id
Kanadi Sumapraja
1
Sistem endokrin
Hormon akan dikeluarkan sebagai sinyal melalui aliran darah atau cairan
ekstraseluler dan akan diterima oleh sel-sel yang memiliki reseptor spesifik
terhadap hormon tersebut
GnRH
HIPOTALAMUS
HIPOFISIS
FSH
LH
ESTROGEN
PROGESTERON
OVARIUM
ENDOMETRIUM
Hipotalamus
1 14 28
GnRH
HIPOTALAMUS
HIPOFISIS
FSH
LH
ESTROGEN
PROGESTERON
OVARIUM
ENDOMETRIUM
Pre-antral
follicle
Antral
follicle
MATURASI FOLIKEL
2n
2n
Meiosis I
n
PB1
OVULASI
Meiosis II
n
PB2
FERTILISASI
Ovulasi
Rekrutmen kohort folikel
in ansi
D om
120 hari 71 hari e lek si -
S
2-5 mm
INITIAL RECRUITMENT
14 hari
CYCLIC RECRUITMENT
+ 180 HARI
Antral
Sekunder
ATRESIA
Primer CADANGAN
OVARIUM
Primordial
McGee E et al. Endocr Rev. 2000
The entry of an arrested primordial follicle into the pool of growing follicles is
termed recruitment.
Three activators of recruitment are known, namely, granulose-derived kit
ligand, theca-derived Bone Morphogenetic Protein-7, and high plasma
levels of pituitary FSH. Müllerian Inhibiting Substance (MIS) has been found
to inhibit recruitment.
PERTUMBUHAN FOLIKEL
+ 180 days
PERKEMBANGAN FOLIKEL
Two cell two systems
FSH MATURASI FOLIKEL LH
LDL
ESTROGEN PROGESTERON
FSH WINDOW
FOLIKEL DOMINAN
PRESTIGMA OVULASI
OOSIT
ENZIM
OTOT POLOS
EKSPANSI
KUMULUS
PROSTAGLANDIN
MATURASI
KORPUS LUTEUM
LONJAKAN
LH
CORPUS LUTEUM
GnRH
HIPOTALAMUS
HIPOFISIS
FSH
LH
ESTROGEN
PROGESTERON
OVARIUM
ENDOMETRIUM
Proliferasi Proliferasi Sekresi Sekresi akhir Menstruasi
awal akhir awal
HAID
VASOKONSTRIKSI
VASODILATASI
MMP
EKSTRAVASASI DARAH
HEMATOMA
A. Spiralis sensitif
Lepasnya lapisan fungsional
terhadap hormon steroid
HAID
Apa yang terjadi jika kadar progesteron menurun ?
Prostaglandin
HAID STOP
Menstrual disorders
Pregnancy Structural
Ovulation Functional
-Endometrium
Endometrium -Ovulation