g6pd Dan Ferritin

G6PD & FERRITIN
KAPITA SELEKTA HEMATOLOGI
Oleh:
Nurlatifah Fitrianingsih
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GLUKOSA 6 FOSFAT DEHIDROGENASE
(G6PD)
DEFINISI
Defisiensi Glukosa-6-Fosfat Dehidrogenase (G6PD) adalah suatu jenis
penyakit genetik yang diturunkan. G6PD itu senditi merupakan enzim
yang berfungsi untuk memastikan proses oksidasi dan jangka hidup sel
darah merah (eritrosit) normal.
Pada kondisi defisiensi G6PD, terjadi pemecahan sel darah merah

(hemolysis) sebelum waktunya sehingga dapat terjadi anemia.
PENYEBAB
Disebabkan oleh kelainan genetik. Penyakit ini diturunkan dari orang tua secara
X-linked. Artinya, biasanya ibu menjadi karier penyakit (membawa gen penyakit
namun tidak menunjukkan gejala) dan menurunkannya kepada anaknya.
Pada anak laki-laki, umumnya akan menampakkan gejala tertentu. Sementara

pada anak perempuan umumnya akan menjadi karier penyakit ini kembali.
.
DIAGNOSIS
Adanya hemolysis ( sel darah merah pecah)
01 Konsumsi obat-stres oksidasi- tingginya radikal bebas.
Hiperblirubinemia
02 Get a modern PowerPoint Presentation that is beautifully designed.
Anemia Hemolitik
03
04
Untuk memastikan diagnosis, dapat dilakukan beberapa langkah
pemeriksaan, seperti:
1 2 3 4 5
pemeriksaan
6
Darah Rutin Retikulosit Biirubin (bilirubin analisis urine enzim G6PD
( (jumlah yang darah tepi
( dapat yang meningkat (mencari melaui
menunjukan HB meningkat (mencari Heinz
dapat adanya pemeriksaan
rendah) menandakan Body, yaitu
menandakan komponen sel darah
respon sumsum gambaran
pemecahan sel darah merah
tulang terhadap hemoglobin
darah merah dalam air seni)
adanya kondisi yang
yang
anemia) terdenaturasi
berlebihan)
atau tidak aktif)
Gejala
Peningkatan Suhu Tubuh disertai
kekuningan kulit dan selaput lendir
Pembesaran limpa (splenomegaly)
Air seni beerwarna gelap
Pucat, kelelahan, penurunan kondisi

umum tubuh
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G6PD & FERRITIN

KAPITA SELEKTA HEMATOLOGI

Pada kondisi defisiensi G6PD, terjadi pemecahan sel darah merah

Pada anak laki-laki, umumnya akan menampakkan gejala tertentu. Sementara

Pembesaran limpa (splenomegaly)

Air seni beerwarna gelap

Pucat, kelelahan, penurunan kondisi

Name Here Name Here Name Here Name Here

35minute Your Text Here Your Text Here

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