CV

Name : Prof. Dr. Iris Rengganis, PhD, FINASIM

DOB : Jakarta, 29 June 1958
Education :
- GP : Faculty of Medicine, Universitas Indonesia, 1983
- Internist : Faculty of Medicine, Universitas Indonesia, 1994
- Consultant in Allergy-Immunology : Faculty of Medicine, Universitas Indonesia, 2000
- PhD : Bogor Agricultural Institute, 2009
- Professor : Faculty of Medicine, Universitas Indonesia, 2019

Working Experiences :
- Community Health Center, South Jakarta, 1984-1988
- Dr. Cipto Mangunkusumo Hospital, Central Jakarta, as a fellow, 1989-1994
- Jakarta Hajj Hospital, East Jakarta, 1995-1997
- Dr. Cipto Mangunkusumo Hospital, Central Jakarta, 1998-now

Organization :
- Board Member of PB.IDI (Indonesian Doctors Association)
- Treasurer of PB.PAPDI (Indonesian Society of Internal Medicine)
- President of PP.PERALMUNI / ISAI (Indonesian Society of Allergy and Clinical Immunology)
- Board Member of APAAACI (Asia Pacific Association of Allergy, Asthma and Clinical Immunology)
 Immunology of Vaccine,
Various Types of Adult
Vaccines

Prof.Dr.dr. Iris Rengganis,SpPD,K-AI

Division of Allergy - Clinical Immunology
Department of Internal Medicine
Faculty of Medicine, Universitas Indonesia
Dr. Cipto Mangunkusumo Hospital
 Vaksinasi
 Adalah suatu cara untuk meningkatkan kekebalan seseorang secara
aktif terhadap suatu antigen, sehingga bila kelak terpajan dengan
antigen yang sama, sudah mempunyai zat kekebalan/antibodi
sehingga tidak terjadi penyakit.

 Tujuannya untuk mencegah terjadinya penyakit tertentu pada

seseorang, masyarakat/populasi, bahkan melenyapkan penyakit
tertentu dari dunia seperti cacar.
Immunity
Mekanisme Kerja Vaksin
 Imunisasi
Imunitas alami/natural Imunitas artifisial/adaptif

Pasif/maternal Aktif/infeksi Pasif/transfers Aktif/

antibodi vaksinasi

Transfer Injeksi Pemaparan

antibodi Setelah antibodi antigen
melalui Infeksi
placenta Imunisasi Imunisasi
Pasif Aktif
Konsep Imunisasi
1. Imunisasi adalah upaya yang dilakukan
dengan sengaja memberikan kekebalan
(vaksinasi) kepada anak maupun dewasa
sehingga terhindar dari penyakit.

2. Imunitas pasif: tubuh tidak membentuk

antibodi, tetapi menerima antibodi.

3. Imunitas aktif terjadi bila tubuh

membentuk kekebalan/antibodi sendiri.
Imunisasi Aktif / Vaksinasi

>
Antigen (vaksin)
disuntikkan ke
orang yang non-imun

Penerima adalah Penerima menjadi

orang non-imun imun
Imunisasi Aktif / Vaksinasi
Keuntungan :
Proteksi jangka panjang
Konsentrasi antibodi
Murah dan efektif
Aman

4 8 12 16 20 Minggu
Injeksi vaksin
Imunisasi Pasif

Antibodi
disuntikkan
kepada orang
>
yang non imun

Tidak ada
kekebalan Ada kekebalan

Penerima imunisasi pasif

Donor Imunisasi Pasif

(Orang sehat yang imun) Tidak terbentuk respon imun memori, karena
imunisasi pasif tidak mengaktifkan sistem imun.
 Imunisasi pasif
Kerugian :
Proteksi jangka pendek, tidak ada sel
memori
Harga mahal
Efek samping
Konsentrasi antibodi

4 8 12 16 20 Minggu
Injeksi
PASSIVE & ACTIVE IMMUNIZATION
What Is Vaccine??
Bahan ACTIVE Bahan INACTIVE

Preservative
Antigen Adjuvant pengawet Stabilizer

• Mikroorganisme Memperkuat Mencegah Menjaga

yg dilemahkan vaksin - pertumbuhan efektifitas
atau dimatikan imunitas bakteri atau vaksin selama
• Komponen fungi penyimpanan
antigen dari
mikroorganisme

Adapted from: Plotkin SA,Orenstein WA,

eds. Vaccines 3rd ed.;1999: 40-46
Pembuatan vaksin
Sifat yang dibutuhkan vaksin

Vaksin yang ideal :

Imunogenik → meniru infeksi yang alami
Memberikan proteksi jangka panjang
Tidak memberikan efek samping yang tinggi
Stabil
 Ajuvan
Respon Ajuvan

Konsentasi antibodi

Respon Primer

2 4 6 8 10 Minggu
Vaksinasi
 Type of Vaccines
Vaksin virus
• Hidup yang dilemahkan
• Inaktif / dimatikan
• Sub unit

Vaksin bakteri
• Sel utuh
• Toxoid
• Sub-unit
• Polisakarida

Vaksin kombinasi (MMR)

 Klasifikasi Vaksin
Vaksin Bakteri Vaksin Virus

BCG Campak OPV

Parotitis
Vaksin Rubela Yellow
Hidup Varisela Fever
Influenza

Difteria Meningo HPV

Vaksin Tetanus Pneumo Infuenza
Inaktif Pertusis Hib Hepatitis A
Kolera Typhim Vi Hepatitis B
Rabies
 General
Recommendation
in Vaccination
Principles of Vaccination
General Rule
1. All vaccines can be administered at the same visit as all
other vaccines.
2. Nonsimultaneous administration of 2 live parenteral vaccines.
3. Administration of live vaccine should be given on same time.
4. Interference can occur between two live vaccines given less
than 28 days apart.
5. If two live parenteral vaccines (MMR, varicella, zooster,
yellow fever), or live intranasal influenza vaccine, are given
less than 28 days apart the vaccine given second should be
repeated.
6. Exception is yellow fever vaccine given less than 4 weeks
after measles vaccine.

Epidemiology and Prevention of Vaccine-Preventable Diseases. Chapter 2 General Recommendation. National

Center for Immunization and Respiratory Diseases. CDC. Revised April 2009.
Why Vaccinate
Top 5 Reasons for Adults to Get
Vaccinated

Vaccine-preventable
diseases haven’t
gone away

Vaccines are safe and Vaccines will help

effective keep you healthy

Vaccination can Vaccines are as

mean the difference important to your
between life and overall health as
death diet and exercise
REKOMENDASI SATGAS
IMUNISASI DEWASA
What is the purpose of vaccinations?
Some, such as smallpox, have now been eradicated. The purpose
of vaccination is to produce immunity. Immunity means the
presence in a person's body of cells and substances known as
antibodies that can produce a protective immune response.

Why do we immunize?
Vaccination protects children from serious illness and
complications of vaccine-preventable diseases which can
include amputation of an arm or leg, paralysis of limbs,
hearing loss, convulsions, brain damage, and death. Vaccine-
preventable diseases, such as measles, mumps, and
whooping cough, are still a threat.
Why adults should get vaccinated?
You may also be at risk for vaccine-preventable disease due to your
age, job, lifestyle, travel, or health conditions.
All adults need immunizations to help them prevent getting and
spreading serious diseases that could result in poor health, missed
work, medical bills, and not being able to care for family.

How many diseases do vaccines prevent?

The most common and serious vaccine-
preventable diseases tracked by the World Health
Organization (WHO) are: diphtheria, Haemophilus
influenzae serotype b infection, hepatitis B, measles,
meningitis, mumps, pertussis, poliomyelitis, rubella, tetanus,
tuberculosis, and yellow fever.
Why is vaccination considered a prevention of disease?
Vaccination is the most effective method
of preventing infectious diseases; widespread immunity due
to vaccination is largely responsible for the worldwide eradication of
smallpox and the elimination of diseases such as polio and tetanus
from much of the world.

Which cancer can be prevented by vaccination?

Traditional vaccines
Some types of cancer, such as cervical cancer and some
liver cancers, are caused by viruses (oncoviruses).
Traditional vaccines against those viruses, such as
HPV vaccine and hepatitis B vaccine, prevent those types
of cancer.
THANK YOU