COMPOUNDING &

DISPENSING
Henny Lucida, PhD, Apt
Pretest
Jawablah soal berikut ini pada kertas yang
disediakan:
1. Hitunglah jumlah kalium permanganat yang
diperlukan untuk membuat larutan PK dengan
rasio 1:25 sebanyak 300 mL. Larutan berapa %
kah itu?
2. Berapakah mg aluminium asetat dibutuhkan
untuk membuat larutan 0,03 g b/v sebanyak
500 mL
Pretest (contd)
3. Nyatakan dalam %, bila 900 mg NaCl
dilarutkan dalam 100 mL aqua pi
4. Berapa mg/L kah 0,7 ppm b/v batas fluorida
dalam air minum
5. Sebanyak 25 g salep mengandung 5 g calamin.
Berapa jumlah calamin dalam 60 g salep?

Pretest (contd)
6. Dosis fenitoin yang direkomendasikan untuk
pasien A adalah 840 mg. Injeksi fenitoin
mengandung 50 mg/mL zat aktif. Berapa
volume injeksi yang diperlukan untuk
memenuhi dosis tersebut?
7. Setiap 5 mL suspensi mengandung
parasetamol 120 mg. Berapa volume suspensi
yang mengandung 300 mg parasetamol?
Pretest (contd)
8. Sebanyak 5 g sediaan mengandung 250 mg
sulfur di dalam paraffin kuning. Nyatakan
kadar obat dalam rasio ( x bagian dalam y
bagian b/b)
9. Suatu obat cair dicampurkan dengan pelarut
lain sehingga kadarnya 5% v/v. Tentukan rasio
nya terhadap pelarut dan nyatakan kadar dalam
mL/mL.
Pretest (contd)
10. Berapa mg senyawa x terdapat dalam 100
mL larutan 0,01%?
History
Pharmacy is the art or practice of preparing and
preserving drugs, and of compounding and
dispensing medicines according to the prescriptions
of physicians
Pharmacy is (1) the art, practice, or profession of
preparing, preserving, compounding and dispensing
medical drugs and (2) a place where medicines are
compounded or dispensed
History (contd)
Pharmacy is the science, art, and practice of
preparing, preserving, compounding, and
dispensing medicinal drugs and of giving
instructions for their use
Definition
Compounding: meracik

Pharmaceutical Compounding
Compounded Formulations
Dispensing: menyerahkan

Dispensing of medication
Compounding today
Is rapidly growing component of pharmacy practice,
due to:
Individualized patient therapy
Lack of commercially available products
Home health care
Intravenous admixture programs
Total parenteral nutrition programs
Problem solving for the physician and patient to
enhance compliance with a specific therapeutic
regimen



Trends kematian di AS akibat peresepan vs kecelakaan berbagai
alat transportasi,19791998 (1979 D 1).
Increase in US medication error deaths, Lancet, February 28, 1998
Annual Accidental Deaths (IOM
1999)
0
20000
40000
60000
80000
100000
Medical Auto Workplace Air
Pharmacist
A unique professionals
A single mistake in the daily practice of their
profession may result in potential tragedy
Possess knowledge and skills that are not
duplicated by any other profession
Compounding
Means the preparation, mixing, assembling,
packaging, or labeling of a drug or device
(1) As the result of a practitioners Prescription
(2) For the purpose of doing research, teaching
or chemical analysis