Zubir
Pengantar
Imunologi adalah ilmu yang
mempelajari tentang imunitas atau
kekebalan akibat adanya rangsangan
molekul asing dari luar maupun dari
dalam tubuh hewan atau manusia,
baik yang bersifat infeksius maupun
non infeksius.
Defenisi
Sel imunokompeten yaitu semua sel yang
berfungsi dalam respon imun
Sel yang mampu membedakan sel tubuh
dengan zat asing dan menyelenggarakan
inaktivasi atau perusakan benda-benda
asing
Semua sel ini berasal dari sel induk
pluripoten yang kemudian berdiferensiasi
melalui 2 jalur
..cont
2. B cells
B cells derive from hematopoietic stem cells in the bone marrow,
after which they differentiate. They react against foreign antigens
in lymphnodes, the spleen, and peripheral tissues to differentiate
into antibody-forming cells (plasma cells);
B cells produce antibodies in this process. B cells contain MHC
class II and activate T cells as antigen-presenting cells.
Immunoglobulins expressed on the surface of B cells react to the
corresponding targeted antigens to convey information to T cells.
When activated, most of the B cells differentiate into antibody
producing cells that provide antibodies against the antigens and
die in the course of time except for some that differentiate into
memory B cells so that they are able to produce antibodies
immediately upon reinfection.
SELEKSI KLONAL
IMUNITAS HUMORAL
IMUNITAS SELULER
3. Histiocytes (macrophages)
Histiocytes (macrophages) are bone marrow-derived cells that
have intense phagocytic reactivity.
There are dermal-originated histiocytes and monocytes
circulating in the blood.
Histiocytes degrade phagocytosed antigen proteins into peptides
and present the antigen information to T cells by MHC class II. In
inflammation, histiocytes proliferate, migrate to loci, leave
various cytokines, and induce phagocytosis of causative factors
and injure the infected cells.
Histiocytes may fuse to form enlarged cells. They are the main
cells to form granulomas in chronic inflammation
Mechanism of Phagocytosis
18
4. Mast cells
Mast cells play a central roll in type I allergy.
They
contain
high-affinity
IgE
receptors
(FceRI) and
erythema or urticaria.
Mastcytosis is caused by tumorous proliferation of mast cells.
5. Eosinophils
Eosinophils have phagocytic and cytotoxic functions.
Associated with atopic diseases (type I allergy), autoimmune
blistering diseases, and parasitic infections.
Activated by Th2-derived IL-5.
Morphologically, they are characterized by having multiple
eosinophilic granules.
They do not usually exist in normal skin.
6. Neutrophils
Neutrophils are phagocytic and play a large role in
fightingbacterial infections.
They are hardly ever found in normal skin. They are also
activated in inflammatory diseases.
Neutrophilic infiltration (pustule) is observed in psoriasis
vulgaris and Sweets disease.
7. Basophils
Like eosinophils and neutrophils, basophils are also granular
leukocytes, and they contain multiple basophilic granules.
They contain histamines in the granules and have FceRI on the
surface.
They are involved in type I allergy.
The functions of basophils are similar to those of mast cells.