PENGARUH PEMBERIAN EKSTRAK LIDAH BUAYA TERHADAP

KADAR KOLESTEROL HDL DAN LDL SERUM TIKUS PUTIH

HIPERKOLESTEROLEMI

PROPOSAL

Diajukan oleh :
Venda Happy Pinesa
1413010019

PROGRAM STUDI PENDIDIKAN DOKTER

FAKULTAS KEDOKTERAN
UNIVERSITAS MUHAMMADIYAH PURWOKERTO

PURWOKERTO
FEBRUARI
2017

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 Usulan Penelitian untuk Skripsi S-1
PENGARUH PEMBERIAN EKSTRAK LIDAH BUAYA TERHADAP
KADAR KOLESTEROL HDL DAN LDL SERUM TIKUS PUTIH
HIPERKOLESTEROLEMI

yang diajukan oleh

Venda Happy Pinesa
1413010019

telah disetujui oleh :

Pembimbing Utama,

dr. Raden Magfira K, Sp.KK tanggal

Pembimbing Pendamping

dr. Dewandaru Istighfaris, Sp.PD tanggal

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 DAFTAR ISI

Halaman

HALAMAN JUDUL .................................................................................. i

HALAMAN PENGESAHAN ..................................................................... ii

DAFTAR ISI .............................................................................................. iii

DAFTAR GAMBAR .................................................................................. iv

BAB I. PENDAHULUAN

I.1. Latar Belakang ......................................................................... 1

I.2. Perumusan Masalah .................................................................. 3

I.3. Tujuan Penelitian ...................................................................... 4

I.4. Keaslian Penelitian ................................................................... 4

I.5. Manfaat Penelitian .................................................................... 5

BAB II. TINJAUAN PUSTAKA

II. Tinjauan Pustaka ......................................................................... 7

II.1. Tinjauan Biologi Lidah Buaya ........................................... 7

II.2. Kolesterol LDL dan Kolesterol HDL ................................. 9

II.3. Pengaruh Glukomanan Terhadap Kadar LDL dan HDL

Serum Darah ........................................................................ 16

II.4. Kerangka Teori....................................................................... 20

II.4. Kerangka Konsep ................................................................... 22

II.5. Hipotesis ................................................................................ 22

BAB III. METODE PENELITIAN

III.1. Rencana Penelitian ................................................................ 23

III.2. Variable Penelitian ................................................................ 24

III.3. Definisi Operasional .............................................................. 24

III.4. Bahan dan Alat Penelitian ..................................................... 25

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 III.5. Jalannya Penelitian ................................................................ 26

III.6. Analisis dan Model Statistik .................................................. 28

III.7. Jadwal Penelitian ................................................................... 32

DAFTAR PUSTAKA ................................................................................. 33

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 DAFTAR GAMBAR

GAMBAR Halaman

1. Struktur kimia kolesterol ...................................................................... 9

2. Proses pengaturan kolesterol ................................................................ 13

3. Susunan glukomanan dengan unit (GGMM) ........................................ 18

4. Mekanisme penurunan kolesterol oleh ekstrak Lidah Buaya ................. 20