a.

Hasil
Tablet Paracetamol 500 mg
1. Ukuran Tablet
Tablet Diameter (mm) Ketebalan (mm)
1 10 0.42
2 10 0.42
3 10 0.45
4 10 0.44
5 10 0.41
6 10 0.40
7 10 0.44
8 10 0.45
9 10 0.40
10 10 0.42
11 10 0.44
12 10 0.41
13 10 0.43
14 10 0.42
15 10 0.42
16 10 0.43
17 10 0.41
18 10 0.44
19 10 0.40
20 10 0.42
Rata-rata 10 0,42

200 mm
 Nilai rata-rata diameter tablet = = 10 mm
20
8,47 mm
 Nilai rata-rata ketebalan tablet = = 0,4235 mm
20
 Persyaratan diameter tablet = 4/3 x 0,4235 < 10 <3 x 0,4235
= 0,5646 < 10 < 1,2705
2. Kekerasan Tablet
Tablet Kekerasan
1 9
2 9.5
3 11
4 9.5
5 11
6 9
7 9.3
 8 9.7
9 9.2
10 10.2
11 9.5
12 9
Rata-rata 9,66

115,9 kg /cm2
 Nilai rata-rata kekerasan tablet = = 9,66 kg/cm2
12
 Nilai kekerasan tablet bergantung pada bobot tablet. Makin besar tablet, kekerasan
yang diperlukan juga semakin besar.
- Bobot tablet sampai 300 mg: 4 – 7 kg/cm2
- Bobot tablet 400 – 700 mg: 7 – 12 kg/cm2

3. Keragaman Bobot
Tablet Bobot (gram) X-X ( X −X )2 % Penyimpangan
1 0,667 0,009 0,000081 11%
2 0,687 0,029 0,000841 8,4%
3 0,659 0,001 0,000001 12,1%
4 0,661 0,003 0,000009 11,8%
5 0,675 0,017 0,000289 10%
6 0,603 -0,055 0,003025 19,6%
7 0,660 0,002 0,000004 12%
8 0,654 -0,004 0,000016 12,8%
9 0,684 0,026 0,000676 8,8%
10 0,637 -0,021 0,000441 15%
Ʃ = 0,658 Ʃ = 0,005383

− Standar Deviasi − Koefisien Variasi

Ʃ (X −X )2
1 /2
S
SD=
[ n−1 ] CV =
X
x 100 %

0,024
0,005383 CV = x 100 %
SD =
√ 10−1
0,658
CV = 3,6 %
SD = 0,024
 4. Keseragaman Kandungan

Kurva Kalibrasi

Konsentrasi (ppm) Absorbansi

4 0.220
6 0.460
8 0.589
10 0.728
12 0.916
Persamaan Regresi
y =bx±a
y = 0,083x - 0,0814
r = 0,994

Pengukuran absorbansi sampel

Tablet Absorbansi Pengenceran

1 0.349 1 ml ad 10 ml
1 ml ad 10 ml
2 0.273 1 ml ad 10 ml
1 ml ad 10 ml
3 0.282 1 ml ad 10 ml
1 ml ad 10 ml
4 0.328 1 ml ad 10 ml
1 ml ad 10 ml
5 0.302 1 ml ad 10 ml
1 ml ad 10 ml
6 0.338 1 ml ad 10 ml
1 ml ad 10 ml
Catatan : pengenceran bertingkat

Tablet 1

y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar

%kadar = x
0,349 = 0,083 x - 0,0814 mg = 5,1855 μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,349 mg = 5185,5 μg/mL 100%
-0,083 x = -0,4304 mg = 5,1855 mg 5,1855m g
%kadar = x 100%
−0,4304 500 mg
x=
−0,083 %kadar = 1,0371 %
x = 5,1855 μg/mL
x = 5,1855 ppm
Tablet 2
y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar
%kadar = x
0,273 = 0,083 x - 0,0814 mg = 4,2699 μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,273 mg = 4269,9 μg/mL 100%
-0,083 x = -0,3544 mg = 4,2699 mg 4,2699 m g
%kadar = x 100%
−0,3544 500 mg
x=
−0,083 %kadar = 0,8539 %
x = 4,2699 μg/mL
x = 4, 2699 ppm
Tablet 3
y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar
%kadar = x
0,282 = 0,083 x - 0,0814 mg = 4,3783 μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,282 mg = 4378,3 μg/mL 100%
-0,083 x = -0,3634 mg = 4,3783 mg 4,3783 m g
%kadar = x 100%
−0,3634 500 mg
x=
−0,083 %kadar = 0,87566 %
x = 4,3783μg/mL
x = 4,3783 ppm
Tablet 4
y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar
%kadar = x
0,328 = 0,083 x - 0,0814 mg = 4,9325μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,328 mg = 49325,5 μg/mL 100%
-0,083 x = -0,4094 mg = 4,9325 mg 4,9325 m g
%kadar = x 100%
−0,409 4 500 mg
x=
−0,083 %kadar = 0,9865 %
x = 4,9325μg/mL
x = 4,9325 ppm
Tablet 5
y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar
%kadar = x
0,302 = 0,083 x - 0,0814 mg = 4,6192μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,302 mg = 4619,2 μg/mL 100%
-0,083 x = -0,3834 mg = 4,6192 mg 4,6192 m g
%kadar = x 100%
−0,3834 500 mg
x=
−0,083 %kadar = 0,9238 %
x = 4,6192μg/mL
x = 4,6192 ppm
Tablet 6
y = 0,083 x - 0,0814 Kadar = nilai x . Volume . fp hasil dari kadar
%kadar = x
0,338 = 0,083 x - 0,0814 mg = 5,0530 μg/mL x 100 mL x10/1 bobot pct tiap tablet
-0,083 x = -0,0814 – 0,338 mg = 5053,0 μg/mL 100%
-0,083 x = -0,4194 mg = 5,0530 mg 5,0530 m g
%kadar = x 100%
−0,4194 500 mg
x=
−0,083 %kadar = 1,0106 %
x = 5,0530 μg/mL
x = 5,0530 ppm

5. Friabilitas
W0 10.706 gram
Wt 10.697 gram
Presen friabilitas
% F = (Wo – Wt)/Wo x 100%
(10,706 gram−10,697 gram)
%F= x 100%
10,706 gram
% F= 0,084 %

6. Freksibilitas
W0 10.710 gram
Wt 10.602 gram

Persen freksibilitas
% F = (Wo – Wt)/Wo x 100%
(10,710 gram−10,602 gram)
%F= x 100%
10 , 710 gram
% F = 1, 008 %

7. Waktu hancur
Tablet Waktu
1 2 menit 29 detik
2 2 menit 30 detik
3 2 menit 30 detik
4 2 menit 10 detik
5 2 menit 7detik
6 2 menit 45 detik
Ʃ = 14 menit 31 detik
Ʃ = 871 detik
871 detik
Rata – rata waktu hancur =
6
= 145,16 detik
 145,16 detik
= 60
= 2 menit 25 detik