DAFTAR ISI

HALAMAN JUDUL.............................................................................................i
DAFTAR ISI ........................................................................................................ii
DAFTAR TABEL ................................................................................................iii
DAFTAR GAMBAR ............................................................................................iv
DAFTAR SINGKATAN.......................................................................................v
BAB I. PENDAHULUAN ..................................................................................1
BAB II. NON ALCOHOLIC FATTY LIVER DISEASE....................................3
2.1 Definisi .............................................................................................3
2.2 Epidemiologi ....................................................................................4
2.3 Faktor Resiko....................................................................................5
2.4 Patogenesis........................................................................................6
2.5 Diagnosis...........................................................................................8
2.7 Penatalaksanaan................................................................................12
BAB III. INFLAMASI PADA NASH..................................................................17
3.1 Sistem Imun Pada Hati .....................................................................17
3.2 Respon Inflamasi Sebagai Patogenesis NASH.................................20
3.3 Modalitas Pada Tatalaksana NASH dari Sudut Pandang Inflamasi . .33
BAB IV. SIMPULAN...........................................................................................38
DAFTAR PUSTAKA............................................................................................39

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DAFTAR TABEL

Tabel 1. Guideline Terapi NAFLD ..................................................................... 15

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DAFTAR GAMBAR

Gambar 1. Perjalanan alami NAFLD................................................................. 4

Gambar 2. Patogenesis NAFLD......................................................................... 7
Gambar 3. Sistem skoring histologis untuk NAFLD ........................................ 9
Gambar 4. Tatalaksana Pada NASH.................................................................. 13
Gambar 5. Imunitas pada Hati............................................................................ 17
Gambar 6. Mekanisme inflamasi pada NASH................................................... 20
Gambar 7. Peran Caspase pada apoptosis hepatosit........................................... 23
Gambar 8. Peran LSEC pada NASH.................................................................. 24
Gambar 9. Sel Kupfer pada NASH.................................................................... 26
Gambar 10. Peran ILC terhadap progresi NASH............................................... 28
Gambar 11. Peran TLR pada pathogenesis NASH............................................ 30
Gambar 12. Peran ASK-1 pada pathogenesis NASH......................................... 33
Gambar 13. Patogenesis dan terapi baru pada NASH........................................ 34
Gambar 14. Terapi target pada NASH pada clinical trial 2 dan 3...................... 37
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DAFTAR SINGKATAN

NAFLD : Non-alcoholic fatty liver disease

NASH : Non Alcoholic Steatohepatitis
AASLD : American Association for the Study of Liver Disease
TGF-ß : transforming growth factor-beta
NF-κß : nuclear factor kappa beta
HCC : Hepatocellular carcinoma
PPAR : peroxisome proliferator-activated receptors
TLR : toll like receptor
PAMP : Pattern-associated Molecular Pattern
DAMP : Damage-associated Molecular Pattern
LSEC : liver sinusoidal endothelial cells
ILC : innate lymphoid Cell
MAIT : Mucosal associated invariant T cell
iNKT : invariant natural killer cell
DGAT2 : diasilgliserol asiltransferase 2
PRR : Pattern Recognition Receptors
FFA : Free Fatty Acid
ER : Retikulum endoplasma
MOMP : mitochondrial outer membrane permeabilization
VCAM : Vascular cell adhesion protein
ICAM : Intercellular adhesion molecule
VAP : vascular adhesion protein
NET : Neutrofil extracellular Trap
MAPK : mitogen-activated protein kinase
JNK : c-Jun N-terminal kinases
MKK : Mitogen-activated protein kinase
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ASK-1 : Apoptosis signal-regulating kinase 1

SSAO : semicarbazide-sensitive amine oxidase
FGF : Fibroblast Growth Factor
ECM : extracellular matrix