkatkan aktivitas penyerapan tulang melalui rangsangan osteoblas untuk mensekresi RANKL, sementara anak panah yang terputus-putus mengurangi aktivitas penyerapan tulang dengan menghambat jalur RANKL. Osteoklas menempel pada permukaan tulang melalui integrin (V3) yang kemudian akan mensekresikan ion H+ dan enzim cathepsin untuk mendegradasi kolagen (Joseph T. Dipiro). TREATMENT OF FRACTURE I. Treatment of closed fractures II. Treatment of open fractures and gunshot wounds TREATMENT OF CLOSED FRACTURES General treatment is the first consideration
TREAT THE PATIENT, NOT SIMPLY THE INJURED PART Sequence in treating patients with fractures: I. First aid II. Transport III. Treatment of shock, haemorrhage, and associated injuries Pre-hospital scene Wooden splint for pre-hospital immobilization PRINCIPLES OF TREATMENT OF FRACTURES 1. Manipulation to improve the position of fragments (REDUCE) 2. Followed by splintage to hold the fragments together until they unite (HOLD) 3. Meanwhile, joint movement and function must be preserved (EXERCISE) Remember: Treatment determined not only by the TYPE OF FRACTURE, but also by the condition of the SOFT TISSUES Conflicts In treating fractures a surgeon will meet some conflicts: 1. How to hold a fracture adequately and yet use the limb sufficiently
2. How to resolve as rapidly as possible, yet to avoid unnecessary risks HOLD vs MOVE SPEED vs SAFETY These dual conflicts epitomizes the FOUR FACTORS THAT DOMINATE fracture management Term FRACTURE QUARTET used to represent these factors (HOLD, MOVE, SPEED, SAFETY) THE FRACTURE QUARTET MOVE HOLD SAFETY SPEED REDUCE NO UNDUE DELAY
Swelling of the soft parts during the first 12 hours makes reduction is increasingly difficult
Reduction is UNNECESSARY if: 1. Little / no displacement 2. Displacement does not matter (like in the fractures of the clavicle) 3. Reduction is unlikely to succeed (eg. compression fractures of the vertebrae) ALIGNMENT IS MORE IMPORTANT THAN APPOSITION Fractures involving articular surface: Should be reduced as near to perfection as possible because any irregularity will predispose to degenerative arthritis Methods of reduction: 1. Closed reduction 2. Open reduction CLOSED REDUCTION Done under appropriate anesthesia and muscle relaxation Most effective when the periosteum and muscle on one side of the fracture remain intact Soft tissue strap prevents over-reduction and stabilizes the fracture after reduction Some fractures (e.g. of the femoral shaft) are difficult to reduce by manipulation because of powerful muscle pull and may need prolonged traction Indications: 1. All minimally displaced fractures 2. Most fractures in children 3. Fractures that are not unstable after reduction Contraindications: 1. Fractures with severe soft tissue damage 2. Inherently unstable fractures 3. Multiple fractures 4. Fractures in confused or uncooperative patients Cervical Collar Devices used for protection Mitela Devices used for protection Arm Sling Devices used for protection Shoulder Immobilizer Devices used for protection Clavicle Brace Devices used for protection OPEN REDUCTION Reduction under direct vision Indications: 1. When closed reduction fails 2. There is a large articular fragment that needs accurate positioning 3. For traction fractures in which the fragments are held apart HOLD REDUCTION The word immobilization should deliberately AVOIDED because the objective is seldom complete immobility, usually it is the prevention of displacement Nevertheless, some restriction of movement is needed to promote soft tissue healing and to allow free movement of the unaffected parts Methods of holding reduction: 1. Continuous traction 2. Cast splintage 3. Functional bracing 4. Internal fixation 5. External fixation CONTINUOUS TRACTION Traction is applied to the limb distal to the fracture, so as to exert a continuous pull in the long axis of the bone Indications: Particularly useful for shaft fractures which are oblique and spiral and easily displaced by muscle contraction Disadvantages: Traction cannot HOLD a fracture still, maintain accurate reduction is sometimes difficult SPEED is slow because traction keeps the patient in hospital
CONTINUOUS TRACTION
Speed is the weak member of the quartet MOVE HOLD SAFETY SPEED As soon as the fracture is STICKY (deformable but not displaceable) traction should be replaced by bracing Methods of Traction 1. Traction by gravity 2. Skin traction 3. Skeletal traction TRACTION BY GRAVITY Only for upper limb injuries Weight of the arm provides continuous traction to the humerus For the patients comfort and stability of the fragments, a U-slab or a removable plastic sleeve may be applied from the axilla to just above the elbow SKIN TRACTION Also called Bucks traction Can sustain a pull of no more than 4 to 5 kg Skin traction (Ankle traction) Skin traction Skin Traction SKELETAL TRACTION Traction/weight applied through a Kirschner, Steinmann pin or Denham pin that inserted through the bone Skeletal traction Place of pin insertion: 1. Behind the tibial tubercle for hip, thigh and knee injuries 2. Lower in the tibia, or through the calcaneum for tibial fractures Steinmann Pin for Skeletal Traction Traction must always be apposed by counter traction; that is, the pull must be exerted against something, or it merely drags the patient down the bed Fixed Traction The pull is exerted against a fixed point
Balanced Traction The pull is exerted against an opposing force provided by the weight of the body when the foot of the bed raised Combined Traction A Thomas splint is used Complications: In children: traction tapes and circular bandages may constrict the circulation In older people: leg traction may predispose to peroneal nerve injury Compartment syndrome following excessive traction through a calcaneal pin Thomas Splint with Pearson Attachment 90 90 traction CAST SPLINTAGE Plaster of Paris is still widely used as a splint, especially for distal limb fractures and for most childrens fractures Disadvantages: Joints in plaster are liable to stiffen Cartilage defects heal slower CAST SPLINTAGE Move is the weak member of the quartet MOVE HOLD SAFETY SPEED Application of Plaster of Paris for forearm fracture Below knee cast Complications: 1. Tight cast 2. Pressure sooner 3. Skin abrasion or laceration FUNCTIONAL BRACING Segments of a cast are applied only over the shafts of the bones, leaving the joints free Using Plaster of Paris or lighter materials Cast segments are connected by metal or plastic hinged which allow movements in one plane
Indications: Most widely used for fractures of the femur or tibia Brace is NOT VERY RIGID Apply only when the fracture is beginning to unite, i.e. after 3-6 weeks of traction or conventional plaster Advantages: Fracture can be held reasonably well Joints can be moved Fracture joints heal at normal speed without keeping the patient in hospital Method safe Disadvantage: Greater risk of malunion Simple Arm Brace Functional Braces for Lower Extremity Functional Brace for the Hip INTERNAL FIXATION Bone fragments may be fixed using: - Screws - Transfixing pins or nails - A metal plate held by screws - Intramedullary nails (with or without locking screws) - Circumferential bands - Or combinations of these methods Wires used for Internal Fixation Plates for Internal Fixation Protheses for hemiarthroplasty of the hip Rod for Internal Fixation Advantages: Internal fixation holds a fracture securely so that movements can begin at once Good speed outcome, the patient can leave the hospital as soon as the wound healed Disadvantages: Risk of operation complications Risk of infection INTERNAL FIXATION Safety is the weak member of the quartet MOVE HOLD SAFETY SPEED Indications: 1. Fractures that cannot be reduced except by operation 2. Fractures that are inherently unstable and prone to redisplacement after reduction, and those liable to be pulled apart by muscle action 3. Fractures that unite poorly and slowly, principally fractures of the femoral neck 4. Pathological fractures, in which bone disease may prevent healing 5. Multiple fractures 6. Fractures in patients who present nursing difficulties Complications: 1. Infection 2. Non-union 3. Metal failure 4. Refracture Most of the complications of internal fixation are due to POOR TECHNIQUE, POOR EQUIPMENT, or POOR OPERATING CONDITIONS Non-union resulting from poor technique Non-union resulting from poor technique EXTERNAL FIXATION A fracture may be held by transfixing screws or tensioned wire which pass through the bone above and below the fracture and are attached to an external frame Indications: 1. Fractures associated with severe soft tissue damage 2. Fractures with nerve or vessel damage 3. Severely comminuted and unstable fractures 4. Ununited fractures 5. Fractures of the pelvis, which often cannot be controlled by any other method 6. Infected fractures 7. Severe multiple injuries Complications: 1. Overdistraction of the fragments, which are then held rigidly apart 2. Reduced load transmission through the bone, which delays fracture healing and causes osteoporosis 3. Pin-track infection External fixators should be DYNAMIZED or REMOVED after 6-8 weeks, and REPLACED by some alternative form of splintage which will allow bone loading External Fixation for Metacarpal Fracture External Fixation External fixation Ilizarov device EXERCISE Restore function is a more correctly term Applied not only to the injured parts but also to the patient as a whole Objectives: 1. To reduce oedema 2. To preserve joint movement 3. To restore muscle power 4. To guide the patient back to normal activity Methods: 1. Prevention of oedema 2. Elevation 3. Active exercise 4. Assisted movement 5. Functional activity Prevention of Oedema persistent oedema is an important cause of joint stiffness, especially in the hand Reduce / prevent oedema by: 1. Elevate the injured parts 2. Exercise Active exercise Elevation Elevate the limb after reduction Do not dangle the injures limb Elevate the limb even after the plaster removed until circulatory control is fully restored
Active Exercise Active movement helps to pump away oedema fluid, stimulates the circulation, prevents soft-tissue adhesion, promotes fracture healing For limbs those encased in plaster static muscle contraction Start muscle-building exercises after splintage is removed Remember: Exercise unaffected joints also Assisted Movement Gentle assistance during active exercises may help to retain function or regain movement after fractures involving the articular surfaces Nowadays this is done with machines that can be set to provide a specified range and rate of movement (Continuous passive motion) Functional Activity As the patients mobility improves, an increasing amount of directed activity is included in the programme The patient may need to be taught to do his daily activity Encourage the patient to use the injured limb as much as possible TREATMENT OF OPEN FRACTURES General Considerations Many patients with open fractures have multiple injuries and severe shock
Appropriate treatment at the scene of the accident is essential
Cover the wound with a sterile dressing or clean material and left undisturbed until the patient reaches the accident department In the hospital a rapid general assessment is the first step, any life-threatening conditions are addressed
Inspect the wound after initial assessment Ideally the wound should be photographed with a Polaroid/digital camera so that it can again be covered and left undisturbed until the patient in the operating theatre Important points in wound assessment: 1. What is the nature of the wound? 2. What is the state of the skin around the wound? 3. Is the circulation satisfactory? 4. Are the nerves intact? All open fractures, no matter how trivial they may seem, MUST BE ASSUMED TO BE CONTAMINATED PRINCIPLES OF OPEN FRACTURE MANAGEMENT 1. Immediate wound cover 2. Antibiotic prophylaxis 3. Early wound debridement 4. Stabilization of the fracture Early Management The wound should be kept covered until the patient reaches the operating theatre Antibiotics are given as soon as possible, no matter how small the lacerations are Continue antibiotic therapy until the danger of infection has passed Give tetanus prophylaxis Debridement Objective:
To render the wound devoid of foreign material and of dead tissue, leaving a good blood supply throughout Irrigate the wound thoroughly with cupious amounts of physiological saline Final irrigation may be with an antibacterial agent Do not use torniquet because it would endanger the circulation still further and make it difficult to recognize wiche structures are devitalized Intra-operative tissue management How to manage: 1. Skin? 2. Fascia? 3. Muscle? 4. Blood vessels? 5. Nerves? 6. Tendons? 7. Bone? 8. Joints ? SKIN: spare as much skin as possible
FASCIA: devide fascia extensively so that the circulation is not impeded
MUSCLE: excise all dead and doubtfully viable muscle
BLOOD VESSELS: tied or clamped bleeding vessels NERVES: - Usually best to leave cut nerves undisturbed for later repair - The sheath can be sutured if the wound is clean and the nerve ends need no dissection
TENDONS: - Best to leave cut tendons undisturbed for later repair - Tendons can be sutured if the wound is clean and need no dissection BONE: - Fracture surfaces are gently cleaned and replaced in the correct position - Spare bone as much as possible - Remove fragments only if they are small and totally detached JOINTS: - Open joint injuries are best treated by wound toilet, closure of synovium and capsule, and systemic antibiotics - Drainage or suction irrigation is used only if contamination is severe Wound Closure To close or not to close the skin can be a difficult decision A small uncontaminated wound can be sutured without tension, or skin grafted after early debridement All other wound MUST BE LEFT OPEN until the dangers of tension and infection have passed Pack the wound with sterile gauze, inspect for 5 days. If it is clean, the wound sutured or skin grafted (DELAYED PRIMARY CLOSURE) Stabilization of the Fracture Stability of the fracture is important in reducing the likelihood of infection For a type I or small type II wound with a stable fracture a widely split plaster, or traction can be used More severe wounds demand a more secure fixation External fixation is THE SAFEST method of fixation for open fractures Other implants can be used only by experienced surgeon and the circumstances are ideal Aftercare Shock may still require treatment Elevate the limb in the ward Carefully watch the circulation Continue antibiotic therapy Culture and sensitivity test Wound closure using delayed primary closure or skin graft If toxaemia or septicaemia persists in spite of chemotherapy the wound is drained GUNSHOT INJURIES General Considerations Missile wounds are looked upon as a special type of open injury Tissue damage produced by: 1. Direct injury in the immediate path of the missile 2. Contusion of muscles around the missile track 3. Bruising and congestion of soft tissues at a greater distance from the primary track
Fractures caused by gunshot injury Low-velocity missile High-velocity missile In all gunshot injuries debris is sucked into the wound, which is therefore CONTAMINATED from the outset Early Management Bleeding control and general resuscitation is the first priority Examine the wounds for artery or nerve damage Cover the wounds using sterile dressings Antibiotics should be given immediately Definitive Treatment All missile injuries are treated as severe open injuries Perform exploration of missile track and debridement Low-velocity wounds with relatively clean entry and exit wounds can be treated as Gustilo type I injuries High-velocity injuries demand thorough cleansing and debridement, ischaemia prevention, the wounds should left open The SAFEST PLAN, if the contamination is considerable, and if anatomical considerations permit, is to JOIN THE ENTRY AND EXIT WOUNDS and LEAVE THE ENTIRE TRACK OPEN Delayed primary closure after 7 days If there are comminuted fractures, these are best managed by EXTERNAL FIXATION Post-mortem specimen of an osteomyelitic bone following gunshot injury references Apleys System of Orthopaedics and Fractures A. Graham Apley, Louis Solomon Pengantar Ilmu Bedah Ortopedi Chairuddin Rasjad Textbook of Disorders and Injuries of the Musculoskeletal System Robert Bruce Salter Traction and Orthopaedic Appliances John D.M. Stewart, Jeffrey P. Hallet
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