Hal Awal Modul Ganjil 22-23 - Farmasi - Kimia Farmasi 1-Merged

M OD UL PR AK TI KUM KI MI A F AR MA SI I
POLITEKNIK KESEHATAN (POLTEKKES)KEMENKES

RI PANGKALPINANG
JURUSAN FARMASI
DISUSUN OLEH :
TIM PENGAMPU KIMIA FARMASI I
NAMA : _______________________________________________
NIM : _______________________________________________
JURUSAN : _______________________________________________
LABORATORIUM PENDIDIK DASAR

FAKULTAS PERTANIAN, PERIKANAN DAN BIOLOGI
UNIVERSITAS BANGKA BELITUNG
2022
MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I ii
POLTEKKES KEMENKES RI PANGKALPINANG
JURUSAN FARMASI
TA. SEMESTER GANJIL 2022/2023
KATA PENGANTAR
Puji dan syukur tim penyusun panjatkan kepada Allah SWT karena atas rahmat dan
izin-Nya buku Panduan Praktikum Kimia Farmasi I ini dapat diselesaikan.
Modul praktikum ini berisi materi-materi praktikum yang akan dipraktekkan pada
semester ganjil tahun ajaran 2022/2023 ini. Dengan ditulisnya buku panduan praktikum ini
diharapkan mampu membantu para mahasiswa dalam melaksanakan kegiatan praktikum.
Ucapan terima kasih penyusun sampaikan kepada semua pihak yang telah membantu
dalam penyusunan buku ini. Kritik dan saran kami harapkan demi perbaikan dalam penyajian
materi praktikum Kimia Farmasi I yang akan datang.
Balunijuk, September 2022

Penyusun,
Tim Pengampu Kimia Farmasi I

MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I iii
JURUSAN FARMASI
DAFTAR ISI
Halaman
HALAMAN JUDUL ................................................................................................................... i
KATA PENGANTAR .................................................................................................................. ii
DAFTAR ISI............................................................................................................................... iii
TATA TERTIB LABORATORIUM .............................................................................................. iv
PERCOBAAN I-IV Praktikum Kering dengan aplikasi
Pengantar Kimia Farmasi, Metabolisme Obat, Mekanisme
Kerja Obat dan struktur Aktivitas Obat ................................................ 1
PERCOBAAN V Analisa Kualitatif Obat Antibiotik : Amoksisilin & Cepadroksil.............. . 4
PERCOBAAN VI Analisa Kualitatif Obat Antibiotik : Penisilin & Griseofulvin .................. . 9
PERCOBAAN VII Analisa Kualitatif Obat Analgetik Narkotika : Codein ........................... 14
PERCOBAAN VIII Analisa Kualitatif Obat Analgetik non Narkotika & Antipiretik:
Metampiron & Paracetamol ................................................................ 18
PERCOBAAN IX Analisa Kualitatif Obat Analgetik non Narkotika & Antipiretik:
Asam Mafenamat & Piroksikam .......................................................... 23
PERCOBAAN X Analisa Kualitatif Obat Susunan Saraf Pusat :
Fenitoin dan Asam Valproat ................................................................ 28
PERCOBAAN XI Analisa Kualitatif Obat Susunan Saraf Pusat : Fenobarbital ............... 33
PERCOBAAN XII Analisa Kualitatif Obat Antihistamin Jenis AH 1:
Definhidramin dan Klorfeniraminmaleat .............................................. 37
PERCOBAAN XIII Analisa Kualitatif Obat Antihistamin Jenis AH 1:
Promezatin dan Terfenadin ................................................................ 42
PERCOBAAN XIV Analisa Kualitatif Obat Antihistamin Jenis AH 2:
Simetifin dan Ranitidin ........................................................................ 47

MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I iv
JURUSAN FARMASI
KONTRAK PERILAKU DAN KESELAMATAN BEKERJA
PRAKTIKUM DI LABORATORIUM PENDIDIK DASAR
Setiap Laboratorium memiliki serangkaian tata tertib yang ditujukan untuk menjaga keselamatan dan kesehatan
kerja pengguna laboratorium. Sebab itu, praktikan tidak diperkenankan melaksanakan kegiatan di laboratorium
sebelum memahami dokumen ini secara keseluruhan. Tata tertib ini harus disosialisasikan di awal pelaksanaan
praktikum di laboratorium.
Melalui surat ini. Saya yang bertanda tangan di bawah ini :
Nama :
Instansi/Jurusan :
Mata Praktikum :
Peralatan 1. Jas Laboratorium 2. Sepatu Tertutup

Keselamatan 3. Masker 4. Safety glooves
:
yang wajib 5. Face Shield 6. Fume Hoods
digunakan** 7. Chemical Glooves 8. Safety Glasses
9. ............................... 10. ...............................
* Coret dan isi seperlunya; **Centang seperlunya
Menyatakan bahwa saya akan bertanggung jawab atas:
1. Pemahaman Tata Tertib Bekerja di Lab Pendidik Dasar, FPPB, Universitas Bangka Belitung
2. Tanggung jawab untuk mematuhi Aturan Bekerja di Laboratorium
3. Pemahaman bahwa perilaku praktikan selama bekerja di Laboratorium akan mempengaruhi keselamatan
praktikan dan orang lain yang berada di Laboratorium.
4. Pemahaman bahwa kelalaian untuk mengikuti Aturan Bekerja di Laboratorium tersebut bisa mengakibatkan
kecelakaan dan cedera yang serius.
5. Pemahaman bahwa tidak mengikuti Aturan Bekerja di Laboratorium akan mendapatkan sanksi yang tegas
sebagaimana diatur dalam dokumen ini.
6. Pemahaman bahwa di Laboratorium terdapat bahan – bahan yang jika tidak ditangani dengan tepat bisa
membahayakan khususnya bagi penderita gangguan kesehatan kronis. Jika praktikan mempunyai masalah
kesehatan, saya akan berkonsultasi dengan dokter dan menunda kegiatan di laboratorium dan pemahaman
bahwa praktikan sendiri yang sepenuhnya akan menanggung semua akibat jika memutuskan tetap meneruskan
pekerjaan di Laboratorium.
Mahasiswa/Praktikan,
( )
MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I v
JURUSAN FARMASI
TATA TERTIB MELAKSANAKAN PRAKTIKUM
DI LABORATORIUM PENDIDIK DASAR
A. Kewajiban Mahasiswa Praktikan

1. Praktikan diwajibkan mengetahui jadwal praktikum (lokasi/ruang, waktu,dosen pengampu), datang tepat
waktu dan mengisi absensi (tidak boleh diwakilkan).
2. Praktikan wajib melapor pada Pembimbing praktikum apabila tidak dapat mengikuti kegiatan praktikum.
Kewajiban mengganti atau penugasan merupakan wewenang dan kesepakatan dengan pembimbing.
3. Praktikan wajib mempelajari modul sebelum melaksanakan praktikum serta memperhatikan hazard
awareness dan safety factors di setiap kegiatan praktikum.
4. Praktikan cukup menggunakan alat dan bahan yang sudah disediakan dan tidak diperkenankan memasuki
ruang bahan tanpa izin Staf.
5. Praktikan/kelompok bertanggungjawab atas peralatan yang dipergunakan dan mengembalikan dalam
keadaan bersih, lengkap dan utuh/ tidak rusak. Praktikan harus menjaga fasilitas dan instrumentasi .
6. Praktikan menggunakan pakaian yang sopan dan rapi (bukan kaos) dan sepatu tertutup.
7. Praktikan harus menjaga ketenangan dan ketertiban selama praktikum serta tidak boleh melakukan
kegiatan yang mengganggu (misalnya tidak mematikan mode suara gawai/HP, merokok dan makan)
8. Setiap praktikan TIDAK DIPERKENANKAN meninggalkan laboratorium tanpa ijin dari asisten atau
pengawas.
9. Praktikan diwajibkan mematuhi dan melaksanakan protokol kesehatan selama pandemi dan
protokol keselamatan dalam melaksanakan praktikum (Poin C dan D)
B. Kewajiban Pembimbing dan atau Asisten Praktikum

1. Pembimbing praktikum dihimbau untuk menyerahkan modul praktikum sebagai arsip laboratorium jauh
hari sebelum waktu pelaksanaan praktikum.
2. Asisten praktikum diwajibkan untuk memeriksa kesiapan laboratorium sebelum hari pelaksanaan
praktikum dan melaporkan kepada pembimbing praktikum.
3. Asisten praktikum diwajibkan untuk mengikuti briefing/pembekalan dari pengelola laboratorium sebelum
hari pelaksanaan kegiatan praktikum.
4. Asisten praktikum diwajibkan untuk melakukan pengecekan alat dan bahan yang diperlukan untuk
kegiatan praktikum selambat-lambatnya H-2 ke Laboratorium Pendidik Dasar.
5. Asisten Praktikum diwajibkan untuk mempersiapkan alat dan bahan sebelum hari pelaksanaan, serta
melakukan pengisian form/bon alat dan bahan yang digunakan.
6. Asisten Praktikum wajib hadir setidaknya 15 menit sebelum praktikum dimulai untuk memastikan
kesiapan praktikan (termasuk memantau self hygiene praktikan dan cek suhu tubuh) dan mendampingi
proses pelaksanaan praktikum.
MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I vi
JURUSAN FARMASI
7. Asisten Praktikum harus memantau dan mengecek peralatan yang telah digunakan praktikan serta
memastikan pengembalian alat dan bahan sesuai dengan kode atau lokasi semula.
8. Asisten praktikum diharapkan memastikan kelengkapan dan kebersihan laboratorium sebelum praktikan
meninggalkan ruangan serta memeriksa kran air, gas, listrik agar ruangan dalam kondisi aman.
9. Asisten praktikum diwajibkan mencatat dan melaporakan alat/bahan yang hilang/rusak kepada pengelola
laboratorium.
10. Pembimbing dan asisten praktikum wajib memastikan praktikan mematuhi dan melaksanakan
protokol kesehatan selama pandemi dan protokol keselamatan dalam melaksanakan praktikum
(Poin C dan D)
C. Protokol Kesehatan di Laboratorium Pendidik Dasar Selama Pandemi

1. Praktikan diharapkan membawa keperluan sendiri untuk menerapkan self-hygiene seperti alat tulis,
modul/laptop, jas laboratorium, hand sanitizer, dan masker.
2. Praktikan harus melakukan pengecekan suhu tubuh sebelum melaksanakan kegiatan di laboratorium.
Apabila sakit, pengguna laboratorium diharapkan tidak melaksanakan kegiatan di laboratorium.
3. Praktikan diharapkan selalu memakai masker dan menjaga jarak selama kegiatan praktikum.
4. Praktikan harus mencuci tangan atau menggunakan hand sanitizer secara berkala baik sebelum, saat
dan sesudah melaksanakan penelitian.
5. Batas okupansi ruangan laboratorium untuk praktikum adalah 20 orang. Jika lebih dari 20 orang,
maka harus dilakukan koordinasi dan pengaturan jadwal yang tepat.
6. Praktikan disarankan untuk menghindari kontak fisik dengan Praktikan yang lain.
7. Praktikan diharapkan untuk tidak merokok, makan dan minum.
D. Protokol Keselamatan Kerja di Laboratorium Pendidik Dasar Selama Pandemi

1. Selalu menggunakan APD minimum yaitu jas laboratorium dan sepatu tertutup. APD yang lain digunakan
sesuai dengan jenis/aktivitas penelitian yang dilaksanakan.
2. Mematuhi prosedur kerja dan peralatan dengan mempertimbangkan keselamatan diri dan lingkungan
3. Menggunakan peralatan laboratorium sesuai fungsinya dan prosedur. Khusus alat instrumentasi, tidak
diperkenankan mengoperasikan tanpa supervisi Staf Laboratorium dan harus konfirmasi/melapor waktu
rencana penggunaan paling lambat H-1. Pemakaian tanpa izin dan konfirmasi tidak akan dilayani oleh
pihak laboratorium.
4. Mengetahui bahan kimia yang digunakan dalam percobaan di laboratorium dan bahaya yang berkaitan
dengannya.
5. Melaporkan setiap kecelakaan, sekecil apapun kepada asisten laboratorium.
6. Membaca label bahan dengan teliti.
7. Tutup kembali botol bahan kimia segera setelah digunakan untuk menghindari kontaminasi.
8. Jaga kebersihan neraca/ timbangan dan bebas dari kontaminasi, dan jangan pernah menimbang bahan-
MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I vii
JURUSAN FARMASI
bahan kimia secara langsung diatas panci timbangan.

9. Gunakan penjepit/pelapis panas ketika memindahkan barang pecah belah dalam keadaan panas.
10. Buanglah sampah kimia ke dalam tempat yang ditunjuk atau sesuai dengan prosedur.
11. Jangan pernah mengembalikan bahan kimia yang sudah tidak digunakan ke dalam botol reagen.
12. Jangan menunjukkan ujung tabung reaksi yang terbuka kepada siapapun di dalam laboratorium.
13. Dilarang melakukan eksperimen di dalam laboratorium tanpa ijin
14. Selalu waspada terhadap adanya kondisi dan tindakan yang tidak aman dan melaporkannya kepada staf
laboratorium atau dosen pembimbing. Misal adanya tumpahan bahan kimia, kabel listrik yang terkelupas
dan menggunakan nyala api tanpa ijin.
15. Hindari membawa botol-botol yang berisi bahan kimia ke bangku laboratoriummu.
16. Mengetahui letak seluruh perlengkapan penyelamat di dalam laboratorium: pancuran/shower, handuk,
pembasuh mata, alat pemadam kebakaran, P3K.
17. Penggunaan laboratorium di luar jam kerja (lewat jam 16.00 WIB) diwajibkan mengisi dan menyerahkan
form penggunaan laboratorium di luar jam kerja diketahui oleh dosen pembimbing dan disetujui oleh
Kalab Pendidik Dasar maksimal H-2 (dibuat rangkap 3). Pemakaian laboratorium di luar jam kerja tidak
diperkenankan bekerja sendirian.
18. Selalu memberi label identitas resmi pada saat menyimpan suatu bahan atau limbah hasil percobaan.
(Nama Bahan, rumus kimia, konsentrasi, tanggal pembuatan dan PIC/pembuat)
19. Dilarang menghalangi akses ke peralatan keselamatan, lorong dan pintu.
20. Dilarang bergurau dan tidur selama di dalam laboratorium.
21. Dilarang menggunakan peralatan yang menghalangi pendengaran. Misal memakai headset sehingga tidak
mendengar tanda bahaya.
22. Dilarang mempersiapkan, menyimpan atau mengkonsumsi makanan/minuman di laboratorium.
23. Dilarang merokok di dalam laboratorium.
Aturan setelah bekerja

24. Melepas semua kabel dan alat listrik lainnya (misal steker dan sambungan kecil), yang penyambungannya
hanya bersifat sementara.
25. Membersihkan alat – alat dan tempat kerja, meletakkan dan mengembalikan alat – alat , termasuk kursi,
yang digunakan ke tempat semula.
26. Menempatkan limbah percobaan pada tempat yang disediakan.
27. Memastikan bahwa tempat kerja dan laboratorium dalam keadaan aman. Misalnya mematikan listrik,
lampu, kran air atau kran gas.
28. Mencuci tangan dengan air dan sabun sebelum meninggalkan laboratorium.
MODUL PRAKTIKUM KERJASAMA UBB - PRAKTIKUM KIMIA FARMASI I viii
JURUSAN FARMASI
E. Standar Penilaian Praktikum

1. Pre test 10%
2. Keaktifan praktikum 10%
3. Laporan 20%
4. Responsi tengah 30%
5. Responsi akhir 30%
F. Sanksi Ketidakpatuhan
1. Praktikan yang menghilangkan, merusak atau memecahkan peralatan harus mengganti sesuai dengan
spesifikasi alat dengan kesepakatan antara laboran dan kepala laboratorium dalam batas waktu penggantian
alat satu (1) bulan setelah adanya laporan atau sesuai kesepakatan.
2. Apabila praktikan sampai dengan jangka waktu yang ditentukan tidak bisa mengganti alat tersebut, maka
peminjam tidak akan mendapatkan surat bebas laboratorium
3. Terlambat mengembalikan alat akan dikenakan denda per jenis alat per haro(kecuali hari libur).
4. Praktikan yang tidak mematuhi tata tertib maupun protokol kesehatan akan dikeluarkan dari laboratorium
dan jika lebih dari tiga kali peringatan maka praktikan akan diskors/dilarang mengikuti kegiatan
praktikum di laboratorium.
Pelanggaran Tata Tertib Sanksi

Pelanggaran pertama Peringatan (Lisan/tertulis)
Pelanggaran kedua Diminta menghentikan percobaan yang sedang
berlangsung.
Pelanggaran ketiga Tidak diperkenankan untuk mengikuti ataupun
melaksanakan praktikum di Labioratorium
(skorsing beberapa pertemuan)
Pelanggaran terberat Pelaporan ke pihak Poltekkes Pangkalpinang dan
yang bersangkutan tidak akan diberi nilai
praktikum
Buku Panduan dan Lembar Kerja Praktikum Kerjasama UBB 1
Mata Praktikum Kimia Dasar I
Jurusan Farmasi, Poltekkes Kemenkes Pangkalpinang
PERCOBAAN I -IV
PRAKTIKUM KERING DENGAN APLIKASI
(PENGANTAR KIMIA FARMASI, METABOLISME OBAT, MEKANISME KERJA
OBAT DAN STRUKTUR AKTIVITAS OBAT)
I. TUJUAN PERCOBAAN
Memanfaatkan penggunaan aplikasi untuk mempelajari pengantar kimia farmasi,
metabolism obat, mekanisme kerja obat dan struktur aktivitas obat)
II DASAR TEORI
Kimia Farmasi adalah ilmu kimia yang mempelajari penggunaan bahan untuk
digunakan sebagai obat. Dengan mempelajari struktur, modifikasi struktur dan sifat
kimia obat, maka mekanisme kerja obat dapat dipahami.
Ilmu Kimia Farmasi juga menetapkan hubungan struktur kimia dan aktivitas Biologis,
menghubungkan perilaku biodinamik melalui sifat fisika dan reaktivitas kimia
senyawa obat, serta mempelajari identifikasi dan analisis obat-obatan baik secara
kualitatif maupun kuantitatif.
Dengan mempelajari Kimia Farmasi, diharapkan adanya pemahaman dalam penerapan
berbagai teknik, metode dan prosedur kimia analisis untuk menganalisis bahan-bahan
atau sediaan farmasi karena pengetahuannya melibatkan penggunaan sejumlah teknik
dan metode untuk memperoleh aspek kualitatif, kuantitatif dan informasi struktur dari
suatu senawa obat pada khususnya dan bahan kimia pada umumnya.
Ada beberapa analisis yang dipelajari dalam Kimia Farmasi, yaitu analisis kuantitatif,
analisa kualitatif dan analisis struktur. Analisis kualitatif dilakukan untuk melakukan
identifikasi elemen, spesies, dan atau senyawa-senyawa yang ada di dalam sampel.
Analisis kuantitatif dilakukan untuk menentukan jumlah kadar absolut atau relative.
Sedangkan analisis struktur dilakukan untuk penentuan letak dan pengaturan ruang
tempat atom serta identifikasi gugus-gugus karakteristik dalam suatu molekul.
Obat adalah zat baik kimiawi, hewani maupun nabati yang dalam dosis tertentu dapat
meringankan, mencegah maupun menyebuhkan penyakit serta gejala-gejalanya.

III. PROSEDUR
1. Melakukan instalasi aplikasi edupymol pada link yang sudah disiapkan

PyMol - Google Drive
(https://drive.google.com/drive/u/0/mobile/folders/1q8qrLa_VG2FX4lQqeKI-
A8yuRmsiJUY9?usp=sharing)
2. Mempelajari video aplikasi di link yang sudah disiapkan

(https://drive.google.com/file/d/1eXZl6KOqI8QMbSbWUxalVfOw4CDH5XkH/view
?usp=share_link )
3. Membuka aplikasi PyRx dan menjalankan aplikasi sesuai penjelasan video aplikasi
dan arahan dari dosen pengampu
4. Mengerjakan tugas yang diberikan oleh dosen pengampu.
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
Dosen/Instruktur Praktikum
(………………………………………………)
PERCOBAAN V
ANALISA KUALITATIF OBAT ANTIBIOTIK
(AMOKSISILIN DAN CEPADROKSIL)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat antibiotik: Amoksisilin dan Cepadroksil
II PROSEDUR KERJA
2.1 Amoksisilin
Bentuk sediaan : tablet 250mg, 500mg
Indikasi : Antibiotik
1. Uji Organoleptik : Perhatikan Bentuk, warna, rasa, dan bau sample

2. Uji Kelarutan :
a. Gerus tablet lalu ambil sedikit
b. Masukkan kedalam tabung reaksi 1 dan 2,
c. Tabung 1 dimasukkan dengan akuades 1 ml,
d. Tabung 2 dimasukkan dengan etanol 1 ml,
e. Dikocok dan amati kelarutannya, apabila tidak larut dipanaskan langsung
dengan bunsen.
3. Uji Keasaman :
Tabung reaksi yang telah berisi sampel (hasil uji kelarutan) dimasukkan dengan
lakmus merah dan biru, amati perubahan warna kertas lakmus.
4. Reaksi – reaksi :
a. Masukkan sedikit serbuk dalam plat tetes ditambahkan H2SO4 terjadi
perubahan warna kuning kehijauan.
b. Masukkan sedikit serbuk kedalam tabung reaksi lalu ditambahkan FeCl3,
warna menjadi merah/biru/hijau/ungu tua/hitam menandakan positif
mengandung gugus hidroksil.
c. Masukkan sedikit serbuk kedalam tabung reaksi lalu ditambahkan Fehling a +
b. Amati perubahan warnanya.
2.2 Cepadroksil
Bentuk sediaan : Kapsul 500 mg, Larutan suspensi 250 mg/5 ml, Larutan suspensi 500
mg/ml, Tablet 1 mg

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Masukkan sedikit serbuk kedalam tabung reaksi lalu ditambahkan FeCl3, warna
menjadi merah/biru/hijau/ungu tua/hitam menandakan positif mengandung gugus
hidroksil.
b. Masukkan sedikit serbuk kedalam tabung reaksi lalu ditambahkan Fehling a + b.
Amati perubahan warnanya.
III. HASIL PENGAMATAN

3.1 Tabel Hasil Pengujian Pendahuluan
Zat Uji
Pengujian
Amoksisilin Sefradoksil
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
3.2 Tabel Hasil Pengujian dengan pereaksi kimia
Sampel Hasil Keterangan
Uji 1
Amoksisilin Uji 2
Uji 3
Uji 1
Cepadroksil
Uji 2
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN VI
ANALISA KUALITATIF OBAT ANTIBIOTIK
(PENISILIN DAN GRISEOFULVIN)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat antibiotik: Penisilin dan Griseofulvin.
II PROSEDUR KERJA
2.1 Penisilin
Bentuk sediaan : Kapsul atau tablet dengan kandungan 250 mg, 500 mg atau 1000
mg. Sirup dengan kandungan 125 mg atau 250 mg/5 ml sirup.

6. Uji Kelarutan :
dengan bunsen.
7. Uji Keasaman :
a. Tablet digerus dan dimasukkan sedikit kedalam tabung reaksi,
diencerkan dengan aquades, ditetesi dengan iodium terbentuk endapan coklat.
b. Tablet digerus dan dimasukkan secukupnya kedalam tabung reaksi, diencerkan
dengan aquades, ditetesi dengan FeCl3, Larutan bewarna kuning.
2.2 Griseofulvin
Bentuk sediaan : Kapsul 500 mg, Larutan suspensi 250 mg/5 ml, Larutan suspensi 500
mg/ml, Tablet 1 mg

6. Uji Kelarutan :
dengan bunsen.
7. Uji Keasaman :
a. Gerus tablet hingga halus, lalu ambil sedikit serbuk, jadikan sebagai zat uji.
Suspensikan dalam 1 ml etanol 96 % lalu tambahkan sedikit serbuk Na2S2O3
dan 1ml NaOH.
Panaskan diatas penangas air sekitar 10 menit akan dihasilkan warna kuning
lemon.
b. Pada sedikit zat uji ditambahkan 0,5 ml larutan H2SO4 akan terbentuk warna
kuning orange. Tambahkan 1 tetes K2CrO4 warnanya akan berubah menjadi
merah anggur.

Zat Uji
Pengujian
Penisilin Griseofulfin
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Penisilin
Uji 2
Uji 1
Griseofulvin
Uji 2
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN VII
ANALISA KUALITATIF OBAT ANALGETIK NARKOTIKA
(CODEIN)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat analgetik narkotika : Codein
II. Cara Kerja test Codein

Bentuk sediaan : Kapsul / tablet dengan kandungan 250 mg, 500 mg atau 1000 mg.
Sirup dengan kandungan 125 mg atau 250 mg/5 ml sirup.
Indikasi : Analgetik narkotika

6. Uji Kelarutan :
dengan bunsen.
7. Uji Keasaman :

Zat Uji
Pengujian
Codein
Bentuk
Warna
Organoleptik
Bau
Rasa
Kelarutan Air
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN VIII
ANALISA KUALITATIF OBAT ANALGETIK NON NARKOTIKA DAN
ANTIPIRETIK (METAMPIRON DAN PARACETAMOL)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat analgetik non narkotika dan antipiretik:
Metampiron Dan Paracetamol
II. CARA KERJA

2.1 Metampiron (Antalgin)
Bentuk sediaan : tablet 500mg dan injeksi
Indikasi : Analgetik

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a) Gerus tablet hingga halus, lalu ambil sedikit serbuk, jadikan sebagai zat uji.
Masukan dalam tabung reaksi, larutkan dalam 1 ml air .
Lalu tambahkan 1 ml larutan HCl encer dan beberapa tetes larutan .FeCl3,
akan terbentuk warna biru yang berubah menjadi merah lalu beberapa saat
kemudian menjadi tidak berwarna.
b) Ambil sedikit serbuk, masukan dalam tabung reaksi, lalu larutkan dalam 1 ml air
Tambahkan 3 tetes larutan AgNO3.
Maka akan terbentuk warna ungu dan endapan perak (lihat dalam tempat gelap)
2.2 Paracetamol (Asetaminofen)

Bentuk sediaan : tablet (250 mg dan 500 mg)
Indikasi : analgesik (anti nyeri) dan antipiretik (penurun panas)

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a) Gerus tablet hingga halus, lalu ambil sedikit serbuk, jadikan sebagai zat uji.
Masukan dalam tabung reaksi, larutkan dalam 1 ml air
Lalu tambahkan 3 tetes larutan FeCl3 akan timbul warna biru violet.
b) Tambahkan 1 ml larutan HCl encer ke dalam sedikit zat uji,
Lalu panaskan hingga mendidih.
Tambah 5 ml air lalu dinginkan.
Tambahkan 3 tetes Kalium Bikromat akan terbentuk warna violet yang berubah
menjadi merah.
c) Pada plat tetes ditambahkan serbuk parasetamol tetesi dengan HNO 3 encer,
amati warna yang terjadi.

Zat Uji
Pengujian
Metampiron Paracetamol
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Metampiron
Uji 2
Uji 1
Paracetamol Uji 2
Uji 3
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN IX
ANALISA KUALITATIF OBAT ANALGETIK NON NARKOTIKA DAN
ANTIPIRETIK (ASAM MAFENAMAT DAN PIROKSIKAM)
III. TUJUAN PERCOBAAN

Mempelajari test dasar untuk senyawa obat analgetik non narkotika dan antipiretik: Asam
Mafenamat dan Piroksikam
IV. CARA KERJA

2.1 Asam Mafenamat
Bentuk sediaan : tablet 250 mg dan 500 mg
Indikasi : Anti inflamasi non-steroid

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Tablet digerus sampai halus
Ambil sedikit ke dalam tabung reaksi, lalu dilarutkan dalam etanol
Ditambahkan FeCL3, hingga nantinya terbentuk warna ungu/jingga
b. Sedikit serbuk ditambahkan dengan H2SO4 menjadi warna putih-biru
Lalu ditambahkan dengan K2CrO7 0,1 N terbentuk warna hijau biru
c. Sedikit serbuk ditambahkan dengan HNO3,
Terbentuk warna hijau lumut/kekuningan
2.2Piroksikam
Bentuk sediaan : tablet 10 mg dan 20 mg
Indikasi : aanti inflamasi non steroid

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a) Tablet digerus halus
Sedikit serbuk ditambahkan dengan H2O2 30% 1 ml
Ditambahkan 2 tetes FeCl3, 3 tetes HNO3 dan BaCL2
Terbentuk endapan putih BaSO4
b) Tambahkan 1 ml larutan HCl encer ke dalam sedikit zat uji,
Lalu ke dalamnya dicelupkan korek apo, maka timbul warna jingga hingga warna
jingga kuning
c) Sedikit zat ditambahkan 2 ml akuades
Ditambahkan 3 tetes FeCl3, tidak berwarna

Zat Uji
Pengujian Asam
Piroksikam
Mafenamat
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Asam Mafenamat Uji 2
Uji 3
Uji 1
Piroksikam Uji 2
Uji 3
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN X
ANALISA KUALITATIF OBAT SUSUNAN SARAF PUSAT
(FENITOIN DAN ASAM VALPROAT)
V. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat susunan saraf pusat: Fenitoin dan Asam Valproat
VI. CARA KERJA

2.1 Fenitoin
Bentuk sediaan : tablet 25 mg dan 100 mg, Injeksi 25 mg/l
Indikasi : Antipsikotik fenotiazina

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Tablet digerus sampai halus
Ambil sedikit dan ditambahkan dengan air 1 ml,
Ditambahkan dengan HCl encer, membentuk endapan putih
b. Zat ditambahkan dengan CuSO4 menjadi warna biru
2.2 Asam Valproat

Bentuk sediaan : Sirup
Indikasi : Antikonvulsan

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :

Zat Uji
Pengujian
Fenitoin Asam Valproat
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Fenitoin Uji 2
Uji 3
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN XI
ANALISA KUALITATIF OBAT SUSUNAN SARAF PUSAT
(FENOBARBITAL)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat susunan saraf pusat: Fenobarbital
II. CARA KERJA

2.1 Fenobarbital
Bentuk sediaan : Tablet 25 mg dan 100 mg, Injeksi 25 mg/ml
Indikasi : Antipsikotik fenotiazina

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
4. Reaksi - Reaksi :
a) Tablet digerus halus, sedikit serbuk ditambahkan dengan air 1 ml, ditambahkan
dengan AgNO3, membentuk endapan putih.
b) Zat ditambahkan dengan pereaksi Merkurium Nitrat, membentuk warna hitam.
c) Zat ditambahkan dengan Formalin, Asam sulfat Pekat, membentuk warna merah.

Zat Uji
Pengujian
Fenobarbital
Bentuk
Organoleptik Warna
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Fenobarbital Uji 2
Uji 3
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN XII
ANALISA KUALITATIF OBAT ANTIHISTAMIN JENIS AH1
(DEFINHIDRAMIN DAN KLORFENIRAMINMALEAT)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat antihistamin jenis AH1 : Definhidramin dan
Klorfeniraminmaleat
II. CARA KERJA

2.1 Definhidramin
Bentuk sediaan : ampul 1 ml (10 mg/ml), vial 15 ml (10 mg/ml), tablet 25 mg, sirup
(12,5 mg/5 ml).
Indikasi : Antihistamin

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. zat dimasukkan secukupnya kedalam tabung reaksi, diencerkan dengan
aquades, ditetesi dengan HNO3 + kloroform + H2SO4 pekat, larutan berwarna
putih.
2.2 Klorfeniramin Maleat

Bentuk sediaan : Tablet 4 mg, 8 mg, 12 mg
Indikasi : Anti Histamin

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
4. Reaksi-reaksi :
a. Tablet digerus dan dimasukkan secukupnya kedalam tabung reaksi, diencerkan
dengan aquades, ditetesi dengan NaOH dan CuSO4, Larutan berwarna biru
muda atau biru kehijau-hijauan.

Zat Uji
Pengujian Klorfeniramin
Definhidramin
maleat
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Definhidramin
Klorfeniraminmaleat
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN XIII
ANALISA KUALITATIF OBAT ANTIHISTAMIN JENIS AH 1
(PROMEZATIN DAN TERFENADIN)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat antihistamin jenis AH 1: Promezatin dan
Terfenadin
II. CARA KERJA

2.1Promezatin
Bentuk sediaan : Sirop

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Zat ditambahkan FeCl3, terbentuk warna jingga
b. Zat ditambahkan H2SO4 Pekat terbentuk warna merah muda / merah
c. Zat ditambahkan KMNO4 + NaOH terbentuk warna hijau kecoklat-coklatan
2.2 Terfenadin
Bentuk sediaan : Sirop

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :

Zat Uji
Pengujian
Promezatin Terfenadin
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru
Uji 1
Promezatin
Uji 2
Uji 3
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)
PERCOBAAN XIV
ANALISA KUALITATIF OBAT ANTIHISTAMIN JENIS AH 2
(SIMETIDIN DAN RANITIDIN)
I. TUJUAN PERCOBAAN
Mempelajari test dasar untuk senyawa obat antihistamin jenis AH 2: Simetidin dan Ranitidin
II. CARA KERJA

2.1 Simetidin
Bentuk sediaan : 200 mg atau 400 mg / tablet, 200 mg / 5 ml sirup dan 100 mg / ml
sediaan injeksi.

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Tablet digerus halus, lalu ambil sedikit serbuk ke dalam tabung reaksi,
Larutkan ke dalam etanol 1 ml,
Ditambahkan 5 ml HCl 0,1 N lalu dipanaskan
Tambahkan 3 ml NaOH
Celupkan kertas lakmus merah , maka kertas lakmus akan berubah menjadi
warna biru
2.2 Ranitidin
Bentuk sediaan : Tablet 75 mg, 150 mg, dan 30 mg, Sirup 15 mg/ml.

2. Uji Kelarutan :
dengan bunsen.
3. Uji Keasaman :
a. Tablet digerus halus, lalu ambil sedikit serbuk ke dalam tabung reaksi,
Larutkan ke dalam aquadest, dan lakukan penyaringan
Reaksikan filtrat dengan perak nitrat, terbentuk endapan putih.
Tambahkan hasil uji dengan asam nitrat pekat, putih tidak larut.
b. Sedikit serbuk dengan akuades di dalam tabung reakso. Dilakukan penyaringan
Reaksikan filtrat dengan perak nitrat, terbentuk endapan putih.
Tambahkan hasil uji dengan ammonium hidroksida 6N berlebih,maka endapan
putih akan larut

Zat Uji
Pengujian
Simetidin Ranitidin
Bentuk
Warna
Organoleptik
Bau
Rasa
Air
Kelarutan
Etanol
Lakmus Merah
Keasaman
Lakmus Biru

Simetidine Uji 1
Uji 1
Ranitidin
Uji 2
IV. PEMBAHASAN
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V. KESIMPULAN
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VI. DAFTAR PUSTAKA
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Balunijuk,……………………………20……….
(………………………………………………)

Hal Awal Modul Ganjil 22-23 - Farmasi - Kimia Farmasi 1-Merged

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Informasi Dokumen

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Hal Awal Modul Ganjil 22-23 - Farmasi - Kimia Farmasi 1-Merged

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Format Tersedia

M OD UL PR AK TI KUM KI MI A F AR MA SI I

POLITEKNIK KESEHATAN (POLTEKKES)KEMENKES

LABORATORIUM PENDIDIK DASAR

Balunijuk, September 2022

Tim Pengampu Kimia Farmasi I

HALAMAN JUDUL ................................................................................................................... i

KATA PENGANTAR .................................................................................................................. ii

DAFTAR ISI............................................................................................................................... iii

TATA TERTIB LABORATORIUM .............................................................................................. iv

PERCOBAAN I-IV Praktikum Kering dengan aplikasi

Pengantar Kimia Farmasi, Metabolisme Obat, Mekanisme

Kerja Obat dan struktur Aktivitas Obat ................................................ 1

PERCOBAAN V Analisa Kualitatif Obat Antibiotik : Amoksisilin & Cepadroksil.............. . 4

PERCOBAAN VI Analisa Kualitatif Obat Antibiotik : Penisilin & Griseofulvin .................. . 9

PERCOBAAN VII Analisa Kualitatif Obat Analgetik Narkotika : Codein ........................... 14

Metampiron & Paracetamol ................................................................ 18

PERCOBAAN IX Analisa Kualitatif Obat Analgetik non Narkotika & Antipiretik:

Asam Mafenamat & Piroksikam .......................................................... 23

PERCOBAAN X Analisa Kualitatif Obat Susunan Saraf Pusat :

Fenitoin dan Asam Valproat ................................................................ 28

PERCOBAAN XI Analisa Kualitatif Obat Susunan Saraf Pusat : Fenobarbital ............... 33

PERCOBAAN XII Analisa Kualitatif Obat Antihistamin Jenis AH 1:

Definhidramin dan Klorfeniraminmaleat .............................................. 37

PERCOBAAN XIII Analisa Kualitatif Obat Antihistamin Jenis AH 1:

Promezatin dan Terfenadin ................................................................ 42

PERCOBAAN XIV Analisa Kualitatif Obat Antihistamin Jenis AH 2:

Simetifin dan Ranitidin ........................................................................ 47

KONTRAK PERILAKU DAN KESELAMATAN BEKERJA

PRAKTIKUM DI LABORATORIUM PENDIDIK DASAR

Peralatan 1. Jas Laboratorium 2. Sepatu Tertutup

TATA TERTIB MELAKSANAKAN PRAKTIKUM

DI LABORATORIUM PENDIDIK DASAR

A. Kewajiban Mahasiswa Praktikan

B. Kewajiban Pembimbing dan atau Asisten Praktikum

C. Protokol Kesehatan di Laboratorium Pendidik Dasar Selama Pandemi

D. Protokol Keselamatan Kerja di Laboratorium Pendidik Dasar Selama Pandemi

bahan kimia secara langsung diatas panci timbangan.

Aturan setelah bekerja

E. Standar Penilaian Praktikum

Pelanggaran Tata Tertib Sanksi

kimia obat, maka mekanisme kerja obat dapat dipahami.

menghubungkan perilaku biodinamik melalui sifat fisika dan reaktivitas kimia

kualitatif maupun kuantitatif.

Dengan mempelajari Kimia Farmasi, diharapkan adanya pemahaman dalam penerapan

atau sediaan farmasi karena pengetahuannya melibatkan penggunaan sejumlah teknik

tempat atom serta identifikasi gugus-gugus karakteristik dalam suatu molekul.

meringankan, mencegah maupun menyebuhkan penyakit serta gejala-gejalanya.

1. Melakukan instalasi aplikasi edupymol pada link yang sudah disiapkan

2. Mempelajari video aplikasi di link yang sudah disiapkan

4. Mengerjakan tugas yang diberikan oleh dosen pengampu.

VI. DAFTAR PUSTAKA

1. Uji Organoleptik : Perhatikan Bentuk, warna, rasa, dan bau sample

1. Uji Organoleptik : Perhatikan Bentuk, warna, rasa, dan bau sample

III. HASIL PENGAMATAN

3.2 Tabel Hasil Pengujian dengan pereaksi kimia

Sampel Hasil Keterangan

VI. DAFTAR PUSTAKA

5. Uji Organoleptik : Perhatikan Bentuk, warna, rasa, dan bau sample

5. Uji Organoleptik : Perhatikan Bentuk, warna, rasa, dan bau sample

III. HASIL PENGAMATAN

3.2 Tabel Hasil Pengujian dengan pereaksi kimia

Sampel Hasil Keterangan

VI. DAFTAR PUSTAKA