RESPON INDIVIDUAL TERHADAP

OBAT
KELOMPOK 6

OLEH:
ADINA MELIANA FATAWATI
AKHMAD HAFI REDHAYA
AULIA SUCI RAHMINI
CHELSA NADIA
ULYA ULFAH
PENGERTIAN

MENURUT WHO
(2005)
ROTD atau adverse drug reaction
merupakan respon tubuh terhadap obat
yang tidak diharapkan atau
membahayakan, respon ini muncul
pada dosis terapi yang digunakan oleh
pasien.
 RESPON YANG TIMBUL
Beberapa respon yang timbul akibat nasib
obat di dalam tubuh diantaranya
Efek Samping
Efek Toksisitas
Reaksi Idiosinkrasi
 Reaksi imunologik
01
EFEK
02 Hipoglikemia berat
SAMPING
merupakan suatu efek yang
tidak dikehendaki dan merugikan
sehingga membahayakan
03 Osteoporosis keselamatan pasien dari suatu
pengobatan

04 Hipertensi

05 Fokomelia pada anak

 Gangguan Pencernaan
01
EFEK
02 Nyeri Dada
TOKSISITAS
sering dikenal dengan
keracunan. Efek toksik dapat
03 Jantung Berdebar terjadi akibat penggunaan dosisi
obat yang berlebihan (overdosis)

04 Kejang

Penurunan Kesadaran,
05
dll.
Reaksi
INDOSINKRASI
Indosinkrasi adalah peristiwa, di mana suatu obat
memberi efek berbeda dengan efek normalnya

Kondisi ini bersifat individual, akibat kelainan genetik.

Contohnya, penggunaan neuroplektik yang efeknya
menenangkan, namun pada beberapa individu bisa terjadi
reaksi yang berlawanan seperti pasien menjadi gelisah
dan cemas

Indosinkrasi ini timbul pada pasien suspentibel dan

kejadian bisa / tidak bisa diperkirakan. Terjadi karena
metabolisme obat ataupun defisiensi enzim
Reaksi
ALERGI
Reaksi alergi adalah mekanisme Gejala alergi ringan seperti
pertahanan tubuh yang gatal-gatal dan kemerahan
menyimpang. pada kulit. Bisa mengarah
pada hal yang membahayakan
Saat allergen(bahan penyebab alergi)
seperti demam, serangan asma
masuk ke dalam tubuh, ia bereaksi
sampai syok anafilaksis.
dengan antibodi.
Reaksi alergi bisa berkembang cepat,
mula-mula ruam merah di kulir, bentol,
kemudian pembengkakan pada mata,
bibir, tangan/kaki sampai pusing dan
pingsan.
Reaksi Teratogenik
Ini efek toksik obat pada janin. Obat memberi manfaat
terapi bagi ibu, tapi berefek buruk berupa cacat pada janin.

Terjadi karena beberapa obat tertentu

dapat melintasi plasenta dan dapat
diabsorbsi oleh janin.
 FAKTOR YANG
MEMPENGARUHI
RESPONS KLINIS
OBAT
LANJUTAN

FAKTOR KLINIS YANG MEMPENGARUHI

RESPON KLINIS

1 Status pasien.

1 2
2 Penyakit dan gangguan
3
4
3 Faktor fisiologis

4 Interaksi obat dan interaksi obat-makanan

THANK YOU
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 Reaksi Indokrinasi
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