TUGAS INDIVIDU

FARMAKOKINETIKA DASAR

OLEH

NAMA : SITI NURUL AISYAH

NIM : O1A116177
KELAS : A
DOSEN : Apt. SUNANDAR IHSAN, S.Farm., M.Sc.

PROGRAM STUDI S1 FARMASI

JURUSAN FARMASI
FAKULTAS FARMASI
UNIVERSITAS HALU OLEO
KENDARI
2021
 SOAL MODEL 1 KOMPARTEMEN
PEMBERIAN INTRAVASKULER METODE RESIDUAL

Waktu (Jam) Kadar(Cp) (ug/ml)

0 0

0,5 5,36

1 9,95

2 17,18

3 25,75

8 29,78

12 26,63

18 19,40

24 13,26

36 5,88

48 2,56

72 0,49

Pertanyaan :
1. Berapa tetapan kecepatan absorbsi dan eliminasi?
2. Bagaimana persamaannnya?
3. Hitung t ½ eliminasi dan absorbsi, C maks, T maks, AUC, Vd, Cl jika ketersediaan
hayati 0,80
4. Berapa jumlah obat 50 jam kemudian?
Jawab:

t Cp (ug/ml) Ln Cp Kadar Kadar Ln

Ekstrapolasi Residual
(ug/ml) setelah
anti ln

0 0 69,338 69,338 4,238

0,5 5,36 66,980 61,62 4,120

1 9,95 64,761 54,811 4,003

2 17,18 60,462 43,282 3,767

3 25,75

8 29,78

12 26,63

18 19,40

24 13,26 2,584

36 5,88 1,771

48 2,56 0,940

72 0,49 -0,713

1. Tetapan kecepatan absorpsi dan eliminasi

 Perhitungan kadar eliminasi menggunakan regresi, hingga didapatkan persamaan
y=a+bx.
- A= 4,239
- B= -0,068
- r= -0,999
- Cp= e4,239 = 69,338
- Persamaan eliminasi= y= 4,239 + 0,068x
- K eliminasi = 0,068/jam
 Perhitungan kadar ekstrapolasi setelah anti ln

Cp.e-k.t

- t=0= 69,338
- t=0,5; Cp.e-k.t 69,338. e-(-0,068).0,5 = 66,980
- t=1; Cp.e-k.t 69,338. e-(-0,068).1 = 64,761
 - t=2; Cp.e-k.t 69,338. e-(-0,068).2 = 60,462

 Perhitungan kadar residual

C.Residual= C ekstrapolasi – Cp

- t=0= 69,338 ln= 4,238

- t=0,5; 66,980 – 5,36 = 61,62 ln= 4,120
- t=1; 64,761 – 9,95 = 54,811 ln= 4,003
- t=2; 60,462 – 17,18 = 43,282 ln= 3,767

 Perhitungan kadar absorpsi dengan ln residual menggunakan regresi, hingga

didapatkan persamaan y=a+bx
- A= 4,238
- B= -0,235
- r= -0,999
- Cp= e4,238= 69,269
- Persamaan absorpsi= y= 4,238 + 0,235x
- K absorpsi= 0,235/jam

2. Persamaan farmakokinetik:
Ct= C0 x (e-k – e-ka.t)
Ct= 69,338 x (e-0,068 – e-0,235.t)

3. – t1/2 eliminasi= = 10,19 jam

– t1/2 absorpsi= = 2,94 jam

- Tmax = = = = 9,371 Jam

- Cmax = (e-(kxTmax)) = (e-(0,068x9,371)) = 49,32 x 0,52 = 25,64 μg/L

- AUC= = = 1,019 ml/jam

- Vd = = = = 0,811 L
- Cl jika F= 0,80 = K x Vd 0,068 x 0,811 = 0,055 ml/jam

4. Jumlah obat 50 jam kemudian

t=50 masuk kedalam fase eliminasi sehingga :
C50= 69,338 x (e-0,068xt)
C50= 69,338 x (e-0,068x50) = 69,338 x (46,713)
= 3238,98 mg/ml
 METODE WAGNER NELSON 1 KOMPARTEMEN EKSTRA VAKSULER

Waktu Ct (AUC)t (AUC) k (AUC) Ct+k Ab/ 1- Ab/ Ln

(Jam) (ug/mL) n-tn-1 t-0 t-0 (AUC)t-0 Ab Ab (1-
Ab/
Ab

0 0

0,5 5,36

1 9,95

2 17,18

4 25,75

8 29,78

12 26,63

18 19,40

24 13,26

36 5,88

48 2,56

72 0,49

Tentukan nilai ka !

1. (AUC) tn-tn-1
a) AUC 0-0,5 = = 2,93

b) AUC 0,5-1 = = 3,82

c) AUC 1-2 = = 13,56

d) AUC 2-4 = = 42,93

e) AUC 4-8 = = 54,75

f) AUC 8-12 = = 112,82

g) AUC 12-18 = = 138,09

 h) AUC 18-24 = = 97,98

i) AUC 24-36 = = 114,84

j) AUC 36-48 = = 50,64

k) AUC 48-72 = = 36,6

2. (AUC) t-0
a) AUC t 0,5 =
=
= 2,93 μg/L

b) AUC t 1 =
=
= 6,75 μg/L

c) AUC t 2 =
=
= 20,31 μg/L

d) AUC t 4 =
=
= 63,24 μg/L

e) AUC t 8 =
=
= 117,99 μg/L

f) AUC t 12 =
=
= 230,81 μg/L

g) AUC t 18 =
=
= 368,9 μg/L

h) AUC t 24 =
=
 = 466,88 μg/L

i) AUC t 36 =
=
= 581,72 μg/L

j) AUC t 48 =
=
= 632,36 μg/L

k) AUC t 72 =
=
= 668,96 μg/L

3. k (AUC) t-0
a) (K.AUC) 0,5 =

= 0,19 μg/jam.mL

b) (K.AUC) 1 =

= 0,45 μg/jam.mL

c) (K.AUC) 2 =

= 1,35 μg/jam.mL

d) (K.AUC) 4 =

= 4,23 μg/jam.mL

e) (K.AUC) 8 =

= 7,89 μg/jam.mL

f) (K.AUC) 12 =

= 15,44 μg/jam.mL

g) (K.AUC) 18 =

= 24,67 μg/jam.mL
 h) (K.AUC) 24 =

= 31,23 μg/jam.mL

i) (K.AUC) 36 =

= 38,91 μg/jam.mL

j) (K.AUC) 48 =

= 42,30 μg/jam.mL

k) (K.AUC) 72 =

= 44,75 μg/jam.mL

4. Ct+k (AUC) t-0

a) Ct+k (AUC) 0,5 =
= 5,55 μg/jam.mL

b) Ct+k (AUC) 1 =
= 10,4 μg/jam.mL

c) Ct+k (AUC) 2 =
= 18,53 μg/jam.mL

d) Ct+k (AUC) 4 =
= 29,98 μg/jam.mL

e) Ct+k (AUC) 8 =
= 37,67 μg/jam.mL

f) Ct+k (AUC) 12 =
= 42,07 μg/jam.mL

g) Ct+k (AUC) 18 =
= 44,07 μg/jam.mL

h) Ct+k (AUC) 24 =
= 44,49 μg/jam.mL
 i) Ct+k (AUC) 36 =
= 44,79 μg/jam.mL

j) Ct+k (AUC) 12 =
= 44,86 μg/jam.mL

k) Ct+k (AUC) 12 =
= 45,24 μg/jam.mL

5. Ab/ Ab

a) Ab/ Ab 0,5 =

= 0,12 μg/jam.mL

b) Ab/ Ab 1=

= 0,23 μg/jam.mL

c) Ab/ Ab 2=

= 0,41 μg/jam.mL

d) Ab/ Ab 4=

= 0,66 μg/jam.mL

e) Ab/ Ab 8=

= 0,84 μg/jam.mL

f) Ab/ Ab 12 =

= 0,94 μg/jam.mL

g) Ab/ Ab 18 =

= 0,98 μg/jam.mL

h) Ab/ Ab 24 =

= 0,99 μg/jam.mL
 i) Ab/ Ab 36 =

= 1 μg/jam.mL

j) Ab/ Ab 48 =

= 1 μg/jam.mL

k) Ab/ Ab 72 =

= 1 μg/jam.mL

6. 1- Ab/ Ab
a) 1-Ab/ Ab 0,5 =
= 1,00 μg/jam.mL

b) 1-Ab/ Ab 1=
= 0,88 μg/jam.mL

c) 1-Ab/ Ab 2=
= 0,77 μg/jam.mL

d) 1-Ab/ Ab 4=
= 0,59 μg/jam.mL

e) 1-Ab/ Ab 8=
= 0,34 μg/jam.mL

f) 1-Ab/ Ab 12 =
= 0,16 μg/jam.mL

g) 1-Ab/ Ab 18 =
= 0,06 μg/jam.mL

h) 1-Ab/ Ab 24 =
= 0,02 μg/jam.mL

i) Ab/ Ab 36 =
= 0,01 μg/jam.mL

j) Ab/ Ab 48 =
 = 0 μg/jam.mL

k) Ab/ Ab 72 =
= 0 μg/jam.mL

TABEL HASIL PERHITUNGAN

METODE WAGNER NELSON 1 KOMPARTEMEN EKSTRA VAKSULER
Waktu Ct (AUC) (AUC) k (AUC) Ct+k Ab/ 2- Ab/ Ln (1-Ab/ Ln Ct
(Jam) (ug/m tn-tn-1 t-0 t-0 (AUC) Ab Ab Ab
L) t-0

0 0 0 0 0.00 0.00 0.00 1.00 0.00 0.00

0,5 5,36 2.93 2.93 0.19 5.55 0.12 0.88 -0.12 1,67

1 9,95 3.82 6.75 0.45 10.4 0.23 0.77 -0.26 2,29

2 17,18 13.56 20.31 1.35 18.53 0.41 0.59 -0.52 2,84

4 25,75 42.93 63.24 4.23 29.98 0.66 0.34 -1.07 3,24

8 29,78 54.75 117.99 7.89 37.67 0.84 0.16 -1.83 3,39

12 26,63 112.82 230.81 15.44 42.07 0.94 0.06 -2.81 3,28

18 19,40 138.09 368.9 24.67 44.07 0.98 0.02 -3.91 2,96

24 13,26 97.98 466.88 31.23 44.49 0.99 0.01 -4.60 2,58

36 5,88 114.84 581.72 38.91 44.79 1 0 1,77

48 2,56 50.64 632.36 42.30 44.86 1 0 0,94

72 0,49 36.6 668.96 44.75 45.24 1 0 -0,71

Untuk mencari nilai Ka maka kita meregresikan t vs Ln Ct (hingga t=4)

Didapatkan hasil regresi sbb :
A= 1,661
B= 0,402
R= 0,963
Persamaannya menjadi :
y=a+bx
y= 1,661+0,402x
Maka Ka = b = 0,402/jam