TUGAS INFORMASI OBAT I

STUDI KASUS

KP E Kelompok 4 :
Anis Rizky Norantika 110117143
Aurelia Andyny Harijanto 110117191
Fatwa Hakim Kharisma 110117201
Yolanda Virgi Firdaus 110117207
Aprilia Havis Damayanti 110117208

Pusat Informasi Obat dan Layanan Kesehatan

Fakultas Farmasi Universitas Surabaya
Surabaya
2019
KASUS 4

Suatu hari seorang perawat di ICU menelpon anda di pusat informasi obat. Ia menanyakan
beberapa hal mengenai 3 macam pengobatan yang diterima pasiennya, yaitu :

1. Apa pelarut yang sesuai untuk Cordarone dan Vascon yang akan diberikan secara
infus pump ?
2. Apakah Cordarone (diberikan dalam infus pump), Vascon (diberikan dalam infus
pump) dan Flukonazol (secara infus) dapat diberikan secara Y-site ?

Ia membutuhkan informasi tersebut agar obat dapat diberikan segera kepada pasien.

PENELURUSAN PUSTAKA

 Mencari Kandungan Bahan Aktif dari Obat yang ditanyakan

Pustaka Lampiran Gambar Informasi yang Diperoleh

 Cordarone adalah nama

dagang dari Amiodarone
HCl
ISO Volume
 Vascon adalah nama
51 halaman
dagang dari Norepinephrine
288, 309, 192
bitatrate
 Fluconazole adalah nama
agang dari Flukonazol
  Mencari informasi kompatibilitas dari Amiodarone HCl, Norepinheprine
bitartrate dan Flukonazol
 Amiodarone HCl

Kompatibilitas amiodarone HCl dalam larutan (Trissel, Lawrence A.

Handbook On Injectable Drugs 13th Edition. Page 81)

Solution Mfr Mfr Conc/L Remarks Ref C/I

Dextrose 5% in MGa LZ 1.8 g Physically compatible with little or 1031 C
water no amiodarone loss in 24 oC under
fluorescent light
TRb LZ 0.6 g Approximately 25% drug loss in 24 1443 I
hr at room temperature

TRc LZ 0.6 g Physically compatible with little or 1443 C

no drugs loss in 5 days at room
temperature
BAd WY 2g Visually compatible with no loss at 5 527 C
o
C and 3% loss at 25 oC in 32 days
Sodium Chloride MGa LZ 1.8 g Physically Compatible with little or 1031 C
0,9% no amiodarone loss in 24 hr at 24 oC
under fluorescent light
TRc LZ 0.6 g Physically incompatible in 24 hr at 1443 I
room temperature
BAd WY 2g Visually compatible with no loss at 5 2110 C
oC and 3% loss at 25 oC in 32 days
 MYRc EBE 0.84 g 5% drug loss in 6 hr at room 2258 ?
temperature under fluorescent light

Informasi yang
Pustaka Lampiran Gambar
Diperoleh

.
Pelarut yang dapat
Martindale
digunakan adalah
edisi 36
Glukosa 5%
page 1213

Y-Site Injection
Trissel,
Compatibility :
Lawrence
A.
- Norepinephrin
Handbook
bitartrate (C)
On
Injectable
- Flukonazole (C)
Drugs 13th
Edition.
Page 84 C = Compatibility
Injectable
Medicines Y-Site Injection
Administr Compatibility :
ation
Guide : - Norepinephrin
Pharmacy bitartrate (C)
Departme
nt (3rd - Flukonazole (C)
Edition).
page 83 C = Compatibility

Alistair Y-Site Injection

gray,Jane Compatibility :
Wright,
Vincent - Norepinephrin
Goodey, bitartrate (C)
and Lynn
Bruce. - Flukonazole (NI)
Injectable
drugs C = Compatibility
guide page NI = No information
56

Y-Site Injection
Gahart, Compatibility :
Betty L and
Adrienne - Norepinephrin
R. bitartrate (C)
Nazareno.
2014. - Flukonazole (C)
Intravenous
Medication
s 30th C = Compatibility
Edition.
Page 81
  Norepinheprine bitartrate
- Kompatibilitas Norepinephrine bitartate dalam larutan (Trissel,
Lawrence A. Handbook On Injectable Drugs 13th Edition. Page 864 )

Solution Mfr Mfr Conc/L Remorks Ref C/I

Amino acids MG W1 4 mg No increase in partuculate in 24 349 C
4,25%, dextrose at 5O C
25%

Dextrose 5% in W1 8 mg Physically comapatible 74 C

sodium chloride
0,9%

Dextrose 5% in W1 8 mg Physically comapatible 74 C

water
AB -W1 8 mg v Physical compertible and 527 C
chemically stable, 10%
decomposition is calsulate to
occur 2500 hr at 25oC

TR* W1 4 mg 2 to 4% loss in 24 r at room 1163 C

8 mg temperatur exposed to light
BA* W1 16 mg 5% loss by HPLC in 47,2 days. At 1610 C
5oC from light
BA* W1 40 mg 5% loss by HPLC in 87,2 days. At 1610 C
5oC from light
TR* RC 4 mg Visually compatible wit No 1802 C
8 mg norephineprin loss by HPLC in 48
tour no temo noarpinephrin
 BA* W1 42 mg No norepineprin loss by hplc in 2085 C
24 at 23oC protected from light
Ringer’s injection, TR* W1 8,8 Physically compatibel, 2% loss in 74 C
lactated W1 4 24 hr at room temperatur 1163
exposed to light

Informasi yang
Pustaka Lampiran Gambar
Diperoleh

Pelarut yang dapat

digunakan adalah
Martindale
- Glukose 5%
ed 36 page
- Sodium chloride
1360
0,9% dan Glukose
5%

Gahart, Y-Site Injection

Compatibility :
Betty L and
Adrienne R. - Amiodarone
HCl (C)
Nazareno.
2014. - Flukonazole
(NI)
Intravenous
Medications
C = Compatibility
th
30 Edition.
NI = No
Page 983
information
Injectable Y-Site Injection
Medicines Compatibility :
Administrati
on Guide :
- Amiodarone
Pharmacy
Department HCl (C)
(3rd
Edition).
page 252 - Flukonazol
(NI)

C = Compatibility
NI = No
information

Trissel,
Y-Site Injection
Lawrence
Compatibility :
A.
Handbook
On - Amiodarone
Injectable
HCl (C)
Drugs 13th
Edition.
Page 864
- Flukonazol
(NI)

C = Compatibility
NI = No
information
Alistair
gray,Jane Y-Site Injection
Wright, Compatibility :
Vincent
Goodey,
- Amiodarone
and Lynn
Bruce. HCl (NI)
Injectable
drugs guide
page 600 - Flukonazol
(NI)

NI = No
information
Shulman
Robert, dkk. Y-Site Injection
Injectable Compatibility :
Drug
Administrati
- Amiodarone
on Guide.
Page 128 HCl (C)

- Flukonazol
(NI)

C = Compatibility
NI = No
information
  Flukonazol
Kompatibilitas Fluconazol dalam larutan (Trissel, Lawrence A.
Handbook On Injectable Drugs 13th Edition page 513 )

Mf Conc/
Solution Mfr Remarks Ref C/I
r L
Dextrose 5% BAa PF 1g Fluconazole chemically stable 167 C
by gas chromatography for at 6
least 24 hr at 25 C under
fluorescent light
Ringer’s BAa PF 1g Fluconazole chemically stable 167 C
injection, by gas chromatography for at 6
lactated least 24 hr at 25 C under
fluorescent light

Informasi yang
Pustaka Lampiran Gambar
Diperoleh

Injectable Y-site Injection

compatibility :
Medicines - Amiodarone
Administration (C)

Guide: - Norepinephrine
Pharmacy (NI)

Departement
(3rd edition) C = Compatibility
page 171 NI = No
information

Alistair gray, Y-site Injection

Jane compatibility :
- Amiodarone
Wright,Vincent (NI)
Goodey, and
- Norepinephrine
Lynn Bruce. (NI)
Injectable
drugs guide
page 348 NI = No
information

Y-site Injection
Gahart, Betty L
compatibility :
and Adrienne - Amiodarone
(C)
R. Nazareno.
2014. - Norepinephrine
(NI)
Intravenous
Medications
30th Edition
C = Compatibility
Page 534
NI = No
information
 Y-site Injection
compatibility :
- Amiodarone
Drug Guide for (C)
Nursing
- Norepinephrine
Students 12th (C)
Edition Page
428
C = Compatibility
 MENJAWAB PERTANYAAN

Pertanyaan :

1. Apa pelarut yang sesuai untuk Cordarone dan Vascon yang akan diberikan
secara infus pump ?
2. Apakah Cordarone (diberikan dalam infus pump), Vascon (diberikan dalam
infus pump) dan Flukonazol (secara infus) dapat diberikan secara Y-site ?

Jawaban
1. Menurut penelusuran pustaka, pelarut yang dapat digunakan untuk melarutkan
Cordarone (Amiodarone) dan Vascon (Norepinephrine) adalah glukosa 5% atau
dextrose 5%.

2. Menurut penelusuran pustaka, ketiga obat tersebut bisa diberikan secara y-

site, karena Cordarone, Vascon dan Flukonazol apabila dicampur dapat
tercampur dengan sempurna.