EFEKTIVITAS GASTROPROTEKTIF INFUSA RAMUAN AKAR MANIS

(Glycyrrhiza glabra), KULIT BATANG PULASARI (Alyxia reinwardtii Bl)  

DAN DAUN SEMBUNG (Blumea balsamifera) PADA TIKUS MODEL
TUKAK LAMBUNG
  Agustin Wijayanti
Universitas Gadjah Mada, 2013 | Diunduh dari http://etd.repository.ugm.ac.id/

DAFTAR ISI
Halaman
HALAMAN JUDUL .................................................................................... i

HALAMAN PENGESAHAN ...................................................................... ii

HALAMAN PERNYATAAN ..................................................................... iii

HALAMAN PERSEMBAHAN ..................................................................... iv

KATA PENGANTAR ................................................................................. v

DAFTAR ISI ............................................................................................... viii

DAFTAR TABEL ........................................................................................ xii

DAFTAR GAMBAR ................................................................................... xiii

DAFTAR LAMPIRAN ................................................................................ xv

INTISARI ..................................................................................................... xvi

ABSTRACT ................................................................................................... xvii

BAB I PENDAHULUAN ............................................................................ 1

A. Latar Belakang ........................................................................................ 1

B. Rumusan masalah .................................................................................... 6

C. Keaslian penelitian .................................................................................. 6

D.Tujuan Penelitian .................................................................................... 8

1. Tujuan Umum ………………………………………………………. 8

2. Tujuan Khusus ……………………………………………………… 8

E. Manfaat Penelitian ……………………………………………………… 9

BAB II TINJAUAN PUSTAKA ................................................................. 10

A. Ananotomi Fisiologi Lambung ............................................................... 10

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 EFEKTIVITAS GASTROPROTEKTIF INFUSA RAMUAN AKAR MANIS
(Glycyrrhiza glabra), KULIT BATANG PULASARI (Alyxia reinwardtii Bl)
DAN DAUN SEMBUNG (Blumea balsamifera) PADA TIKUS MODEL
TUKAK LAMBUNG
Agustin Wijayanti
Universitas Gadjah Mada, 2013 | Diunduh dari http://etd.repository.ugm.ac.id/

B. Ulkus Lambung ....................................................................................... 14

1. Definisi ............................................................................................... 14

2. Patofisiologi ...................................................................................... 14

3. Proses Kerusakan Mukosa ................................................................ 15

4. Etiologi ............................................................................................. 16

5. Patogenesis ....................................................................................... 17

6. Obat Ulkus Lambung ........................................................................ 17

C. Asam Asetil salisilat ............................................................................... 20

D. Akar Manis (Glycyrhiza glabra)………………………………………… 21

1. Taksonomi ......................................................................................... 21

2. Kandungan dan kegunaan .................................................................. 22

E. Pulasari (Alyxia reinwardtii) ................................................................. 23

1. Taksonomi ......................................................................................... 24

2. Kandungan dan kegunaan .................................................................. 24

F. Sembung (Blumea balsamifera) ............................................................. 25

1. Taksonomi .......................................................................................... 25

2. Kandungan dan kegunaan ................................................................... 26

G. Sel Mast ................................................................................................. 27

H. Eosinofil ................................................................................................ 29

I. Landasan Teori ...................................................................................... 31

J. Hipotesis ................................................................................................ 33

BAB III METODE PENELITIAN .............................................................. 34

A. Desain Penelitian ...................................................................................... 34

viii 

 
 EFEKTIVITAS GASTROPROTEKTIF INFUSA RAMUAN AKAR MANIS
(Glycyrrhiza glabra), KULIT BATANG PULASARI (Alyxia reinwardtii Bl)  
DAN DAUN SEMBUNG (Blumea balsamifera) PADA TIKUS MODEL
TUKAK LAMBUNG
  Agustin Wijayanti
Universitas Gadjah Mada, 2013 | Diunduh dari http://etd.repository.ugm.ac.id/

B. Tempat Penelitian .................................................................................... 34

C. Hewan Uji ................................................................................................ 35

D. Bahan dan Alat Penelitian ....................................................................... 35

E. Jalannya Penelitian ................................................................................. 36

1. Perhitungan dosis asetosal dan sukralfat .............................................. 36

2. Identifikasi tanaman ............................................................................. 36

3. Pembuatan infusa …………………………………………………….. 36

4. Perlakuan uji aktifitas gastroprotektif ………………………………... 37

5. Nekropsi tikus ………………………………………………………… 37

6. Pengamatan makroskopik terhadap ulkus lambung tikus ……………. 38

7. Pemeriksaan histopatologik lambung ………………………………… 38

F. Definisi Operasional dan Variabel Penelitian ........................................... 41

1. Definisi Operasional …………………………………………………. 41

2. Variabel Penelitian …………………………………………………… 42

G. Analisa Data ............................................................................................ 43

H. Skema Kerja …………………………………………………………….. 44

BAB IV HASIL DAN PEMBAHASAN ..................................................... 45

A. Studi Pendahuluan .................................................................................. 45

B. Identifikasi Simplisia ............................................................................... 46

C. Pembuatan Sediaan Infusa ....................................................................... 46

D. Keadaan Umum dan Berat Badan Hewan Uji ......................................... 47

E. Jumlah dan luas lesi pada permukaan mukosa lambung tikus model

yang diinduksi asetosal ........................................................................... 48

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 EFEKTIVITAS GASTROPROTEKTIF INFUSA RAMUAN AKAR MANIS
(Glycyrrhiza glabra), KULIT BATANG PULASARI (Alyxia reinwardtii Bl)
DAN DAUN SEMBUNG (Blumea balsamifera) PADA TIKUS MODEL
TUKAK LAMBUNG
Agustin Wijayanti
Universitas Gadjah Mada, 2013 | Diunduh dari http://etd.repository.ugm.ac.id/

F. Skor kerusakan mukosa lambung tikus yang diinduksi asetosal ............. 53

G. Jumlah sel mast pada mukosa dan sub mukosa jaringan lambung tikus

model yang diinduksi asetosal ................................................................. 57

H. Jumlah eosinofil pada mukosa dan sub mukosa jaringan lambung tikus

model yang diinduksi asetosal ................................................................. 61

BAB V. KESIMPULAN DAN SARAN ...................................................... 69

A. Kesimpulan .............................................................................................. 69

B. Saran ........................................................................................................ 69

DAFTAR PUSTAKA .................................................................................. 70

LAMPIRAN ................................................................................................. 76

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