Nama : Pamor Faizal Ghani

NPM : 1102014208
Kelompok : B12

Skenario
Seorang ibu datang ke RS Pendidikan YARSI untuk berkonsultasi dengan
seorang dokter spesialis penyakit dalam. Ibu tersebut mengeluhkan benjolan
seperti gondok yang muncul di lehernya. Benjolan tersebut lunak, tidak nyeri,
namun mengganggu. Dokter memvonis bahwa itu adalah kelenjar tiroid yang
membengkak, namun ditemukan sel kanker yang jinak. Dokter mengatakan bahwa
ibu tersebut kekurangan yodium. Dokter menyarankan untuk operasi pengambilan
kelenjar tiroid yang mengandung sel kanker, lalu ibu tersebut mengatakan bahwa
ekstrak kulit manggis dapat mencegah sel kanker.

Pertanyaan klinis (foreground question) :

1. Apakah kandungan dalam kulit manggis efektif mencegah sel kanker
datang kembali?
P (patient/problem) : kelenjar tiroid yang membengkak dan mengandung sel
kanker
I (indicator) : operasi lalu mengonsumsi ekstrak kulit manggis
C (comparison) : operasi tanpa mengonsumsi ekstrak kulit manggis
O (outcome) : sel kanker tidak muncul lagi

PICO :
Seorang ibu mengalami pembengkakan kelenjar tiroid yang
mengandung sel kanker disarankan dokter untuk operasi, lalu ibu tersebut
menanyakan apakah ekstrak kulit manggis efektif untuk mencegah sel
kanker.

Kata kunci :
Anticancer AND mangosteen skin extract

Pemilihan situs :
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635669/

Limitation :
Summary, 20 per page, sorted by Journal

Hasil pencarian : 22
1. The Role and Place of Medicinal Plants in the Strategies for Disease Prevention
2. Natural Products as Aromatase Inhibitors
3. Altered mRNA Expression Related to the Apoptotic Effect of Three Xanthones on
Human Melanoma SK-MEL-28 Cell Line
4. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel
methanolic extract
5. Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene
6. Gambogic Acid Inhibits STAT3 Phosphorylation Through Activation of Protein
Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis
7. Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents:
Potential Anticancer Drugs
8. In Vitro Screening of 10 Edible Thai Plants for Potential Antifungal Properties
9. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain
Malignant Glioma GBM 8401 Cells
10.Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and
prostate cancer
11.Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
12.Cellular trafficking and anticancer activity of Garcinia mangostana extractencapsulated polymeric nanoparticles
13.Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and
its synthetic analogs
14.Chronic inflammation and cancer: potential chemoprevention through nuclear factor
kappa B and p53 mutual antagonism
15. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones
from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement
16.Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by
withaferin A and Siamois polyphenols
17.Hydroxybenzoic acid isomers and the cardiovascular system

18.Antiviral Effects of Blackberry Extract Against Herpes Simplex Virus Type 1

19.Cancer is a Preventable Disease that Requires Major Lifestyle Changes
20.In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs
21.Growth Inhibition of Human Gynecologic and Colon Cancer Cells by Phyllanthus
watsonii through Apoptosis Induction
22.Effects of -mangostin on apoptosis induction of human colon cancer

Artikel yang dipilih :

Gongbo Li, Stacey Thomas, Jeremy J. Johnson. Polyphenols from the
mangosteen (Garcinia mangostana) fruit for breast and prostate cancer. Front
Pharmacol. 2013; 4: 80.