CRITICAL APPRAISAL

JURNAL READING

Oleh :
Ilma Putri Dewanti (10711054)

Pembimbing :
dr. A. Ralibi, Sp. B

Pendidikan Klinik Ilmu Bedah

FK UII/ RSUD CARUBAN KAB. MADIUN
2015

Jurnal Terapi
Judul Jurnal

: Quality of life in patients with chronic anal fissure after

topical treatment with diltiazem

Penerbit

: World Journal Gastrointestinal Surgery. Vol. 4, No.251 - 255, November 27,

2012. World Journal Gastrointestinal Surgery.

Validitas
1a.
Apakah Tidak

Alokasi pasien dilakukan secara penelitian prospektif.

alokasi

Pasien

pasien

berturut-turut

yang

terhadap

dalam

penelitian.

terapi/perlakuan

dengan

dilakukan secara

dan setelah pengobatan 6-minggu dengan diltiazem.

survei

kesehatan

K
pendek

random?

Consecutive patients were enrolled prospectively into the study.

survey (SF-36) before and after 6-wk treatment with diltiazem.

1b.

Apakah Tidak ()

(Terdapat dalam Materials and Methods halaman252.)

Pihak peneliti tidak merandomisasi secara tersembunnyi terhadap terapi

randomisasi
dilakukan

(Tidak tercantumkan dalam Materials and Methods halaman252.)

tersembunyi?
1c. Apakah antara Tidak()

Subyek penelitian dan peneliti mengetahui intervensi apa yang diterima o

subyek penelitian
dan

peneliti

blind

terhadap

terapi/ perlakuan
yang

akan

diberikan?
2a.

Apakah Ya ()

semua
yang

Patients were advised to squeeze 2 cm of the diltiazem gel onto

margin. Each patient was given a 6-wk course of the diltiazem ge
Objective changes were assessed by the inspection of the anus t
or persistent) at baseline and weeks 1, 3 and 6.

pasien Tidak
ikut

dalam

kelompok AMC yang tidak menyelesaikan penelitian.

serta

penelitian

diperhitungkan
dalam

(Terdapat dalam Materials and Methods halaman252.)

Semuasubyek yang ikutsertadalampenelitiandiperhitungkandalamhasild

hasil

kesimpulan?
(apakah
pengamatannya

Of the 60 enrolled patients, 49 patients (81.7%) completed the trial. 5 pa

compliance, self discontinuation or adverse reactions. There was no signi

/

(Terdapatdalam Resultspada bagianDemographics and clinical charac

cukup lengkap?)
2b.

Ya ()

Intervensi yang dilakukancukuppanjangyaitu14 hari untuk tiap kelompo

Apakahpengamat

Tidak

diberikan.

an

yang

dilakukancukuppa

Patients were randomly assigned to either CP or AMC groups using th

njang?

three times daily (450 mg/day) and the latter 625 mg tablet three times da

were instructed to visit the clinic on days 7, 14, and 28 after initial treatm

2c.

Ya ()

Apakahsubyekdia Tidak

(TerdapatdalamMaterials and Methodshalaman84.)

Subyekdianalisisberdasarkanpadakelompokdimanasubyektersebutdialoka
AMCterdiridari24subyek.

nalisispadakelom
pokdimanasubyek

(TerdapatpadaTabel3 di bagianResultshalaman86.)

tersebutdikelomp
okkandalamrando
misasi?
3a.

Ya ()

Setiap subyek dalam masing-masing kelompok dievaluasi dengan nasa

Selainperlakuan

Tidak

sinus pada hari 1 dan 14 setelah intervensi.

yang
dieksperimenkan,

Nasal endoscopy and paranasal sinuses X-rays (Waters and Caldw

apakahsubyekdip

day for confirmation of the diagnosis and follow up images were perform

erlakukansama?

were performed on days 1, 7, and 14 and paranasal sinus X-rays on days

3b.

Ya ()

(TerdapatdalamMaterials and Methodspada bagian Clinical assessmen

Subyekpadaawalpenelitianadalahsamaberdasarkankriteriainklusidaneksk

Apakahkelompok

Tidak

AMC berjumlah 24 subyek.

dalampenelitiansa
mapadaawalpene

Any patients who had hypersensitivity to penicillin, cephalosporin and b

litian?

enrollment were excluded from this study. Patients who experienced orb

to be hospitalized are considered to have severe disease are excluded

age with a clinical diagnosis of ARS were recruited from the outpatient c
ARS (presumed bacterial) was made based on the guidelines provided

Diagnosis required symptoms consistent with ARS plus objective findings

Patients with symptoms of ARS that showed the following patterns we

patients with severe disease with presence of nasal purulence for 3-4 da

worsen within the first 10 days. Symptoms of ARS included at least 2 maj

(TerdapatdalamMaterials and Methodshalaman84)

Importance
1. 1. Berapa besar Perubahan gejala pada hari ke 7, 14 dan 28 menunjukkan hasil yang signifikan untu

efek terapi?

kelompok AMC.

On their second visit (day 7), complete remission of symptoms or partial improvemen

AMC groups, respectively; on the third visit (day 14), 96.0% and 95.8% of the patients in

and 95.9% showed improvement compared to pretreatment. The change of sympto

groups (P<0.001), however there was no difference between the two groups in any visit

(Terdapat pada Results di bagian Therapeutic outcomeshalaman 85.)

2. 2. Seberapa tepat Meskipunterdapat11subyek yang tidakmenyelesaikanpenelitian, namuntidakadaperbeda
estimasi

efek

terapi?

Of the 60 enrolled patients, 49 patients (81.7%) completed the trial. 5 patients in the C

self discontinuation or adverse reactions. There was no significant difference regardi

(TerdapatpadaResults di bagianDemographics and clinical characteristicshalaman8

3. Applicable
4. 1. Apakah hasil Ya, karena tidak ada aspek budaya yang membedakan pada kriteria inklusi maupun eks
penelitian

dapat

diterapkan untuk

pasien saya?
5. 2. Apakah pasien Ya, karena terapi pada penelitian sudah terbukti secara klinis memberikan perbaikan sig
saya

dapat

menerima

dan

puas pada terapi

dalam

penelitian

ini?
Simpulan: dari hasil critical appraisal didapatkan bahwa jurnal ini valid, penting dan dapat
diaplikasikan.