TELAAH JURNAL

Nama : Ismi Adilla Karimah

NIM : 30101700079
Judul Penelitian : PENGARUH GLUKOMANAN PORANG (Amorphophallus muelleri Blume) TERHADAP KADAR
MALONDIALDEHID (MDA) (Studi Eksperimental pada Tikus Putih Jantan Galur Wistar yang
Diinduksi Streptozotocin-Nicotinamide (STZ-NA))
No Tittle
1. Int J Diab Dev Ctries |
Volume 30 | Issue 1
“Significantly increased levels
of serum malonaldehyde in
type 2 diabetics with
myocardial infarction”
2. COMPARATIVE STUDY
ON MDA, SOD AND HbA1c
LEVELS IN PATIENTS OF
TYPE 2 DIABETES
MELLITUS WITH
RETINOPATHY AND
WITHOUT RETINOPATHY
3. INDIAN JOURNAL OF
Authors Country, Objective Result
Years
Rashida January- Untuk melihat level serum MDA Ditemukan bahwa level serum
Mahreen, M. March 2010 pada DM tipe 2 dengan Infark MDA naik secara signifikan
Mohsin1 , Myocard. Serum malonaldehid pada kedua grup diabetes
Zahida merupakan produk akhir dari dibandingkan dengan control
Nasreen, M. peroksidasi lipid yang dihasilkan oleh (P<0,01)
Siraj2 , M. interaksi dari radikal bebas dengan
Ishaq3 membrane fosfolipid. Pada grup 1 dan 2 terjadi
kenaikan level MDA yang
Kelompok subjek : signifikan dibanding grup 3.
1. 30 orang dm2 dengan infark Namun MDA pada dm2
miokard dengan IM lebih tinggi
2. 30 orang dm2 tanpa komplikasi dibanding dengan kelompok
3. 30 orang sehat tanpa dm (control) dm tanpa komplikasi.
Manish published 01 Penelitian ini dilakukan untuk melihat Serum MDA lebih naik
Kumar Verma October, HbA1c, MDA, dan SOD pada 54 signifikan pada dm tipe 2
, Shashi 2016 orang dm2 dengan retinopati, dan 54 dengan retinopati dibanding
Prabha orang dm2 tanpa retinopati dengan tanpa retinopati (4.25±1.03
Singh , rentang umur 35-74 tahun. Hasil µmol/l vs 2.12±1.55 µmol/l
Roshan Alam dianalisis menggunakan SPSS 16,0 and p<0.0001*).
and Poonam version SOD sebagai antioksidan
Verma sangat turun pada dm2 dengan
retinopati dibanding tanpa
retinopati (0.53±0.07 U/mg
protein/min vs 0.91±0.10 U/mg
protein/min and p<0.0001*)
HbA1c sebagai biomarker
diabetes lebih naik signifikan
dibanding tanpa
retinopati(9.28±2.31% vs
7.95±1.77 % and p < 0.001)..
Khushbu May 2016 Untuk mengetahui peran marker Adanya kenaikan signifikan
 APPLIED RESEARCH
“MDA, Oxidative Stress
Marker-Role in Diabetic
Nephropathy With Special
Reference to Type II Diabetes
Mellitus”
4 INTERNATIONAL
JOURNAL OF
CONTEMPORARY
MEDICAL RESEARCH
Volume 2| Issue 1| “Study Of
Oxidative Stress Status In
Type 2 Diabetic Patients”
Rani, Pratibha stress oksidatif yaitu MDA pada pada FBG/GDP dan glycated
Gavel, Sujit pasien dm2 dengan nefropati dan haemoglobin/HbA1c pada
Bharti tanpa nefropati pasien dm2 dengan komplikasi
Dan untuk menentukan hubungannya ataupun nonkomplikasi.
terkait durasi Serum MDA secara signifikan
Serta menentukan parameter biokimia berkorelasi dengan durasi
lainnya (FBG/GDP, HbA1c, MDA, diabetes dengan komplikasi
microalbuminuria) dan juga sangat tinggi kadar
mda nya.
S. Rajen 2015 To estimate the levels of antioxidant The mean ± SD MDA levels of
Singh, Davina glutathione peroxidase (GPX), type 2 DM patients with
Hijam, superoxide dismutase (SOD) and microvascular complications
Abhishek lipid peroxidation marker i.e. (6.08 ± 0.47 µmol/l) were
Dubey, malondialdehyde (MDA) in type 2 found to be significantly higher
Ningthoujam DM patients with and without (P˂0.000) than those without
Omita Devi, microvascular complications and to complications (4.01+0.22
Sungdirenla compare the results with that of µmol/l) and controls
Jamir, healthy individuals. To assess the (2.79±0.27 µmol/l). A
Chubalemla correlation between oxidative stress significant decrease in GPX
Longkumer et and diabetes in relation to metabolic and SOD was observed in type
al. control 2 DM with microvascular
complications as compared to
those without complications
and controls (19.18 ± 0.97
U/gHb, 24.07 + 0.88 U/gHb,
29.48 + 0.92 U/gHb
respectively for GPX and
578.98 + 25.78U/gHb,799.94+
55.39 U/gHg and
1146.48+61.05U/gHg
respectively for SOD). There
was a significant negative
 correlation between GPX and
HbA1C and a positive
correlation between
Malondialdehyde and HbA1C
which was highly significant
(P<0.01).

5. Indonesian Eva Nurinda, 2018, Mengetahui efek tepung porang Pemberian tepung porang ekstrak
. Journal of Hamam Yogyakart (Amor phophallus oncophyllus) Strobilanthes crispa dapat
Nutrition and Hadi, a dengan maserasi keji beling menurunkan kadar kolesterol total
Dietetics Vol. 6, Anggun Putri ( Strobilanthes crispa) terhadap kadar lebih baik sebesar 28,76%
No. 2, 2018: 64- Lestari kolesterol total pada tikus wistar dibandingkan tepung porang murni
69 “Porang flour jantan (Rattus norvegicus) DM tipe 2. yang dapat menurunkan kadar
with keji beling kolesterol total sebesar 15,35%
maceration (p=0,05). Kadar air feses hari ke-1 dan
reduced total hari ke-14 tidak berbeda nyata pada
cholesterol semua kelompok
levels in diabetic
rats male wistar
rats”
6. Article Sellen 2017, Porang is a local plant of Indonesia, The effect of OSA-PG on
Immunomodulat Gurusmatika Ehime which has a high content of In this in macrophage-like J774.1 cells and
ory Activity of 1,2 ID , University this study, we investigated the peritoneal macrophages was analyzed
Octenyl Succinic Kosuke , immunomodulatory effect of OSA- by evaluating the production of TNF-α
Anhydride Nishi 1,3 Matsuyam modified PG (OSA-PG) on mouse and IL-6. Production of both IL-6 and
Modified Porang ID , Eni a, Japan macrophage-like J774.1 cells and TNF-α significantly increased in
(Amorphophallu Harmayani 2, mouse primary peritoneal concentration-
s oncophyllus) Yudi Pranoto macrophages. The effects of OSA-PG dependentmannersbytreatingJ774.1cel
Glucomannan on 2 and Takuya on phagocytotic activity, lswithOSA-
Mouse Sugahara proinflammatory cytokine production, PG,whereasuntreatedJ774.1cells
Macrophage- and the activation of mitogen- secreted very little amounts of
 Like J774.1 activated protein kinases (MAPK) are cytokines
Cells and Mouse described in this study. The findings
Primary shown in this paper may generate
Peritoneal further value in expanding porang
Macrophages tuber use in the food industry as a
functional food.
7. Original Hsiao-Ling 2003, The present study was designed to Compared with placebo, KGM
Research Konjac Chen, RD, Taiwan evaluate effects of konjac effectively reduced plasma
Supplement PhD, Wayne glucomannan (KGM) supplement (3.6 cholesterol, (LDL-cholesterol,
Alleviated Huey-Herng g/day) for 28 days on blood lipid and total/HDL cholesterol, ApoB. and
Hypercholestero Sheu, MD, glucose levels in hyperlipidemic type fasting glucose.
lemia and PhD, Tsai- 2 diabetic patients and the possible Plasma triglyceride, HDL-cholesterol,
Hyperglycemia Sung Tai, mechanism for the reductions in LDL/HDL cholesterol, postprandial
in Type 2 MD, Yung- blood lipid levels. glucose and body weight were not
Diabetic Po Liaw, significant after adjustment by the
Subjects—A PhD, Yi- Bonferroni-Hochberg procedure. Fecal
Randomized Chuan Chen, neutral sterol and bile acid
Double-Blind MS concentrations were increased by
Trial 18.0% and 75.4% respectively, with
KGM supplement.
8. Effects of Kuan-Un 2017, A randomized, double-blind, placebo- There were no statistical difference in
Glucomannan Cheang1, Taiwan controlled, crossover study, 32 calories, carbohydrate, protein, fat and
Noodle on Chiao-Ming individuals with metabolic syndrome dietary fiber intake from 24 h food
Diabetes Risk Chen2, C-Y. were received a daily servings of 400 recalls between glucomannan noodles
Factors in Oliver gram glucomannan noodles for a and placebo noodles groups. However,
Patients with Chen3, Feng- period of four weeks. After two the body weight, body mass index,
Metabolic Yu Liang4, weeks of wash out period, they and waist circumference had
Syndrome: A Chun-Kuang received a placebo noodles for four significantly decreased after 4-week
Double-Blinded, Shih1, Sing- weeks. intervention in both groups, but high
Randomized Chung Li1,* sensitivity C-reactive protein was
Crossover lowered only in glucomannan noodles
Controlled Trial group. Moreover, the 24 individuals
with type 2 diabetes had significantly
 decreased body weight, BMI, waist
circumference, hs-CRP, and glycated
hemoglobin after glucomannan
noodles intervention. The rest of lipid
profile, fasting blood glucose, insulin,
and HOMA-IR of the subjects did not
show any significant difference. This
study showed that glucomannan
noodles as a staple food can contribute
to metabolic syndrome in adults
predisposed to type 2 diabetes.
9. Streptozotocin- A Ghasemi, Budapest, The aim of this study is an overview Keuntungan induksi STZ-NA pada
nicotinamide- S Khalifi, S 2014. on one of the most frequently used tikus adalah lebih menyerupai dengan
induced rat Jedi. models of type 2 diabetes in rat, diabetes tipe 2 manusia sehingga
model of type 2 induced by streptozotocin and mampu untuk menguji potensi efek
diabetes nicotinamide, considering its antidiabetik farmakologis dan alami
(Review) advantages and disadvantages for pada perjalanan penyakit diabetes.
Acta diabetes research in humans. Selain itu, terdapat dosis STZ dan NA
Physiologica . bervariasi untuk menginduksi diabetes
Hungarica, yang dapat menjelaskan beberapa
Volume 101 (4), perbedaan yang diamati dalam studi
pp. 408–420 yang berbeda.
(2014) DOI:
10.1556/APhysi
ol.101.2014.4.2
10 Pengaruh Diet Y. Marssono, Yogyakart Tujuan penelitian ini untuk Pemberian kacang merah sebesar 20%
Kacang Merah Zuheid noor, a, 2003 mengevaluasi efek dari diet kacang lebih efektif dalam menurunkan kadar
Terhadap Kadar dan fitri merah (Vigna umbellata) gula darah pada tikus diabetic induksi
Gula Darah Rahmawati dibandingkan dengan kacang kedelai aloksan dibandingkan dengan pakan
Tikus Diabetik terhadap kadar glukosa darah pada kedelai. Selama 28 hari intervensi
Induksi Alloxan tikus SD yang diinduksi alloxan. kacang merah mampu menurunkan
kadar gula darah sebesar 69%,
Catatan : terdapat penjelasan sedangkan kedelai sedikit lebih rendah
mengenai komposisi pakan standar yaitu 65%. Data ini sesuai dengan
tikus (Vit AIN 93 VX dan Mineral nilai indeks glisemiknya.
AIN 93 MX)