Makna Pengukuran Kadar Obat dan Kurva kadar obat-

waktu
Pengukuran kadar Obat
darah atau plasma darah
 Ppengukuran kadar obat dalam plasma Cp sangat relevan dalam
memantau pengobatan karena kadar obat dalam darah atau plasma
terjadi kesetimbangan dengan kadar obat pada jaringan-jaringan ,
dengan demikian kadar obat dalam darah mencerminkan kadar obat
di tempat aksi obat
Peningkatan kadar obat dalam darah menggambarkan peningkatan
kadar obat ditempat aksinya, sebaliknya menurunnya kadar obat
dalam darah menggambarkan penurunan kadar obat ditempat
aksinya.
Hal tersebut bukan berarti kadar obat dalam darah sama dengan
kadar obat di tempat aksinya.
 Seringkali terjadi perbedaan farmakokinetik obat pada
penggunaan klinik, sehingga pemeriksaan kadar obat dalam
darah atau plasma cp berguna untuk mengetahui sejauh ,mana
dosis yang diberikan kepada penderita benar-benar memberikan
kadar obat dalam plasma yang dibutuhkan dalam terapi. Dengan
diketahuinya kadar obat dalam plasma , dengan bantuan
parameter farmakokinetiki lainnya dapat dilakukan penyesuaian
dosis yang lbh tepat
Adanya perbedaan kepekaan reseptor terhadap beberapa obat pada individu yang berbeda ,
maka pemeriksaan cp bermanfaat untuk mengukur penggunaan obat secara individual,
sehingga individual yang terlalu peka terhadap obat tersebut tidak menerima terlalu banyak
dosis obat.
 Adanya penyakit tertentu, makanan maupun obat lain yang menyebabkan
interaksi dengan obat tersebut dapat mempengaruhi fungsi fisiologis organ
tubuh, maka pemeriksaan cp berguna untuk mengetahui nperubahan-perubahan
yang di timbulkan akibat pengaruh tersebut
 Kadar obat dalam plasma cp Bersama-sama model farmakokinetik dan
parameter farmakokinetika dapat memberikan penafsiran yang teliti mengenai
hubungan cp dan respon farmakologik suatu obat.
Data satu titik cp dari penderita belum memberikan infromasi yang cukup untuk
dapat digunakan, masih perlu penjelasan yang terkait . Antara lain ; kapan cp
diambil kaitan penggunaan obat, berapa besar dosis, dan cara pemberian obat
 Ex:
Suatu obat diberikan secara oral didapatkan cp 10 ug/ml. data ini belum dapat
digunakan bagi penderita. Untuk dapat diguanakan diperlukan data yang lain :
MEC (minimun effectivity concentration) , MTC (minimun toxicity concentration).

Kedua batas tersebut akan memberikan informasi dimana cp tersebut berada

untuk mengetahui efektifitas dan keamanan obat tersebut.
Informasi ini belum cukup yaitu kapan obat diberikan, seperti dapat dilihat dari
kurve, apa cp terletak sebelum atau sesudah puncak atau mungkin cp tersebut
dipuncak kurve, masing-masing mempunyai manfaat yang berbeda bagi
penderita dalam regimen dosis
Dosis obat juga diperlukan karena dapat terjadi cp yang sama tetapi dosisnya
berbeda missal adanya gangguan eliminasi obat karena menurunnya fungsi
organ eliminasi dengan dosis kecil akan memberikan kadar obat yang besar.
Hal tersebut menjadi berbahaya jika obat diberikan berulang dapat
memberikan akumulasi obat yang drastis.
Kurva kadar obat Vs waktu
 Kurve dapat dibuat setelah diperolleh hasil pengukuran cp pada serial waktu sampling
setelah produk obat diberikan pada subjek uji. Tiap cp digambarkan pada koordinat kertas
grafik rektanguler, terhadap- waktu (t) untuk masing-masing cuplikan darah pada absis.

Cp pda sumbu y, t pada sumbub x

 Pada pemberian cara oral atau ekstravaskular, cp akan naik smpai titik maksimum yang
umumnya lebih cepat dari fase eliminasi. Selama obat diabsorpsi kedalam sirkulasi sistemik,
obat didistribusikan ke seluruh tubuh dan serentak juga dieliminasikan yang berupa
metabolism dan ekskresi.
 Aspek farmakologik
Penempatan MEC dan MTC pada curve akan terlihat are yang efektif dalam
pengobatan dan daerah berbahaya yang merupakan resiko efek toksis obat yang
harus dihindari.

Penempatan MEC dan MTC ini jga akan dapat diketahui mulai kerja obat onset of
action, kekuatan obat atau intensity of action dan lama obat verefek atau duration of
action,
Obat dalam tubuh dinamis artinya selalu berubah sehubungan berjalannya waktu,
dalam tubuh dianggap obat dalam darah atau plasma terjadi suatu kesetimbangan
dengan obat dalam jaringan.

MEC mencerminkan kadar obat yang diperlukan reseptor obat untuk menghasilkan
efek farmakologik, sedangkan MTC mencerminkan konsentrasi obat pada reseptor
yang menimbulkan efek toksit.
 Onzet??
Intensitas?
Durasi??
 Aspek Farmakokinetik
Kadar puncak obat dalam plasma, adalah konsentrasi obat dalam plasma yang
paling tinggi cuplikan hayati yang diperiksa. Waktu kadar puncak yaitu waktu yaitu
waktu yang diperlukan obat mencapai kadar puncak dalam darah atau plasma yang
secara kasar sebanding dengan laju absorbs obat rata-tata.

Luas daerah di bwah kurve –area under curve (AUC) pada umumnya dikaitkan
dengan jumlah obat yang terabsorbsi untuk mencapai sirkulasi sistemik.
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You can simply impress your audience and add a unique zing and appeal to your
Presentations. Easy to change colors, photos and Text.
Columns 01 Easy to change colors,
photos and Text.
Style PowerPoint Presentation
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a
unique zing and appeal to your Reports
and Presentations with our Templates.
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a
unique zing and appeal to your Reports
and Presentations with our Templates.
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation.
Easy to change colors, photos and Text.
02 Easy to change colors,
photos and Text.
PowerPoint Presentation
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a
unique zing and appeal to your Reports
and Presentations with our Templates.
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a
unique zing and appeal to your Reports
and Presentations with our Templates.
Get a modern PowerPoint Presentation
that is beautifully designed. I hope and I
believe that this Template will your Time,
Money and Reputation.
Easy to change colors, photos and Text.
Get a modern PowerPoint Presentation that is beautifully designed.
You can simply impress your audience and add a unique zing and
appeal to your Presentations.
You can simply impress your audience and add a unique zing and appeal to your
Presentations. I hope and I believe that this Template will your Time, Money and
Reputation. Get a modern PowerPoint Presentation that is beautifully designed. Easy
to change colors, photos and Text. You can simply impress your audience and add a
unique zing and appeal to your Presentations. You can simply impress your audience
and add a unique zing and appeal to your Presentations. I hope and I believe that this
Template will your Time, Money and Reputation. You can simply impress your audience
and add a unique zing and appeal to your Presentations. You can simply impress your
audience and add a unique zing and appeal to your Presentations. Get a modern
PowerPoint Presentation that is beautifully designed. Easy to change colors, photos
and Text. You can simply impress your audience and add a unique zing and appeal to
your Presentations. I hope and I believe that this Template will your Time, Money and
Reputation. Get a modern PowerPoint Presentation that is beautifully designed. Easy
to change colors, photos and Text. You can simply impress your audience and add a
unique zing and appeal to your Presentations. I hope and I believe that this Template
will your Time, Money and Reputation. Get a modern PowerPoint Presentation that is
beautifully designed.

Get a modern PowerPoint Presentation that is beautifully designed. Easy to change

colors, photos and Text. You can simply impress your audience and add a unique zing
and appeal to your Presentations. I hope and I believe that this Template will your Time,
Money and Reputation.
Column
You can simply impress your audience and add a unique zing and appeal to your
Presentations. I hope and I believe that this Template will your Time, Money and
Reputation.
Style
Fully Editable Shapes
Fully Editable Shapes
 Fully Editable Icon Sets: A
You can Resize without
losing quality
You can Change Fill
Color &
Line Color

FREE
PPT
TEMPLATES
www.allppt.com
 Fully Editable Icon Sets: B
You can Resize without
losing quality
You can Change Fill
Color &
Line Color

FREE
PPT
TEMPLATES
www.allppt.com
 Fully Editable Icon Sets: C
You can Resize without
losing quality
You can Change Fill
Color &
Line Color

FREE
PPT
TEMPLATES
www.allppt.com