Pemanfaatan Senyawa Antosianin pada

Solanum lycopersicum
Sebagai Mouth Spray dalam Penanganan
Halitosis

Chandrasasi Berlian Pratiwi, Wardah Yusriyah, Aisyah Qonita Nurfitri

 BAB 1

Pendahuluan
Latar Belakang
10
- 20
% luar
rongga
mulut

80-90%

rongga
mulut
Halitosis menjadi permasalahan krusial pada berbagai
kalangan usia karena menimbulkan dampak psikologis
pada penderita
Irianti, et.al. (2015)
Penemuan yang sudah ada -> Inovasi ->
Terdapat efek samping Mouth Spray dari Tomat
 Merupakan sayuran kedua yang paling banyak
dibudidayakan di seluruh dunia
WHY
Quinet, et.al. (2019)
TOMATO?
Antioksidan tinggi
MOUTH
SPRAY??
ANTOSIANIN

Penghancur dan penangkal radikal

bebas alami
 Tujuan
1 2

Menjelaskan senyawa- Menjelaskan pengaruh

senyawa aktif yang senyawa antosianin pada
terdapat pada Solanum Solanum lycopersicum
lycopersicum. dalam penanganan
halitosis.
 BAB 2

Tinjauan Pustaka
 Halitosis

Delusional Halitosis

Physiological
Halitosis Pseudo Halitosis

Genuine Halitosis
Halitophobia
Pathological
Halitosis
Tungare, et.al. (2021)
 Oral hygiene yang buruk,
dental problems Gangguan pada
Hati

Peningkatan jumlah sel Infeksi saluran

bakteri anaerob pernapasan, saluran
cerna

Menghasilkan VSC
Kebiasaan merokok
dan minum alkohol

Halitosis
INTRA ORAL EKSTRA ORAL
Thoppay, et.al. (2018) J Wu, et.al. (2019)
PENANGANAN

Metode mekanis ->

memiliki efek samping
Tomat (Solanum lycopersicum)

Kandungan tomat antara lain :

• Karotenoid
• Polifenol
• Asam organik
• mineral
• Gula larut
• Vitamin C dan E
Antosianin
Merupakan sub kelompok metabolit
sekunder flavonoid

Klasifikasi berdasarkan pada flavylium B-ring, yaitu

cyanidin, delphinidin, malvidin, pelargonidin, peonidin
dan petunidin

Manfaat:
• Aktivitas antimikroba
• Antioksidan
• Antikanker
• Antidiabetes
• Antiinflamasi
• Pencegahan penyakit kardiovaskular
Lee, et al. (2017); Delhi (2020)
 BAB 3

Metode
 Artikel Review

Review literatur ditulis dengan Menggunakan data dan teori

metode sistematis, eksplisit dan yang diambil dari database
reprodusibel untuk melakukan Google Scholar, PubMed,
identifikasi, evaluasi dan sintesis
Researchgate, dan
terhadap karya-karya hasil penelitian
Sciencedirect
sebelumnya
 BAB 4

Pembahasan
Mekanisme Kerja Antosianin

Penghancuran dinding sel, membran, dan matriks antar sel pada

bakteri

Terjadi penyerapan ion esensial untuk stabilitas protein

sehingga dapat menjadi agen antibakteri.

Senyawa ini bekerja melalui interaksinya ,seperti aktivitas

penghambatan dan modulasi, dengan berbagai reseptor, enzim,
dan molekul transkripsi
Khoo, et.al. 2017; Fernandes, et.al. (2017)
Penggunaan Mouth Spray

Praktis Efisien

Efek samping Ramah lingkungan

 BAB 5

Penutup
 KESIMPULAN SARAN

Penanganan halitosis yang memanfaatkan Penelitian lebih lanjut diperlukan

kandungan antosianin dari tumbuhan untuk mengidentifikasi efektivitas
Solanum lycopersicum dalam bentuk senyawa antosianin pada Solanum
sediaan mouthspray dapat menjadi cara lycopersicum dalam menghambat
alternatif alami yang dapat digunakan oleh penyebab halitosis.
banyak kalangan dan tidak mengandung
efek samping yang berbahaya apabila
digunakan dalam jangka panjang.
 DAFTAR PUSTAKA

Ah-Reum, S., Seoul-Hee, N. 2018. The effect of various mouthwash on the oral environment change for oral health
care. Biomed Res, 29 (8): pp. 1724-9.
Alappat, B. and Alappat, J. 2020. Anthocyanin Pigments : Beyond Aesthetics.
Anastasia, A., Yuliet, Y., & Tandah, M. R. 2017. Formulasi sediaan mouthwash pencegah plak gigi ekstrak biji kakao
(theobroma cacao L) dan uji efektivitas pada bakteri streptococcus mutans. Jurnal Farmasi Galenika (Galenika
Journal of Pharmacy)(e-Journal), 3(1), pp. 84-92.
Ariyanta, I.P.B, Sudiarta, I.P., Widaningsih, D., Sumiartha, I.K., Wirya, G.A.S., Utama, M.S. 2015. Penggunaan
trichodermasp.dan penyambungan untuk mengendalikan penyakit utama tanaman tomat (licopersicum
esculentum mill.) di desa bangli, kecamatan baturiti, tabanan. E-Jurnal Agroekoteknologi Tropika, 4(1): hal. 1-15.
Altaie, A.M.A. 2018. Evaluation of different risk factors of halitosis and their relation to level of volatile sulphur
compounds by using spectrophotometric technique. Thesis. Collage of medicine University of Basra, pp. 14-23.
Ballester, A. R., Tikunov, Y., Molthoff, J., Grandillo, S., Viquez-Zamora, M., de Vos, R., et. al. 2016. Identification of loci
affecting accumulation of secondary metabolites in tomato fruit of a solanum lycopersicum×solanum chmielewski
introgression line population. Front. Plant Sci, 7: p.1428.
Bicak, D.A. 2018. a current approach to halitosis and oral malodor- a mini review. Open Dent. J, 12: pp. 322–330.
Cultivars, R. et al. 2021. anthocyanin profile, antioxidant, anti-Inflammatory, and antimicrobial against foodborne
pathogens activities of purple rice Cultivars in Northern Thailand.
Delhi, N. 2020. Anthocyanin profiling using UV-Vis spectroscopy and liquid chromatography mass spectrometry, (1).
Fernandes, I., Pérez-Gregorio, R., Soares, S., Mateus, N., & de Freitas, V. 2017. Wine Flavonoids in Health and Disease
Prevention. Molecules (Basel, Switzerland), 22(2): pp.292.
Ferrari, R. 2015. Writing narrative style literature reviews. The European Medical Writers Association, 24 (4): p. 230-
235.
Gonzali, S., & Perata, P. 2020. Anthocyanins from purple tomatoes as novel antioxidants to promote human health.
Antioxidants, 9(10), 1017.
Hampelska, K. et al. 2020. The role of oral microbiota in intra-oral halitosis, Journal of Clinical Medicine, 9(8), pp. 1–17.
Jo, J. K., Seo, S.H., Park, S.E., Kim, H.W., Kim, E.-J., Na, C.S., Cho, K.M., Kwon, S.J., Moon, Y.H., Son, H.S. 2021.
Identification of salivary microorganisms and metabolites associated with halitosis. Metabolites 2021, 11: pp. 362.
Irianti, R., Pandelaki, K. and Mintjelungan, C. 2015. Gambaran Pengetahuan Tentang Halitosis Pada Buruh Di
Pelabuhan Manado, e-GIGI, 3(1).
J Wu, RD Cannon, P Ji, M Farella, L Me. 2019. Halitosis: prevalence, risk factors, sources, measurement and treatment -
a review of the literature. Australian Dental Journal, 65 (1): p. 4-11.
Kuzhalvaimozhi, P., Krishnan, M. 2019. Self-Perception, knowledge and attitude of halitosis among patients attending a
dental hospital in south india-a questionnaire based study. res. J. Pharm. Technol, 12: pp. 129.
Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. 2017. Anthocyanidins and anthocyanins: colored pigments as food,
pharmaceutical ingredients, and the potential health benefits. Food & nutrition research, 61(1), 1361779.
Lee, Y. M. et al. 2017. Dietary anthocyanins against obesity and inflammation, Nutrients, 9(10), pp. 1–15.
Li, Y., Wang, H., Zhang, Y., Martin, C. 2018. Can the world’s favorite fruit, tomato, provide an effective biosynthetic
chassis for high-value metabolites?. Plant Cell Rep, 37, p. 1443–1450.
Liu, Y., Tikunov, Y., Schouten, R. E., Marcelis, L. F., Visser, R. G., & Bovy, A. 2018. Anthocyanin biosynthesis and
degradation mechanisms in solanaceous vegetables: A Review. Frontiers in Chemistry, 6.
Lima, T. S., Borges, M. M., Buarque, F. S., Souza, R. L., Soares, C. M., & Lima, Á. S. 2022. Purification of vitamins from
tomatoes (solanum lycopersicum) using ethanolic two-phase systems based on ionic liquids and polypropylene
glycol. Fluid Phase Equilibria, 557, 113434.
Martí, R., Roselló, S., Cebolla-Cornejo, J. 2016. Tomato as a source of carotenoids and polyphenols targeted to cancer
prevention. Cancers, 8: pp. 58.
Melfi, M.T., Nardiello, D., Cicco, N., Candido, V., Centonze, D. 2018. Simultaneous determination of water-and fat
soluble vitamins, lycopene and beta-carotene in tomato samples and pharmaceutical formulations: Double
injection single run by reverse-phase liquid chromatography with uv detection. Journal of Food Composition and
Analysis, 70: pp. 9-17.
Oktanauli, P., Taher, P., & Prakasa, A. D. 2017. Efek obat kumur beralkohol terhadap jaringan rongga mulut (kajian
pustaka). Jurnal Ilmiah dan Teknologi Kedokteran Gigi, 13(1), p. 4-7.
Quinet, M., Angosto, T., Yuste-Lisbona, F.J., Blanchard-Gros, R.; Bigot, S.; Martinez, J.P.; Lutts, S. 2019. Tomato fruit
development and metabolism. Front Plant Sci., 10: pp. 1554.
Outchkourov, N. S., Karlova, R., Holscher, M., Schrama, X., Blilou, I., Jongedijk, E., Simon, C. D., van Dijk, A. D. J., Bosch,
D., Hall, R. D., & Beekwilder, J. 2018. Transcription factor-mediated control of anthocyanin biosynthesis
in vegetative tissues. Plant Physiology, 176: pp. 1862 – 1878.
Rao, A.V., Young, G.L., Rao, L.G. 2018. Lycopene and tomatoes in human nutrition and health. 1st Edition.
Resmisari, R. S., Wicaksono, S. T., Alfiani, N., & Effendi, S. R. N. 2021. Siwak (Salvadora persica) extract as a natural anti
halitosis mouth spray. In IOP Conference Series: Earth and Environmental Science, 733(1), pp. 1-7.
Salehi, B., Sharifi-Rad, R., Sharopov, F., Namiesnik, J., Roointan, A., Kamle, M., Kumar, P., Martins, N., Sharifi-Rad, J.
2019. Beneficial effects and potential risks of tomatoes consumption for human health: an overview. Nutrition.
Saha, S. et al. 2021. Anthocyanin profiling using UV-vis spectroscopy and liquid chromatography mass spectrometry,
Journal of AOAC International, 103(1), pp. 23–39.
Smeriglio, A., Barreca, D., Bellocco, E., Trombetta, D. 2016. Chemistry, pharmacology and health benefits of
anthocyanins. Phytother. Res, 30: p. 1265–1286.
Thoppay, J.R., Filippi, A., Ciarrocca, K., Greenman, J., De Ross, S.S. 2018. Halitosis. Springer International Publishing AG.
Tohge, T., de Souza, L. P., Fernie, A. R. 2017. Current understanding of the pathways of flavonoid biosynthesis in model
and crop plants. J. Exp. Bot, 68: p. 4013–4028.
Tohge, T., Fernie, A. R. 2015. Metabolomics-inspired insight into developmental, environmental and genetic aspects of
tomato fruit chemical composition and quality. Plant Cell Physiol, 56: p. 1681–1696.
Tungare, S., Zafar, N., Paranjpe, AG. 2021. Halitosis. StatPearls Publishing. Treasure Island (FL).
Vale, K.L.D., Horliana, A.C.R.T., dos Santos, S.R., Schalch, T.O., de Ana, A.M.; Ferrari, R.A.M., Bussadori, S.K., Fernandes,
K.P.S. 2021. Treatment of halitosis with photodynamic therapy in older adults with complete dentures: A
randomized, controlled, clinical trial. Photodiagn. Photodyn. Ther, 33: p. 102128.
Wang, Y., Luo, Z., Lu, C., Zhou, R., Zhang, H., Zhao, L., et al. 2019. Transcriptome profiles reveal new regulatory factors
of anthocyanin accumulation in a novel purple-colored cherry tomato cultivar Jinling Moyu. Plant Growth Regul,
87: pp. 9–18.
Wyszyńska, M., Nitsze-Wierzba, M., Białozyt-Bujak, E., Kasperski, J., Skucha-Nowak, M. 2021. The problem of halitosis
in prosthetic dentistry, and new approaches to its treatment: a literature review, J. Clin. Med, 10: p. 5560.
Zhou, Y., Li, Y., Zhou, T., Zheng, J., Li, S., & Li, H.-B. 2016. Dietary natural products for prevention and treatment of
liver cancer. Nutrients, 8(3), pp. 156.
Zunic, B., Peter S. 2017. World’s Largest Science. Technology & Medicine Open Access book publisher, INTECH, 11: pp.
205–255.
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