ABSTRAK

Uji Aktivitas Pemberian Infusa Daun Kenikir (Cosmos caudatus) Terhadap

Penurunan Kadar Kolesterol Pada Mencit (Mus musculus)

Afrina Fajar Ekowati., Erni Anika S.¹, Shofiatul Fajriyah²

Kenikir merupakan salah satu tanaman obat yang daunnya sering dikonsumsi
sebagai sayuran. Daun kenikir mengandung senyawa flavonoid yang diyakini
dapat mencegah berbagai penyakit. Flavonoid dapat bersifat sebagai antioksidan
dengan cara menangkal radikal bebas yang terbentuk di dalam tubuh. Daun
kenikir mengandung flavonoid yang cukup tinggi dan dapat dikembangkan
dengan mudah. Untuk membuktikan infusa daun kenikir dapat sebagai
antioksidan dan hipolipidemik, dilakukan penelitian pre experimental designs.
Rancangan penelitian adalah one group pretest posttest. Penelitian dilakukan
menggunakan 15 ekor mencit dibagi menjadi tiga kelompok dengan masing-
masing kelompok terdapat 5 ekor mencit. Masing-masing kelompok dilakukan
pemberian pakan kuning telur puyuh agar mengalami kenaikkan kadar kolesterol.
Infusa daun kenikir diberikan selama 3 hari dengan dosis 800 mg/kgBB, 1600
mg/kgBB dan 2500 mg/kgBB. Pengukuran kadar kolesterol total yang diambil
melalui vena ekor mencit dilakukan dengan menggunakan alat digital Autocheck
dengan satuan mg/dL. Hasil penelitian menunjukkan bahwa kadar kolesterol total
darah mencit pada dosis 800 mg/kgBB rata-rata penurunan sebesar 5,44%; 1600
mg/kgBB sebesar 10,77%; 2500 mg/kgBB sebesar 14,60%. Berdasarkan data
tersebut dapat disimpulkan bahwa infusa daun kenikir dapat menurunkan kadar
kolesterol total darah mencit pada semua dosis, tetapi dosis paling efektif yaitu
infusa daun kenikir dosis 2500 mg/kgBB.

Kata Kunci : infusa daun kenikir; penurunan kadar kolesterol total; mencit (Mus
musculus).
 ABSTRACT
Test Activity Giving Kenikir Leaf (Cosmos caudatus) Infusion Against
Decreased Cholesterol Levels In Mice (Mus musculus)

Afrina Fajar Ekowati., Erni Anika S.¹, Shofiatul Fajriyah²

Kenikir is a medicinal plant whose leaves are often consumed as vegetables.

Kenikir leaves contain flavonoid compound which are believed to prevent various
diseases. Flavonoids can act as antioxidants by countering free radicals that form
in the body. Kenikir leaves contain flavonoids which are quite high and can be
developed easily. To prove kenikir leaf infusion can be as an antioxidant and
hypolipidemic, pre experimental designs research was conducted. The study
design was one group pretest posttest. The study was conducted using 15 mice
divided into three groups with 5 mice each group. Each group was given feeding
quail egg yolk to increase cholesterol levels. Kenikir leaf infusion was given for 3
days at a dose of 800 mg/kgBB, 1600 mg/kgBB and 2500 mg/kgBB.
Measurement of total cholesterol levels taken through the tail veins of mice was
done using a digital Autocheck with mg/dL units. The result showed that the total
cholesterol level of blood of mice at a dose of 800 mg/kgBB decreased by an
average of 5,44%; 1600 mg/kgBB by 10,77%; 2500 mg/kgBB of 14,60%. Based
on these data in can be concluded that kenikir leaf infusion can reduce total
cholesterol levels of blod of mice at all doses, but the most effective dose is
kenikir leaf infusion dose 2500mg/kgBB.

Key words : kenikir leaf infusion; reduction in total cholesterol levels; mice (Mus
musculus).