Temperature

Regula-on

M Aryadi Arsyad
Physiology Department
Hasanuddin University


 Study objec-ves

Mengetahui suhu tubuh normal

Menger- bagaimana tubuh
mempertahankan suhunya
Menger- akibat dari ke-dakseimbangan
suhu tubuh
 Homeostasis
Internal factors need to be maintained:
1. Concentra-on of nutrients
2. Concentra-on of O2 & CO2
3. Concentra-on of waste products
4. pH
5. Concentra-ons of water, salt & other
electrolytes
6. Volume & pressure
7. Temperature
 Introduc-on

Temperature mempengaruhi laju reaksi dan

karakteris-k macromolecules
Karena organisme adalah mesin yg terbuat
dari macromolecules dimana reaksi kimia
terjadi, maka temperature adalah salah satu
bagian pen-ng dari lingkungan
 Introduc-on
Suhu Normal Body Tubuh
Manusia umumnya berada pada lingkungan
yang lebih dingin dari tubuh mereka
Dari 36 37.5oC (97 99.5oF), rata-rata 37oC
(98.6oF)
Fluktuasi Diurnal (1oF or 0.6oC)
Sangat bergantung pada metabolisme makanan
Exercise
Temperatur pada in anak, ortu lebih dingin
Ovulasi
 Body temperatures

Temperatur core tubuh : inner core

termasuk: organ thorax & abdomen, the
central nervous system & otot skelet = 37.8oC
(100oF)
Skin temperature : umumnya lebih dingin
20-40oC (68-104oF)
Body temperature range
 Sites for monitoring

Oral
Rectal (0.5oC or 1oF dierent from oral)
Eardrum (convert to oral equivalent)
Temporal (close to rectal temp)
Body temperature maintenance
 Body temperature maintenance

Produksi panas
Metabolisme dari makanan
Ak-vitas otot
Keadaan emosi
Catecholamines
Brown fat
Hormon thyroid

 Body temperature maintenance

Kehilangan panas
Radiasi
Konduksi
Konveksi
Evaporasi
Heat loss
 Heat loss

Laju kehilangan panas bergantung pada:
1. Seberapa cepat panas bisa dikonduksikan
dari dalam tubuh ke kulit
2. Seberapa cepat panas bisa ditransfer dari
kulit ke lingkungan
 Temperature eect on body

Lalu apa efek temperatur terhadap proses
siologis dan reaksi biokimia tubuh?
Meningkat sebanyak 2-3 kali lipat untuk se-ap
kenaikan 10C.
 Body temperature regula-on
Temperature Regula-ng Mechanisms
Hypothalamic
Anterior hypothalamic nuclei
Preop-c area
Coetaneous receptors
Cold receptors
Warm receptors
Deep body temperature receptors
 Hypothalamus role

Anterior hypothalamic and preop-c area contain

large number of:
Heat-sensi-ve neurons
Cold-sensi-ve neurons
Heat-sensi-ve neurons increase their ring rate as
the temperature rises, twofold to tenfold with
increase in body temperature of 10oC
Responses to cold & heat
 Fever

Eleva-on of body temperature usually due to

infec-on/inama-on
Endogenous pyrogen
Changes thermostat seing in hypothalamus
Fever
 Other cause of Fever

Other cause : exercise-induced hyperthermia

and diseases (hyperthyroid)
 Why do I Feel Cold When I Have A
Fever?

Microbes changes Thermostat in Brain

Brain Thinks you are cold & try to increase
heat
Vasoconstric-on
Shiver
 What Fever can do to you?

Heat exhaus-on : collapse due to

vasodila-on & low plasma volume of
swea-ng
Heat stroke : protein denatura-on, death
 What Cold can do to you?

Frostbite
Hypothermia can lead to death
 References

Human physiology, Laura lee Sherwood, 7th

ed.
Human anatomy and physiology, Elaine N
Marieb, 9th ed.
Textbook of medical physiology, Arthur C.
Guyton, 11th ed.