Universitas Al-ghifari Bandung

DIFUSI &
DISOLUSI OBAT
Dosen pengampu : Meiry Akmara Dhina, M. Pd

Disusun oleh kelompok 5

Deny Hadia (D1A210215)
Nurul Putri Anggraeni (D1A210007)
Opi Sopiani (D1A210054)
 Difusi
Difusi adalah proses perpindahan zat
dari konsentrasi yang tinggi ke
konsentrasi yang lebih rendah.

Contoh :
Gula pada cairan teh tawar akan
berubah menjadi manis

Difusi akan terus terjadi hingga seluruh partikel tersebar luas secara merata atau mencapai
keadaan kesetimbangan
 Jenis – jenis Difusi
● Difusi berdasarkan energi yang ● Menurut jenis membrannya
dibutuhkan

1. Difusi molekuler atau permeasi melalui

1. Difusi biasa, tidak membran homogen tanpa pori.
memerlukan energi. 2. Membran dari zat padat dengan pori-
2. Difusi khusus, memerlukan pori lurus.
energi. 3. Difusi melalui suatu membran dengan
susunan anyaman polimer yang memiliki
saluran
yang bercabang dan saling bersilangan.
.
FAKTOR-FAKTOR YANG MEMENGARUHI
DIFUSI
1. Ukuran Partikel 5. suhu

2. Ketebalan Membran 6. Konsentrasi Obat

3. Luas Suatu Area 7. Koefisien disfusi

8. Viskositas
4. Jarak
9. Koefisien Partisi
 Hukum Fick
Menurut hukum difusi Fick, molekul obat berdifusi dari daerah
dengan konsentrasi obat tinggi ke daerah konsentrasi obat rendah

Dq/DT = Laju Difusi A = Luas Permukaan

Membran
D = Koefisien Difusi h = Tebal Membran

K = Koefisien Partisi Cs-C = Perbedaan

antara konsentrasi obat
dalam pembawa dan
medium
 Uji Difusi

Salah satu metode yang digunakan dalam uji difusi

adalah metode flow through. Adapun prinsip kerjanya
yaitu pompa peristaltik menghisap cairan reseptor dari
gelas kimia kemudian dipompa ke sel difusi melewati
penghilang gelembung sehingga aliran terjadi secara
hidrodinamis, kemudian cairan dialirkan kembali ke
reseptor. Cuplikan diambil dari cairan reseptor dalam
gelas kimia dengan rentang waktu tertentu dan
diencerkan dengan pelarut campur. Kemudian, diukur
3 4 absorbannya dan konsentrasinya pada panjang
gelombang maksimum, sehingga laju difusi dapat
dihitung berdasarkan hukum Fick di atas.
 DISOLUSI OBAT
Disolusi adalah proses
Disolusi mengacu pada pelepasan senyawa obat
proses ketika fase padat dari sediaan dan melarut
(misalnya tablet atau dalam media pelarut
serbuk) masuk ke dalam
fase larutan, seperti air.
KONSEP

Intinya, ketika obat

melarut, partikel-partikel
DISOLUSI
padat memisah dan
molekul demi molekul
bercampur dengan cairan
dan tampak menjadi
bagian dari cairan
tersebut.
 KECEPATAN DISOLUSI
Jumlah zat aktif yang dapat larut dalam waktu tertentu pada kondisi antar permukaan cair-padat, suhu
dan komposisi media yang dibakukan. Laju disolusi telah dirumuskan Noyes dan Whitney pada tahun
1997.

M = massa zat terlarut yang dilarutkan

t = waktu yang dibutuhkan untuk melarutkan zat
atau dM/dt = laju disolusi dari massa tersebut (massa/waktu)
D = koefisien difusi dari zat terlarut dalam larutan
S = luas permukaan zat padat yang menyentuh larutan
h = ketebalan lapisan difusi
Cs = kelarutan dari zat padat (konsentrasi larutan jenuh dari
senyawa tersebut)
C = konsentrasi zat terlarut pada waktu t
dC/dt = laju disolusi
V = volume larutan
ju Disolusi Obat Secara In Vitro Dipengaruhi Beberapa Fakt
Sifat kimia Faktor
obat Formulasi
1 3

2 4
Faktor yang terkait dalam
Faktor alat &
bentuk sediaan
kondisi lingkungan
1. Sifat fisika kimia obat.
Sifat fisika kimia obat berpengaruh besar terhadap kinetika disolusi berupa:
a. Sifat kelarutan
b. Luas permukaan

2. Faktor Formulasi.
Faktor formulasi dan proses pembuatan memengaruhi laju disolusi yaitu
c. Jumlah & tipe eksipien, seperti garam netral.
d. Tipe pembuatan tablet yang digunakan.
e. Ukuran granul dan distribusi ukuran granul.
f. Jumlah dan tipe penghancur serta metode
g. Jumlah dan tipe surfaktan (kalau ditambahkan) serta metode pencampurannya.
h. Gaya pengempaan dan kecepatan pengempaan.
 UJI DISOLUSI
Uji disolusi yang diterapkan pada sediaan obat bertujuan untuk mengukur serta mengetahui jumlah zat
aktif yang terlarut dalam media pelarut yang diketahui volumenya pada waktu dan suhu tertentu,
menggunakan alat tertentu yang didesain untuk uji parameter disolusi.

1. Peranan Uji Disolusi 3. Medium Disolusi

2. Alat Uji Disolusi 4. Metodologi Disolusi

 Pharmacy Infographics

Jupiter Neptune
It’s the biggest planet It’s the farthest
in the Solar System planet from the Sun

30 % 50 %

Mars Saturn
Despite being red, Saturn is a gas giant
Mars is a cold place and the ringed planet
20 % 60 %
 Pharmacy Infographics
Venus 1 2 Mercury
It’s the second planet It’s the smallest planet
from the Sun in the Solar System

Mars 3 5 Neptune
4
Despite being red, Mars Neptune is the farthest
is actually a cold planet planet from the Sun
Saturn
It’s composed mostly of
hydrogen and helium
 Pharmacy Infographics

Mercury Saturn
50 Mercury is the Saturn is composed 75
% smallest planet in mostly of hydrogen %
the Solar System and helium

Venus Mars
25 Venus is really hot Despite of being red, 50
% and is the second Mars is actually a %
planet from the Sun cold place
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Mars Venus Mercury Saturn

Despite being Venus is the Mercury is the Saturn is a gas
red, Mars is a second planet closest planet giant and the
cold place from the Sun to the Sun ringed one
 Pharmacy Infographics
30 % 15 % 10 % 25 % 30 %
Saturn Venus Jupiter Neptune Mercury
It’s a gas It’s second Jupiter is big It’s the It’s the
giant and planet from and a gas farthest smallest of
has rings the Sun giant planet them all
 Pharmacy Infographics
A B
Venus Neptune
Venus is the second Neptune is the farthest
planet from the Sun planet from the Sun

C C
Mars Mercury
Despite being red, It’s the closest planet
Mars is a cold place to the Sun
Pharmacy Infographics

1 Mars
Despite being red,
Mars is a cold place

2 Venus
Venus is the second
planet from the Sun

3 Mercury
It’s the closest planet
to the Sun 70 % 80 % 30 %
Pharmacy Infographics

30 % Mars
Despite being red,
Mars is a cold place

20 % Mercury
It’s the closest
planet to the Sun

50 % Venus
Venus is the
second planet from
the Sun
 Pharmacy Infographics

Venus Saturn
01 It’s the second planet 03 It’s composed mostly of
from the Sun hydrogen and helium

Mars Neptune
Despite being red, Mars 02 Neptune is the farthest
04
is a cold place planet from the Sun
 Pharmacy Infographics

Mars Mercury Saturn

Despite being Mercury is the Saturn is a gas
red, Mars is a closest planet to giant and the
cold place the Sun ringed one
 Pharmacy Infographics

25 % 25 %

Mars Saturn
Despite being red, Mars Saturn is a gas giant and
is a cold place the ringed one

25 % 25 %

Mercury Neptune
Mercury is the closest Neptune is the farthest
planet to the Sun planet from the Sun
Pharmacy Infographics
Mercury is the closest
Mercury planet to the Sun

Despite being red,

Mars Mars is a cold place

Saturn is a gas giant

Saturn and the ringed one

Neptune is the farthest

Neptune planet from the Sun
 Pharmacy Infographics

40 % 15 %
Mars Neptune
Despite being red, It’s the farthest
Mars is a cold place planet from the Sun

20 % 25 %
Venus Saturn
Venus is the second Saturn is a gas giant
planet from the Sun and the ringed one
 Pharmacy Infographics

50 % 90 %
Venus Mercury
Venus is the second It’s the closest
planet from the Sun planet to the Sun

30 % 75 %
Mars Neptune
Despite being red, It’s the farthest
Mars is a cold place planet from the Sun
 Pharmacy Infographics

1 2 3 4

Venus Mars Mercury Saturn

Venus is the Despite being red, Mercury is the Saturn is a gas
second planet Mars is a cold closest planet to giant and the
from the Sun place the Sun ringed one
 Pharmacy Infographics

Mercury Venus Mars

01 02 03

25 50 75
% % %
 Pharmacy Infographics
60
Venus %
Venus is the
second planet from
the Sun

Mars
Despite being red,
Mars is a cold place EFFECTIVENESS

Mercury
It’s the closest
planet to the Sun
30 % 10 %
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