PKSolver 2.

0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst user
Dose 825 Date 2023-1-26
Dose Unit mg Time 21:43:26

Time Conc ln(C) AUC AUMC R R_adj

0 0 0 0
0.25 0.1556 -1.8604667 0.01945 0.0048625
0.5 1.9637 0.67483045 0.2843625 0.13245625
0.75 2.3335 0.84736929 0.8215125 0.47395313
1 2.464 0.90178605 1.4212 1.00071875
2 2.825 1.03850836 4.0657 5.05771875 -0.9879903 0.95224959
3 2.5355 0.93039086 6.74595 11.6859688
4 2.1 0.74193734 9.0637 19.6892188
Concentration (μg/ml)

2.5

1.5

0.5

0
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
Concentration (μg/ml)

10
 1
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
Concentration (μg/ml)

10

1
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
vascular Input

Parameter Unit Value

Lambda_z 1/h 0.14828551
t1/2 h 4.674409394
Tmax h 2
Cmax μg/ml 2.825
Tlag h 0
Clast_obs/Cmax 0.743362832
AUC 0-t μg/ml*h 9.0637
AUC 0-inf_obs μg/ml*h 23.22556923
AUC 0-t/0-inf_obs 0.390246625
AUMC 0-inf_obs μg/ml*h^2 171.8407623
MRT 0-inf_obs h 7.398775059
Vz/F_obs (mg)/(μg/ml) 239.5459688
Cl/F_obs (mg)/(μg/ml)/h 35.52119614
PKSolver 2.0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst user
Dose 825 Date 2023-1-26
Dose Unit mg Time 21:45:50

Time Conc ln(C) AUC AUMC R R_adj

0 0 0 0
0.25 2.8036 1.03090431 0.35045 0.0876125 -0.9193616 0.81427092
0.5 2.6714 0.98260268 1.034825 0.3421875 -0.9002684 0.76310397
0.75 2.1793 0.77900372 1.6411625 0.71345938 -0.8718652 0.68019856
1 2.064 0.72464585 2.171575 1.17576875 -0.8349212 0.5456401
2 1.771 0.57154436 4.089075 3.97876875 -0.7904085 0.24949126
3 1.9006 0.64216963 5.924875 8.60066875
4 1.17231 0.15897616 7.46133 13.7961888
Concentration (μg/ml)

2.5

1.5

0.5

0
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
Concentration (μg/ml)

10
 1
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
Concentration (μg/ml)

10

1
0 0.5 1 1.5 2Time (h)2.5 3 3.5 4 4.5
vascular Input

Parameter Unit Value

Lambda_z 1/h 0.189439511
t1/2 h 3.658936703
Tmax h 0.25
Cmax μg/ml 2.8036
Tlag h 0
Clast_obs/Cmax 0.418144528
AUC 0-t μg/ml*h 7.46133
AUC 0-inf_obs μg/ml*h 13.64963777
AUC 0-t/0-inf_obs 0.546632088
AUMC 0-inf_obs μg/ml*h^2 71.21582472
MRT 0-inf_obs h 5.21741499
Vz/F_obs (mg)/(μg/ml) 319.0525776
Cl/F_obs (mg)/(μg/ml)/h 60.44116435
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Waktu Data1 Data2

0 0 0
0.25 0.1556 2.8036
0.5 1.9637 2.6714
0.75 2.3335 2.1793
1 2.464 2.064
2 2.825 1.771
3 2.5355 1.9006
4 2.1 1.17231
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