PRAKTIKUM PATOLOGI ANATOMI

BLOK 4 – ADAPTASI SEL TERHADAP JEJAS

Fakultas Kedokteran
Universitas Kristen Duta Wacana
1. Degenerasi albuminoid/ cellular
swelling
 Perubahan degeneratif yang terdeteksi paling
awal.
 Gangguan integrites membran
 Tanda pertama cedera
 Sesaat
2. Degenerasi hidropik
 Cellular swelling lanjut.
 Sel membengkak atau menunjukkan cairan berupa
vakuola dalam sitoplasma.
 Lepuh= ruptur sel- sel menyebabkan pembentukan
vesikel.
 Dapat disebabkan infeksi virus
 Mekanisme cedera: cedera sel -> hipoksia -> produksi
ATP ↓ -> influk Na dan H2O ke dalam sel -> K keluar
dari sel -> tekanan osmotik ↑ -> air masuk lebih
banyak lagi -> pembengkakan ER, ruptur, membentuk
vakuola -> vakuolisasi luas = degenerasi hidropik
Normal cell Granularity change Hydropic change
DEGENERASI HIDROPIK PADA KULIT
DEGENERASI HIDROPIK PADA KULIT
DEGENERASI HIDROPIK PADA HEPATOSIT
DEGENERASI HIDROPIK PADA HEPATOSIT
DEGENERASI HIDROPIK PADA VILLI CHORIALIS
DEGENERASI HIDROPIK PADA VILLI CHORIALIS
DEGENERASI HIDROPIK PADA VILLI CHORIALIS
3. Degenerasi hialin
Degenerasi hialin
 Kata hialin berarti seperti kaca (hyalos= glass)

 Hialin adalah istilah histologis untuk

mendeskripsikan massa homogen, pada

pemeriksaan H&E tampak eosinofilik dan tidak
menunjukkan suatu substasi yang spesifik
 Degenerasi hialin berhubungan dengan berbagai
kondisi patologis intraseluler atau ekstraseluler.
Hialin intraseluler
Microphotograph of part of kidney after 96 hr exposure (H/E × 400) showing disorganized
tubules (DT) Hydropic swelling (HS) Vacuolization (V), hyaline degeneration of tubular
epithelium (HD), desquamation (D) and damaged blood vessel (DBV)
At high magnification can be seen globular red hyalinematerial within hepatocytes. This is
Mallory's hyaline, also known as "alcoholic" hyaline because it is most often seen in conjunction with
chronic alcoholism. The globules are aggregates of intermediate filaments in the cytoplasm
resulting from hepatocyte injury.
Russell bodies
Clusters of plasma cells with intracytoplasmic Russell bodies and independent eosinophilic
structures in the dermis
The differential diagnosis of Russell bodies includes –
organisms such as histoplasmosis and cryptococcosis,

fungal organisms and Michaelis-Gutmann bodies found

in histiocytes in the setting of malakaplakia.
Other eosinophilic structures in the

skin include amyloid deposits, colloid bodies resulting

from degenerated keratinocytes and often associated
witha lichenoid reaction pattern, and PAS-positive elastic
bodies that can be found in the setting of lupus
erythematosus or scleroderma.
Hialin Ekstraseluler
Glomerulus dan arteriol aferen dengan degenerasi hialin pada intima.
Disebabkan oleh Diabetes Melitus dan/ atau hipertensi
Leiomyoma with hyaline degeneration, uterus : Low power shows a massive hyalinization
of the myoma. The hyaline manifests as homogeneously red pink substances replacing the
preexisting bundles of long smooth muscle cells.
Leiomyoma with hyaline degeneration, uterus : Medium power shows a massive
hyalinization of the myoma. The hyaline manifests as homogeneously red pink substances
replacing the preexisting bundles of long smooth muscle cells.
4. Degenerasi lemak
5. Degenerasi musinosum
6. Degenerasi amiloid
7. Kalsifikasi distrofik
8. anthracosis
9. Jaringan nekrosis
THANK YOU
God Bles You