Gout

Arthritis

Nama:
Nadilla Sitepu (G1A221115)
 
Pengampu:
dr. Iin Dwiyanti, Sp,PD. FINASIM
 Introduction

Mercury is the closest planet to the Sun and the smallest one in the Solar System—it’s only
a bit larger than the Moon. The planet’s name has nothing to do with the liquid metal since
it was named after the Roman messenger god
 Table of contents
01 Objectives 02 Methodology
Here you could describe the topic Here you could describe the topic
of the section of the section

03 Results analysis 04 Conclusions

Here you could describe the topic Here you could describe the topic
of the section of the section
01
PENDAHULUA
N
deposisi kristal monosodium urat pada jaringan atau akibat supersaturasi asam urat di dalam cairan
ekstraseluler.. peradangan sendi akibat peningkatan kadar asam urat dalam darah/hiperurisemia

Tahapan gout terdiri dari 4 fase yaitu tanpa gejala, gout akut, interkritikal dan
kronis
DEFINISI

• Gout merupakan istilah yang dipakai untuk sekelompok gangguan metabolik yang
ditandai oleh meningkatnya konsentrasi asam urat (hiperurisemia).
• Gout merupakan penyakit progresif akibat deposisi kristal MSU di persendian, ginjal,
dan jaringan ikat lain sebagai akibat hiperurisemia yang telah berlangsung kronik
• Penyakit asam urat atau gout merupakan penyakit akibat penimbunan kristal
monosodium urat di dalam tubuh sehingga menyebabkan nyeri sendi disebut gout artritis
Epidemiologi Gout Arthritis
Etiologi Gout Arthritis

Gout
Gout Primer
Sekunder
Faktor Resiko Gout Arthritis
Patogenesis Gout Arthritis
 Manifestasi Klinis Gout Arthritis

Tahap 1 (Tahap Tahap 2 (Tahap

Gout Artritis akut) Gout interkritikal)
Tahap 3 (Tahap Tahap 4 (tahap
Gout Artritis Akut Gout Arthritis
Intermitten) Kronik Tofaceous)
Kriteria Diagnosis Gout Arthritis
Diagnosis Banding Gout Arthritis
KOMPLIKASI

Komplikasi dari gout arthritis meliputi severe degenerative arthritis, infeksi sekunder,
batu ginjal dan fraktur pada sendi. Sitokin, kemokin, protease, dan oksidan yang
berperan dalam proses inflamasi akut juga berperan pada proses inflamasi kronis
sehingga menyebabkan sinovitis kronis, dekstruksi kartilago, dan erosi tulang.
Kristal monosodium urat dapat mengaktifkan kondrosit untuk mengeluarkan
Interleukin-1, merangsang sintesis nitric oxide dan matriks metaloproteinase yang
nantinya menyebabkan dekstruksi kartilago. Kristal monosodium urat
mengaktivasi osteoblas sehingga mengeluarkan sitokin dan menurunkan fungsi
anabolik yang nantinya berkontribusi terhadap kerusakan juxta artikular tulang.
gout arthritis telah lama diasosiasikan dengan peningkatan resiko terjadinya batu
ginjal. Penderita dengan gout arthritis membentuk batu ginjal karena urin memilki
pH rendah yang mendukung terjadinya asam urat yang tidak terlarut.
Prognosis artritis gout dapat dianggap
sebuah sistem bukan penyakit sendiri.
Dengan kata lain prognosis penyakit
artritis gout merupakan prognosis
penyakit yang menyertainya. Artritis
gout sering dikaitkan dengan
morbiditas yang cukup besar, dengan
episode serangan akut yang sering
menyebabkan penderita cacat. Namun,
artritis gout yang diterapi lebih dini
dan benar akan membawa prognosis
yang baik jika kepatuhan penderita
terhadap pengobatan juga baik
 
Artritis gout merupakan suatu gangguan metabolik dimana terjadi peningkatankadar asam
urat dalam darah/hiperurisemia. Kadar asam urat dalam darah dipengaruhioleh produksi dan
ekskresi. Peningkatan kadar asam urat dalam darah dapatmenyebabkan penumpukkan
kristal monosodium urat monohidrat terutama dalam sendi dan jaringan sekitar serta
berperan pada reaksi radang akut yang berkembang, menyebabkan nyeri berat. Terdapat 4
stadium perkembangan klinis artritis gout yaituhiperurisemia asimptomatik, artritis gout akut,
stadium interkritikal dan stadiumartritis gout kronis. Pengobatan biasanya ditujukan pada
gout stadium akut yaitudengan analgesi, NSAID, kortikosteroid, urikosurik dengan tujuan
untuk menurunkankadar asam urat yang tinggi. Komplikasi yang paling sering ditemukan
adalah severe degenaritve arthritis, infeksi sekunder, batu ginjal dan fraktur pada sendi.
Prognosis pada penyakit ini baik apabila diterapi dengan cepat dan tepat.
Sasaran terapi gout artritis yaitu mempertahankan kadar asam urat dalam serum dibawah
6 mg/dL dan nyeri yang diakibatkan oleh penumpukan asam urat. Secara umum
penanganan arthritis gout adalah memberikan edukasi, pengaturan diet, istirahat sendi
dan pengobatan. Pengobatan dilakukan secara dini agar tidak terjadi kerusakan sendi
ataupun komplikasi lain, misalnya gagal ginjal.
02
Objectives
Here you can write the topic
of the section
 Risk factors to consider

Factors you CAN control Factors you CAN’T control

Overweight Infection Age Gender

Injuries Occupation Genetics and inherited traits

Some behaviors and characteristics, called risk factors, increase an

Smoking
adult’s likelihood of getting arthritis
 Clinical trial

Preclinical Phase 1 Human safety

Lab studies Phase 2 Expanded safety

Phase 3 Efficacy and safety

 Trial timeline
Experime
Research Preclinical Results
nt
01 02 03 04
Venus has a Despite being red, Mercury is the Earth is the
beautiful name, Mars is a cold closest planet to beautiful planet
but it is hot place the Sun we live on
Awesome
words
Because key words are great for
catching your audience’s attention
 Phase 1
Secondary effects
20-80 participants Venus has a beautiful name

80%
Success rate
Results
Venus has a
lovely name
Goal
Test safety of the
medication
6 months
Experiment time
duration
Tendency
Venus Mars Saturn

Arthritis will increase in

the future as the
population grows and get
older
If you want to modify these graphs, click on them, follow
the link, change the data and replace them
Results
Outcome
Treatmen
Test 1 Test 2 Test 3
t

Group 1 315 285 600

Group 2 432 567 500

Group 3 654 689 906

 Results analysis
Saturn Neptune
Sun

Pluto

Earth
Mercury Venus Jupiter
Moon

20% 15% 25% 10%

 Arthritis types
Osteoarthritis Reumatoid
It’s the closest planet to the Sun and Venus has a beautiful name, but it’s
the smallest in the System terribly hot

Fibromyalgia Osteoarthritis
Despite being red, Mars is actually a Saturn is a gas giant and has several
cold place rings
A picture always
helps to reinforce
the concept

Images reveal large amounts of data, so

remember: use an image instead of long
texts
A picture is worth a
thousand words
Our centers’ location
Venus

Jupiter

Saturn
Neptune is the farthest planet from the Sun. It's
also the fourth-largest object
543,678,35
7
A big number catches the attention
3,456,746 456,789 987,654
Improvement patients Number of recoveries Investigation budget
Success rate
97%
Patients cured
75%
Without secondary effects
Conclusions

Mercury is the closest planet to the Sun and

the smallest one in the Solar System—it’s
only a bit larger than the Moon. The planet’s
name has nothing to do with the liquid metal
since it was named after the Roman
messenger god, Mercury
Our team
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