Simulasi HKSA Hansch

Ukurlah hubungan struktur-aktivitas dengan pendekatan Hansch (LFER) menggunakan SPSS, ikuti
prosedur yang sudah disediakan

HUBUNGAN STRUKTUR DAN AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus DARI

TURUNAN KLORAMFENIKOL

TUGAS:

1. Tentukanlah persamaan HKSA untuk dan koefisien korelasi untuk:

a. σ terhadap Log A
Log A = (2.061 ± 0.604)σ + (0.037 ± 0.287)
R = 0.790
R2 = 0.625
F = 11.649
Sig = 0.011
 Nilai R dan R2 mendekati 1, artinya σ berkorelasi dengan Log A, serta dapat
mempengaruhi nilai Log A.

Descriptive Statistics
 Mean Std. Deviation N
LogA .8956 .63536 9
σ .4167 .24367 9

Model Summary
b. π terhadap Log A
Adjusted R Std. Error of the
Model R R Square Square Estimate
1 .790a .625 .571 .41614
a. Predictors: (Constant), σ

Log A = (0.037 ± 0.313) π + (0.890± 0.232)

R = 0.045
R2 = 0.002
F = 0.014
Sig = 0.909
 Nilai R dan R2 jauh mendekati 1, artinya σ tidak berkorelasi dengan Log A, serta
dapat tidak mempengaruhi nilai Log A.

Descriptive Statistics
Mean Std. Deviation N
LogA .8956 .63536 9
π .1589 .76546 9

Model Summary
Adjusted R Std. Error of the
Model R R Square Square Estimate
a
1 .045 .002 -.141 .67855
 a. Predictors: (Constant), π

ANOVAa
Model Sum of Squares df Mean Square F Sig.
1 Regression .006 1 .006 .014 .909b
Residual 3.223 7 .460
Total 3.229 8
a. Dependent Variable: LogA
b. Predictors: (Constant), π

Coefficientsa
Standardized
Unstandardized Coefficients Coefficients
Model B Std. Error Beta t Sig.
1 (Constant) .890 .232 3.841 .006
π .037 .313 .045 .118 .909
a. Dependent Variable: LogA

c. Kuadratik π terhadap Log A

R2 = 0.203

Variable Processing Summary

Variables
Dependent Independent
LogA π
Number of Positive Values 8 3
Number of Zeros 0 0
Number of Negative Values 1 6
Number of Missing Values User-Missing 0 0
System-Missing 0 0

Model Summary and Parameter Estimates

Dependent Variable: LogA
Model Summary Parameter Estimates
Equation R Square F df1 df2 Sig. Constant b1 b2
Quadratic .203 .764 2 6 .506 1.078 .481 -.473
The independent variable is π.
d. RM terhadap
Log A
Log A = (-0.027
± 0.020)RM +
(1.295 ± 0.361)
R = 0.451
R2 = 0.203
F = 1.785
Sig = 0.223
 Nilai R dan R2 jauh mendekati 1, artinya RM tidak berkorelasi dengan Log A,
serta dapat tidak mempengaruhi nilai Log A.

Descriptive Statistics
Mean Std. Deviation N
LogA .8956 .63536 9
RM 14.9811 10.74361 9

Model Summary
Adjusted R Std. Error of the
Model R R Square Square Estimate
1 .451a .203 .089 .60632
a. Predictors: (Constant), RM

ANOVAa
Sum of
Model Squares df Mean Square F Sig.
1 Regression .656 1 .656 1.785 .223b
Residual 2.573 7 .368
Total 3.229 8
a. Dependent Variable: LogA
b. Predictors: (Constant), RM

Coefficientsa
Unstandardized Standardized
Coefficients Coefficients
Model B Std. Error Beta t Sig.
 1 (Constant) 1.295 .361 3.589 .009
RM -.027 .020 -.451 -1.336 .223
a. Dependent Variable: LogA

e. π dan σ terhadap Log A

Log A = (2.073 ± 0.655)σ + (-0.035±0.208) π + (0.037 ± 0.310)
R = 0.791
R2 = 0.626
F = 5.031
Sig = 0.052
 Nilai R dan R2 mendekati 1, artinya π dan σ berkorelasi dengan Log A, serta
dapat mempengaruhi nilai Log A.

Descriptive Statistics
Mean Std. Deviation N
LogA .8956 .63536 9
σ .4167 .24367 9
π .1589 .76546 9

Model Summary
Adjusted R Std. Error of the
Model R R Square Square Estimate
a
1 .791 .626 .502 .44841
a. Predictors: (Constant), π, σ

ANOVAa
Model Sum of Squares df Mean Square F Sig.
1 Regression 2.023 2 1.012 5.031 .052b
Residual 1.206 6 .201
Total 3.229 8
a. Dependent Variable: LogA
b. Predictors: (Constant), π, σ

Coefficientsa
Model Unstandardized Coefficients Standardized t Sig.
Coefficients
 B Std. Error Beta
1 (Constant) .037 .310 .121 .908
σ 2.073 .655 .795 3.167 .019
π -.035 .208 -.043 -.170 .871
a. Dependent Variable: LogA

f. σ dan RM terhadap Log A

Log A = (1.923 ± 0.557)σ + (-0.020±0.013)RM + (0.390 ± 0.345)
R = 0.856
R2 = 0.733
F = 8.255
Sig = 0.019
 Nilai R dan R2 mendekati 1, artinya σ dan RM berkorelasi dengan Log A, serta
dapat mempengaruhi nilai Log A.

Descriptive Statistics
Mean Std. Deviation N
LogA .8956 .63536 9
σ .4167 .24367 9
RM 14.9811 10.74361 9

Model Summary
Adjusted R Std. Error of the
Model R R Square Square Estimate
1 .856a .733 .645 .37878
a. Predictors: (Constant), RM, σ

ANOVAa
Model Sum of Squares df Mean Square F Sig.
1 Regression 2.369 2 1.184 8.255 .019b
Residual .861 6 .143
Total 3.229 8
a. Dependent Variable: LogA
b. Predictors: (Constant), RM, σ
 Coefficientsa
Standardized
Unstandardized Coefficients Coefficients
Model B Std. Error Beta t Sig.
1 (Constant) .390 .345 1.130 .302
σ 1.923 .557 .737 3.455 .014
RM -.020 .013 -.334 -1.565 .169
a. Dependent Variable: LogA

g. π2, π, dan σ terhadap Log A

Log A = (-0.522 ± 0.176)π2 + (0.467±0.218) π + (2.110 ± 0.431)σ + (0.216±0.213)
R = 0.930
R2 = 0.856
F = 10.678
Sig = 0.013
 Nilai R dan R2 mendekati 1, artinya π2, π, dan σ berkorelasi dengan Log A, serta
dapat mempengaruhi nilai Log A.

Descriptive Statistics
Mean Std. Deviation N
LogA .8956 .63536 9
phi2 .523856 .9480466 9
π .1589 .76546 9
σ .4167 .24367 9

Model Summary
Adjusted R Std. Error of the
Model R R Square Square Estimate
1 .930a .865 .784 .29529
a. Predictors: (Constant), σ, phi2, π

ANOVAa
Model Sum of Squares df Mean Square F Sig.
1 Regression 2.793 3 .931 10.678 .013b
Residual .436 5 .087
Total 3.229 8
a. Dependent Variable: LogA
 b. Predictors: (Constant), σ, phi2, π

Coefficientsa
Standardized
Unstandardized Coefficients Coefficients
Model B Std. Error Beta t Sig.
1 (Constant) .216 .213 1.015 .357
phi2 -.522 .176 -.779 -2.972 .031
π .467 .218 .563 2.146 .085
σ 2.110 .431 .809 4.893 .005
a. Dependent Variable: LogA

2. Tetapkanlah persamaan HKSA yang terbaik!

Persamaan HKSA yang terbaik yaitu pada point terkahir, g). π 2, π, dan σ terhadap Log A
dengan Persamaan Log A = (-0.522 ± 0.176)π2 + (0.467±0.218) π + (2.110 ± 0.431)σ +
(0.216±0.213), karena memiliki nilai R yang paling mendekati 1 dibandingkan dengan yang
lainnya