DAFTAR ISI

HALAMAN JUDUL ..................................................................................... i

LEMBAR PERNYATAAN .......................................................................... ii
LEMBAR PENGESAHAN........................................................................... iii
LEMBAR PEDOMAN PENGGUNAN SKRIPSI ....................................... iv
ABSTRAK .................................................................................................... v
ABSTRACT ................................................................................................... vi
KATA PENGANTAR ................................................................................... vii
DAFTAR ISI ................................................................................................. ix
DAFTAR TABEL ......................................................................................... xi
DAFTAR GAMBAR..................................................................................... xii
DAFTAR LAMPIRAN ................................................................................. xiii
BAB I PENDAHULUAN .............................................................................. 1
1.1. Latar Belakang Masalah ...................................................................... 1
1.2. Rumusan Masalah ............................................................................... 3
1.3. Batasan Masalah ................................................................................. 3
1.4. Tujuan Penelitian ................................................................................ 4
1.5. Manfaat Penelitian .............................................................................. 4

BAB II TINJAUAN PUSTAKA .................................................................... 5

2.1. Luka dan Penyembuhan ...................................................................... 5
2.1.1. Fase Inflamasi ............................................................................ 6
2.1.2. Fase Profilerasi ........................................................................... 6
2.1.3. Fase Maturasi ............................................................................. 7
2.2. Penutup Luka (Wound Dressing) ......................................................... 7
2.3. Hidrogel .............................................................................................. 8
2.4. Kitosan................................................................................................ 9
2.5. Alginat ................................................................................................ 13
2.6. Mekanisme Ikatan Silang Kitosan-Alginat........................................... 16
2.7. Madu ................................................................................................... 16
2.8.Uji Ketebalan ....................................................................................... 17
2.9.Uji FTIR .............................................................................................. 18
2.10.Uji Tensile Strength ............................................................................ 21
2.11.Uji SDP (Swelling Degree at PBS) ..................................................... 25

ix
BAB III METODE PENELITIAN ................................................................ 26
3.1. Tempat dan Waktu Penelitian .............................................................. 26
3.2. Alat dan Bahan .................................................................................... 26
3.3. Diagram Alir Pelaksanaan Penelitian ................................................... 26
3.4. Prosedur Penelitian.............................................................................. 27
3.4.1. Persiapan Sampel ....................................................................... 25
3.4.2. Pembuatan Larutan Kitosan, Larutan Alginat dan Larutan Madu
....................................................................................................... 28
3.4.3.Tahap Pembuatan Lembaran Sampel ........................................... 29
3.4.4.Uji Karakterisasi Sampel ............................................................. 30
3.4.4.1. Uji Ketebalan ..................................................................... 30
3.4.4.2. Uji Kekuatan Tarik ............................................................ 31
3.4.4.3. Uji FT-IR ........................................................................... 32
3.4.4.4. Uji SDP (Swelling Degree at PBS)..................................... 33
BAB IV HASIL DAN PEMBAHASAN ........................................................ 34
4.1. Hasil Pembuatan Hidrogel Kitosan-Alginat-Madu ............................... 34
4.2. Hasil Karaterisasi Hidrogel Kitosan-Alginat-Madu
4.2.1. Hasil Uji FT-IR ............................................................................. 34
4.2.2. Hasil Uji Ketebalan ....................................................................... 43
4.2.3. Hasil Uji Tarik (Tensile Strength) dan Kemuluran (Elongation) ....
.......................................................................................................... 46
4.2.4. Hasil Uji SDP (Swelling Degree at PBS) ....................................... 50

BAB V KESIMPULAN DAN SARAN .......................................................... 54

5.1. Kesimpulan ........................................................................................ 54
5.2. Saran ................................................................................................... 54

Daftar Pustaka ............................................................................................... 55

Lampiran ....................................................................................................... 56