DAFTAR ISI

Halaman

DAFTAR ISI ......................................................................................................... i

DAFTAR TABEL .............................................................................................. iv

DAFTAR GAMBAR ........................................................................................... v

DAFTAR SINGKATAN .................................................................................... vi

BAB 1 PENDAHULUAN ............................................................................. 1

1.1 Latar Belakang ............................................................................. 1

1.2 Rumusan Masalah ........................................................................ 2

1.3 Tujuan Penelitian ......................................................................... 3

1.3.1 Tujuan Umum .................................................................... 3

1.3.2 Tujuan Khusus ................................................................... 3

1.4 Manfaat Penelitian........................................................................ 3

1.4.1 Manfaat akademis .............................................................. 3

1.4.2 Manfaat klinis..................................................................... 3

1.4.3 Manfaat bagi masyarakat ................................................... 4

BAB 2 TINJAUAN PUSTAKA ................................................................... 5

2.1 Ketepeng Cina (Cassia alata) ...................................................... 5

2.1.1 Deskripsi tanaman .............................................................. 5

2.1.2 Taksonomi .......................................................................... 5

2.1.3 Morfologi ........................................................................... 6

2.1.4 Kandungan kimia dau ketepeng cina ................................. 7

2.2 Diabetes melitus (DM) ................................................................. 9

2.2.1 Kriteria diagnosis DM ...................................................... 11

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 2.2.2 Tipe DM ........................................................................... 11

2.2.3 Patogenesis Diabetes ........................................................ 12

2.2.4 Tatalaksana DM ............................................................... 14

2.3 Kadar glukosa darah pada tikus ................................................. 17

2.4 Aloksan....................................................................................... 17

2.5 Peran Ketepeng Cina dalam memperbaiki kerusakan sel 

pankreas ....................................................................................... 19

2.6 Tikus Wistar ............................................................................... 22

BAB 3 KERANGKA KONSEP & HIPOTESIS PENELITIAN ............ 24

3.1 Kerangka Konseptual Penelitian ................................................ 24

3.2 Hipotesis ..................................................................................... 26

BAB 4 METODE PENELITIAN .............................................................. 27

4.1 Rancangan Penelitian ................................................................. 27

4.2 Lokasi dan Waktu Penelitian...................................................... 27

4.3 Populasi dan Sampel .................................................................. 27

4.3.1 Populasi ............................................................................ 27

4.3.2 Sampel .............................................................................. 27

4.3.3 Besar Sampel .................................................................... 27

4.3.4 Teknik Pengambilan Sampel............................................ 29

4.3.5 Karakteristik Sampel Penelitian ....................................... 30

4.4 Variabel Penelitian ..................................................................... 30

4.4.1 Variabel Bebas ................................................................. 30

4.4.2 Variabel Tergantung......................................................... 30

4.5 Definisi Operasional ................................................................... 30

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 4.6 Bahan dan Instrumen Penelitian ................................................. 31

4.6.1 Bahan ............................................................................... 31

4.6.2 Instrumen ......................................................................... 31

4.7 Prosedur Penelitian ..................................................................... 33

4.6.1 Proses adaptasi ................................................................. 33

4.6.2 Induksi Aloksan ............................................................... 33

4.6.3 Pemberian Ekstrak Daun Ketepeng Cina ......................... 33

4.6.4 Penentuan Dosis ............................................................... 34

4.6.5 Proses anastesi .................................................................. 34

4.6.6 Proses pembedahan .......................................................... 35

4.6.7 Pemeriksaan Glukosa Darah ............................................ 35

4.6.8 Alur Penelitian ................................................................. 36

4.6.1 Analisis Data .................................................................... 36

4.8 Jadwal Penelitian ........................................................................ 38

DAFTAR PUSTAKA ........................................................................................ 39

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 DAFTAR TABEL

Tabel Halaman

2.1 Kandungan fitokimia 570 g daun ketepeng cina dalam presentase ............... 7

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 DAFTAR GAMBAR

Gambar Halaman

2.1 Daun dan Bunga Tumbuhan ketepeng Cina ....................................... 6

2.2 Contoh Struktur Kimia Flavonoid C6-C3-C6 .................................... 8

2.3 Struktur Kimia Aloksan ................................................................... 18

2.4 Mekanisme Kerja Aloksan ............................................................... 19

2.5 Mekanisme Kerja Saponin ............................................................... 22

2.6 Tikus Wistar (Rattus norvegicus) ..................................................... 23

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 DAFTAR SINGKATAN

ADA : American Diabetes Association

ATP : Adenosine triphosphate

DNA : deoxyribonucleic acid

GLUT : glucose transporter

GOD-PAP : Glucose Oxidase Phenol Aminophenazone

MHC : major histocompatibility complex

MRNA : Messenger ribonucleic acid

OH : hydroxide

ROS : reactive oxygen species

SOD : superoxide dismutase

TGM : Terapi Gizi Medis

UCP : uncoupling protein

WHO : world health organization

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