MONOKLONAL
Diah Puspita Rini, dr., SpPK
Suatu kelainan
hematologi yang
berasal dari limfosit
yang menghasilkan
paraprotein
(globulin gamma)
yang bersifat
monoklonal
1. Multiple Myeloma
2. Waldenstorm Macroglobulinemia
3. Monoclonal Gammopathy of Undetermined
Significance
Paraproteinemia
PARAPROTEINEMIA
MENYEBABKAN :
TUMOR PARAPROTEINEMIA
EFFECTS
Bone lession
EFFECTS
Renal failure
Marrow failure Immune suppression
Plasmacytoma Hiperviscosity
Amyloid
Multiple Myeloma
Tumor Effects
Neoplasm of C: hypercalcemia from
plasma cells in bone bone resorption
marrow which R: renal failure caused by
secretes a free light chain (myeloma
monoclonal kidney)
immunoglobulin A: anemia from marrow
failure
B: bone lesions
Multiple Myeloma (Plasma Cell Myeloma)
Ig secretion
52% Ig G
18% Ig A
11% Ig M
1% Ig D
rare Ig E
LABORATORIUM (1)
Ureum-creatinin >>
( Kegagalan fungsi ginjal )
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