Plasmodium Falciparum

Plasmodium Vivax
Plasmodium Malariae
Plasmodium Ovale
Plasmodium Knowlesi
Plasmodium Falciparum

Stages of P. falciparum in thick blood smears.
 Plasmodium falciparum (1)
• Stadium ring (bentuk cincin)


– Parasit  bentuk cincin, inti 1 warna merah, sitoplasma bentuk cincin
warna biru
– Eritrosit  tidak membesar dan terdapat titik maurer (kasar)
• Stadium ring (bentuk acole)
– Parasit  melekat di tepi eritrosit dan inti menonjol di pinggir eritrosit
– Eritrosit  tidak membesar dan tidak maurer
• Stadium ring (bentuk cincin atau acole)
– Parasit  terdapat 2 atau lebih parasait dalam eritrosit, inti kecil kadang
terdapat inti ganda, sitoplasma bentuk cincin halus, bentuk acole inti
menonjol di pinggir eritrosit
– Eritrosit  tidak membesar dan tidak maurer
• Stadium trofozoit muda
– Parasit  inti 1, sitoplasma kompak (kurang dari ½ eritrosit), pigmen
mengumpul
– Eritrosit  tidak membesar
• Stadium trofozoit tua
– Parasit  inti 1, sitoplasma kompak (lebih dari ½ eritrosit), pigmen
menggumpal
– Eritrosit  tidak membesar
 Plasmodium falciparum (2)
 Stadium schizont muda
 Parasit  mengisi hanya 1/3 – 2/3 eritrosit, jumlah inti kurang dari 8,
pigmen menggumpal
 Eritrosit  tidak membesar
 Stadium schizont tua 
 Parasit  mengisi 2/3 eritrosit, jumlah inti 8-24 buah, sitoplasma besar,
pigmen menggumpal
 Eritrosit  tidak membesar
 Stadium schizont matang
 Parasir  biasanya tidak mengisi seluruh eritrosit (2/3 eritrosit), jumlah
inti 8-24 buah, masing-masing inti dilapisi oleh sitoplasma (merozoit),
pigmen menggumpal
 Eritrosit  tidak membesar
 Stadium makrogametosit
 Parasit  inti merah kompak (padat) di tengah, sitoplasma bentuk
pisang langsing kebiruan, pigmen mengelilingi inti
 Eritrosit  ikut memanjang bersama parasit
 Stadium mikrogametosit
 Parasit  inti besar merah difus (tidak padat) di tengah , sitoplasma
bentuk pucat seperti sosis kemerahan (pucat), pigmen tersebar sekitar
inti
 Plasmodium Falciparum
Ring

A: Ring-form trophozoites of P. falciparum.

Fig. 1: Normal red cell;
Figs. 2-10: Increasingly mature ring stage parasites.
 Plasmodium Falciparum
Ring
Hapusan Darah Tebal

Ring-form trophozoites of P. falciparum in a thick blood smear.

 Plasmodium Falciparum
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. falciparum in a thin blood

smear.
 Plasmodium Falciparum
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. falciparum in a thin blood

smear.
 Plasmodium Falciparum
Ring
Hapusan Darah Tipis

Ring-form trophozoites in a thin blood smear, exhibiting Maurer's

clefts.
 Plasmodium Falciparum
Trofozoit Muda - Tua

A: Developing trophozoites of P. falciparum.

Figs. 11-18: Increasingly mature trophozoites
 Plasmodium Falciparum
Trofozoit
Hapusan Darah Tebal (kanan)
Hapusan Darah Tipis (kiri)

Trophozoites of P. falciparum in a thick blood Trophozoites of P. falciparum in a thin blood

smear. smear.
Plasmodium Falciparum
Trofozoit
Hapusan Darah Tipis

Trophozoites of P. falciparum in thin blood

smears.
 Plasmodium Falciparum
Skizon

A: Schizonts of P. falciparum.
Figs. 19-25: Increasingly mature schizonts;
Fig. 26: Ruptured schizont.
 Plasmodium Falciparum
Skizon
Hapusan Darah Tipis

Schizonts of P. falciparum in a thin blood smear

 Plasmodium Falciparum
Skizon
Hapusan Darah Tipis

Schizonts of P. falciparum in a thin blood smear

 Plasmodium Falciparum
Gametosit

A: Gametocytes of P. falciparum.
Figs. 27, 28: Mature macrogametocytes (female);
Figs. 29, 30: Mature microgametocytes (male).
 Plasmodium Falciparum
Gametosit
Hapusan Darah Tebal

Gametocytes of P. falciparum in thick blood

smears
 Plasmodium Falciparum
Gametosit
Hapusan Darah Tipis

Gametocytes of P. falciparum in a thin blood smears. Gametocytes of P. falciparum in a thin blood smears.
Also seen in this image are ring-form trophozoites Also seen in this image are ring-form trophozoites
and an RBC exhibiting basophilic stippling (upper exhibiting Maurer's clefts.
 Plasmodium Falciparum
Gametosit
Hapusan Darah Tipis

Gametocytes of P. falciparum in a thin blood smears. In these

specimens, Laveran's bibs can be seen.
Plasmodium Stages found in Appearance of
species blood Erythrocyte (RBC) Appearance of Parasite

normal; multiple infection of

delicate cytoplasm; 1 to 2
RBC more common than in
small chromatin dots;
Ring other species; Maurer's
occasional appliqué (accolé)
clefts (under certain staining
forms
conditions)

normal; rarely, Maurer's seldom seen in peripheral

Trophozoite clefts (under certain staining blood; compact cytoplasm;
conditions) dark pigment

P. falciparum seldom seen in peripheral

normal; rarely, Maurer's blood; mature = 8 to 24
Schizont clefts (under certain staining small merozoites; dark
conditions) pigment, clumped in one
mass

crescent or sausage shape;

chromatin in a single mass
Gametocyte distorted by parasite (macrogametocyte) or
diffuse (microgametocyte);
dark pigment mass
Plasmodium Vivax

Stages of P. vivax in thick blood smears.
 Plasmodium vivax (1)
 Stadium ring (bentuk cincin)


 Parasit  inti 1 berwarna merah sitoplasma bentuk cincin
berwarna biru
 Eritrosit  membesar, titik-titik schuffner (halus) mulai
tampak
 Stadium trofozoit muda (bentuk ameboid)
 Parasit  inti 1, sitoplasma amoeboid (terdapat vakuola yang
besar), pigmen tersebar
 Eritrosit  membesar dan titik schuffner jelas
 Stadium trofozoit tua
 Parasit  inti 1, sitoplasma besar bentuk amoeboid (lebih dari
½ eritrosit), pigmen banyak tersebar
 Eritrosit  membesar dan titik schuffner jelas
 Stadium schizont muda
 Parasit  inti membelah jumlah kurang dari 12 dan sitoplasma
besar dengan pigmen tersebar
 Eritrosit  membesar dan titik-titik Schuffner jelas
 Plasmodium vivax (2)
 Stadium schizont tua
 Parasit  jumlah inti 12-24, sitoplasma besar, pigmen kuning
tengguli berkelompok

 Eritrosit  membesar dan titik Schuffner jelas
 Stadium schizont matang
 Parasit  jumlah inti 12-24 dengan sitoplasma terbagi-bagi
menurut inti masing-masing (merozoit) dan pigmen
menggumpal 1-2 bagian.
 Eritrosit  membesar dan titik-titik Schuffner di bagian
pinggir eritrosit
 Stadium makrogametosit
 Parasit  inti 1 kecil, kompak merah di pinggir, sitoplasma
biru, pigmen-pigmen tersebar
 Eritrosit  membesar dan titik-titik Schuffner di pinggir
 Stadium mikrogametosit
 Parasit  inti 1 besar dan difus, letak biasa di tengah,
sitoplasma warna biru kemerahan, pigmen tersebar
 Eritrosit  membesar, titik Schuffner di pinggir
 Plasmodium Vivax
Ring

A: Ring-form trophozoites of P. vivax.

Fig. 1: Normal red cell;
Figs. 2-6: Ring stage parasites (young trophozoites).
 Plasmodium Vivax
Ring
Hapusan Darah Tebal

Ring-form trophozoites in a thick blood smear.

 Plasmodium Vivax
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. vivax in a thin blood smear.

 Plasmodium Vivax
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. vivax in a thin blood smear.

 Plasmodium Vivax
Trofozoit

A: Trophozoites of P. vivax in thin blood smears.

Figs. 8-18: Increasingly mature trophozoites of P. vivax.
 Plasmodium Vivax
Trofozoit
Hapusan Darah Tebal (kiri)
Hapusan Darah Tipis (kanan)

Trophozoite of P. vivax in a thick blood smear. Trophozoite of P. vivax in a thin blood

smear. Note the amoeboid appearance, enlarged
infected RBC and Schüffner's dots.
 Plasmodium Vivax
Trofozoit
Hapusan Darah Tipis

Trophozoites of P. vivax in a thin blood smear. Note the amoeboid appearance and
Schüffner's dots.
 Plasmodium Vivax
Trofozoit
Hapusan Darah Tipis

Trophozoites of P. vivax in a thin blood smear.

 Plasmodium Vivax
Skizon

A: Schizonts of P. vivax in thin blood smears.

Figs. 19-21: Early schizonts;
Figs. 22-23: Developing schizonts;
Figs. 24-27: Nearly mature and mature schizonts.
 Plasmodium Vivax
Skizon
Hapusan Darah Tebal

Schizonts of P. vivax in thick blood smears

 Plasmodium Vivax
Skizon
Hapusan Darah Tipis

Schizonts of P. vivax in thin blood smears.

 Plasmodium Vivax
Skizon
Hapusan Darah Tipis

Schizonts of P. vivax in thin blood smears. Ruptured schizont of P. vivax in a thin blood
smear, showing free merozoites and pigment.
 Plasmodium Vivax
Gametosit

A: Gametocytes of P. vivax in thin blood smears.

Fig. 28 and 29: Nearly mature and mature macrogametocyte (female);
Fig. 30: Microgametocyte (male).
 Plasmodium Vivax
Gametosit
Hapusan Darah Tebal

Gametocyte (upper) and trophozoite (lower) Gametocyte of P. vivax in a thick blood smear.
of P. vivax in a thick blood smear.
 Plasmodium Vivax
Gametosit
Hapusan Darah Tipis

Macrogametocytes of P. vivax in a thin blood smear. Note the enlargement of the

gametocytes compared to uninfected RBCs.
 Plasmodium Vivax
Gametosit
Hapusan Darah Tipis

Macrogametocytes of P. vivax in a thin blood smear.

 normal to 1.25×, round;
occasionally fine large cytoplasm with
Ring Schüffner's dots; multiple occasional pseudopods;
infection of RBC not large chromatin dot
uncommon
large amoeboid
enlarged 1.5 to 2×; may
cytoplasm; large
Trophozoite be distorted; fine
chromatin; fine,
Schüffner's dots
yellowish-brown pigment
large, may almost fill
P. vivax enlarged 1.5 to RBC; mature = 12 to 24
Schizont 2×; may be distorted; fine merozoites; yellowish-
Schüffner's dots brown, coalesced
pigment

round to oval; compact;

may almost fill RBC;
chromatin compact,
enlarged 1.5 to 2×; may
eccentric
Gametocyte be distorted; fine
(macrogametocyte) or
Schüffner's dots
diffuse
(microgametocyte);
scattered brown pigment
Plasmodium Malariae

Stages of P. malariae in thick blood smears.
 Plasmodium malariae (1)
 Stadium ring


 Parasit  inti 1, sitoplasma bentuk cincin tebal 1/3 eritrosit
 Eritrosit  tidak membesar dan tidak nampak titik-titik
 Stadium trofozoit muda (bentuk pita halus)
 Parasit  inti merah bulat/memanjang, sitoplasma bentuk
seperti pita halus/bulat dan lebih tebal, pigmen (kasar)
tersebar (tidak lebih dari ½ eritrosit)
 Eritrosit  tidak membesar
 Stadium trofozoit tua (bentuk pita lebar)
 Parasit  inti besar (memanjang) merah, sitoplasma bentuk
seperti pita lebar/bulat kompak llebihd ari ½ eritrosit, pigmen
(kasar) tersebar
 Eritrosit  tidak membesar
 Stadium schizont muda
 Parasit  jumlah inti < 8, sitoplasma besar, dan pigmen (kasar)
masih tersebar
 Eritrosit  tidak membesar
 Plasmodium malariae (2)
 Stadium schizont matang

 Parasit  mengisi seluruh eritrosit, jumlah merozoit 8-12
letaknya teratur seperti “bunga seruni”, pigmen kasar
berkumpul di tengah
 Eritrosit  tidak membesar
 Stadium makrogametosit
 Parasit  inti merah kompak di pinggir, sitoplasma
kompak kebiruan, pigmen tersebar
 Eritrosit  tidak membesar dan tidak nampak titik-titik
 Stadium mikrogametosit
 Parasit  inti pucat diffus, sitoplasma pucat merah
muda, pigmen tersebar
 Eritrosit  tidak membesar dan tidak nampak titik-titik
 Plasmodium Malariae
Ring

A: Ring-form trophozoites of P. malariae.

Fig. 1: Normal red cell;
Figs. 2-5: Ring-form trophozoites.
 Plasmodium Malariae
Fase Ring
Hapusan Darah Tebal (kanan)
Hapusan Darah Tipis (kiri)

Ring-form (lower right) and developing "Birds-eye" trophozoite of P. malariae in a

(upper left) trophozoites of P. malariae in a thin blood smear.
thick blood smear
 Plasmodium Malariae
Fase Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. malariae in thin blood

smears.
 Plasmodium Malariae
Trofozoit

A: Developing trophozoites of P. malariae.

Figs. 6-13: Increasingly mature trophozoites;
Figs. 10 and 13 are "band forms."
 Plasmodium Malariae
Trofozoit
Hapusan Darah Tebal

Trophozoites of P. malariae in thick blood

smears.
 Plasmodium Malariae
Trofozoit
Hapusan Darah Tipis

Band-form trophozoites of P. malariae in a thin blood smear.

 Plasmodium Malariae
Trofozoit
Hapusan Darah Tipis

Basket-form trophozoites of P. malariae in a thin blood smear

Plasmodium Malariae
Skizon

A: Schizonts of P. malariae.
Figs. 14-20: Developing schizonts;
Figs. 21-22: Mature schizonts.
 Plasmodium Malariae
Skizon
Hapusan Darah Tebal

Schizonts of P. malariae in thick blood smears

 Plasmodium Malariae
Skizon
Hapusan Darah Tipis

Schizonts of P. malariae in thin blood smears.

 Plasmodium Malariae
Skizon
Hapusan Darah Tipis

Schizonts of P. malariae in thin blood smears.

 Plasmodium Malariae
Gametosit

A: Gametocytes of P. malariae.
Fig. 23: Developing gametocyte;
Fig. 24: Mature macrogametocyte (female);
Fig. 25: Mature microgametocyte (male).
 Plasmodium Malariae
Gametosit
Hapusan Darah Tebal

Gametocytes of P. malariae in thick blood

smears.
 Plasmodium Malariae
Gametosit
Hapusan Darah Tipis

Gametocytes of P. malariae in thin blood smears

 Plasmodium Malariae
Gametosit
Hapusan Darah Tipis

Developing gametocytes of P. malariae in thin blood

smears.
 sturdy cytoplasm; large
Ring normal to 0.75×
chromatin

compact cytoplasm;
normal to 0.75×; rarely,
large chromatin;
Ziemann's stippling
Trophozoite occasional band forms;
(under certain staining
coarse, dark-brown
conditions)
pigment

mature = 6 to 12
normal to 0.75×; rarely, merozoites with large
Ziemann's stippling nuclei, clustered around
Schizont
P. malariae (under certain staining mass of coarse, dark-
conditions) brown pigment;
occasional rosettes

round to oval; compact;

may almost fill RBC;
normal to 0.75×; rarely, chromatin compact,
Ziemann's stippling eccentric
Gametocyte
(under certain staining (macrogametocyte) or
conditions) more diffuse
(microgametocyte);
scattered brown pigment
Plasmodium Ovale

Stages of P. ovale in thick blood smears.
 Plasmodium ovale (1)
 Stadium Ring


 Parasit  inti 1 dan sitoplasma bentuk cincin
 Eritrosit  membesar, bentuk lonjong dengan ujung rusak, titik-
titik Schuffner
 Stadium Trofozoit muda
 Parasit  inti 1, sitopalsma kurang amuboid dibanding P. vivax
 Eritrosit  membesar, bentuk lonjong dengan ujung
rusak/bergerigi, titik-titik Schuffner/james
 Stadium Trofozoit tua
 Parasit  inti 1 dan sitoplasma lebih besar (amuboid)
 Eritrosit  membesar, bentuk lonjong dengan ujung
rusak/bergerigi, titik-titik Schuffner/james
 Stadium schizont muda
 Parasit  jumlah inti < 8, pigmen tersebar. Sitoplasma < dan lebih
kompak dibanding P.vivax
 Eritrosit  memebsar, bentuk lonjong dengan ujung
rusak/bergerigi, titik-titik Schuffner/james
 Plasmodium ovale (2)
 Stadium schizont tua
 Parasit  jumlah inti 8-12, sitoplasma mengisi ± ¾ eritrosit,
pigmen berkelompok

 Eritrosit  membesar, ebntuk lonjong dengan ujung rusak
(bergerigi), tititk-titik Schuffner
 Stadium schizont matang
 Parasit  jumlah merozoit 8-12, pigmen mengelompok
 Eritrosit  membesar (< P.vivax) dan bentuk lonjong dengan
ujung rusak (bergerigi)
 Stadium makrogametosit
 Parasit  inti 1 kompak merah di pinggir, sitoplasma biru,
pigmen tersebar
 Eritrosit  membesar (< P.vivax) dan titik-titik Schuffner/james
di pinggir
 Stadium mikrogametosit
 Parasit  1 inti pucat diiffus, sitoplasma pucat merah muda,
pigmen tersebar
 Eritroisit  membesar dan bergerigi
 Plasmodium Ovale
Trofozoit fase Ring

A: Ring-form trophozoites of P. ovale in thin blood smears.

Fig. 1: Normal red cell;
Figs. 2-5: Ring-form trophozoites.
 Plasmodium Ovale
Trofozoit Fase Ring
Hapusan Darah Tebal

Ring-form trophozoites of P. ovale in thick blood smears.

 Plasmodium Ovale
Trofozoit Fase Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. ovale in thin Ring-form trophozoites of P. ovale in thin blood

blood smears. Note the multiply-infected RBC smears.
in Figure
 Plasmodium Ovale
Trofozoit Fase Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. ovale in thin blood

smears. Note the multiply-infected RBC in
Figure
 Plasmodium Ovale
Trofozoit

A: Developing trophozoites of P. ovale in thin blood smears.

Figs. 6-15: Increasingly mature trophozoites.
Note the fimbriated red cells (Figs. 8 and 13)
 Plasmodium Ovale
Trofozoit Hapusan Darah Tebal (kiri)
Hapusan Darah Tipis (kanan)

Trophozoite of P. ovale in a thick blood smear. Trophozoite of P. ovale in a thin blood

smear. Note the fimbriation.
 Plasmodium Ovale
Trofozoit Hapusan Darah Tipis

Trophozoites of P. ovale in thin blood smears. Note the fimbriation and Schüffner's dots.
 Plasmodium Ovale
Trofozoit Hapusan Darah Tipis

Infected RBCs showing developing (lower)

and ring-form (upper two) trophozoites of P. Trophozoites of P. ovale in thin blood smears.
ovale in a thin blood smear
 Plasmodium Ovale
Skizon

A: Schizonts of P. ovale.
Figs16-22: Developing schizonts;
Fig. 23: Mature schizont.
 Plasmodium Ovale
Skizon
Hapusan Darah Tebal

Schizonts of P. ovale in thick blood smears.

 Plasmodium Ovale
Skizon
Hapusan Darah Tipis

Schizonts of P. ovale in thin blood smears.

 Plasmodium Ovale
Gametosit

A: Gametocytes of P. ovale.
Fig. 24: Macrogametocyte (female);
Fig. 25: Microgametocyte (male)..
 Plasmodium Ovale
Gametosit
Hapusan Darah Tebal

B C
.

Gametocyte of P ovale in a thick blood Gametocyte of P. ovale (red arrow) nestled

smear. between two white blood cells in a thick
blood smear.
 Plasmodium Ovale
Gametosit
Hapusan Darah Tipis

Microgametocyte of P. ovale in a thin blood Macrogametocyte of P. ovale in a thin blood smear

smear. Note the elongated, oval shape and Note the fimbriation.
the Schüffner's dots.
 Plasmodium Ovale
Gametosit
Hapusan Darah Tipis

Macrogametocytes of P. ovale in thin blood smears, showing Schüffner's dots

 normal to 1.25×, round to
oval; occasionally
Schüffner's dots; sturdy cytoplasm; large
Ring
occasionally fimbriated; chromatin
multiple infection of RBC
not uncommon

normal to 1.25×; round to compact with large

Trophozoite oval; some fimbriated; chromatin; dark-brown
Schüffner's dots pigment
mature = 6 to 14
P. ovale normal to 1.25×, round to merozoites with large
Schizont oval, some fimbriated, nuclei, clustered around
Schüffner's dots mass of dark-brown
pigment

round to oval; compact;

may almost fill RBC;
chromatin compact,
normal to 1.25×; round to
eccentric
Gametocyte oval, some fimbriated;
(macrogametocyte) or
Schüffner's dots
more diffuse
(microgametocyte);
scattered brown pigment
 P. Falciparum P. Vivax P. Ovale P. Malariae

Daur pra-eritrosit 5,5 hari 8 hari 9 hari 10-15 hari

Hipnozoit - + + -
Jumlah merozoit 40.000 10.000 15.000 2.000
Skizon hati 60 mikron 45 mikron 70 mikron 55 mikron
Daur eritrosit 48 jam 48 jam 50 jam 72 jam
Eritrosit yg Muda & Retikulosit & Retikulosit & Normosit
dihinggapi normosit monosit normosit muda
Pembesaran Erit - ++ + -

Titik-titik eritrosit Maurer Schuffner Schuffner (James) Ziemann

Kuning Tengguli
Pigmen Hitam Tengguli tua
tengguli hitam
Jumlah merozoit
8-24 12-18 8-12 8-12
eri
Daur dalam
10 hari 8-9 hari 12-14 hari 26-28 hari
nyamuk (27oC)
Plasmodium Knowlesi

Sebagai Tambahan
 Plasmodium Knowlesi
Ring

A: Ring-form trophozoites of P. knowlesi.

Fig. 1: Normal red cell;
Figs. 2-6: Increasingly mature ring-form parasites.
 Plasmodium Knowlesi
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. knowlesi in a thin blood smear from a human patient that
traveled to the Philippines.
 Plasmodium Knowlesi
Ring
Hapusan Darah Tipis

Ring-form trophozoites of P. knowlesi in a thin blood smear from a human patient that traveled
to the Philippines.
 Plasmodium Knowlesi
Trofozoit

A: Trophozoites of P. knowlesi.
Figs. 11-12: Developing trophozoites;
Figs 13-15: Mature trophozoites.
 Plasmodium Knowlesi
Trofozoit
Hapusan Darah Tipis

Band-form trophozoite of P. knowlesi in a Band-form (upper) and ring-form (lower)

trophozoites of P. knowlesi, from the same
blood smear from a human patient that
traveled to the Philippines. specimen as Figure at left.
 Plasmodium Knowlesi
Skizon

A: Schizonts of P. knowlesi.
Figs. 16-23: Increasingly mature schizonts.
 Plasmodium Knowlesi
Skizon
Hapusan Darah Tipis

C
B

Mature schizonts of P. knowlesi in a thin blood smear from a patient that traveled to the
Philippines. Note also a ring-form trophozoite to the right of the schizont in Figure C.
 Plasmodium Knowlesi
Skizon
Hapusan Darah Tipis

D E

Developing schizont of P. knowlesi in a thin Mature schizont of P. knowlesi in a thin blood

blood smear from the same patient seen in smear from the same patient seen in Figures B-
Figures B and C. D.
 Plasmodium Knowlesi
Gametosit

A: Gametocytes of P. knowlesi.
Fig. 24: Mature macrogametocyte (female);
Fig. 25: Mature microgametocyte (male).
 Plasmodium Knowlesi
Gametosit
Hapusan Darah Tipis

Gametocytes of P. knowlesi in a thin blood smear from a human patient that traveled to the
Philippines. Note also a ring-form trophozoite in the lower left of Figure C.

normal to 0.75×; multiple
Ring
infection not uncommon.
normal to 0.75×; rarely, Sinton
Trophozoite and Mulligan's stippling (under
certain staining conditions)
P. knowlesi
normal to 0.75×; rarely, Sinton
Schizont and Mulligan's stippling (under
certain staining conditions)
normal to 0.75×; rarely, Sinton
Gametocyte and Mulligan's stippling (under
certain staining conditions)
delicate cytoplasm; 1 to 2
prominent chromatin dots;
occasional appliqué (accolé)
forms
compact cytoplasm; large
chromatin; occasional band
forms; coarse, dark-brown
pigment
mature = up to 16 merozoites
with large nuclei, clustered
around mass of coarse, dark-
brown pigment; occasional
rosettes; mature merozoites
appear segmented
round to oval; compact; may
almost fill RBC; chromatin
compact, eccentric
(macrogametocyte) or more
diffuse (microgametocyte);
scattered brown pigment
http://www.dpd.cdc.gov/dpdx/HTML/Frames/M-R/Malaria/body_Malariadiagfind2.htm