Contoh soal sediaan Serbuk : R/ Atropin sulfat 0,5 mg (DM sekali: 1 mg, DM sehari 3 mg) Sacchar.lact. qs m.f.pulv. d.t.d. no.X. S. t.d.d. Pulv. I Pro: Rifki
(12th)
Analisa resep : dari resep diketahui untuk membuat 10 bungkus serbuk sediaan, mengandung 0,5 mg atropin sulfat setiap bungkus, aturan pakai 3 kali sehari satu bungkus. Jawab :
a. DM sekali pakai untuk anak 12 tahun DM sekali pakai = (12/20) x 1 mg = 0,6 mg DM atropin sulfat sekali pakai sedangkan untuk Persentase DM sekali :
= (0,5/0,6 mg) x 100% = 83,3% (boleh diracik dan diserahkan karna tidak lebih dari 100%)
b. DM untuk sehari untuk anak 12 tahun DM sehari = (12/20) x 3 mg = 1,8 mg DM dosis atropin untuk sehari .
= (3x0,5)/1,8 x 100% = 83,3 % (boleh diracik dan diserahkan karna tidak lebih dari 100%)
Untuk Lebih lengkap maka saya tambahkan rumus dibawah ini : Rumus menghitung dosis untuk anak-anak : 1. Berdasarkan umur a. Rumus young (untuk anak <8 tahun)
b. Rumus
dilling (untuk
anak
lebih Besar
atau
sama
dengan
tahun)
umur
dalam
tahun
c. Rumus
Fried (untuk
bayi)
umur
dalam
bulan
umur
dalam
tahun
b. Rumus
dilling (untuk
anak Besar-sama
dengan
tahun)
umur
dalam
tahun bayi)
umur
dalam
bulan
2. Berdasarkan berat badan Perhitungan dosis berdasarkan berat badan sebenarnya lebih tepat karna sesuai dengan kondisi pasien ketimbang umur yang terkadang tidak sesuai dengan berat badan, bila memungkinkan hitung dosis melalui berat badan d. Rumus Thermich n : berat badan dalam kilogram
Persentase
DM
sehari
Category Archives: Obat yang aman untuk ibu Hamil & Menyusui
Drugsafety Antikonvulsan, Obat Tidur, Sedatif, dan Migren
DEC 30 Posted by dr.Rozi Abdullah
DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Antikonvulsan, Obat Tidur, Sedatif, dan Migren
Nama Obat
R.Hamil
R.Menyusui
Sumatriptan
C Chloral hydrate Methyprylon Bromide Secobarbital Zolpidem Bishydroxycoumarin Warfarin Carbamazepine Ethosuximide Magnesium sulfate C D D B D C C B
L3 L3 NR L5 L3 L3 NR L2 L2 L4 L1
L2
Phenytoin
Valproic acid
L2
Pregnancy Risk Categories A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy) NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Obat TBC dan Malaria
Nama Obat Obat TB Cycloserine Ethambutol Isoniazid
C B C L3 L2 L3 Risiko Kehamilan Risiko Menyusui
L2
C C C D
L3 L2 L4 L2
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Anti Hipertensi, Anti Aritmia, dan Diuretik
Kategori Risiko Kehamilan** C
Nama Generik
RisikoMenyusui** L2
Acetazolamide
Bendroflumethiazide Chlorothiazide Chlorthalidone Hydrochlorothiazide (HCT) Spironolactone Disopyramide Flecainide Mexiletine Procainamide Quinidine Captopril Diltiazem/Diltiazem HCL
L2 L2 L2 L2 L3 L2(topically) L3 (orally) L4 L2
C C C
NR
C C C
L2 L2 L2
Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution NR: Not Reviewed. This drug has not yet been reviewed by the AAP.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Anti Jamur dan Anti Virus
Nama Generik Risiko Kehamilan RisikoMenyusui
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution NR: Not Reviewed. This drug has not yet been reviewed by the AAP.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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Drugsafety Antibiotik
DEC 27 Posted by dr.Rozi Abdullah
DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Antibiotik
Kategori Risiko Kehamilan B B B B B B C B B C B
Nama Generik
Amoxicillin Aztreonam Cefadroxil Cefazolin Cefotaxime Cefoxitin Cefprozil Ceftazidime Ceftriaxone Ciprofloxacin Clindamycin
Erythromycin
NR
NR
Penicillin Streptomycin
B D
L1 L3
NR
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution NR: Not Reviewed. This drug has not yet been reviewed by the AAP.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Antasida, Laksan (Pelancar BAB) dan Obat Diare
Nama Generik Cimetidine (Antacid) Cisapride (GI tract stimulant) Domperidone (used for nausea & vomiting, stimulates lactation) Cascara/Cascara Sagrada Danthron Magnesium sulfate Senna Loperamide B C C B B
Risiko Kehamilan Risiko Menyusui
L2 L2 L1 L3 NR L1 L3 L2
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution NR: Not Reviewed. This drug has not yet been reviewed by the AAP.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk)
L5 (contraindicated)
X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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Drugsafety Antihistamin
DEC 27 Posted by dr.Rozi Abdullah
DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Antihistamin
AAP approved?*
Nama Obat
Risiko Menyusui**
not reviewed
L3 (moderately safe)
L3 (moderately safe)
not reviewed
L2 (safer)
L2 (safer) not
reviewed
yes
L2 (safer)
yes
L1 (safest)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution NR: Not Reviewed. This drug has not yet been reviewed by the AAP.
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
Obat Asma, Obat Batuk, dan Spray Hidung
Nama Generik Dyphylline Terbutaline Theophylline Nama Obat Codeine Dextromethorphan Guaifenesin Phenylephrine Pseudoephedrine (Sudafed, Actifed) Beclomethasone (Vanceril, Beclovent, Beconase, Vancenase) Cromlyn sodium (Nasalcrom) Fluticasone (Flonase) Mometasone (Nasonex) Phenylephrine (in some forms Kategori Risiko Kehamilan** C B C RisikoMenyusui** L3 L2 L3
Risiko Menyusui**
L3 (moderately safe) L1 (safest) L2 (safer) L3 (moderately safe) L3 (moderately safe) for acute use L4 (possibly hazardous) for chronic use due to potential for decreasing milk supply
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI
NSAIDs dan Steroid
Nama Generik Azapropazone (apazone) Dipyrone Flufenamic acid Ibuprofen Kategori Risiko Kehamilan** B (1st, 2nd trim.) D (3rd trim.) RisikoMenyusui** L2 NR NR L1
Indomethacin Ketorolac Mefenamic acid Naproxen Phenylbutazone Piroxicam Suprofen Tolmetin Methylprednisolone Prednisolone Prednisone
Lactation Risk Categories
L1 (safest) L2 (safer) L3 (moderately safe) L4 (possibly hazardous) L5 (contraindicated)
B (1st, 2nd trim.) D (3rd trim.) B (1st, 2nd trim.) D (3rd trim.) B B C C C C
L3 L2 NR L3 L4 NR L2 NR L3 L2 L2 L2
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Drugsafety ANALGETIK
DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI ANALGETIK
Risiko Menyusui L1
Aspirin
L3
L2
L3
Butorphanol (Stadol) Celecoxib (Celebrex)) Codeine (in Tylenol #3, #4) Colchicine Diclofenac (Cataflam, Voltaren) Fentanyl (Sublimaze) Flurbiprofen (Ansaid, Froben, Ocufen) Hydrocodone (Lortab, Vicodin) Hydromorphone(Dilaudid) Ibuprofen (Advil, Nuprin, Motrin, Pediaprofen)
L3 L2 L3 L4 L2 L2
L2 L3 L3
L1
L3 L2
Meperidine (Demerol) Methadone (Dolophine) Morphine (Duramorph, Infumorph, Epimorph, MS Contin) Nalbuphine (Nubain) Naproxen (Anaprox, Naprosyn, Naproxen, Aleve)
B B
L3 early postpartum L3
B B
NR
Nefopam (Acupan) Oxycodone (Tylox, Percodan,Oxycontin, Roxicet, Endocet, Roxiprin, Percocet) Pentosan polysulfate(Elmiron) Piroxicam (Feldene) Propoxyphene(Darvocet N, Propacet, Darvon) Secobarbital (Seconal) Tolmetin (Tolectin) Tramadol HCL(Ultram, Ultracet)
B B B
L3 L2 L2
L2 L3 L3 L3
Meperidine Methadone
B B
Morphine Propoxyphene
B C
L3 L2
** Per Medications and Mothers Milk by Thomas Hale, PhD (2004 edition).
L1 (safest) L2 (safer) L3 (moderately safe) L4 (possibly hazardous) L5 (contraindicated) A (controlled studies show no risk) B (no evidence of risk in humans) C (risk cannot be ruled out) D (positive evidence of risk) X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
1. Aspirin use is discouraged in children and nursing mothers due to the risk o 2. f Reyes syndrome and internal bleeding. 3. Fioricet (Fiorinal, Bancap, Two-dyne) contains acetaminaphen or asprin, caffeine, and butalbital. Per Hale, baby should be observed for sedation. 4. Hale suggests weakened or premature infants be observed for sedation and apnea. 5. Hale suggests newborns be observed for sedation, apnea, constipation. 6. Per Hale, use of frequent, higher dose may result in infant sedation. 7. Per Hale, Meperidine use during labor or early postpartum has been associated with sedation, poor sucking reflex, and neurobehavioral delay in infants. 8. Per Hale, observe infant for sedation, respiratory depression, addiction, withdrawal syndrome. 9. Per Hale, higher doses may result in infant sedation. 10. Per Hale, should be used with caution due to its long half-life and its effect on babys cardiovascular system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible with breastfeeding. 11. Roxicet, Endocet, Roxiprin, Percocet also contain acetaminophen. Per Hale, observe infant for sedation. 12. Per Hale, observe infant for sedation. 13. Per Hale, observe infant for GI cramping, distress, diarrhea. 14. Per Hale, observe infant for sedation. 15. Per Hale, observe infant for sedation.
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