LAPORAN RESMI PRAKTIKUM

TEKNOLOGI FORMULASI SEDIAAN STERIL

PERCOBAAN II
PEMBUATAN INJEKSI AMINOFILLIN 2,4%

Disusun oleh :
Golongan C-II / Kelompok A
1. Moh. Arikus Wibowo (17/411937/FA/11366)
2. Muhammad Sulhan Hadi (17/411939/FA/11368)
3. Ni Putu Desy Anggraeni (17/411941/FA/11370)

Kelas/Golongan : C/II A
Dosen Pembimbing : Dr. Eng. Khadijah, M.Si., Apt.

LABORATORIUM TEKNOLOGI FARMASI

DEPARTEMEN FARMASETIKA
FAKULTAS FARMASI
UNIVERSITAS GADJAH MADA
YOGYAKARTA
2020
 MASTER FORMULA
Laboratorium Teknologi Farmasi Fakultas Farmasi UGM
Kode Produksi : P2 Nama Produksi : Pembuatan Injeksi Aminofilin 2,4%
Departemen/ Bagian : Ukuran Batch : 100 mL
Teknologi Formulasi
Sediaan Steril
Tgl. Pembuatan Tgl. Selesai Pelaksana Penanggung jawab
Dr. Eng. Khadijah, M.Si., Apt.

Jumlah Bahan
No. Pemerian Bahan Baku Tiap Satuan Tiap Batch
Kode (tiap 10 mL) (untuk 100 mL)
1. Teofilin (C7H8N4O2)
 Sinonim: 1,3-dimetilxantin
 Struktur senyawa: 2 𝑔𝑟𝑎𝑚 2 gram
=
10
= 0,2 gram/10
mL
= 200 mg/10
mL

 Fungsi dalam formula: zat aktif Dalam larutan: Dalam larutan:

 Fungsi lainnya dalam sediaan farmasi: untuk 0,2 𝑔𝑟𝑎𝑚 𝑣 = 0,0008 𝑚𝐿 𝑥 10
𝑣 =
mengatasi bronkospasme, sebagai obat untuk 247,6 𝑣 = 0,008 𝑚𝐿
gangguan pernapasan. 𝑣 = 0,0008 𝑚𝐿
 Pemerian : serbuk hablur, putih, tidak berbau, rasa pahit,
stabil di udara.
 Karakteristik fisik
- Bobot jenis : 247,6 g/mL
- Titik leleh : 270-274 oC
- Berat molekul : 180,16 g/mol
 Kelarutan: 7,36 mg/L pada 25 oC dalam air. Sukar larut
dalam air; tetapi lebih mudah larut dalam air panas;
mudah larut dalam larutan alkali hidroksida dan dalam
amonia; agak sukar larut dalam etanol, dalam kloroform
dan dalam eter.
 Stabilitas
- Suhu : stabil pada suhu penyimpanan suhu ruang
- Udara : stabil di udara
- pKa : 8,81
- Cahaya: di bawah cahaya fluoresensi stabil
- Penyimpanan: dalam wadah tertutup baik

 Inkompatibiltas : oksidator kuat, isosianat, organik
halogen, perkosida, fenol, epoksida, anhidrida, asam
halida.
 Dosis aman : 300 mg-450 mg

(Farmakope Indonesia Edisi V, 2014; PubChem,

2020)
2. Etilendiamin (C2H8N2)
 Sinonim : 1,2-diaminoethane, 1,2-ethanediamine 0,3 𝑔𝑟𝑎𝑚 0,3 gram
 Struktur senyawa:
=
10
= 0,03 gram/10
mL
= 30 mg/10 mL

Dalam larutan: Dalam larutan:

0,03 𝑔𝑟𝑎𝑚 𝑣 = 0,33 𝑚𝐿 𝑥 10
𝑣 =
 Fungsi dalam formula : meningkatkan kelarutan 0,899 𝑣 = 3,3 𝑚𝐿
teofilin, pembentuk aminofilin 𝑣 = 0,33 𝑚𝐿
 Fungsi lainnya dalam sediaan farmasi: pelarut,
1
 adhesif, buffer
 Pemerian : cairan jernih tidak berwarna atau agak
kuning, bau seperti amoniak, bereaksi alkali kuat.
 Karakteristik fisik
- Bobot jenis : 0,899 g/mL
- Titik leleh : 8,5-11 oC
- Berat molekul : 60,1 g/mol
 Kelarutan: 1x106 mg/L dalam air
 Stabilitas
- Suhu : <385 oC
- Udara : higroskopis
- pH : 8,6-9
- Cahaya: stabil
 Inkompatibiltas : senyawa organik berklorin, asam kuat.

(PubChem, 2020)

3. Aqua p.i (H2O) ad. 10 mL ad. 100 mL

 Sinonim : air, aqua sterile pro injection, aqua, hydrogen
oxide
 Struktur senyawa:

 Fungsi dalam formula : pelarut

 Fungsi lainnya dalam sediaan farmasi: sebagai
bahan pembawa sediaan iv, pengencer, pencuci
 Pemerian : cairan jernih, tidak berwarna, tidak berbau,
dan tidak berasa.
 Karakteristik fisik
- Bobot jenis : 1 kg/m3
- Titik leleh : 0 oC
- Berat molekul : 18 g/mol
 Kelarutan: sangat larut dalam etanol, metanol, dan
aseton.
 Stabilitas
- Air secara kimia stabil dalam segala kondisi atau bentuk
fisik
- Suhu : stabil dalam suhu berapapun
- Udara : stabil di udara
- pH : 5-7
- Penyimpanan: dalam wadah dosis tunggal, dari kaca
atau plastik, tidak lebih besar dari 1 Liter.
 Inkompatibiltas :
- Dalam formulasi, air dapat bereaksi dengan obat dan
eksipien yang mudah terhidrolisis pada suhu normal dan
tinggi.
- Dapat bereaksi dengan logam alkali dan bereaksi
dengan cepat bila kontak dengan logam alkali dan
oksidanya, seperti magnesium oksida dan kalium
oksida.
- minyak
 Dosis aman : -

(HOPE ed.6, 2009, hal.766; Farmakope Indonesia Edisi

V, 2014, hal. 64)

2
 4. Natrium Klorida
 Sinonim : garam dapur, natrii chloridum qs qs
 Struktur senyawa:

 Fungsi dalam formula : tonicity agent

 Fungsi lainnya dalam sediaan farmasi: lubrikan,
diluent.
 Pemerian : serbuk kristal berwarna putih, rasa asin
 Karakteristik fisik
- Bobot jenis : 2,17 g/cm3
- Titik leleh : 800,7 oC
- Berat molekul : 58,44 g/mol
 Kelarutan: 357 g/mL dalam air, larut dalam gliserin,
sukar larut dalam etanol.
 Stabilitas
- Suhu : termostabil
- Udara : higroskopis (RH > 75%)
- pH : 6,7-7,3
- Lembab/air: harus disimpan pada tempat kering dan
dalam wadah tertutup
 Inkompatibiltas : oksidator kuat
 Dosis aman: <0,75 g/kgBB
 Konsentrasi lazim untuk mendukung fungsi dalam
formulasi: ≤ 0,9%

(HOPE ed.6, 2009, hal.637; Farmakope Indonesia Edisi

V, 2014, hal. 917; PubChem, 2020)
Catatan :

Dokumen hanya untuk kalangan sendiri , segala bentuk peniruan dan penggandaan harus seijin
laboratorium.

3
PERHITUNGAN TONISITAS

4
 PRODUKSI
Lab. Teknologi Farmasi Fakultas Farmasi UGM Jumlah Halaman : No.Halaman :

Kode Produksi : P2 Nama Produksi : Pembuatan Injeksi Aminofilin 2,4%

Departemen/Bagian :
Teknologi Formulasi Sediaan Steril Ukuran Batch : 100 mL
Tgl.Pelaksanaan : Selesai : Pelaksana Penanggung jawab
Dr. Eng. Khadijah, M.Si., Apt.
Metode Produksi

Disiapkan alat dan bahan

Ditimbang bahan yang

dibutuhkan: teofilin (2
gram), etilendiamin (0,3 Diambil 110 mL aquadest
gram)

Difilter menggunakan kertas saring

Dibuat aqua bebas
karbondioksida (CO2)
Disterilkan dalam autoclave pada
suhu 110ºC selama 20 menit

Difilter dengan membran 0,45 µm (bila

perlu)

Dipanaskan hingga mendidih

Disuspensikan teofilin Dilarutkan etilendiamin

dengan 32,2 mL aqua dengan 32,2 mL aqua
bebas CO2 bebas CO2

Suspensi teofilin ditambahkan dengan larutan etilendiamin

tetes demi tetes sampai larut sempurna dan pH antara 9,5-9,6

+ NaCl qs

5
 Diukur volume campuran, jika volume belum 100 mL, ad
100 mL aqua bebas CO2

Digojog larutan dengan karboadsorben 0,1% yang telah

diaktifkan selama 5-10 menit sampai berwarna merah
bara, didiamkan kemudian disaring hingga jernih

Dimasukkan larutan ke dalam 4 buah ampul, masing-

masing 10 mL, ditutup, lalu disterilkan dengan autoclave
(110ºC selama 30 menit atau 120ºC selama 20 menit)

Dilakukan kontrol kualitas sediaan injeksi meliputi: pH,

kebocoran, partikel asing, kejernihan dan keseragaman
volume/bobot

Uji pH Uji Partikel Asing Uji Kejernihan

Dicelupkan indikator ph pada Dilihat sediaan dalam wadah Dilihat dengan mata apakah
larutan injeksi yang diproduksi pada background hitam/putih sediaan yang dibuat jernih
atau tidak

Diamati perubahan warna yang Dilihat apakah ada partikel di

terjadi dan dicocokkan pada dalam sediaan
warna indikator
Uji Keragaman Bobot (FI V)
Uji Kebocoran Ditimbang saksama sejumlah cairan yang dikeluarkan dari
Wadah sediaan diposisikan 10 wadah satu per satu seperti penggunaan normal
terbalik

Jika perlu dilakukan perhitungan kesetaraan volume

setelah penetapan bobot jenis
Dilihat apakah ada cairan
yang menetes atau tidak
Dihitung jumlah zat aktif dalam tiap wadah dari hasil
penetapan kadar

Dihitung nilai penerimaan

Diberi etiket yang sesuai

Dimasukkan sediaan injeksi ke dalam pengemas yang

sesuai dan diserahkan dalam bentuk lengkap (seperti
sediaan yang ada dalam perdagangan)
6
Dokumen hanya untuk kalangan sendiri, segala bentuk peniruan dan penggandaan harus seijin
laboratorium

7
 ANALISIS DATA
1. Pemilihan Formula dan Penentuan Konsentrasi Komponen Formula
Formula
R/ Teofilin 2
Etilendiamin 0,3
Aqua p.i. ad 100 mL
NaCl q.s.

Konsentrasi komponen formula

Konsentrasi tiap Konsentrasi tiap Konsentrasi dalam
No. Nama Bahan
satuan batch larutan
1 Teofilin 2 gram/100 ml 0,008 ml/100 ml
200 mg/10 ml = 20 g/1000 ml = 0,08 ml/1000 ml
= 20% b/v = 0,08% v/v
2 Etilendiamin 0,3 gram/100 ml 3,3 ml/100 ml
30 mg/10 ml = 3 g/1000 ml = 33 ml/1000 ml
= 3% b/v = 33% v/v
3 Aqua p.i. Volume air yang perlu ditambahkan untuk membuat 100 mL
sediaan injeksi aminofilin adalah 96,636 ml
4 NaCl 0,1216 g/100 ml 0,056 ml/100 ml
= 1,216 g/1000 = 0,56 ml/1000 ml
0,01216 g/10 ml
ml = 0,56% v/v
= 1,216% b/v

Pada percobaan ini bertujuan untuk mengetahui cara pembuatan sediaan injeksi aminofilin
2,4%, cara sterilisasi dan kontrol kualitas sediaan tersebut. Sediaan injeksi adalah sediaan yang
steril, yaitu sediaan harus bebas dari mikroorganisme, yang mana sediaan steril ini disuntikkan
melalui kulit atau selaput lendir. Aminofilin adalah golongan xantin yang memiliki gugus metil
dan rumus kimia 2,6-Dioksipurin. Dalam Daftar Obat Esensial Nasional (DOEN) tahun 2013,
aminofilin adalah obat yang digunakan untuk terapi saat terjadi eksaserbasi asma.
Injeksi aminofilin adalah larutan steril aminofilin dalam air untuk injeksi atau laurtan steril
teofilin dalam air untuk injeksi yang dibuat dengan penambahan etilendiamin. Tiap ml
mengandung aminofilin setara dengan tidak kurang dari 93,0% dan tidak lebih dari 107,0%
teofilin anhidrat, C7H8N4O2, dari jumlah yang tertera pada etiket. Injeksi aminofilin boleh
mengandung etilendiamin berlebih tetapi tidak boleh ditambah zat lain untuk pengaturan pH
(Depkes RI, 2014).
Teofilin dalam formula berfungsi sebagai zat aktif yang dapat mengatasi bronkospasme.
Etilendiamin dalam formula berfungsi untuk membantu kelarutan teofilin agar mudah larut
dalam air sehingga diharapkan sediaan injeksi yang terbentuk adalah larutan sejati yang mana
semua bahan yang digunakan dapat larut sempurna dalam air (pembawa). Teofilin memiliki
kelarutan yang rendah dalam air sehingga memerlukan etilendiamin agar teofilin dapat larut
dalam air, karena teofilin dan etilendiamin akan membentuk garam yang mudah larut dalam
air. Aqua p.i. merupakan pembawa sediaan injeksi yang umum digunakan. NaCl dalam
formula berfungsi untuk menjaga tonisitas sediaan agar tetap isotonis dengan cairan biologis
tubuh manusia sehingga sediaan injeksi yang dihasilkan tidak akan mengganggu
keseimbangan sel-sel tubuh maupun memberikan efek yang merugikan bagi tubuh pasien.

2. Perhitungan Tonisitas Sediaan dan Penyesuaian Komponen Formula

Terdapat sedikit perbedaan jumlah bahan yang digunakan jika dibandingkan dengan
formula aslinya dalam buku petunjuk praktikum. Adapun formula asli untuk sediaan injeksi
aminofillin 2,4% di buku petunjuk praktikum adalah sebagai berikut.
 R/ Teofilin 2
Etilendiamin 0,55
Aqua p.i. ad 100 mL

Jumlah etilendiamin yang digunakan dalam praktikum ini dikurangi, karena jika dilihat
dari reaksi yang terjadi pada pembentukan aminofilin, jumlah etilendiamin yang digunakan
berlebihan sehingga dapat memberikan sisa atau residu etilendiamin yang tidak bereaksi
menjadi aminofilin. Hal ini dapat mempengaruhi tonisitas dari sediaan injeksi sehingga sediaan
injeksi menjadi hipertonis. Untuk menghindari hal tersebut maka etilendiamin dikurangi
jumlahnya menjadi 0,3 gram untuk 100 mL larutan injeksi. Dengan jumlah yang baru ini,
sediaan injeksi menjadi hipotonis dan akan ditambahkan Natrium klorida agar menjadi
isotonis. Jumlah NaCl yang harus ditambahkan dalam sediaan akan dihitung dengan
perhitungan tonisitas.

Berikut adalah reaksi pembentukan aminofilin dari teofilin dan etilendiamin.

Reaksi sebelum disesuaikan.

2. +

m 0,01 mol 0,01 mol

r 0,01 mol 0,005 mol 0,005 mol
s 0 0,005 mol (berlebih) 0,005 mol

Reaksi setelah disesuaikan.

2. +

m 0,01 mol 0,005 mol

r 0,01 mol 0,005 mol 0,005 mol
s 0 0 0,005 mol
𝑔𝑟
• 0,005 mol = 𝐵𝑀 → gr = 0,3 gram (berat etilendiamin)

Berat molekul:
- Teofilin :180,16 g/mol
- Etilendiamin : 60,1 g/mol
Kadar zat dalam g/L
2 𝑔𝑟𝑎𝑚 20 𝑔𝑟𝑎𝑚
- Teofilin : 100 𝑚𝐿 = 1000 𝑚𝐿 = 20 g/L
0,3 𝑔𝑟𝑎𝑚 3 𝑔𝑟𝑎𝑚
- Etilendiamin : = 1000 𝑚𝐿 = 3 g/L
100 𝑚𝐿

Faktor disosiasi
Dikatakan suatu larutan isotonis bila terpenuhi:
𝐹𝑎 𝐹𝑏
×𝑎+ × 𝑏 + … = 0,28
𝑀𝑎 𝑀𝑏

Perhitungan:
1,5 1,5
× 20 + 60,1 × 3 = 0,242 → 0,242 < 0,28 sehingga larutan sediaan injeksi tersebut bersifat
180,16
Hipotonis, maka perlu penambahan bahan pengisotonis yaitu NaCl agar larutan menjadi
 isotonis. Larutan yang bersifat hipotonis tidak boleh digunakan untuk sediaan steril karena
dapat menyebabkan sel mengalami lisis akibat pergerakan air ke dalam sel secara terus
menerus.

NaCl yang ditambahkan dapat dihitung sebagai berikut.

𝑀ℎ 𝐹𝑎 𝐹𝑏
h= × (0,28 − 𝑀𝑎 × 𝑎 + 𝑀𝑏 × 𝑏 )
𝐹ℎ
h = 32 × (0,28 – 0,242)
h = 1,216 g/L
h = 0,1216 g/100 mL

3. Alur Prosedur Pencampuran dan Produksi Sediaan

Disiapkan alat dan bahan

Ditimbang bahan yang

dibutuhkan: teofilin (2
gram), etilendiamin (0,3 Diambil 110 mL aquadest
gram)

Difilter menggunakan kertas saring

Dibuat aqua bebas
karbondioksida (CO2)
Disterilkan dalam autoclave pada
suhu 110ºC selama 20 menit

Difilter dengan membran 0,45 µm (bila

perlu)

Dipanaskan hingga mendidih

Disuspensikan teofilin Dilarutkan etilendiamin

dengan 32,2 mL aqua dengan 32,2 mL aqua
bebas CO2 bebas CO2

Suspensi teofilin ditambahkan dengan larutan etilendiamin

tetes demi tetes sampai larut sempurna dan pH antara 9,5-9,6

Diukur volume campuran, jika volume belum 100 mL, ad

100 mL aqua bebas CO2
 Digojog larutan dengan karboadsorben 0,1% yang telah
diaktifkan selama 5-10 menit, didiamkan kemudian
disaring hingga jernih

Dimasukkan larutan ke dalam 4 buah ampul, masing-

masing 10 mL, ditutup, lalu disterilkan dengan autoclave
(110ºC selama 30 menit atau 120ºC selama 20 menit)

Dilakukan kontrol kualitas sediaan injeksi meliputi: pH,

kebocoran, partikel asing, kejernihan dan keseragaman
volume/bobot

Uji pH Uji Partikel Asing Uji Kejernihan

Dicelupkan indikator ph pada Dilihat sediaan dalam wadah Dilihat dengan mata apakah
larutan injeksi yang diproduksi pada background hitam/putih sediaan yang dibuat jernih
atau tidak

Diamati perubahan warna yang Dilihat apakah ada partikel di

terjadi dan dicocokkan pada dalam sediaan
warna indikator
Uji Keragaman Bobot (FI V)
Uji Kebocoran Ditimbang saksama sejumlah cairan yang dikeluarkan dari
Wadah sediaan diposisikan 10 wadah satu per satu seperti penggunaan normal
terbalik

Jika perlu dilakukan perhitungan kesetaraan volume

setelah penetapan bobot jenis
Dilihat apakah ada cairan
yang menetes atau tidak
Dihitung jumlah zat aktif dalam tiap wadah dari hasil
penetapan kadar

Dihitung nilai penerimaan

Diberi etiket yang sesuai

Dimasukkan sediaan injeksi ke dalam pengemas yang

sesuai dan diserahkan dalam bentuk lengkap (seperti
sediaan yang ada dalam perdagangan)

4. Peralatan yang Digunakan Dalam Produksi

Nama dan Gambar Alat Fungsi Alat Cara Penggunaan
Autoklaf Untuk sterilisasi Dibuka semua penguncin pada
alat dan bahan autoklaf, kemudian dibuka tutup
autokaf dengan cara diputar dengan
arah melawan jarum jam. Dilakukan
 penambahan akuades pada bagian
bawah dalam autoklaf dengan cara
melepaskan terlebih dahulu
kontainer aluminium. Diletaakkan
kembali kontainer aluminium pada
autoklaf, kemudian dimasukkan
benda-benda yang ingin disterilisasi
pada kontainer aluminium tersebut.
Tutup kembali autoklaf dengan
memperhatikan pipa udara
dimasukkan pada tempatnya.
Diputar tutup autoklaf ke atrah
searah jarum jam sampai tanda
panah pada tutup sesuai pada
tempatnya. Lalu, autoklaf dikunci
dengan melakukan penguncian kunci
yang berseberang bersamaan.
Kemudian, dipasang kabel pada stop
kontak dan dinyalakan autoklaf.
Selanjutnya diputar knop ke arah
angka 8 untuk menaikkan suhu
menuju 121ºC, lalu diatur tekanan
dan waktu 20 menit. Ditunggu waktu
20 menit dengan tanda bunyi alarm.
Jika telah selesai sterilisasi, ditarik
katup kontrol tekanan untuk
mengurangi tekanan internal.
Tekanan turun dulihat di indikator
tekanan. Kemudian, dilakukan
pembukaan autoklaf seperti prosedur
di atas, dengan menggunakan sarung
tangan (Salehuddin, 2017)
Neraca Analitik Menimbang 1. Duduklah dengan nyaman
Bahan
dan posisikan timbangan
analitik dalam jangkauan.
2. Pastikan timbangan sudah
menyala. Jika belum,
pastikan power supply telah
tersambung ke sumber listrik
dan tekanlah tombol power.
3. Setelah timbangan analitik
menyala, tunggu hingga
posisi angka menjadi stabil
(nol). Pada beberapa kasus,
timbangan analitik tidak
menunjukan angka nol, maka
setting menjadi nol kembali
dengan melihat buku
panduan.
4. Bersiap menimbang. Jika
anda menggunakan
timbangan analitik dengan
 pelindung, buka terlebih
dahulu pintu pelindung
sebelum menempatkan
material pada piringan.
5. Tempatkan kertas timbang
atau botol timbang terlebih
dahulu, kemudian ketika
angka sudah stabil, tekan
tomboll setting to zero.
6. Tempatkan material pada
piringan timbangan analitik
secara hati-hati, tempatkan
material sedikit demi sedikit.
Perhatikan bahwa timbangan
analitik anda memiliki batas
maksimal. Jangan
menempatkan material
melebihi batas atas kapasitas
timbangan analitik, karena
hal ini dapat merusak
timbangan analitik.
7. Setelah menempatkan
material pada piringan
timbangan analitik, tunggu
beberapa saat hingga angka
menjadi stabil. Amati dan
catat berapa massa material
yang baru saja kita timbang.
8. Setelah selesai menimbang,
ada baiknya ada
mengeluarkan zat atau
material keluar dari
timbangan analitik, agar
timbangan selalu dalam
keadaan kosong jika tidak
digunakan.
9. Bersihkan timbangan analtik
menggunakan kuas kecil
sebelum anda
meninggalkannya.
10. Jika anda menggunakan
timbangan analitik dengan
 penutup, maka tutup pintu
pelindung sebelum
meninggalkan timbangan
analitik.
Alat Las Penutup Ampul Menutup penutup 1. Siapkan ampul yang
ampul
sudah berisi sediaan
farmasi dan pinset
2. Sebelum menyalakan
alat, jauhkan benda yang
mudah terbakar dari
ujung tempat keluarnya
api
3. Nyalakan alat las penutup
ampul
4. Ambil ampul yang akan
ditutup beserta pinset
5. Pastikan tidak ada air
yang menempel dibagian
atas ampul (kering) yang
akan ditutup (dapat
menyebabkan ampul
berwarna hitam).
6. Peganglah ampul dengan
tangan kiri dan pinset
dengan tangan kanan
(atau sebaliknya
tergantung tangan yang
mudah digunakan untuk
menutup ampul dengan
pinset)
7. Jepit ujung atas penutup
ampul dengan pinset dan
panaskan dengan alat las
8. Sambil dipanaskan, tutup
ampul diputar agar panas
merata dengan pinset
tetap menjepit ujung atas
ampul
9. Pastikan pemutaran
ampul dilakukan dengan
cepat dan tanggap agar
tutup ampul tidak
 meleleh hanya dibagian
satu sisi saja
10. Didapatkan ampul yang
sudah tertutup
11. Tunggu hingga ampul
kembali dingin
Matikan alat jika sudah selesai
menggunakan
Glassware Untuk wadah Digunakan sesuai fungsinya.
dalam Dibersihkan terlebih dahulu sebelum
pencampuran digunakan. Pastikan wadah kering
bahan dan dan tidak bocor. Lalu bersihkan
pengemas kembali setelah selesai digunakan,
(ampul) kemudian disimpan di tempat kering.

Daftar Pustaka
Anonim, 2016, Autoklaf – Cara Aman dan Efektif Menggunakan Autoklaf, tersedia di
http://batavialab.com, diakses pada tanggal 15 April 2020 pada pukul 20.56 WIB.
Depkes RI, 2014, Farmakope Indonesia, Edisi V, Depkes RI, Jakarta.
Kementerian Kesehatan Republik Indonesia, 2013, Keputusan Menteri Kesehatan Republik
Indonesia Nomor 312/MENKES.SK/IX/2013 tentang Daftar Obat Esensial Nasional
(DOEN) 2013, Kementerian Kesehatan Republik Indonesia, Jakarta.
Salehuddin, M.F.H., 2017, STB3182 Standar Oprating Procedure for Handling Autoclave
Machine, tersedia di https://youtu.be/aG-dS5WzFOM, diakses pada tanggal 15 April 2020
pukul 20.53 WIB.
 LAMPIRAN
Gambar Cara Penggunaan Autoklaf

(Batavialab.com)

Next Page
(Salehuddin, 2017)
 LAMPIRAN
Gambar Glassware

Ampul
Erlenmeyer

Beaker glass
Corong

Gelas ukur
Neraca Analitik

Link Video: https://www.youtube.com/watch?v=dTEkRjB4qbg

Alat Las Penutup Ampul

Link Video: https://www.youtube.com/watch?v=tovOIIEjRx8&feature=youtu.be

Scanned by CamScanner
Scanned by CamScanner
Scanned by CamScanner
 Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations
Date of issue: 02/13/2015 Revision date: 05/16/2018 Supersedes: 02/13/2015 Version: 1.1

SECTION 1: Identification
1.1. Identification
Product form : Mixtures
Product name : Ethylenediamine, 70% Technical Grade
Product code : LC14140
1.2. Recommended use and restrictions on use
Use of the substance/mixture : For laboratory and manufacturing use only.
Recommended use : Laboratory chemicals
Restrictions on use : Not for food, drug or household use
1.3. Supplier
LabChem Inc
Jackson's Pointe Commerce Park Building 1000, 1010 Jackson's Pointe Court
Zelienople, PA 16063 - USA
T 412-826-5230 - F 724-473-0647
info@labchem.com - www.labchem.com

1.4. Emergency telephone number

Emergency number : CHEMTREC: 1-800-424-9300 or +1-703-741-5970

SECTION 2: Hazard(s) identification

2.1. Classification of the substance or mixture
GHS-US classification
Flammable liquids H226 Flammable liquid and vapour
Category 3
Acute toxicity (oral) H302 Harmful if swallowed
Category 4
Acute toxicity (dermal) H312 Harmful in contact with skin
Category 4
Skin corrosion/irritation H314 Causes severe skin burns and eye damage
Category 1B
Respiratory sensitization, H334 May cause an allergy or asthma symptoms or breathing difficulties if inhaled
Category 1
Skin sensitization, Category H317 May cause an allergic skin reaction
1
Full text of H statements : see section 16

2.2. GHS Label elements, including precautionary statements

GHS-US labeling
Hazard pictograms (GHS-US) :

GHS02 GHS05 GHS07 GHS08

Signal word (GHS-US) : Danger
Hazard statements (GHS-US) : H226 - Flammable liquid and vapour
H302+H312 - Harmful if swallowed or in contact with skin
H314 - Causes severe skin burns and eye damage
H317 - May cause an allergic skin reaction
H334 - May cause an allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary statements (GHS-US) : P210 - Keep away from heat, sparks, open flames, hot surfaces. - No smoking.
P233 - Keep container tightly closed.
P240 - Ground/bond container and receiving equipment.
P241 - Use explosion-proof electrical, ventilating, lighting equipment
P242 - Use only non-sparking tools.
P243 - Take precautionary measures against static discharge.
P260 - Do not breathe mist, vapors, spray.
P264 - Wash exposed skin thoroughly after handling.
P270 - Do not eat, drink or smoke when using this product.
05/16/2018 EN (English US) Page 1
Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

P272 - Contaminated work clothing should not be allowed out of the workplace.
P280 - Wear protective gloves, protective clothing, eye protection, face protection.
P284 - Wear respiratory protection.
P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P305+P351+P338 - If in eyes: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a poison center or doctor/physician.
P363 - Wash contaminated clothing before reuse.
P403+P235 - Store in a well-ventilated place. Keep cool.
P405 - Store locked up.
P501 - Dispose of contents/container to comply with local, state and federal regulations
If inhaled: Remove person to fresh air and keep comfortable for breathing
2.3. Other hazards which do not result in classification
Other hazards not contributing to the : None under normal conditions.
classification
2.4. Unknown acute toxicity (GHS US)
Not applicable

SECTION 3: Composition/Information on ingredients

3.1. Substances
Not applicable
3.2. Mixtures
Name Product identifier % GHS-US classification
Ethylenediamine (CAS-No.) 107-15-3 70 Flam. Liq. 3, H226
Acute Tox. 4 (Oral), H302
Acute Tox. 3 (Dermal), H311
Skin Corr. 1B, H314
Resp. Sens. 1, H334
Skin Sens. 1, H317
Water (CAS-No.) 7732-18-5 30 Not classified

Full text of hazard classes and H-statements : see section 16

SECTION 4: First-aid measures

4.1. Description of first aid measures
First-aid measures general
First-aid measures after inhalation
First-aid measures after skin contact
First-aid measures after eye contact
First-aid measures after ingestion
4.2. Most important symptoms and effects (acute and delayed)
Symptoms/effects
Symptoms/effects after inhalation
Symptoms/effects after skin contact
Symptoms/effects after eye contact
Symptoms/effects after ingestion
4.3. Immediate medical attention and special treatment, if necessary
Obtain medical assistance.
: Never give anything by mouth to an unconscious person. If you feel unwell, seek medical
advice (show the label where possible).
: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately
call a poison center or doctor/physician.
: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
Immediately call a poison center or doctor/physician. Wash contaminated clothing before reuse.
: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a poison center or doctor/physician.
: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor/physician.
: Causes severe skin burns and eye damage.
: May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an
allergic skin reaction.
: Repeated exposure to this material can result in absorption through skin causing significant
health hazard. Harmful in contact with skin.
: Causes serious eye damage.
: Swallowing a small quantity of this material will result in serious health hazard.

SECTION 5: Fire-fighting measures

5.1. Suitable (and unsuitable) extinguishing media
Suitable extinguishing media : Foam. Dry powder. Carbon dioxide. Water spray. Sand.
Unsuitable extinguishing media : Do not use a heavy water stream.

05/16/2018 EN (English US) 2/8

Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

5.2. Specific hazards arising from the chemical

Fire hazard : Flammable liquid and vapor.
Explosion hazard : May form flammable/explosive vapor-air mixture.
Reactivity : Thermal decomposition generates : Corrosive vapors.
5.3. Special protective equipment and precautions for fire-fighters
Firefighting instructions : Use water spray or fog for cooling exposed containers. Exercise caution when fighting any
chemical fire. Prevent fire-fighting water from entering environment.
Protection during firefighting : Do not enter fire area without proper protective equipment, including respiratory protection.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
General measures : Remove ignition sources. Use special care to avoid static electric charges. No naked lights. No
smoking.

6.1.1. For non-emergency personnel

Protective equipment : Protective goggles. Protective clothing. Gloves. Face-shield. Combined gas/dust mask with
filter type K/P3.
Emergency procedures : Evacuate unnecessary personnel.

6.1.2. For emergency responders

Protective equipment : Equip cleanup crew with proper protection.
Emergency procedures : Ventilate area.
6.2. Environmental precautions
Prevent entry to sewers and public waters. Notify authorities if liquid enters sewers or public waters.
6.3. Methods and material for containment and cleaning up
Methods for cleaning up : Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible. Collect
spillage. Store away from other materials.
6.4. Reference to other sections
See Heading 8. Exposure controls and personal protection.

SECTION 7: Handling and storage

7.1. Precautions for safe handling
Additional hazards when processed : Handle empty containers with care because residual vapors are flammable.
Precautions for safe handling : Wash hands and other exposed areas with mild soap and water before eating, drinking or
smoking and when leaving work. Provide good ventilation in process area to prevent formation
of vapor. No naked lights. No smoking. Take precautionary measures against static discharge.
Use only non-sparking tools. Do not breathe mist, vapors, spray.
Hygiene measures : Do not eat, drink or smoke when using this product. Wash exposed skin thoroughly after
handling. Wash contaminated clothing before reuse. Contaminated work clothing should not be
allowed out of the workplace.
7.2. Conditions for safe storage, including any incompatibilities
Technical measures : Proper grounding procedures to avoid static electricity should be followed. Ground/bond
container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/…
equipment. Comply with applicable regulations.
Storage conditions : Keep only in the original container in a cool, well ventilated place away from : Ignition sources,
Heat sources, incompatible materials. Keep container tightly closed.
Incompatible products : Strong oxidizers. Strong acids.
Incompatible materials : Sources of ignition. Direct sunlight. Heat sources. Air sensitive.

SECTION 8: Exposure controls/personal protection

8.1. Control parameters
Ethylenediamine (107-15-3)
ACGIH ACGIH TWA (mg/m³) 25 mg/m³
ACGIH ACGIH TWA (ppm) 10 ppm
OSHA OSHA PEL (TWA) (mg/m³) 25 mg/m³

05/16/2018 EN (English US) 3/8

Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

Ethylenediamine (107-15-3)
OSHA OSHA PEL (TWA) (ppm) 10 ppm
IDLH US IDLH (ppm) 1000 ppm
NIOSH NIOSH REL (TWA) (mg/m³) 25 mg/m³
NIOSH NIOSH REL (TWA) (ppm) 10 ppm

Water (7732-18-5)
Not applicable

8.2. Appropriate engineering controls

Appropriate engineering controls : Ensure adequate ventilation. Material should be handled in a laboratory hood whenever
possible. Emergency eye wash fountains should be available in the immediate vicinity of any
potential exposure.

8.3. Individual protection measures/Personal protective equipment

Personal protective equipment:
Chemical resistant apron. Gas mask. Gloves. Safety glasses. Protective clothing.

Hand protection:
Wear protective gloves.

Eye protection:
Chemical goggles or face shield

Skin and body protection:

Wear suitable protective clothing

Respiratory protection:
Gas mask

Other information:
Do not eat, drink or smoke during use.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties
Physical state : Liquid
Color : Colorless
Odor : characteristic Amine-like
Odor threshold : No data available
pH : No data available
Melting point : No data available
Freezing point : No data available
Boiling point : No data available
Flash point : No data available
Relative evaporation rate (butyl acetate=1) : No data available
Flammability (solid, gas) : Flammable liquid and vapor.
Vapor pressure : No data available
Relative vapor density at 20 °C : No data available
Relative density : No data available
Solubility : No data available

05/16/2018 EN (English US) 4/8

Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

Log Pow : No data available

Auto-ignition temperature : No data available
Decomposition temperature : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : No data available
Explosion limits : No data available
Explosive properties : No data available
Oxidizing properties : No data available
9.2. Other information
No additional information available

SECTION 10: Stability and reactivity

10.1. Reactivity
Thermal decomposition generates : Corrosive vapors.
10.2. Chemical stability
Flammable liquid and vapor. May form flammable/explosive vapor-air mixture.
10.3. Possibility of hazardous reactions
Reacts vigorously with strong oxidizers and acids.
10.4. Conditions to avoid
Direct sunlight. Extremely high or low temperatures. Open flame. Overheating. Heat. Sparks.
10.5. Incompatible materials
Strong acids. Strong oxidizers.
10.6. Hazardous decomposition products
Carbon monoxide. Carbon dioxide. Hydrogen cyanide. Nitrogen oxides.

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Likely routes of exposure : Inhalation; Skin and eye contact

Acute toxicity : Not classified
Ethylenediamine, 70% Technical Grade
ATE US (oral) 714.286 mg/kg body weight
ATE US (dermal) 1571.429 mg/kg body weight
Ethylenediamine (107-15-3)
LD50 oral rat 1200 mg/kg
LD50 dermal rabbit 656 mg/kg
ATE US (oral) 1200 mg/kg body weight
ATE US (dermal) 656 mg/kg body weight
Water (7732-18-5)
LD50 oral rat ≥ 90000 mg/kg
ATE US (oral) 90000 mg/kg body weight
Skin corrosion/irritation : Causes severe skin burns and eye damage.
Serious eye damage/irritation : Eye damage, category 1, implicit
Respiratory or skin sensitization : May cause an allergy or asthma symptoms or breathing difficulties if inhaled. May cause an
allergic skin reaction.
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified

Reproductive toxicity : Not classified

Specific target organ toxicity – single exposure : Not classified

Specific target organ toxicity – repeated : Not classified

exposure

05/16/2018 EN (English US) 5/8

Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

Aspiration hazard : Not classified

Potential Adverse human health effects and
symptoms
Symptoms/effects after inhalation
Symptoms/effects after skin contact
Symptoms/effects after eye contact
Symptoms/effects after ingestion
: Based on available data, the classification criteria are not met. Harmful if swallowed. Harmful in
contact with skin.
: May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an
allergic skin reaction.
: Repeated exposure to this material can result in absorption through skin causing significant
health hazard. Harmful in contact with skin.
: Causes serious eye damage.
: Swallowing a small quantity of this material will result in serious health hazard.

SECTION 12: Ecological information

12.1. Toxicity
No additional information available

12.2. Persistence and degradability

Ethylenediamine, 70% Technical Grade
Persistence and degradability Not established.

Water (7732-18-5)
Persistence and degradability Not established.

12.3. Bioaccumulative potential

Ethylenediamine, 70% Technical Grade
Bioaccumulative potential Not established.

Water (7732-18-5)
Bioaccumulative potential Not established.

12.4. Mobility in soil

No additional information available

12.5. Other adverse effects

Other information : Avoid release to the environment.

SECTION 13: Disposal considerations

13.1. Disposal methods
Waste disposal recommendations : Dispose in a safe manner in accordance with local/national regulations. Dispose of
contents/container to comply with local, state and federal regulations.
Additional information : Handle empty containers with care because residual vapors are flammable.
Ecology - waste materials : Avoid release to the environment.

SECTION 14: Transport information

Department of Transportation (DOT)
In accordance with DOT
Transport document description : UN1604 Ethylenediamine (solution), 8, II

UN-No.(DOT) : UN1604
Proper Shipping Name (DOT) : Ethylenediamine
solution
Transport hazard class(es) (DOT) : 8 - Class 8 - Corrosive material 49 CFR 173.136
Packing group (DOT) : II - Medium Danger

05/16/2018 EN (English US) 6/8

Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations
Hazard labels (DOT)
DOT Packaging Non Bulk (49 CFR 173.xxx)
DOT Packaging Bulk (49 CFR 173.xxx)
DOT Special Provisions (49 CFR 172.102)
DOT Packaging Exceptions (49 CFR 173.xxx)
DOT Quantity Limitations Passenger aircraft/rail : 1 L
(49 CFR 173.27)
DOT Quantity Limitations Cargo aircraft only (49 : 30 L
CFR 175.75)
DOT Vessel Stowage Location
DOT Vessel Stowage Other
Other information
SECTION 15: Regulatory information
15.1. US Federal regulations
Ethylenediamine, 70% Technical Grade
SARA Section 311/312 Hazard Classes
All components of this product are listed, or excluded from listing, on the United States Environmental Protection Agency Toxic
Substances Control Act (TSCA) inventory
Ethylenediamine (107-15-3)
RQ (Reportable quantity, section 304 of EPA's
List of Lists)
SARA Section 302 Threshold Planning
Quantity (TPQ)
SARA Section 311/312 Hazard Classes
15.2. International regulations
CANADA
Ethylenediamine (107-15-3)
Listed on the Canadian DSL (Domestic Substances List)
EU-Regulations
No additional information available
05/16/2018
: 8 - Corrosive
3 - Flammable liquid
: 202
: 243
: IB2 - Authorized IBCs: Metal (31A, 31B and 31N); Rigid plastics (31H1 and 31H2); Composite
(31HZ1). Additional Requirement: Only liquids with a vapor pressure less than or equal to 110
kPa at 50 C (1.1 bar at 122 F), or 130 kPa at 55 C (1.3 bar at 131 F) are authorized.
T7 - 4 178.274(d)(2) Normal............. 178.275(d)(3)
TP2 - a. The maximum degree of filling must not exceed the degree of filling determined by the
following: (image) Where: tr is the maximum mean bulk temperature during transport, tf is the
temperature in degrees celsius of the liquid during filling, and a is the mean coefficient of
cubical expansion of the liquid between the mean temperature of the liquid during filling (tf) and
the maximum mean bulk temperature during transportation (tr) both in degrees celsius. b. For
liquids transported under ambient conditions may be calculated using the formula: (image)
Where: d15 and d50 are the densities (in units of mass per unit volume) of the liquid at 15 C
(59 F) and 50 C (122 F), respectively.
: 154
: A - The material may be stowed ‘‘on deck’’ or ‘‘under deck’’ on a cargo vessel and on a
passenger vessel.
: 40 - Stow ‘‘clear of living quarters’’,52 - Stow ‘‘separated from’’ acids
: No supplementary information available.
Immediate (acute) health hazard
Fire hazard
Delayed (chronic) health hazard
5000 lb
10000 lb
Physical hazard - Flammable (gases, aerosols, liquids, or solids)
Health hazard - Acute toxicity (any route of exposure)
Health hazard - Skin corrosion or Irritation
Health hazard - Serious eye damage or eye irritation
Health hazard - Respiratory or skin sensitization
EN (English US) 7/8
Ethylenediamine, 70% Technical Grade
Safety Data Sheet
according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations

National regulations
Ethylenediamine (107-15-3)
Listed on the Canadian IDL (Ingredient Disclosure List)

15.3. US State regulations

California Proposition 65 - This product does not contain any substances known to the state of California to cause cancer,
developmental and/or reproductive harm

SECTION 16: Other information

Revision date : 05/16/2018
Other information : None.
Full text of H-phrases: see section 16:
--- H226 Flammable liquid and vapour
---
--- H302 Harmful if swallowed
---
--- H311 Toxic in contact with skin
---
--- H312 Harmful in contact with skin
---
--- H314 Causes severe skin burns and eye damage
---
--- H317 May cause an allergic skin reaction
---
--- H334 May cause an allergy or asthma symptoms or breathing difficulties if inhaled
---
NFPA health hazard : 3 - Materials that, under emergency conditions, can cause
serious or permanent injury.
NFPA fire hazard : 3 - Liquids and solids (including finely divided suspended
solids) that can be ignited under almost all ambient
temperature conditions.
NFPA reactivity : 0 - Material that in themselves are normally stable, even
under fire conditions.

Hazard Rating
Health : 3 Serious Hazard - Major injury likely unless prompt action is taken and medical treatment is
given
Flammability : 3 Serious Hazard - Materials capable of ignition under almost all normal temperature
conditions. Includes flammable liquids with flash points below 73 F and boiling points above
100 F. as well as liquids with flash points between 73 F and 100 F. (Classes IB & IC)
Physical : 0 Minimal Hazard - Materials that are normally stable, even under fire conditions, and will NOT
react with water, polymerize, decompose, condense, or self-react. Non-Explosives.
Personal protection : H
H - Splash goggles, Gloves, Synthetic apron, Vapor respirator

SDS US LabChem

Information in this SDS is from available published sources and is believed to be accurate. No warranty, express or implied, is made and LabChem Inc assumes no liability resulting from the use of this
SDS. The user must determine suitability of this information for his application.

05/16/2018 EN (English US) 8/8

 SAFETY DATA SHEET – Salt

Date Issued: November 3, 2004 Version: 4.0 Revision Issued: March 2, 2017
Section I – Product and Company Identification
INTREPID POTASH – MOAB, LLC
707 17th St. Suite 4200
Denver, CO 80202
Office 303-296-3006
Fax 303-298-7502
Web http://www.intrepidpotash.com/Contact.aspx

EMERGENCIES: Call (800) 424-9300 (CHEMTREC)

HEALTH EMERGENCIES: CONTACT YOUR LOCAL POSION CENTER

Common Name: Fine Salt, Medium Salt, Road Use: Animal Feed and
Formula: NaCl Synonym: Salt
Salt, Coarse Salt Industrial

Section II – Hazard Identification

GHS07 Not Applicable Not Applicable
Lab Elements:

Prevention: Not Applicable

Response: Not Applicable Not Applicable
Storage: Not Applicable Not Applicable
Disposal: Not Applicable Not Applicable

Section III – Composition/Information on Ingredients

Exposure Limits
Chemical Name(s) CAS No.
OSHA PEL TLV - TWA STEL CEIL % by
Weight
mg/m3 ppm mg/m3 ppm mg/m3 ppm mg/m3 ppm
Sodium Chloride 7647-14-5 15 / 5* 10** 98.5 - 99.5
Potassium Chloride 7447-40-7 15 / 5* 10** 0.5 – 1.5
** Total Dust / Respirable dust
* Based on ACGIH nuisance dust limits

Section IV – First Aid Measures

Rinse cautiously with water for several minutes. Flush with water, including under upper & lower lids, for at least 15
Eyes: minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical attention/advice if pain
and irritation persists.
Skin: Wash thoroughly with water. Obtain medical advice/attention if irritation persists.
A large bodily load may cause vomiting, diarrhea, cramps, tingling in hands and feet, weak pulse, and circulatory
Ingestion: disturbances. Administer water to the patient. Ingesting will usually cause purging of the stomach by vomiting. Get
medical attention.
If individual is experiencing respiratory discomfort or irritation remove to fresh air. If discomfort or irritation persists,
Inhalation:
get medical attention/advice.

Page 1 of 5
Section V – Fire Fighting Measures

Flash Point: None Auto-ignition Temperature: Not Applicable Lower Explosive Limit: Not Applicable
Upper Explosive Limit: Not Applicable

Extinguishing Media: As required for surrounding fire. Salt is non-flammable and does not support combustion.
Full structural firefighting (bunker) gear is the minimum acceptable attire. The need for proximity, entry,
flashover and/or special chemical protective clothing (see Section 8) needs to be determined for each
Special Firefighting
incident by a competent firefighting safety professional. Water used for fire suppression and cooling
Procedures and Equipment:
may become exposed to soluble fertilizer. Discharge to sewer system(s) or environment may be
restricted, requiring containment and proper disposal of water.

Section VI – Accidental Release Measures

Small Spill: Sweep up and use as ice melt if non-contaminated by foreign materials.
Collect with appropriate equipment. If on a hard surface, sweep up residue with brooms. If on soil, remove and collect
Large Spill:
the top 5 cm of soil.
Salt is highly soluble and can be quickly diluted by relatively large amounts of water. Prevent spilled materials from
entering sewers, storm drains and other unauthorized treatment drainage systems. Salt which has entered a small non-
permanent pond should be removed by pumping the pond dry. If spill could potentially enter any waterway, including
Release
intermittent dry creeks, contact the local authorities. If in the U.S., contact the US COAST GUARD NATIONAL
Notes:
RESPONSE CENTER toll free number, 800-424-8802. In case of accident or road spill notify: CHEMTRECIN USA AT
800-424-9300; CANUTEC in Canada at 613-996-6666; CHEMTREC in other countries at (International code) +1-703-
527-3887.
See Section XIII for disposal information and Section XV for regulatory requirements. Large and small spills may have a
Comments: broad definition depending on the user’s handling system. Therefore, the spill category must be defined at the point of
release by technically qualified personnel.

Section VII – Handling and Storage

Ventilation: Local exhaust to reduce dust concentrations below recommended levels.
Handling: Avoid generating dust by excessive or unnecessary movement.

Storage: Store in a dry location. Avoid contact with aluminum or carbon steel to minimize corrosion.

Section VIII – Exposure Controls/Personal Protection

Engineering Controls: May be necessary to minimize dust levels.
Personal Protection:
Eye Protection: Use tight-fitting safety goggles in areas of high dust concentration.

Protective Clothing: Gloves, long sleeve shirts and long pants. Launder work clothing regularly.

Minimum NIOSH approved N95 filter type dust respirators until engineering controls are
Respiratory Protection:
implemented.
Other Protective Clothing or Equipment: Optional

Section IX – Physical and Chemical Properties

Appearance/Color/Odor: White crystalline or granular.

Melting Point/Range: 800ºC (1472ºF) Boiling Point: 1465oC (sublimates)

Solubility in Water: 359 grams per liter Boiling Point/Range: 1420 – 1500oC
Specific Gravity: 2.17 Vapor Pressure (mmHg): Not Applicable
Vapor Density: Not Applicable % Volatiles: <0.5
Bulk Density: 35-83 lbs./ft3 (560-1330 kg/m3) Evaporation Rate: No Data Available
pH: Approximately 8 Viscosity: Not applicable

Page 2 of 5
Section X – Stability and Reactivity
Stability: Stable.
Hazardous Polymerization: Will not occur
Conditions to Avoid: None
Strong oxidizing agents, strong acids. In the presence of moisture it may be
Materials to Avoid (Incompatibilities):
mildly corrosive to metals.
When heated to decomposition (above 1413 degree Celsius) may emit toxic
Hazardous Decomposition Products: fumes of Na2O and Cl2. May evolve chlorine gas when in contact with strong
acids.

Section XI Toxicological Information

Significant Routes of Exposure: Eyes, skin, inhalation, ingestion

Substance: Sodium Chloride

Rat, oral, LD50 >3000 mg/kg

Acute Oral Toxicity:
Acute Inhalation Toxicity:
Acute Dermal Toxicity:
Eye & Skin Irritation:
Substance:
Mouse, oral, LD50 > 4000 mg/kg
Rat, LC50 > 42 g/m3 /1hour
No data available
Rabbit, Eye: 100 mg/24 hour, moderate irritant
Rabbit, Eye: 500 mg/ 24 hour, mild irritant
Potassium Chloride

Acute Oral Toxicity: No data available

Acute Inhalation Toxicity: No data available
Acute Dermal Toxicity: No data available
Eye & Skin Irritation: No data available

Section XII – Ecological Information

Acute Toxicity to Fish: 96 hour LC 50 2800mg/l (rainbow trout)

Chronic Toxicity to Fish: No data available

Acute Toxicity to Aquatic 48 hour EC50 337mg/l (Crustacean/Daphnia)
Invertebrates: 96 hour LC 50 940mg/l (Physaheterostropha)
Chronic Toxicity to Aquatic
No data available
Invertebrates:
72 hour ErC 50 2500mg/l
Toxicity to Aquatic Plants:
Ecotoxicology: NEOL 0.6 g/l
Toxicity to Bacteria:
No data available
(activated sludge):
Toxicity to Soil Dwelling
No data available
Organisms:

Toxicity to Terrestrial Plants: No data available

Dissolves in water and disassociates into Na and Cl ions. Ions may be

Stability in Water:
Environmental Fate: absorbed by plants or by animals ingesting water containing Salt.

Stability in Soil: Binds to clay particles

Toxicity: Non-toxic
Degradation Chloride and Sodium Ions

Page 3 of 5
Section XIII – Disposal Considerations
This material, if discarded as produced, is not a RCRA “listed” or “characteristic” hazardous waste.
Product Disposal: Contamination may subject it to hazardous waste regulations. Properly characterize all waste materials.
Consult State and local regulations regarding the proper disposal of this material.
General Comments: Because of its solubility Salt should not be disposed of in a location where run-off will escape.

Section XIV – Transportation Information

Proper Shipping Name: Not Applicable

Hazard Class: Not Applicable

Identification Number: HTS 3104.20.00

Packing Group (Technical Name) Not Applicable

Section XV – Regulatory Information

UNITED STATES:

SARA Hazard This product has been reviewed according to the EPA Hazard Categories promulgated under Section 311 and 312
Category: of the Superfund Amendment and Reauthorization Act of 1986 (SARA Title III) and is considered, under applicable
definitions, to meet the following categories:
Fire: No Pressure Generating: No Reactivity: No Acute: No Chronic: No

SARA Title III This product contains the following substances subject to the reporting requirements of Title III(EPCRA) of the
Information: Superfund Amendments and Reauthorization Act of 1986 and 40 CFR Part 372:

Percent by CERCLA RQ
Chemical CAS No.
Weight (lbs.)

Sodium Chloride 7647-14-5 98.5-99.5 NA

Potassium Chloride 7447-40-7 0.5-1.5 NA

TSCA: Listed in the TSCA Inventory.

CANADA: DSL: Yes NSDL: Not Listed

WHMIS Hazard Symbol and
Not controlled
Classification:

Ingredient Disclosure List: This product does not contain ingredient(s) on this list
Environmental Protection: All intentional ingredients are listed on the DSL (Domestic Substance List).

Page 4 of 5
 Section XVI – Other Information
NFPA Hazard Rating: Health: 1 Flammability: 0 Instability: 0 Special Hazard: N/A

0 = Insignificant 1 = Slight 2 = Moderate 3 = High 4 = Extreme

HMIS Hazard Rating: Health: 1 Flammability: 0 Physical Hazard: 0 PP: E

0 = Insignificant 1 = Slight 2 = Moderate 3 = High 4 = Extreme

E = safety glasses, gloves and dust respirator

Comments: None

Section(s) changed since last revision: SDS is designed to comply with U.S. DOL: OSHA and MSHA HazCom standards in effect on the
revision date.

The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief as of the revision date noted below. This information
is not a warranty or quality specification. The user of the product is solely responsible for determining the suitability of use in each particular situation. This
information relates only to the specific material designated and may not be valid for the material used in combination with any other materials or in any process.
The user of the product assumes all risks and responsibilities in connection with the use of the product, and Intrepid will not be responsible for any damages relating
to the use of the product.

(Revision Date 03/17)

Page 5 of 5
 SAFETY DATA SHEET Page: 1 of 5

Theophylline Revision: 02/06/2020

Supersedes Revision: 12/03/2017

according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 2015/830 and US OSHA HCS 2015

Section 1. Identification of the Substance/Mixture and of the Company/Undertaking

1.1 Product Code: 23760
Product Name: Theophylline
Synonyms: 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 1,3-Dimethylxanthine; NSC 2066;

1.2 Relevant identified uses of the substance or mixture and uses advised against:
Relevant identified uses: For research use only, not for human or veterinary use.

1.3 Details of the Supplier of the Safety Data Sheet:

Company Name: Cayman Chemical Company
1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
Web site address: www.caymanchem.com
Information: Cayman Chemical Company +1 (734)971-3335
1.4 Emergency telephone number:
Emergency Contact: CHEMTREC Within USA and Canada: +1 (800)424-9300
CHEMTREC Outside USA and Canada: +1 (703)527-3887

Section 2. Hazards Identification

2.1 Classification of the Substance or Mixture:
Acute Toxicity: Oral, Category 3
2.2 Label Elements:

GHS Signal Word: Danger

GHS Hazard Phrases:
H301: Toxic if swallowed.
GHS Precautionary Phrases:
P264: Wash {hands} thoroughly after handling.
GHS Response Phrases:
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
GHS Storage and Disposal Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.
UFI:
2.3 Adverse Human Health Material may be irritating to the mucous membranes and upper respiratory tract.
Effects and Symptoms: May be harmful by inhalation or skin absorption.
May cause eye, skin, or respiratory system irritation.
Toxic if swallowed.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated.

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Section 3. Composition/Information on Ingredients

CAS # / Hazardous Components (Chemical Name)/ Concentration EC No./ GHS Classification
RTECS # REACH Registration No. EC Index No.
58-55-9 Theophylline 100.0 % 200-385-7 Acute Tox.(O) 3: H301
XH3850000 01-2119450688-27 NA

Section 4. First Aid Measures

4.1 Description of First Aid
Measures:
In Case of Inhalation: Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel.
Get immediate medical attention.
In Case of Skin Contact: Immediately wash skin with soap and plenty of water for at least 15 minutes. Remove contaminated
clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
In Case of Eye Contact: Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyes examined
and tested by medical personnel.
In Case of Ingestion: Wash out mouth with water provided person is conscious. Never give anything by mouth to an
unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by
medical personnel.

Section 5. Fire Fighting Measures

5.1 Suitable Extinguishing Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.
Media: Use water spray to cool fire-exposed containers.
Unsuitable Extinguishing A solid water stream may be inefficient.
Media:
5.2 Flammable Properties andNo data available.
Hazards:
No data available.
Flash Pt: No data.
Explosive Limits: LEL: No data. UEL: No data.
Autoignition Pt: No data.
5.3 Fire Fighting Instructions: As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved or
equivalent), and full protective gear to prevent contact with skin and eyes.

Section 6. Accidental Release Measures

6.1 Protective Precautions, Avoid raising and breathing dust, and provide adequate ventilation.
Protective Equipment and As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator,
Emergency Procedures: and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).
6.2 Environmental Take steps to avoid release into the environment, if safe to do so.
Precautions:
6.3 Methods and Material For Contain spill and collect, as appropriate.
Containment and Cleaning Transfer to a chemical waste container for disposal in accordance with local regulations.
Up:

Section 7. Handling and Storage

7.1 Precautions To Be Taken Avoid breathing dust/fume/gas/mist/vapours/spray.
in Handling: Avoid prolonged or repeated exposure.
7.2 Precautions To Be Taken Keep container tightly closed.
in Storing: Store in accordance with information listed on the product insert.

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Section 8. Exposure Controls/Personal Protection

8.1 Exposure Parameters:
8.2 Exposure Controls:
8.2.1 Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne
(Ventilation etc.): levels below recommended exposure limits.
8.2.2 Personal protection equipment:
Eye Protection: Safety glasses
Protective Gloves: Compatible chemical-resistant gloves
Other Protective Clothing: Lab coat
Respiratory Equipment NIOSH approved respirator, as conditions warrant.
(Specify Type):
Work/Hygienic/Maintenan Do not take internally.
ce Practices: Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower.
Wash thoroughly after handling.
No data available.

Section 9. Physical and Chemical Properties

9.1 Information on Basic Physical and Chemical Properties
Physical States: [ ] Gas [ ] Liquid [ X ] Solid
Appearance and Odor: A solid
pH: No data.
Melting Point: No data.
Boiling Point: No data.
Flash Pt: No data.
Evaporation Rate: No data.
Flammability (solid, gas): No data available.
Explosive Limits: LEL: No data. UEL: No data.
Vapor Pressure (vs. Air or mm No data.
Hg):
Vapor Density (vs. Air = 1): No data.
Specific Gravity (Water = 1): No data.
Solubility in Water: No data.
Solubility Notes: Soluble (slightly) in: MeOH; DMSO;
Octanol/Water Partition No data.
Coefficient:
Autoignition Pt: No data.
Decomposition Temperature: No data.
Viscosity: No data.
9.2 Other Information
Percent Volatile: No data.
Molecular Formula & Weight: C7H8N4O2 180.2

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Section 10. Stability and Reactivity

10.1 Reactivity: No data available.
10.2 Stability: Unstable [ ] Stable [ X ]
10.3 Stability Note(s): Stable if stored in accordance with information listed on the product insert.
Polymerization: Will occur [ ] Will not occur [ X ]
10.4 Conditions To Avoid: No data available.
10.5 Incompatibility - Materials strong oxidizing agents
To Avoid:
10.6 Hazardous carbon dioxide
Decomposition or carbon monoxide
Byproducts: nitrogen oxides

Section 11. Toxicological Information

11.1 Information on The toxicological effects of this product have not been thoroughly studied.
Toxicological Effects: Theophylline - Toxicity Data: Oral TDLO (woman): 5 mg/kg; Oral TDLO (man): 66 mg/kg;
Subcutaneous TDLO (human): 3500 ug/kg; Oral LD50 (rat): 225 mg/kg; Intraperitoneal LD50 (rat):
150 mg/kg; Subcutaneous LDLO (rat): 325 mg/kg; Oral LD50 (mouse): 235 mg/kg; Intraperitoneal
LD50 (mouse): 70 mg/kg; Subcutaneous LD50 (mouse): 138 mg/kg;
Chronic Toxicological Theophylline - Investigated as a drug, mutagen, natural product, reproductive effector, and
Effects: tumorigen.
Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.
See actual entry in RTECS for complete information.
Theophylline RTECS Number: XH3850000

CAS # Hazardous Components (Chemical Name) NTP IARC ACGIH OSHA

58-55-9 Theophylline n.a. 3 n.a. n.a.

Section 12. Ecological Information

12.1 Toxicity: Avoid release into the environment.
Runoff from fire control or dilution water may cause pollution.
12.2 Persistence and No data available.
Degradability:
12.3 Bioaccumulative No data available.
Potential:
12.4 Mobility in Soil: No data available.
12.5 Results of PBT and vPvB No data available.
assessment:
12.6 Other adverse effects: No data available.

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Section 13. Disposal Considerations

13.1 Waste Disposal Method: Dispose in accordance with local, state, and federal regulations.

Section 14. Transport Information

14.1 LAND TRANSPORT (US DOT):
DOT Proper Shipping Name: Toxic solid, organic, n.o.s. (Theophylline)
DOT Hazard Class: 6.1 POISON
UN/NA Number: UN2811 Packing Group: III

14.1 LAND TRANSPORT (European ADR/RID):

ADR/RID Shipping Name: Toxic solid, organic, n.o.s. (Theophylline)
UN Number: 2811 Packing Group: III
Hazard Class: 6.1 - POISON
14.3 AIR TRANSPORT (ICAO/IATA):
ICAO/IATA Shipping Name: Toxic solid, organic, n.o.s. (Theophylline)
UN Number: 2811 Packing Group: III
Hazard Class: 6.1 - POISON IATA Classification: 6.1
Additional Transport Transport in accordance with local, state, and federal regulations.
Information: When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as Dangerous Goods/Excepted Quantity.

Section 15. Regulatory Information

EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists
CAS # Hazardous Components (Chemical Name) S. 302 (EHS) S. 304 RQ S. 313 (TRI)
58-55-9 Theophylline No No No

CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists

58-55-9 Theophylline CAA HAP,ODC: No; CWA NPDES: No; TSCA: Yes -
Inventory; CA PROP.65: No

Regulatory Information This SDS was prepared in accordance with 29 CFR 1910.1200 and Regulation (EC)
Statement: No.1272/2008.

Section 16. Other Information

Revision Date:
Additional Information About
This Product:
Company Policy or Disclaimer:
02/06/2020
No data available.
DISCLAIMER: This information is believed to be accurate and represents the best information
currently available to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability resulting from its
use. Users should make their own investigations to determine the suitability of the information for
their particular purposes.

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 SDS AquaPro
Conforms to HazCom 2012/United States

SAFETY DATA SHEET

AquaPro®
Section 1. Identification
GHS product identifier : AquaPro® Herbicide
Other means of : Not available.
identification
EPA Registration No. : 62719-324-67690

Supplier's details : SePRO Corporation

11550 North Meridian Street
Suite 600
Carmel, IN 46032 U.S.A.
Tel: 317-580-8282
Toll free: 1-800-419-7779
Fax: 317-580-8290
Monday - Friday, 8am to 5pm E.S.T.
www.sepro.com

Emergency telephone : INFOTRAC - 24-hour service 1-800-535-5053

number (with hours of
operation)

The following recommendations for exposure controls and personal protection are intended for the manufacture, formulation and packaging of this product.
For applications and/or use, consult the product label. The label directions supersede the text of this Safety Data Sheet for application and/or use.

Section 2. Hazards identification

Hazard classification This material is not hazardous under the criteria of the Federal OSHA Hazard Communication
Standard 29CFR 1910.1200.

Other hazards No data available

Section 3. Composition/information on ingredients

This product is a mixture.

Ingredient name % CAS number

Glyphosate IPA Salt 53.8 38641-94-0
Isopropylamine 1.0 75-31-0
Balance 45.2 Not Available

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 SDS AquaPro
Section 4. First aid measures
Description of first aid measures

Inhalation: Move person to fresh air. If person is not breathing, call an emergency responder or
ambulance, then give artificial respiration; if by mouth to mouth use rescuer protection (pocket
mask etc). Call a poison control center or doctor for treatment advice.

Skin contact: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes.
Call a poison control center or doctor for treatment advice.

Eye contact: Hold eyes open and rinse slowly and gently with water for 15-20 minutes. Remove contact
lenses, if present, after the first 5 minutes, then continue rinsing eyes. Call a poison control
center or doctor for treatment advice.

Ingestion: No emergency medical treatment necessary.

Most important symptoms

and effects, both acute
and delayed: Aside from the information found under Description of first aid measures (above) and
Indication of immediate medical attention and special treatment needed (below), any
additional important symptoms and effects are described in Section 11: Toxicology
Information.

Indication of any immediate medical attention and special treatment needed

Notes to physician: No specific antidote. Treatment of exposure should be directed at the control of symptoms
and the clinical condition of the patient. Have the Safety Data Sheet, and if available, the
product container or label with you when calling a poison control center or doctor, or going for
treatment.

Section 5. Fire-fighting measures

Suitable extinguishing media: To extinguish combustible residues of this product use water fog, carbon dioxide, dry
chemical or foam. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers. Foam.
Straight or direct water streams may not be effective to extinguish fire. General purpose
synthetic foams (including AFFF type) or protein foams are preferred if available. Alcohol
resistant foams (ATC type) may function.

Unsuitable extinguishing
media: no data available

Special hazards arising from the substance or mixture

Hazardous combustion
products: During a fire, smoke may contain the original material in addition to combustion products of
varying composition which may be toxic and/or irritating.

Unusual Fire and

Explosion Hazards: This material will not burn until the water has evaporated. Residue can burn. Container may
vent and/or rupture due to fire. Electrically ground and bond all equipment. Flammable
mixtures of this product are readily ignited even by static discharge. May produce flash fire.
Vapors are heavier than air and may travel a long distance and accumulate in low lying areas.

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 SDS AquaPro
Ignition and/or flash back may occur. Flammable mixtures may exist within the vapor space of
containers at room temperature.

Advice for firefighters

Fire Fighting Procedures:
Keep people away. Isolate fire and deny unnecessary entry. Stay upwind. Keep out of low
areas where gases (fumes) can accumulate. Water may not be effective in extinguishing fire.
Eliminate ignition sources. Move container from fire area if this is possible without hazard. To
extinguish combustible residues of this product use water fog, carbon dioxide, dry chemical or
foam. Contain fire water run-off if possible. Fire water run-off, if not contained, may cause
environmental damage. Review the "Accidental Release Measures" and the "Ecological
Information" sections of this SDS.

Special protective
equipment for firefighters:
Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting
clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). Avoid contact with
this material during fire fighting operations. If contact is likely, change to full chemical resistant
fire fighting clothing with self-contained breathing apparatus. If this is not available, wear full
chemical resistant clothing with self-contained breathing apparatus and fight fire from a
remote location. For protective equipment in post-fire or non-fire clean-up situations, refer to
the relevant sections.

Section 6. Accidental release measures

Personal precautions,
protective equipment and
emergency procedures:
Isolate area. Refer to section 7, Handling, for additional precautionary measures. Keep
unnecessary and unprotected personnel from entering the area. Keep personnel out of low
areas. No smoking in area. Eliminate all sources of ignition in vicinity of spill or released vapor
to avoid fire or explosion. Vapor explosion hazard. Keep out of sewers. For large spills, warn
public of downwind explosion hazard. Check area with combustible gas detector before
reentering area. Ground and bond all containers and handling equipment. Use appropriate
safety equipment. For additional information, refer to Section 8, Exposure Controls and
Personal Protection.

Environmental precautions: Prevent from entering into soil, ditches, sewers, waterways and/or groundwater. See Section
12, Ecological Information.

Methods and materials for

containment and cleaning up: Contain spilled material if possible. Pump with explosion-proof equipment. If available, use
foam to smother or suppress. Absorb with materials such as: Clay. Dirt. Sand. Sweep up.
Collect in suitable and properly labeled containers. Large spills: Contact SePRO Corporation
for clean-up assistance. See Section 13, Disposal Considerations, for additional information.

Section 7. Handling and storage

Precautions for safe
handling: Keep away from heat, sparks and flame. No smoking, open flames or sources of ignition in
handling and storage area. Electrically bond and ground all containers and equipment before
transfer or use of material. Use of non-sparking or explosion-proof equipment may be
necessary, depending upon the type of operation. Containers, even those that have been
emptied, can contain vapors. Do not cut, drill, grind, weld, or perform similar operations on or
near empty containers. Vapors are heavier than air and may travel a long distance and
accumulate in low lying areas. Ignition and/or flash back may occur. Never use air pressure
for transferring product. Keep out of reach of children. Do not swallow. Avoid breathing vapor
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 SDS AquaPro
or mist. Avoid contact with eyes, skin, and clothing. Use with adequate ventilation. Wash
thoroughly after handling. Keep container closed.

Conditions for safe storage: Minimize sources of ignition, such as static build-up, heat, spark or flame. Keep container
closed. Do not store in: Carbon steel. Galvanized containers. Steel. Flammable mixtures may
exist within the vapor space of containers at room temperature. Store in a dry place. Store in
original container. Do not store near food, foodstuffs, drugs or potable water supplies.

Section 8. Exposure controls/personal protection

Control parameters

Exposure limits are listed below, if they exist.

Component Regulation Type of listing Value/Notation
Isopropylamine ACGIH TWA 5 ppm
ACGIH STEL 10 ppm
OSHA Z-1 TWA 12 mg/m3 5 ppm

RECOMMENDATIONS IN THIS SECTION ARE FOR MANUFACTURING, COMMERCIAL BLENDING AND PACKAGING
WORKERS. APPLICATORS AND HANDLERS SHOULD SEE THE PRODUCT LABEL FOR PROPER PERSONAL
PROTECTIVE EQUIPMENT AND CLOTHING.

Exposure controls
Engineering controls: Good general ventilation should be sufficient for most conditions. Local exhaust ventilation
may be necessary for some operations.

Individual protection measures

Eye/face protection: Use safety glasses (with side shields).
Skin protection
Hand protection: Chemical protective gloves should not be needed when handling this material. Consistent with
general hygienic practice for any material, skin contact should be minimized.
Other protection: No precautions other than clean body-covering clothing should be needed.

Respiratory protection: Atmospheric levels should be maintained below the exposure guideline. When respiratory
protection is required for certain operations, use an approved air-purifying respirator.
The following should be effective types of air-purifying respirators: Organic vapor cartridge
with a particulate pre-filter.

Section 9. Physical and chemical properties

Appearance
Physical State Liquid
Color Yellow
Odor Odorless
Odor Threshold No test data available
pH 4.6 1% NAPM 11A.00 1% aqueous solution
Melting point/range Not applicable
Freezing point No test data available
Boiling point (760 mmHg) 110 °C (230 °F)
Flash point Closed cup > 93 °C (>199 °F) Setaflash Closed Cup ASTM D3828
none below boiling point
Evaporation Rate
(Butyl Acetate =1) No test data available
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Flammability (solid, gas)
Lower explosion limit
Upper lower explosion limit
Vapor pressure
Relative Vapor Density
(air = 1)
Relative Density (water = 1)
Water solubility
Partition coefficient:
n-octanol/water
Auto-ignition temperature
Decomposition temperature
Dynamic Viscosity
Kinematic Viscosity
Explosive properties
Oxidizing properties
Liquid Density
Molecular weight
NOTE: The physical data presented above are typical values and should not be construed as a specification.
Section 10. Stability and reactivity
Reactivity:
Chemical stability:
Possibility of hazardous
reactions:
Conditions to avoid:
Incompatible materials:
Hazardous decomposition
products:
Section 11. Toxicological information
Toxicological information appears in this section when such data is available.
Acute toxicity
Acute oral toxicity
Acute dermal toxicity
Acute inhalation toxicity
Skin corrosion/irritation
®: AquaPRO is a registered trademark of Dow Agrosciences LLC.
SDS AquaPro
Not applicable
No test data available
No test data available
No test data available
No test data available
1.2 at 22 °C (72 °F) / 4 °C Pyknometer
Soluble
No data available
None below 400 °C
No test data available
64.6 mPa.s at 20 °C (68 °F)
53.4 mm2/s at 20 °C (68 °F)
No Koenen Apparatus
No data available
1.20 g/cm3 at 20 °C (68 °F) Digital density meter
No data available
No data available
Thermally stable at recommended temperatures and pressures.
Polymerization will not occur.
Active ingredient decomposes at elevated temperatures. Avoid static discharge.
Heat produced by the reaction with water will cause vaporization. Flammable hydrogen may
be generated from contact with metals such as:
Decomposition products depend upon temperature, air supply and the presence of other
materials.
Very low toxicity if swallowed. Harmful effects not anticipated from swallowing small amounts.
LD50, Rat, > 5,000 mg/kg
Prolonged skin contact is unlikely to result in absorption of harmful amounts.
LD50, Rabbit,> 5,000 mg/kg
Brief exposure (minutes) is not likely to cause adverse effects.
LC50, Rat, 4 Hour, Aerosol, > 6.37 mg/L
Essentially nonirritating to skin.
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 SDS AquaPro
Serious eye damage/
eye irritation May cause slight temporary eye irritation. Corneal injury is unlikely.

Sensitization Did not cause allergic skin reactions when tested in guinea pigs.

Respiratory sensitization: No relevant data found.

Specific Target Organ

Systemic Toxicity
(Single Exposure) Evaluation of available data suggests that this material is not an STOT-SE toxicant.

Specific Target Organ

Systemic Toxicity
(Repeated Exposure) For similar material(s): Glyphosate.
In animals, effects have been reported on the following organs: Liver.

Carcinogenicity For similar material(s): Glyphosate. Did not cause cancer in laboratory animals.

Teratogenicity For the active ingredient(s): Available data are inadequate for evaluation of potential to cause
birth defects.

Reproductive toxicity For the active ingredient(s): Available data are inadequate to determine effects on
reproduction.

Mutagenicity For the active ingredient(s): In vitro genetic toxicity studies were negative in some cases and
positive in other cases.
For similar material(s): Glyphosate. In vitro genetic toxicity studies were negative. Animal genetic
toxicity studies were negative.

Aspiration Hazard Based on physical properties, not likely to be an aspiration hazard.

Section 12. Ecological information

Ecotoxicological information appears in this section when such data is available.

Acute toxicity to fish Material is practically non-toxic to aquatic organisms on an acute basis
(LC50/EC50/EL50/LL50 > 100 mg/L in the most sensitive species tested).

LC50, Oncorhynchus mykiss (rainbow trout), 96 Hour, > 2,500 mg/L,

OECD Test Guideline 203 or Equivalent

Acute toxicity to
aquatic invertebrates EC50, Daphnia magna (Water flea), 48 Hour, 918 mg/L,
OECD Test Guideline 202 or Equivalent

Acute toxicity to
algae/aquatic plants EC50, Pseudokirchneriella subcapitata (green algae), 72 Hour, Biomass, 10- 127 mg/L,
OECD Test Guideline 201 or Equivalent

Toxicity to
Above Ground Organisms Material is practically non-toxic to birds on an acute basis (LD50 > 2000 mg/kg).
oral LD50, Colinus virginianus (Bobwhite quail), > 2,000 mg/kg
contact LD50, Apis mellifera (bees), > 100µg/bee
oral LD50, Apis mellifera (bees), > 100µg/bee

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®: AquaPRO is a registered trademark of Dow Agrosciences LLC.


Persistence and degradability
Biodegradability:
SDS AquaPro
Based on stringent OECD test guidelines, this material cannot be considered as readily
biodegradable; however, these results do not necessarily mean that the material is not
biodegradable under environmental conditions. For similar active ingredient(s).
Biodegradation may occur under aerobic conditions (in the presence of oxygen).

Bloaccumulative potential
Bioaccumulation: For similar active ingredient(s). Bioconcentration potential is low (BCF < 100 or Log Pow< 3).

Mobility in soil For similar active ingredient(s): Expected to be relatively immobile in soil (Koc > 5000).

Section 13. Disposal considerations

Disposal methods: If wastes and/or containers cannot be disposed of according to the product label directions,
disposal of this material must be in accordance with your local or area regulatory authorities.
This information presented below only applies to the material as supplied. The identification
based on characteristic(s) or listing may not apply if the material has been used or otherwise
contaminated. It is the responsibility of the waste generator to determine the toxicity and
physical properties of the material generated to determine the proper waste identification and
disposal methods in compliance with applicable regulations. If the material as supplied
becomes a waste, follow all applicable regional, national and local laws.

Section 14. Transport information

DOT Not regulated for transport

Classification for
SEA transport (IMO-IMDG): Not regulated for transport

Transport in bulk Consult IMO regulations before transporting ocean bulk

according to Annex I or II
of MARPOL 73/78 and the
IBC or IGC Code

Classification for AIR

transport (IATA/ICAO): Not regulated for transport

This information is not intended to convey all specific regulatory or operational requirements/information relating to this product.
Transportation classifications may vary by container volume and may be influenced by regional or country variations in regulations.
Additional transportation system information can be obtained through an authorized sales or customer service representative. It is the
responsibility of the transporting organization to follow all applicable laws, regulations and rules relating to the transportation of the
material.

Section 15. Regulatory information

OSHA Hazard
Communication Standard This product is not a "Hazardous Chemical" as defined by the OSHA Hazard Communication
Standard, 29 CFR 1910.1200.

Superfund Amendments and

Reauthorization Act of 1986
Title Ill (Emergency Planning

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®: AquaPRO is a registered trademark of Dow Agrosciences LLC.

 SDS AquaPro
and Community Right-to-
Know Act of 1986)
Sections 311 and 312 Chronic Health Hazard

Superfund Amendments and

Reauthorization Act of 1986
Title Ill (Emergency Planning
and Community Right-to-
Know Act of 1986)
Section 313 This material does not contain any chemical components with known CAS numbers that
exceed the threshold (De Minimis) reporting levels established by SARA Title Ill, Section 313.

California Proposition 65
(Safe Drinking Water and
Toxic Enforcement Act
of 1986) This product contains no listed substances known to the State of California to cause cancer,
birth defects or other reproductive harm, at levels which would require a warning under the
statute.

Pennsylvania (Worker and

Community Right-To-Know
Act): Pennsylvania Hazardous
Substances List and/or
Pennsylvania Environmental
Hazardous Substance List: The following product components are cited in the Pennsylvania Hazardous Substance List
and/or the Pennsylvania Environmental Substance List, and are present at levels which
require reporting.

Components CASRN
lsopropylamine 75-31-0

Pennsylvania (Worker and

Community Right-To-Know
Act): Pennsylvania Special
Hazardous Substances List: To the best of our knowledge, this product does not contain chemicals at levels which require
reporting under this statute.

United States TSCA Inventory This product contains chemical substance(s) exempt from U.S. EPA TSCA Inventory
requirements. It is regulated as a pesticide subject to Federal Insecticide, Fungicide, and
Rodenticide Act (FIFRA) requirements.

Federal Insecticide, Fungicide

and Rodenticide Act
This chemical is a pesticide product registered by the Environmental Protection Agency and is
subject to certain labeling requirements under federal pesticide law. These requirements differ
from the classification criteria and hazard information required for safety data sheets, and for
workplace labels of non-pesticide chemicals. Following is the hazard information as required
on the pesticide label:

CAUTION
Harmful if inhaled

Section 16. Other information

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®: AquaPRO is a registered trademark of Dow Agrosciences LLC.

 SDS AquaPro
Hazard Rating System
NFPA

Health: 1 Fire: 1 Reactivity: 0

Legend
ACGIH USA. ACGIH Threshold Limit Values (TLV
OSHA Z-1 USA. Occupational Exposure Limits (OSHA) - Table Z-1 Limits for Air Contaminants
STEL Short-term exposure limit
TWA 8-hour, time-weighted average

History
Date of issue: 08/11/2015

Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above -named supplier, nor any of its subsidiaries,
assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any
material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards
are described herein, we cannot guarantee that these are the only hazards that exist.

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®: AquaPRO is a registered trademark of Dow Agrosciences LLC.