Vaskularisasi serebral
• Emboli serebriàoklusi large vessel
• PSAàrupture AVM/mikroaneurisma
àteritorial infark Faktor Risiko Stroke
Small vessel occlusive disease
Large vessel occlusive disease
Hematologic disorders
Cardiac disease
Genetics 3
STROKE
Gejala dan Stroke iskemik Stroke iskemik Stroke hemoragik Stroke hemoragik
tanda klinis Thrombosis serebri Emboli serebri PIS PSA
Reflek Babinski - + + -
Kaku kuduk - - -/+(PIV) +
Ct scan/MRI Kepala Lakunar infark Teritorial infark Lesi hiperdens/hiperintens Lesi hiperdens/
pada jaringan otak hiperintens
4
ruang subarkhnoid
Manajemen Stroke Akut
Covid-19 Pandemic Protected Code Stroke
Anamnesis dan pemeriksaan neurologi, vital sign General Supportive Care & Emergency Treatment
Ct scan/MRI kepala, EKG, Foto torak, Echocardio, Lab darah Airway, Breathing, and Oxygenation
CODE STROKE (NIHSS) Airway support & ventilatory assistance
Perawatan Ruang Unit Stroke/Ruang Rawat Neurologi (decreased consciousness/bulbar dysfunction)
Perawatan Neuro Intensive Care Unit Supplemental oxygen (oxygen saturation >94%)
Neurointervensi/tindakan bedah saraf (selektif)
Ischemic Stroke Hemorrhagic Stroke
Reperfusi Regulasi tekanan darah
-Intravenous Alteplase
(0,9 mg/kgbb; max 90 mg) Efficacy of early intensive
4.5 hours of AIS symptom onset BP-Lowering Treatment
-Endovascular Mechanical
Thrombectomy BP Recommedation
Procedure/Surgery
6
Sumber Belajar
Adams and Victor’s. Principles of Neurology, 2019
BMC Neurology 2018, 18(8), 1–7
Circulation J 2016; 80
Depkes RI 2018; Riset Kesehatan Daerah
J Am Coll Cardiol 2020; 75(23): 2950–73
J Am Heart Assoc.2016;5
J Stroke and Cerv Dis 2019; 28 (9) : 2363-75
Terimakasih
Pharmacotherapy 2016;36(5):488–495
Revue Neurol 2020, 2179, 1-9
Stroke 2020, 51
Stroke 2019;51:00-00. DOI: 10.1161/STROKEAHA.120.029838.)
Stroke 2018;49;e46-e99
Stroke 2019; 50, e344– e418
Stroke, 2019; 50,e187-e210
Stroke. 2016;47:2075-2082
Ther Clin Risk Manag 2015; 11: 967–977
US Pharm 2018; 43(2):13-14AHA/ASA